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An ocular glymphatic clearance system removes β-amyloid from the rodent eye.

Wang X, Lou N, Eberhardt A, Yang Y, Kusk P, Xu Q, Förstera B, Peng S, Shi M, Ladrón-de-Guevara A, Delle C, Sigurdsson B, Xavier ALR, Ertürk A, Libby RT, Chen L, Thrane AS, Nedergaard M.

Sci Transl Med. 2020 Mar 25;12(536). pii: eaaw3210. doi: 10.1126/scitranslmed.aaw3210.


Gabor domain optical coherence microscopy combined with laser scanning confocal fluorescence microscopy.

Yoon C, Qi Y, Mestre H, Canavesi C, Marola OJ, Cogliati A, Nedergaard M, Libby RT, Rolland JP.

Biomed Opt Express. 2019 Nov 14;10(12):6242-6257. doi: 10.1364/BOE.10.006242. eCollection 2019 Dec 1.


DDIT3 (CHOP) contributes to retinal ganglion cell somal loss but not axonal degeneration in DBA/2J mice.

Marola OJ, Syc-Mazurek SB, Libby RT.

Cell Death Discov. 2019 Oct 10;5:140. doi: 10.1038/s41420-019-0220-4. eCollection 2019.


The polyether ionophore salinomycin targets multiple cellular pathways to block proliferative vitreoretinopathy pathology.

Heffer AM, Proaño J, Roztocil E, Phipps RP, Feldon SE, Huxlin KR, Sime PJ, Libby RT, Woeller CF, Kuriyan AE.

PLoS One. 2019 Sep 17;14(9):e0222596. doi: 10.1371/journal.pone.0222596. eCollection 2019.


Axon injury signaling and compartmentalized injury response in glaucoma.

Syc-Mazurek SB, Libby RT.

Prog Retin Eye Res. 2019 Nov;73:100769. doi: 10.1016/j.preteyeres.2019.07.002. Epub 2019 Jul 10. Review.


Author Correction: Mkk4 and Mkk7 are important for retinal development and axonal injury-induced retinal ganglion cell death.

Syc-Mazurek SB, Rausch RL, Fernandes KA, Wilson MP, Libby RT.

Cell Death Dis. 2019 Jan 25;10(2):64. doi: 10.1038/s41419-018-1233-2.


Mkk4 and Mkk7 are important for retinal development and axonal injury-induced retinal ganglion cell death.

Syc-Mazurek SB, Rausch RL, Fernandes KA, Wilson MP, Libby RT.

Cell Death Dis. 2018 Oct 26;9(11):1095. doi: 10.1038/s41419-018-1079-7. Erratum in: Cell Death Dis. 2019 Jan 25;10(2):64.


Jnk2 deficiency increases the rate of glaucomatous neurodegeneration in ocular hypertensive DBA/2J mice.

Harder JM, Williams PA, Soto I, Foxworth NE, Fernandes KA, Freeburg NF, Libby RT, John SWM.

Cell Death Dis. 2018 Jun 13;9(6):705. doi: 10.1038/s41419-018-0705-8.


Transcriptome-pathology correlation identifies interplay between TDP-43 and the expression of its kinase CK1E in sporadic ALS.

Krach F, Batra R, Wheeler EC, Vu AQ, Wang R, Hutt K, Rabin SJ, Baughn MW, Libby RT, Diaz-Garcia S, Stauffer J, Pirie E, Saberi S, Rodriguez M, Madrigal AA, Kohl Z, Winner B, Yeo GW, Ravits J.

Acta Neuropathol. 2018 Sep;136(3):405-423. doi: 10.1007/s00401-018-1870-7. Epub 2018 Jun 7.


Ciliary margin-derived BMP4 does not have a major role in ocular development.

Rausch RL, Libby RT, Kiernan AE.

PLoS One. 2018 May 8;13(5):e0197048. doi: 10.1371/journal.pone.0197048. eCollection 2018.


Assessment of intrinsic and extrinsic signaling pathway in excitotoxic retinal ganglion cell death.

Fahrenthold BK, Fernandes KA, Libby RT.

Sci Rep. 2018 Mar 15;8(1):4641. doi: 10.1038/s41598-018-22848-y.


Role of SARM1 and DR6 in retinal ganglion cell axonal and somal degeneration following axonal injury.

Fernandes KA, Mitchell KL, Patel A, Marola OJ, Shrager P, Zack DJ, Libby RT, Welsbie DS.

Exp Eye Res. 2018 Jun;171:54-61. doi: 10.1016/j.exer.2018.03.007. Epub 2018 Mar 8.


Trabecular meshwork morphogenesis: A comparative analysis of wildtype and anterior segment dysgenesis mouse models.

Rausch RL, Libby RT, Kiernan AE.

Exp Eye Res. 2018 May;170:81-91. doi: 10.1016/j.exer.2018.02.011. Epub 2018 Feb 13.


Together JUN and DDIT3 (CHOP) control retinal ganglion cell death after axonal injury.

Syc-Mazurek SB, Fernandes KA, Wilson MP, Shrager P, Libby RT.

Mol Neurodegener. 2017 Oct 2;12(1):71. doi: 10.1186/s13024-017-0214-8.


KLF9 and JNK3 Interact to Suppress Axon Regeneration in the Adult CNS.

Apara A, Galvao J, Wang Y, Blackmore M, Trillo A, Iwao K, Brown DP Jr, Fernandes KA, Huang A, Nguyen T, Ashouri M, Zhang X, Shaw PX, Kunzevitzky NJ, Moore DL, Libby RT, Goldberg JL.

J Neurosci. 2017 Oct 4;37(40):9632-9644. doi: 10.1523/JNEUROSCI.0643-16.2017. Epub 2017 Sep 4.


JUN is important for ocular hypertension-induced retinal ganglion cell degeneration.

Syc-Mazurek SB, Fernandes KA, Libby RT.

Cell Death Dis. 2017 Jul 20;8(7):e2945. doi: 10.1038/cddis.2017.338.


Early immune responses are independent of RGC dysfunction in glaucoma with complement component C3 being protective.

Harder JM, Braine CE, Williams PA, Zhu X, MacNicoll KH, Sousa GL, Buchanan RA, Smith RS, Libby RT, Howell GR, John SWM.

Proc Natl Acad Sci U S A. 2017 May 9;114(19):E3839-E3848. doi: 10.1073/pnas.1608769114. Epub 2017 Apr 26.


G-Protein-Coupled Receptor-2-Interacting Protein-1 Controls Stalk Cell Fate by Inhibiting Delta-like 4-Notch1 Signaling.

Majumder S, Zhu G, Xu X, Senchanthisai S, Jiang D, Liu H, Xue C, Wang X, Coia H, Cui Z, Smolock EM, Libby RT, Berk BC, Pang J.

Cell Rep. 2016 Dec 6;17(10):2532-2541. doi: 10.1016/j.celrep.2016.11.017.


Col4a1 mutations cause progressive retinal neovascular defects and retinopathy.

Alavi MV, Mao M, Pawlikowski BT, Kvezereli M, Duncan JL, Libby RT, John SW, Gould DB.

Sci Rep. 2016 Jan 27;6:18602. doi: 10.1038/srep18602.


Novel axon projection after stress and degeneration in the Dscam mutant retina.

Fernandes KA, Bloomsburg SJ, Miller CJ, Billingslea SA, Merrill MM, Burgess RW, Libby RT, Fuerst PG.

Mol Cell Neurosci. 2016 Mar;71:1-12. doi: 10.1016/j.mcn.2015.12.003. Epub 2015 Dec 10.


Strain-Dependent Anterior Segment Dysgenesis and Progression to Glaucoma in Col4a1 Mutant Mice.

Mao M, Smith RS, Alavi MV, Marchant JK, Cosma M, Libby RT, John SW, Gould DB.

Invest Ophthalmol Vis Sci. 2015 Oct;56(11):6823-31. doi: 10.1167/iovs.15-17527.


Quantitative measurement of retinal ganglion cell populations via histology-based random forest classification.

Hedberg-Buenz A, Christopher MA, Lewis CJ, Fernandes KA, Dutca LM, Wang K, Scheetz TE, Abràmoff MD, Libby RT, Garvin MK, Anderson MG.

Exp Eye Res. 2016 May;146:370-85. doi: 10.1016/j.exer.2015.09.011. Epub 2015 Oct 22.


Dysregulated miRNA biogenesis downstream of cellular stress and ALS-causing mutations: a new mechanism for ALS.

Emde A, Eitan C, Liou LL, Libby RT, Rivkin N, Magen I, Reichenstein I, Oppenheim H, Eilam R, Silvestroni A, Alajajian B, Ben-Dov IZ, Aebischer J, Savidor A, Levin Y, Sons R, Hammond SM, Ravits JM, Möller T, Hornstein E.

EMBO J. 2015 Nov 3;34(21):2633-51. doi: 10.15252/embj.201490493. Epub 2015 Sep 1.


Using genetic mouse models to gain insight into glaucoma: Past results and future possibilities.

Fernandes KA, Harder JM, Williams PA, Rausch RL, Kiernan AE, Nair KS, Anderson MG, John SW, Howell GR, Libby RT.

Exp Eye Res. 2015 Dec;141:42-56. doi: 10.1016/j.exer.2015.06.019. Epub 2015 Jun 24. Review.


Tumor necrosis factor alpha has an early protective effect on retinal ganglion cells after optic nerve crush.

Mac Nair CE, Fernandes KA, Schlamp CL, Libby RT, Nickells RW.

J Neuroinflammation. 2014 Nov 19;11:194. doi: 10.1186/s12974-014-0194-3.


DBA/2J mice are susceptible to diabetic nephropathy and diabetic exacerbation of IOP elevation.

Soto I, Howell GR, John CW, Kief JL, Libby RT, John SW.

PLoS One. 2014 Sep 10;9(9):e107291. doi: 10.1371/journal.pone.0107291. eCollection 2014.


DLK-dependent signaling is important for somal but not axonal degeneration of retinal ganglion cells following axonal injury.

Fernandes KA, Harder JM, John SW, Shrager P, Libby RT.

Neurobiol Dis. 2014 Sep;69:108-16. doi: 10.1016/j.nbd.2014.05.015. Epub 2014 May 27.


Phospholipid flippase ATP8A2 is required for normal visual and auditory function and photoreceptor and spiral ganglion cell survival.

Coleman JA, Zhu X, Djajadi HR, Molday LL, Smith RS, Libby RT, John SW, Molday RS.

J Cell Sci. 2014 Mar 1;127(Pt 5):1138-49. doi: 10.1242/jcs.145052. Epub 2014 Jan 10.


Focal damage to macaque photoreceptors produces persistent visual loss.

Strazzeri JM, Hunter JJ, Masella BD, Yin L, Fischer WS, DiLoreto DA Jr, Libby RT, Williams DR, Merigan WH.

Exp Eye Res. 2014 Feb;119:88-96. doi: 10.1016/j.exer.2013.11.001. Epub 2013 Dec 5.


Expression levels of DNA replication and repair genes predict regional somatic repeat instability in the brain but are not altered by polyglutamine disease protein expression or age.

Mason AG, Tomé S, Simard JP, Libby RT, Bammler TK, Beyer RP, Morton AJ, Pearson CE, La Spada AR.

Hum Mol Genet. 2014 Mar 15;23(6):1606-18. doi: 10.1093/hmg/ddt551. Epub 2013 Nov 3.


Adding metabolomics to the toolbox for studying retinal disease.

Howell GR, Libby RT.

Invest Ophthalmol Vis Sci. 2013 Jun 21;54(6):4260. doi: 10.1167/iovs.13-12479. No abstract available.


Notch2 regulates BMP signaling and epithelial morphogenesis in the ciliary body of the mouse eye.

Zhou Y, Tanzie C, Yan Z, Chen S, Duncan M, Gaudenz K, Li H, Seidel C, Lewis B, Moran A, Libby RT, Kiernan AE, Xie T.

Proc Natl Acad Sci U S A. 2013 May 28;110(22):8966-71. doi: 10.1073/pnas.1218145110. Epub 2013 May 15.


Transcription factors SOX4 and SOX11 function redundantly to regulate the development of mouse retinal ganglion cells.

Jiang Y, Ding Q, Xie X, Libby RT, Lefebvre V, Gan L.

J Biol Chem. 2013 Jun 21;288(25):18429-38. doi: 10.1074/jbc.M113.478503. Epub 2013 May 6.


JUN regulates early transcriptional responses to axonal injury in retinal ganglion cells.

Fernandes KA, Harder JM, Kim J, Libby RT.

Exp Eye Res. 2013 Jul;112:106-17. doi: 10.1016/j.exer.2013.04.021. Epub 2013 May 3.


Lack of C9ORF72 coding mutations supports a gain of function for repeat expansions in amyotrophic lateral sclerosis.

Harms MB, Cady J, Zaidman C, Cooper P, Bali T, Allred P, Cruchaga C, Baughn M, Libby RT, Pestronk A, Goate A, Ravits J, Baloh RH.

Neurobiol Aging. 2013 Sep;34(9):2234.e13-9. doi: 10.1016/j.neurobiolaging.2013.03.006. Epub 2013 Apr 16.


Deficiency in Bim, Bid and Bbc3 (Puma) do not prevent axonal injury induced death.

Harder JM, Libby RT.

Cell Death Differ. 2013 Jan;20(1):182. doi: 10.1038/cdd.2012.119. Epub 2012 Sep 21. No abstract available.


Mutations in a P-type ATPase gene cause axonal degeneration.

Zhu X, Libby RT, de Vries WN, Smith RS, Wright DL, Bronson RT, Seburn KL, John SW.

PLoS Genet. 2012;8(8):e1002853. doi: 10.1371/journal.pgen.1002853. Epub 2012 Aug 9.


BCL2L1 (BCL-X) promotes survival of adult and developing retinal ganglion cells.

Harder JM, Ding Q, Fernandes KA, Cherry JD, Gan L, Libby RT.

Mol Cell Neurosci. 2012 Aug;51(1-2):53-9. doi: 10.1016/j.mcn.2012.07.006. Epub 2012 Jul 24.


The Bcl-2 family member BIM has multiple glaucoma-relevant functions in DBA/2J mice.

Harder JM, Fernandes KA, Libby RT.

Sci Rep. 2012;2:530. doi: 10.1038/srep00530. Epub 2012 Jul 25.


Adaptive optics retinal imaging in the living mouse eye.

Geng Y, Dubra A, Yin L, Merigan WH, Sharma R, Libby RT, Williams DR.

Biomed Opt Express. 2012 Apr 1;3(4):715-34. doi: 10.1364/BOE.3.000715. Epub 2012 Mar 15.


Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma.

Howell GR, Soto I, Zhu X, Ryan M, Macalinao DG, Sousa GL, Caddle LB, MacNicoll KH, Barbay JM, Porciatti V, Anderson MG, Smith RS, Clark AF, Libby RT, John SW.

J Clin Invest. 2012 Apr;122(4):1246-61. doi: 10.1172/JCI61135. Epub 2012 Mar 19.


JNK2 and JNK3 are major regulators of axonal injury-induced retinal ganglion cell death.

Fernandes KA, Harder JM, Fornarola LB, Freeman RS, Clark AF, Pang IH, John SW, Libby RT.

Neurobiol Dis. 2012 May;46(2):393-401. doi: 10.1016/j.nbd.2012.02.003. Epub 2012 Feb 14.


Intrinsic axonal degeneration pathways are critical for glaucomatous damage.

Howell GR, Soto I, Libby RT, John SW.

Exp Neurol. 2013 Aug;246:54-61. doi: 10.1016/j.expneurol.2012.01.014. Epub 2012 Jan 18. Review.


Datgan, a reusable software system for facile interrogation and visualization of complex transcription profiling data.

Howell GR, Walton DO, King BL, Libby RT, John SW.

BMC Genomics. 2011 Aug 24;12:429. doi: 10.1186/1471-2164-12-429.


BBC3 (PUMA) regulates developmental apoptosis but not axonal injury induced death in the retina.

Harder JM, Libby RT.

Mol Neurodegener. 2011 Jul 15;6:50. doi: 10.1186/1750-1326-6-50.


CTCF regulates ataxin-7 expression through promotion of a convergently transcribed, antisense noncoding RNA.

Sopher BL, Ladd PD, Pineda VV, Libby RT, Sunkin SM, Hurley JB, Thienes CP, Gaasterland T, Filippova GN, La Spada AR.

Neuron. 2011 Jun 23;70(6):1071-84. doi: 10.1016/j.neuron.2011.05.027.


Ocular fibroblast diversity: implications for inflammation and ocular wound healing.

Xi X, McMillan DH, Lehmann GM, Sime PJ, Libby RT, Huxlin KR, Feldon SE, Phipps RP.

Invest Ophthalmol Vis Sci. 2011 Jul 1;52(7):4859-65. doi: 10.1167/iovs.10-7066.


The Usher 1B protein, MYO7A, is required for normal localization and function of the visual retinoid cycle enzyme, RPE65.

Lopes VS, Gibbs D, Libby RT, Aleman TS, Welch DL, Lillo C, Jacobson SG, Radu RA, Steel KP, Williams DS.

Hum Mol Genet. 2011 Jul 1;20(13):2560-70. doi: 10.1093/hmg/ddr155. Epub 2011 Apr 14.


Optical properties of the mouse eye.

Geng Y, Schery LA, Sharma R, Dubra A, Ahmad K, Libby RT, Williams DR.

Biomed Opt Express. 2011 Feb 28;2(4):717-38. doi: 10.1364/BOE.2.000717.


Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma.

Howell GR, Macalinao DG, Sousa GL, Walden M, Soto I, Kneeland SC, Barbay JM, King BL, Marchant JK, Hibbs M, Stevens B, Barres BA, Clark AF, Libby RT, John SW.

J Clin Invest. 2011 Apr;121(4):1429-44. doi: 10.1172/JCI44646. Epub 2011 Mar 7.

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