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Items: 1 to 50 of 259

1.

Should we target TNF receptors in the intestinal epithelium with glucocorticoids during systemic inflammation?

Van Looveren K, Libert C.

Expert Opin Ther Targets. 2018 Oct 20:1-9. doi: 10.1080/14728222.2018.1539078. [Epub ahead of print]

PMID:
30343600
2.

Do people living with HIV experience greater age advancement than their HIV-negative counterparts?

De Francesco D, Wit FW, Bürkle A, Oehlke S, Kootstra NA, Winston A, Franceschi C, Garagnani P, Pirazzini C, Libert C, Grune T, Weber D, Jansen EHJM, Sabin CA, Reiss P; The Co-morBidity in Relation to AIDS (COBRA) Collaboration.

AIDS. 2018 Oct 16. doi: 10.1097/QAD.0000000000002063. [Epub ahead of print]

PMID:
30325781
3.

Easy Access to and Applications of the Sequences of All Protein-Coding Genes of All Sequenced Mouse Strains.

Timmermans S, Libert C.

Trends Genet. 2018 Sep 19. pii: S0168-9525(18)30150-1. doi: 10.1016/j.tig.2018.08.007. [Epub ahead of print]

PMID:
30243593
4.

Correction to: Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis.

Osuchowski MF, Ayala A, Bahrami S, Bauer M, Boros M, Cavaillon JM, Chaudry IH, Coopersmith CM, Deutschman C, Drechsler S, Efron P, Frostell C, Fritsch G, Gozdzik W, Hellman J, Huber-Lang M, Inoue S, Knapp S, Kozlov AV, Libert C, Marshall JC, Moldawer LL, Radermacher P, Redl H, Remick DG, Singer M, Thiemermann C, Wang P, Wiersinga WJ, Xiao X, Zingarelli B.

Infection. 2018 Oct;46(5):745-747. doi: 10.1007/s15010-018-1197-2.

5.

The autophagy receptor SQSTM1/p62 mediates anti-inflammatory actions of the selective NR3C1/glucocorticoid receptor modulator compound A (CpdA) in macrophages.

Mylka V, Deckers J, Ratman D, De Cauwer L, Thommis J, De Rycke R, Impens F, Libert C, Tavernier J, Vanden Berghe W, Gevaert K, De Bosscher K.

Autophagy. 2018;14(12):2049-2064. doi: 10.1080/15548627.2018.1495681. Epub 2018 Sep 14.

PMID:
30215534
6.

Inhibition of MALT1 decreases neuroinflammation and pathogenicity of virulent rabies virus in mice.

Kip E, Staal J, Tima HG, Verstrepen L, Romano M, Lemeire K, Suin V, Hamouda A, Baens M, Libert C, Kalai M, Van Gucht S, Beyaert R.

J Virol. 2018 Aug 29. pii: JVI.00720-18. doi: 10.1128/JVI.00720-18. [Epub ahead of print]

PMID:
30158289
7.

A screening assay for Selective Dimerizing Glucocorticoid Receptor Agonists and Modulators (SEDIGRAM) that are effective against acute inflammation.

Souffriau J, Eggermont M, Van Ryckeghem S, Van Looveren K, Van Wyngene L, Van Hamme E, Vuylsteke M, Beyaert R, De Bosscher K, Libert C.

Sci Rep. 2018 Aug 27;8(1):12894. doi: 10.1038/s41598-018-31150-w.

8.

Overexpression of Gilz Protects Mice Against Lethal Septic Peritonitis.

Ballegeer M, Vandewalle J, Eggermont M, Van Isterdael G, Dejager L, De Bus L, Decruyenaere J, Vandenbroucke RE, Libert C.

Shock. 2018 Aug 17. doi: 10.1097/SHK.0000000000001252. [Epub ahead of print]

PMID:
30124596
9.

Minimum quality threshold in pre-clinical sepsis studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis.

Osuchowski MF, Ayala A, Bahrami S, Bauer M, Boros M, Cavaillon JM, Chaudry IH, Coopersmith CM, Deutschman C, Drechsler S, Efron P, Frostell C, Fritsch G, Gozdzik W, Hellman J, Huber-Lang M, Inoue S, Knapp S, Kozlov AV, Libert C, Marshall JC, Moldawer LL, Radermacher P, Redl H, Remick DG, Singer M, Thiemermann C, Wang P, Wiersinga WJ, Xiao X, Zingarelli B.

Intensive Care Med Exp. 2018 Aug 14;6(1):26. doi: 10.1186/s40635-018-0189-y. Review.

10.

Minimum Quality Threshold in Pre-Clinical Sepsis Studies (Mqtipss): An International Expert Consensus Initiative for Improvement of Animal Modeling in Sepsis.

Osuchowski MF, Ayala A, Bahrami S, Bauer M, Boros M, Cavaillon JM, Chaudry IH, Coopersmith CM, Deutschman CS, Drechsler S, Efron P, Frostell C, Fritsch G, Gozdzik W, Hellman J, Huber-Lang M, Inoue S, Knapp S, Kozlov AV, Libert C, Marshall JC, Moldawer LL, Radermacher P, Redl H, Remick DG, Singer M, Thiemermann C, Wang P, Wiersinga WJ, Xiao X, Zingarelli B.

Shock. 2018 Oct;50(4):377-380. doi: 10.1097/SHK.0000000000001212.

11.

Part II: Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS) for Types of Infections and Organ Dysfunction Endpoints.

Libert C, Ayala A, Bauer M, Cavaillon JM, Deutschman C, Frostell C, Knapp S, Kozlov AV, Wang P, Osuchowski MF, Remick DG.

Shock. 2018 Aug 14. doi: 10.1097/SHK.0000000000001242. [Epub ahead of print]

PMID:
30106873
12.

Minimum Quality Threshold in Pre-Clinical Sepsis Studies (MQTiPSS): an international expert consensus initiative for improvement of animal modeling in sepsis.

Osuchowski MF, Ayala A, Bahrami S, Bauer M, Boros M, Cavaillon JM, Chaudry IH, Coopersmith CM, Deutschman C, Drechsler S, Efron P, Frostell C, Fritsch G, Gozdzik W, Hellman J, Huber-Lang M, Inoue S, Knapp S, Kozlov AV, Libert C, Marshall JC, Moldawer LL, Radermacher P, Redl H, Remick DG, Singer M, Thiemermann C, Wang P, Wiersinga WJ, Xiao X, Zingarelli B.

Infection. 2018 Oct;46(5):687-691. doi: 10.1007/s15010-018-1183-8. Review. Erratum in: Infection. 2018 Sep 17;:.

13.

IFN-γ stimulates CpG-induced IL-10 production in B cells via p38 and JNK signalling pathways.

Imbrechts M, De Samblancx K, Fierens K, Brisse E, Vandenhaute J, Mitera T, Libert C, Smets I, Goris A, Wouters C, Matthys P.

Eur J Immunol. 2018 Sep;48(9):1506-1521. doi: 10.1002/eji.201847578. Epub 2018 Aug 1.

PMID:
30004580
14.

Overview of inactivating mutations in the protein-coding genome of the mouse reference strain C57BL/6J.

Timmermans S, Libert C.

JCI Insight. 2018 Jul 12;3(13). pii: 121758. doi: 10.1172/jci.insight.121758. [Epub ahead of print]

15.

Reprogramming of basic metabolic pathways in microbial sepsis: therapeutic targets at last?

Van Wyngene L, Vandewalle J, Libert C.

EMBO Mol Med. 2018 Aug;10(8). pii: e8712. doi: 10.15252/emmm.201708712. Review.

16.

Using the inbred mouse strain SPRET/EiJ to provide novel insights in inflammation and infection research.

Timmermans S, Souffriau J, Vandewalle J, Van Wyngene L, Van Looveren K, Vanderhaeghen T, Libert C.

Mamm Genome. 2018 Aug;29(7-8):585-592. doi: 10.1007/s00335-018-9751-x. Epub 2018 Jun 9. Review.

PMID:
29947962
17.

A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation.

Voet S, Mc Guire C, Hagemeyer N, Martens A, Schroeder A, Wieghofer P, Daems C, Staszewski O, Vande Walle L, Jordao MJC, Sze M, Vikkula HK, Demeestere D, Van Imschoot G, Scott CL, Hoste E, Gonçalves A, Guilliams M, Lippens S, Libert C, Vandenbroucke RE, Kim KW, Jung S, Callaerts-Vegh Z, Callaerts P, de Wit J, Lamkanfi M, Prinz M, van Loo G.

Nat Commun. 2018 May 23;9(1):2036. doi: 10.1038/s41467-018-04376-5.

18.

Learning lessons in sepsis from the children.

Timmermans S, Libert C.

Mol Syst Biol. 2018 May 17;14(5):e8335. doi: 10.15252/msb.20188335. No abstract available.

19.

A New Venue of TNF Targeting.

Steeland S, Libert C, Vandenbroucke RE.

Int J Mol Sci. 2018 May 11;19(5). pii: E1442. doi: 10.3390/ijms19051442. Review.

20.

Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice.

Ballegeer M, Van Looveren K, Timmermans S, Eggermont M, Vandevyver S, Thery F, Dendoncker K, Souffriau J, Vandewalle J, Van Wyngene L, De Rycke R, Takahashi N, Vandenabeele P, Tuckermann J, Reichardt HM, Impens F, Beyaert R, De Bosscher K, Vandenbroucke RE, Libert C.

J Clin Invest. 2018 Aug 1;128(8):3265-3279. doi: 10.1172/JCI96636. Epub 2018 Jun 25.

21.

The 'COmorBidity in Relation to AIDS' (COBRA) cohort: Design, methods and participant characteristics.

De Francesco D, Wit FW, Cole JH, Kootstra NA, Winston A, Sabin CA, Underwood J, van Zoest RA, Schouten J, Kooij KW, Prins M, Guaraldi G, Caan MWA, Burger D, Franceschi C, Libert C, Bürkle A, Reiss P; COmorBidity in Relation to AIDS (COBRA) collaboration.

PLoS One. 2018 Mar 29;13(3):e0191791. doi: 10.1371/journal.pone.0191791. eCollection 2018.

22.

Genetic mapping of species differences via in vitro crosses in mouse embryonic stem cells.

Lazzarano S, Kučka M, Castro JPL, Naumann R, Medina P, Fletcher MNC, Wombacher R, Gribnau J, Hochepied T, Van Montagu M, Libert C, Chan YF.

Proc Natl Acad Sci U S A. 2018 Apr 3;115(14):3680-3685. doi: 10.1073/pnas.1717474115. Epub 2018 Mar 21.

23.

How Good Roommates Can Protect against Microbial Sepsis.

Beyaert R, Libert C.

Cell Host Microbe. 2018 Mar 14;23(3):283-285. doi: 10.1016/j.chom.2018.02.007.

PMID:
29544090
24.

Alterations of the serum N-glycan profile in female patients with Major Depressive Disorder.

Boeck C, Pfister S, Bürkle A, Vanhooren V, Libert C, Salinas-Manrique J, Dietrich DE, Kolassa IT, Karabatsiakis A.

J Affect Disord. 2018 Jul;234:139-147. doi: 10.1016/j.jad.2018.02.082. Epub 2018 Feb 27.

PMID:
29529546
25.

Counteracting the effects of TNF receptor-1 has therapeutic potential in Alzheimer's disease.

Steeland S, Gorlé N, Vandendriessche C, Balusu S, Brkic M, Van Cauwenberghe C, Van Imschoot G, Van Wonterghem E, De Rycke R, Kremer A, Lippens S, Stopa E, Johanson CE, Libert C, Vandenbroucke RE.

EMBO Mol Med. 2018 Apr;10(4). pii: e8300. doi: 10.15252/emmm.201708300.

26.

The E3 ubiquitin ligases HOIP and cIAP1 are recruited to the TNFR2 signaling complex and mediate TNFR2-induced canonical NF-κB signaling.

Borghi A, Haegman M, Fischer R, Carpentier I, Bertrand MJM, Libert C, Afonina IS, Beyaert R.

Biochem Pharmacol. 2018 Jul;153:292-298. doi: 10.1016/j.bcp.2018.01.039. Epub 2018 Jan 31.

PMID:
29378181
27.

Mechanistic insights into the protective impact of zinc on sepsis.

Souffriau J, Libert C.

Cytokine Growth Factor Rev. 2018 Feb;39:92-101. doi: 10.1016/j.cytogfr.2017.12.002. Epub 2017 Dec 22. Review.

PMID:
29279185
28.

The choroid plexus epithelium as a novel player in the stomach-brain axis during Helicobacter infection.

Gorlé N, Blaecher C, Bauwens E, Vandendriessche C, Balusu S, Vandewalle J, Van Cauwenberghe C, Van Wonterghem E, Van Imschoot G, Liu C, Ducatelle R, Libert C, Haesebrouck F, Smet A, Vandenbroucke RE.

Brain Behav Immun. 2018 Mar;69:35-47. doi: 10.1016/j.bbi.2017.12.010. Epub 2017 Dec 16.

PMID:
29258921
29.

Therapeutic Mechanisms of Glucocorticoids.

Vandewalle J, Luypaert A, De Bosscher K, Libert C.

Trends Endocrinol Metab. 2018 Jan;29(1):42-54. doi: 10.1016/j.tem.2017.10.010. Epub 2017 Nov 20. Review.

PMID:
29162310
30.

Simultaneous Inhibition of Tumor Necrosis Factor Receptor 1 and Matrix Metalloproteinase 8 Completely Protects Against Acute Inflammation and Sepsis.

Steeland S, Van Ryckeghem S, Vandewalle J, Ballegeer M, Van Wonterghem E, Eggermont M, Decruyenaere J, De Bus L, Libert C, Vandenbroucke RE.

Crit Care Med. 2018 Jan;46(1):e67-e75. doi: 10.1097/CCM.0000000000002813.

PMID:
29095202
31.

TNFR1 inhibition with a Nanobody protects against EAE development in mice.

Steeland S, Van Ryckeghem S, Van Imschoot G, De Rycke R, Toussaint W, Vanhoutte L, Vanhove C, De Vos F, Vandenbroucke RE, Libert C.

Sci Rep. 2017 Oct 20;7(1):13646. doi: 10.1038/s41598-017-13984-y.

32.

Dual-Specificity Phosphatase 3 Deletion Protects Female, but Not Male, Mice from Endotoxemia-Induced and Polymicrobial-Induced Septic Shock.

Vandereyken MM, Singh P, Wathieu CP, Jacques S, Zurashvilli T, Dejager L, Amand M, Musumeci L, Singh M, Moutschen MP, Libert CRF, Rahmouni S.

J Immunol. 2017 Oct 1;199(7):2515-2527. doi: 10.4049/jimmunol.1602092. Epub 2017 Aug 28.

33.

Glucocorticoid Receptor-mediated transactivation is hampered by Striatin-3, a novel interaction partner of the receptor.

Petta I, Bougarne N, Vandewalle J, Dejager L, Vandevyver S, Ballegeer M, Desmet S, Thommis J, De Cauwer L, Lievens S, Libert C, Tavernier J, De Bosscher K.

Sci Rep. 2017 Aug 21;7(1):8941. doi: 10.1038/s41598-017-09246-6.

34.

Complete overview of protein-inactivating sequence variations in 36 sequenced mouse inbred strains.

Timmermans S, Van Montagu M, Libert C.

Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):9158-9163. doi: 10.1073/pnas.1706168114. Epub 2017 Aug 7. Review.

35.

A knock-in/knock-out mouse model of HSPB8-associated distal hereditary motor neuropathy and myopathy reveals toxic gain-of-function of mutant Hspb8.

Bouhy D, Juneja M, Katona I, Holmgren A, Asselbergh B, De Winter V, Hochepied T, Goossens S, Haigh JJ, Libert C, Ceuterick-de Groote C, Irobi J, Weis J, Timmerman V.

Acta Neuropathol. 2018 Jan;135(1):131-148. doi: 10.1007/s00401-017-1756-0. Epub 2017 Aug 5.

36.

The nature of the GRE influences the screening for GR-activity enhancing modulators.

Dendoncker K, Timmermans S, Van Looveren K, De Cauwer L, De Bosscher K, Libert C.

PLoS One. 2017 Jul 7;12(7):e0181101. doi: 10.1371/journal.pone.0181101. eCollection 2017.

37.

Airway Epithelial Cells Are Crucial Targets of Glucocorticoids in a Mouse Model of Allergic Asthma.

Klaßen C, Karabinskaya A, Dejager L, Vettorazzi S, Van Moorleghem J, Lühder F, Meijsing SH, Tuckermann JP, Bohnenberger H, Libert C, Reichardt HM.

J Immunol. 2017 Jul 1;199(1):48-61. doi: 10.4049/jimmunol.1601691. Epub 2017 May 17.

38.

Glucocorticoid resistance as a major drive in sepsis pathology.

Dendoncker K, Libert C.

Cytokine Growth Factor Rev. 2017 Jun;35:85-96. doi: 10.1016/j.cytogfr.2017.04.002. Epub 2017 Apr 23. Review.

PMID:
28479044
39.

Overexpression of Glucocorticoid-induced Leucine Zipper (GILZ) increases susceptibility to Imiquimod-induced psoriasis and involves cutaneous activation of TGF-β1.

Carceller E, Ballegeer M, Deckers J, Riccardi C, Bruscoli S, Hochepied T, Libert C, Pérez P.

Sci Rep. 2016 Dec 9;6:38825. doi: 10.1038/srep38825.

40.

MMP-3 Deficiency Alleviates Endotoxin-Induced Acute Inflammation in the Posterior Eye Segment.

Van Hove I, Lefevere E, De Groef L, Sergeys J, Salinas-Navarro M, Libert C, Vandenbroucke R, Moons L.

Int J Mol Sci. 2016 Nov 1;17(11). pii: E1825.

41.

Proteome-scale Binary Interactomics in Human Cells.

Lievens S, Van der Heyden J, Masschaele D, De Ceuninck L, Petta I, Gupta S, De Puysseleyr V, Vauthier V, Lemmens I, De Clercq DJ, Defever D, Vanderroost N, De Smet AS, Eyckerman S, Van Calenbergh S, Martens L, De Bosscher K, Libert C, Hill DE, Vidal M, Tavernier J.

Mol Cell Proteomics. 2016 Dec;15(12):3624-3639. Epub 2016 Nov 1.

42.

Sizing nanomaterials in bio-fluids by cFRAP enables protein aggregation measurements and diagnosis of bio-barrier permeability.

Xiong R, Vandenbroucke RE, Broos K, Brans T, Van Wonterghem E, Libert C, Demeester J, De Smedt SC, Braeckmans K.

Nat Commun. 2016 Sep 22;7:12982. doi: 10.1038/ncomms12982.

43.

Identification of a novel mechanism of blood-brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles.

Balusu S, Van Wonterghem E, De Rycke R, Raemdonck K, Stremersch S, Gevaert K, Brkic M, Demeestere D, Vanhooren V, Hendrix A, Libert C, Vandenbroucke RE.

EMBO Mol Med. 2016 Oct 4;8(10):1162-1183. doi: 10.15252/emmm.201606271. Print 2016 Oct.

44.

Chromatin recruitment of activated AMPK drives fasting response genes co-controlled by GR and PPARα.

Ratman D, Mylka V, Bougarne N, Pawlak M, Caron S, Hennuyer N, Paumelle R, De Cauwer L, Thommis J, Rider MH, Libert C, Lievens S, Tavernier J, Staels B, De Bosscher K.

Nucleic Acids Res. 2016 Dec 15;44(22):10539-10553. Epub 2016 Aug 30.

45.

Corrigendum: Transient Hepatic Overexpression of Insulin-Like Growth Factor 2 Induces Free Cholesterol and Lipid Droplet Formation.

Kessler SM, Laggai S, Van Wonterghem E, Gemperlein K, Müller R, Haybaeck J, Vandenbroucke RE, Ogris M, Libert C, Kiemer AK.

Front Physiol. 2016 Jul 29;7:328. doi: 10.3389/fphys.2016.00328. eCollection 2016.

46.

Caloric restriction: beneficial effects on brain aging and Alzheimer's disease.

Van Cauwenberghe C, Vandendriessche C, Libert C, Vandenbroucke RE.

Mamm Genome. 2016 Aug;27(7-8):300-19. doi: 10.1007/s00335-016-9647-6. Epub 2016 May 30. Review.

PMID:
27240590
47.

The choroid plexus-cerebrospinal fluid interface in Alzheimer's disease: more than just a barrier.

Balusu S, Brkic M, Libert C, Vandenbroucke RE.

Neural Regen Res. 2016 Apr;11(4):534-7. doi: 10.4103/1673-5374.180372. Review.

48.

Transient Hepatic Overexpression of Insulin-Like Growth Factor 2 Induces Free Cholesterol and Lipid Droplet Formation.

Kessler SM, Laggai S, Van Wonterg E, Gemperlein K, Müller R, Haybaeck J, Vandenbroucke RE, Ogris M, Libert C, Kiemer AK.

Front Physiol. 2016 Apr 25;7:147. doi: 10.3389/fphys.2016.00147. eCollection 2016. Erratum in: Front Physiol. 2016;7:328.

49.

The Interactome of the Glucocorticoid Receptor and Its Influence on the Actions of Glucocorticoids in Combatting Inflammatory and Infectious Diseases.

Petta I, Dejager L, Ballegeer M, Lievens S, Tavernier J, De Bosscher K, Libert C.

Microbiol Mol Biol Rev. 2016 May 11;80(2):495-522. doi: 10.1128/MMBR.00064-15. Print 2016 Jun. Review.

50.

Efficient analysis of mouse genome sequences reveal many nonsense variants.

Steeland S, Timmermans S, Van Ryckeghem S, Hulpiau P, Saeys Y, Van Montagu M, Vandenbroucke RE, Libert C.

Proc Natl Acad Sci U S A. 2016 May 17;113(20):5670-5. doi: 10.1073/pnas.1605076113. Epub 2016 May 4.

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