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Items: 29


Immunotherapy of triple-negative breast cancer with cathepsin D-targeting antibodies.

Ashraf Y, Mansouri H, Laurent-Matha V, Alcaraz LB, Roger P, Guiu S, Derocq D, Robin G, Michaud HA, Delpech H, Jarlier M, Pugnière M, Robert B, Puel A, Martin L, Landomiel F, Bourquard T, Achour O, Fruitier-Arnaudin I, Pichard A, Deshayes E, Turtoi A, Poupon A, Simony-Lafontaine J, Boissière-Michot F, Pirot N, Bernex F, Jacot W, du Manoir S, Theillet C, Pouget JP, Navarro-Teulon I, Bonnefoy N, Pèlegrin A, Chardès T, Martineau P, Liaudet-Coopman E.

J Immunother Cancer. 2019 Feb 4;7(1):29. doi: 10.1186/s40425-019-0498-z.


Proteomic analysis of vascular smooth muscle cells in physiological condition and in pulmonary arterial hypertension: Toward contractile versus synthetic phenotypes.

Régent A, Ly KH, Lofek S, Clary G, Tamby M, Tamas N, Federici C, Broussard C, Chafey P, Liaudet-Coopman E, Humbert M, Perros F, Mouthon L.

Proteomics. 2016 Oct;16(20):2637-2649. doi: 10.1002/pmic.201500006. Epub 2016 Sep 12.


Alteration of cathepsin D trafficking induced by hypoxia and extracellular acidification in MCF-7 breast cancer cells.

Achour O, Ashraf Y, Bridiau N, Kacem M, Poupard N, Bordenave-Juchereau S, Sannier F, Lamerant-Fayel N, Kieda C, Liaudet-Coopman E, Piot JM, Maugard T, Fruitier-Arnaudin I.

Biochimie. 2016 Feb;121:123-30. doi: 10.1016/j.biochi.2015.11.007. Epub 2015 Nov 12.


Nuclear cathepsin D enhances TRPS1 transcriptional repressor function to regulate cell cycle progression and transformation in human breast cancer cells.

Bach AS, Derocq D, Laurent-Matha V, Montcourrier P, Sebti S, Orsetti B, Theillet C, Gongora C, Pattingre S, Ibing E, Roger P, Linares LK, Reinheckel T, Meurice G, Kaiser FJ, Gespach C, Liaudet-Coopman E.

Oncotarget. 2015 Sep 29;6(29):28084-103. doi: 10.18632/oncotarget.4394.


BAG6/BAT3 modulates autophagy by affecting EP300/p300 intracellular localization.

Sebti S, Prébois C, Pérez-Gracia E, Bauvy C, Desmots F, Pirot N, Gongora C, Bach AS, Hubberstey AV, Palissot V, Berchem G, Codogno P, Linares LK, Liaudet-Coopman E, Pattingre S.

Autophagy. 2014 Jul;10(7):1341-2. doi: 10.4161/auto.28979. Epub 2014 May 15.


BAT3 modulates p300-dependent acetylation of p53 and autophagy-related protein 7 (ATG7) during autophagy.

Sebti S, Prébois C, Pérez-Gracia E, Bauvy C, Desmots F, Pirot N, Gongora C, Bach AS, Hubberstey AV, Palissot V, Berchem G, Codogno P, Linares LK, Liaudet-Coopman E, Pattingre S.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4115-20. doi: 10.1073/pnas.1313618111. Epub 2014 Mar 3.


Proteolysis of cystatin C by cathepsin D in the breast cancer microenvironment.

Laurent-Matha V, Huesgen PF, Masson O, Derocq D, Prébois C, Gary-Bobo M, Lecaille F, Rebière B, Meurice G, Oréar C, Hollingsworth RE, Abrahamson M, Lalmanach G, Overall CM, Liaudet-Coopman E.

FASEB J. 2012 Dec;26(12):5172-81. doi: 10.1096/fj.12-205229. Epub 2012 Aug 16.


Cathepsin D is partly endocytosed by the LRP1 receptor and inhibits LRP1-regulated intramembrane proteolysis.

Derocq D, Prébois C, Beaujouin M, Laurent-Matha V, Pattingre S, Smith GK, Liaudet-Coopman E.

Oncogene. 2012 Jun 28;31(26):3202-12. doi: 10.1038/onc.2011.501. Epub 2011 Nov 14.


Cathepsin-D, a key protease in breast cancer, is up-regulated in obese mouse and human adipose tissue, and controls adipogenesis.

Masson O, Prébois C, Derocq D, Meulle A, Dray C, Daviaud D, Quilliot D, Valet P, Muller C, Liaudet-Coopman E.

PLoS One. 2011 Feb 2;6(2):e16452. doi: 10.1371/journal.pone.0016452.


Pro-cathepsin D interacts with the extracellular domain of the beta chain of LRP1 and promotes LRP1-dependent fibroblast outgrowth.

Beaujouin M, Prébois C, Derocq D, Laurent-Matha V, Masson O, Pattingre S, Coopman P, Bettache N, Grossfield J, Hollingsworth RE, Zhang H, Yao Z, Hyman BT, van der Geer P, Smith GK, Liaudet-Coopman E.

J Cell Sci. 2010 Oct 1;123(Pt 19):3336-46. doi: 10.1242/jcs.070938. Epub 2010 Sep 7.


Pathophysiological functions of cathepsin D: Targeting its catalytic activity versus its protein binding activity?

Masson O, Bach AS, Derocq D, Prébois C, Laurent-Matha V, Pattingre S, Liaudet-Coopman E.

Biochimie. 2010 Nov;92(11):1635-43. doi: 10.1016/j.biochi.2010.05.009. Epub 2010 May 21. Review.


LRP1 receptor controls adipogenesis and is up-regulated in human and mouse obese adipose tissue.

Masson O, Chavey C, Dray C, Meulle A, Daviaud D, Quilliot D, Muller C, Valet P, Liaudet-Coopman E.

PLoS One. 2009 Oct 12;4(10):e7422. doi: 10.1371/journal.pone.0007422.


Induction of the lysosomal apoptosis pathway by inhibitors of the ubiquitin-proteasome system.

Berndtsson M, Beaujouin M, Rickardson L, Havelka AM, Larsson R, Westman J, Liaudet-Coopman E, Linder S.

Int J Cancer. 2009 Mar 15;124(6):1463-9. doi: 10.1002/ijc.24004.


Cathepsin D overexpressed by cancer cells can enhance apoptosis-dependent chemo-sensitivity independently of its catalytic activity.

Beaujouin M, Liaudet-Coopman E.

Adv Exp Med Biol. 2008;617:453-61. doi: 10.1007/978-0-387-69080-3_44.


Processing of human cathepsin D is independent of its catalytic function and auto-activation: involvement of cathepsins L and B.

Laurent-Matha V, Derocq D, Prébois C, Katunuma N, Liaudet-Coopman E.

J Biochem. 2006 Mar;139(3):363-71.


Overexpression of both catalytically active and -inactive cathepsin D by cancer cells enhances apoptosis-dependent chemo-sensitivity.

Beaujouin M, Baghdiguian S, Glondu-Lassis M, Berchem G, Liaudet-Coopman E.

Oncogene. 2006 Mar 23;25(13):1967-73.


Cathepsin D: newly discovered functions of a long-standing aspartic protease in cancer and apoptosis.

Liaudet-Coopman E, Beaujouin M, Derocq D, Garcia M, Glondu-Lassis M, Laurent-Matha V, Prébois C, Rochefort H, Vignon F.

Cancer Lett. 2006 Jun 18;237(2):167-79. Epub 2005 Jul 19. Review.


Catalytically inactive human cathepsin D triggers fibroblast invasive growth.

Laurent-Matha V, Maruani-Herrmann S, Prébois C, Beaujouin M, Glondu M, Noël A, Alvarez-Gonzalez ML, Blacher S, Coopman P, Baghdiguian S, Gilles C, Loncarek J, Freiss G, Vignon F, Liaudet-Coopman E.

J Cell Biol. 2005 Jan 31;168(3):489-99. Epub 2005 Jan 24.


Cathepsin-D affects multiple tumor progression steps in vivo: proliferation, angiogenesis and apoptosis.

Berchem G, Glondu M, Gleizes M, Brouillet JP, Vignon F, Garcia M, Liaudet-Coopman E.

Oncogene. 2002 Aug 29;21(38):5951-5.


Down-regulation of cathepsin-D expression by antisense gene transfer inhibits tumor growth and experimental lung metastasis of human breast cancer cells.

Glondu M, Liaudet-Coopman E, Derocq D, Platet N, Rochefort H, Garcia M.

Oncogene. 2002 Aug 1;21(33):5127-34.


A mutated cathepsin-D devoid of its catalytic activity stimulates the growth of cancer cells.

Glondu M, Coopman P, Laurent-Matha V, Garcia M, Rochefort H, Liaudet-Coopman E.

Oncogene. 2001 Oct 18;20(47):6920-9.


Serum induction of the fibroblast growth factor-binding protein (FGF-BP) is mediated through ERK and p38 MAP kinase activation and C/EBP-regulated transcription.

Harris VK, Kagan BL, Ray R, Coticchia CM, Liaudet-Coopman ED, Wellstein A, Tate Riegel A.

Oncogene. 2001 Mar 29;20(14):1730-8.


Differential regulation of a fibroblast growth factor-binding protein by receptor-selective analogs of retinoic acid.

Boyle BJ, Harris VK, Liaudet-Coopman ED, Riegel AT, Wellstein A.

Biochem Pharmacol. 2000 Dec 1;60(11):1677-84.


Cathepsin D in cancer metastasis: a protease and a ligand.

Rochefort H, Liaudet-Coopman E.

APMIS. 1999 Jan;107(1):86-95. Review.


A secreted FGF-binding protein can serve as the angiogenic switch in human cancer.

Czubayko F, Liaudet-Coopman ED, Aigner A, Tuveson AT, Berchem GJ, Wellstein A.

Nat Med. 1997 Oct;3(10):1137-40.


In vivo inhibition of angiogenesis and induction of apoptosis by retinoic acid in squamous cell carcinoma.

Liaudet-Coopman ED, Berchem GJ, Wellstein A.

Clin Cancer Res. 1997 Feb;3(2):179-84.


A tetracycline-responsive promoter system reveals the role of a secreted binding protein for FGFs during the early phase of tumor growth.

Liaudet-Coopman ED, Schulte AM, Cardillo M, Wellstein A.

Biochem Biophys Res Commun. 1996 Dec 24;229(3):930-7.


Regulation of gene expression of a binding protein for fibroblast growth factors by retinoic acid.

Liaudet-Coopman ED, Wellstein A.

J Biol Chem. 1996 Aug 30;271(35):21303-8.

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