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X-shaped Breast Lift to Improve Surgical Ergonomics in Bilateral Axillo-Breast Approach Thyroidectomy.

Tsai CY, Liu SI, Chen IS, Liang TJ.

Surg Laparosc Endosc Percutan Tech. 2019 Aug 14. doi: 10.1097/SLE.0000000000000717. [Epub ahead of print]


Hepatitis C Virus Infection Induces Hepatic Expression of NF-κB-Inducing Kinase and Lipogenesis by Downregulating miR-122.

Lowey B, Hertz L, Chiu S, Valdez K, Li Q, Liang TJ.

MBio. 2019 Jul 30;10(4). pii: e01617-19. doi: 10.1128/mBio.01617-19.


Longitudinal effects of Nucleos(t)ide analogue therapy in chronic hepatitis B patients and the utility of non-invasive fibrosis markers during treatment: A single-center experience for up to 17 years.

Surana P, Kapuria D, Broadwell C, Wright EC, Takyar V, Kleiner DE, Ghany MG, Ben-Yakov G, Heller T, Liang TJ, Koh C.

Antiviral Res. 2019 Aug;168:61-67. doi: 10.1016/j.antiviral.2019.05.007. Epub 2019 May 21.


Hepatitis B Surface Antigen Activates Unfolded Protein Response in Forming Ground Glass Hepatocytes of Chronic Hepatitis B.

Li Y, Xia Y, Cheng X, Kleiner DE, Hewitt SM, Sproch J, Li T, Zhuang H, Liang TJ.

Viruses. 2019 Apr 25;11(4). pii: E386. doi: 10.3390/v11040386.


A global scientific strategy to cure hepatitis B.

Revill PA, Chisari FV, Block JM, Dandri M, Gehring AJ, Guo H, Hu J, Kramvis A, Lampertico P, Janssen HLA, Levrero M, Li W, Liang TJ, Lim SG, Lu F, Penicaud MC, Tavis JE, Thimme R; Members of the ICE-HBV Working Groups; ICE-HBV Stakeholders Group Chairs; ICE-HBV Senior Advisors, Zoulim F.

Lancet Gastroenterol Hepatol. 2019 Jul;4(7):545-558. doi: 10.1016/S2468-1253(19)30119-0. Epub 2019 Apr 10. Erratum in: Lancet Gastroenterol Hepatol. 2019 Jul;4(7):e7.


Discovery and characterization of a novel HCV inhibitor targeting the late stage of HCV life cycle.

Park SB, Boyer A, Hu Z, Le D, Liang TJ.

Antivir Ther. 2019 Mar 18. doi: 10.3851/IMP3303. [Epub ahead of print]


A randomized, proof-of-concept clinical trial on repurposing chlorcyclizine for the treatment of chronic hepatitis C.

Koh C, Dubey P, Han MAT, Walter PJ, Garraffo HM, Surana P, Southall NT, Borochov N, Uprichard SL, Cotler SJ, Etzion O, Heller T, Dahari H, Liang TJ.

Antiviral Res. 2019 Mar;163:149-155. doi: 10.1016/j.antiviral.2019.01.017. Epub 2019 Jan 31.


Single Biaxillary Tunneling for Working Space Creation in Bilateral Axillo-Breast Approach (BABA) Thyroidectomy.

Tsai CY, Liu SI, Chen IS, Liang TJ.

Surg Laparosc Endosc Percutan Tech. 2019 Aug;29(4):e50-e52. doi: 10.1097/SLE.0000000000000625.


Viral Hepatitis and Hepatocellular Carcinoma.

Liang TJ, Terrault N.

Gastroenterology. 2019 Jan;156(2):293. doi: 10.1053/j.gastro.2018.12.016. Epub 2018 Dec 26. No abstract available.


17-Beta Hydroxysteroid Dehydrogenase 13 Is a Hepatic Retinol Dehydrogenase Associated With Histological Features of Nonalcoholic Fatty Liver Disease.

Ma Y, Belyaeva OV, Brown PM, Fujita K, Valles K, Karki S, de Boer YS, Koh C, Chen Y, Du X, Handelman SK, Chen V, Speliotes EK, Nestlerode C, Thomas E, Kleiner DE, Zmuda JM, Sanyal AJ; (for the Nonalcoholic Steatohepatitis Clinical Research Network), Kedishvili NY, Liang TJ, Rotman Y.

Hepatology. 2019 Apr;69(4):1504-1519. doi: 10.1002/hep.30350. Epub 2019 Mar 5.


Development of Direct-acting Antiviral and Host-targeting Agents for Treatment of Hepatitis B Virus Infection.

Xia Y, Liang TJ.

Gastroenterology. 2019 Jan;156(2):311-324. doi: 10.1053/j.gastro.2018.07.057. Epub 2018 Sep 19. Review.


Correlation of 18F-FDG uptake and thyroid cancer stem cells.

Hsieh YJ, Lu TY, Ke CC, Lin YS, Tai HT, Liu SI, Liang TJ, Su HH, Liu RS, Peng NJ.

Q J Nucl Med Mol Imaging. 2018 Aug 28. doi: 10.23736/S1824-4785.18.03088-1. [Epub ahead of print]


TM6SF2 Promotes Lipidation and Secretion of Hepatitis C Virus in Infected Hepatocytes.

Boyer A, Park SB, de Boer YS, Li Q, Liang TJ.

Gastroenterology. 2018 Dec;155(6):1923-1935.e8. doi: 10.1053/j.gastro.2018.08.027. Epub 2018 Aug 23.


Spleen and Liver Volumetrics as Surrogate Markers of Hepatic Venous Pressure Gradient in Patients With Noncirrhotic Portal Hypertension.

Etzion O, Takyar V, Novack V, Gharib AM, Canales R, Adebogun A, Matsumoto E, Eccleston JL, Kleiner DE, Rosenzweig SD, Gunay-Aygun M, Uzel G, Fuss I, Childs R, Holland SM, Levy EB, Liang TJ, Heller T, Koh C.

Hepatol Commun. 2018 Jul 16;2(8):919-928. doi: 10.1002/hep4.1198. eCollection 2018 Aug.


Hepatitis B Virus Deregulates the Cell Cycle To Promote Viral Replication and a Premalignant Phenotype.

Xia Y, Cheng X, Li Y, Valdez K, Chen W, Liang TJ.

J Virol. 2018 Sep 12;92(19). pii: e00722-18. doi: 10.1128/JVI.00722-18. Print 2018 Oct 1.


Removal of non-point source pollutants from domestic sewage and agricultural runoff by vegetated drainage ditches (VDDs): Design, mechanism, management strategies, and future directions.

Nsenga Kumwimba M, Meng F, Iseyemi O, Moore MT, Zhu B, Tao W, Liang TJ, Ilunga L.

Sci Total Environ. 2018 Oct 15;639:742-759. doi: 10.1016/j.scitotenv.2018.05.184. Epub 2018 May 26. Review.


Baseline Intrahepatic and Peripheral Innate Immunity are Associated with Hepatitis C Virus Clearance During Direct-Acting Antiviral Therapy.

Alao H, Cam M, Keembiyehetty C, Zhang F, Serti E, Suarez D, Park H, Fourie NH, Wright EC, Henderson WA, Li Q, Liang TJ, Rehermann B, Ghany MG.

Hepatology. 2018 Dec;68(6):2078-2088. doi: 10.1002/hep.29921. Epub 2018 Jul 16.


Hepatitis C in Injection-Drug Users - A Hidden Danger of the Opioid Epidemic.

Liang TJ, Ward JW.

N Engl J Med. 2018 Mar 29;378(13):1169-1171. doi: 10.1056/NEJMp1716871. No abstract available.


Preclinical Pharmacological Development of Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection.

Rolt A, Le D, Hu Z, Wang AQ, Shah P, Singleton M, Hughes E, Dulcey AE, He S, Imamura M, Uchida T, Chayama K, Xu X, Marugan JJ, Liang TJ.

J Infect Dis. 2018 May 5;217(11):1761-1769. doi: 10.1093/infdis/jiy039.


Cellular microRNA networks regulate host dependency of hepatitis C virus infection.

Li Q, Lowey B, Sodroski C, Krishnamurthy S, Alao H, Cha H, Chiu S, El-Diwany R, Ghany MG, Liang TJ.

Nat Commun. 2017 Nov 27;8(1):1789. doi: 10.1038/s41467-017-01954-x.


N-Myc Downstream-Regulated Gene 1 Restricts Hepatitis C Virus Propagation by Regulating Lipid Droplet Biogenesis and Viral Assembly.

Schweitzer CJ, Zhang F, Boyer A, Valdez K, Cam M, Liang TJ.

J Virol. 2018 Jan 2;92(2). pii: e01166-17. doi: 10.1128/JVI.01166-17. Print 2018 Jan 15.


Intra-Hepatic Depletion of Mucosal-Associated Invariant T Cells in Hepatitis C Virus-Induced Liver Inflammation.

Bolte FJ, O'Keefe AC, Webb LM, Serti E, Rivera E, Liang TJ, Ghany M, Rehermann B.

Gastroenterology. 2017 Nov;153(5):1392-1403.e2. doi: 10.1053/j.gastro.2017.07.043. Epub 2017 Aug 2.


Adjuvant hepatic arterial infusion chemotherapy is beneficial for selective patients with Hepatocellular carcinoma undergoing surgical treatment.

Hsiao JH, Tsai CC, Liang TJ, Chiang CL, Liang HL, Chen IS, Chen YC, Chang PM, Chou NH, Wang BW.

Int J Surg. 2017 Sep;45:35-41. doi: 10.1016/j.ijsu.2017.07.071. Epub 2017 Jul 17.


Hepatitis B virus evades innate immunity of hepatocytes but activates cytokine production by macrophages.

Cheng X, Xia Y, Serti E, Block PD, Chung M, Chayama K, Rehermann B, Liang TJ.

Hepatology. 2017 Dec;66(6):1779-1793. doi: 10.1002/hep.29348.


Development of an Aryloxazole Class of Hepatitis C Virus Inhibitors Targeting the Entry Stage of the Viral Replication Cycle.

He S, Li K, Lin B, Hu Z, Xiao J, Hu X, Wang AQ, Xu X, Ferrer M, Southall N, Zheng W, Aubé J, Schoenen FJ, Marugan JJ, Liang TJ, Frankowski KJ.

J Med Chem. 2017 Jul 27;60(14):6364-6383. doi: 10.1021/acs.jmedchem.7b00561. Epub 2017 Jul 13.


APC hypermethylation for early diagnosis of colorectal cancer: a meta-analysis and literature review.

Liang TJ, Wang HX, Zheng YY, Cao YQ, Wu X, Zhou X, Dong SX.

Oncotarget. 2017 Jul 11;8(28):46468-46479. doi: 10.18632/oncotarget.17576. Review.


Adult-onset cystic fibrosis liver disease: Diagnosis and characterization of an underappreciated entity.

Koh C, Sakiani S, Surana P, Zhao X, Eccleston J, Kleiner DE, Herion D, Liang TJ, Hoofnagle JH, Chernick M, Heller T.

Hepatology. 2017 Aug;66(2):591-601. doi: 10.1002/hep.29217. Epub 2017 Jun 26.


Aglaiabbrevins A-D, New Prenylated Bibenzyls from the Leaves of Aglaia abbreviata with Potent PTP1B Inhibitory Activity.

Sun P, Jiang CS, Zhang Y, Liu AH, Liang TJ, Li J, Guo YW, Jiang JM, Mao SC, Wang B.

Chem Pharm Bull (Tokyo). 2017;65(3):295-299. doi: 10.1248/cpb.c16-00868.


Hepatitis B Reactivation Associated With Immune Suppressive and Biological Modifier Therapies: Current Concepts, Management Strategies, and Future Directions.

Loomba R, Liang TJ.

Gastroenterology. 2017 May;152(6):1297-1309. doi: 10.1053/j.gastro.2017.02.009. Epub 2017 Feb 20. Review.


Analysis of gallstone disease after gastric cancer surgery.

Liang TJ, Liu SI, Chen YC, Chang PM, Huang WC, Chang HT, Chen IS.

Gastric Cancer. 2017 Sep;20(5):895-903. doi: 10.1007/s10120-017-0698-5. Epub 2017 Feb 2.


Rhesus iPSC Safe Harbor Gene-Editing Platform for Stable Expression of Transgenes in Differentiated Cells of All Germ Layers.

Hong SG, Yada RC, Choi K, Carpentier A, Liang TJ, Merling RK, Sweeney CL, Malech HL, Jung M, Corat MAF, AlJanahi AA, Lin Y, Liu H, Tunc I, Wang X, Palisoc M, Pittaluga S, Boehm M, Winkler T, Zou J, Dunbar CE.

Mol Ther. 2017 Jan 4;25(1):44-53. doi: 10.1016/j.ymthe.2016.10.007. Epub 2017 Jan 4.


Complications of percutaneous liver biopsy with Klatskin needles: a 36-year single-centre experience.

Takyar V, Etzion O, Heller T, Kleiner DE, Rotman Y, Ghany MG, Fryzek N, Williams VH, Rivera E, Auh S, Liang TJ, Hoofnagle JH, Koh C.

Aliment Pharmacol Ther. 2017 Mar;45(5):744-753. doi: 10.1111/apt.13939. Epub 2017 Jan 10.


Noninvasive markers for staging fibrosis in chronic delta hepatitis.

Takyar V, Surana P, Kleiner DE, Wilkins K, Hoofnagle JH, Liang TJ, Heller T, Koh C.

Aliment Pharmacol Ther. 2017 Jan;45(1):127-138. doi: 10.1111/apt.13834. Epub 2016 Nov 4.


Gemcitabine-based polymer-drug conjugate for enhanced anticancer effect in colon cancer.

Liang TJ, Zhou ZM, Cao YQ, Ma MZ, Wang XJ, Jing K.

Int J Pharm. 2016 Nov 20;513(1-2):564-571. doi: 10.1016/j.ijpharm.2016.09.018. Epub 2016 Sep 6.


Hepatitis C Virus: From Obscurity to the Lasker.

Liang TJ.

Gastroenterology. 2016 Dec;151(6):1052-1053. doi: 10.1053/j.gastro.2016.10.011. Epub 2016 Oct 17. No abstract available.


Human stem cell-derived hepatocytes as a model for hepatitis B virus infection, spreading and virus-host interactions.

Xia Y, Carpentier A, Cheng X, Block PD, Zhao Y, Zhang Z, Protzer U, Liang TJ.

J Hepatol. 2017 Mar;66(3):494-503. doi: 10.1016/j.jhep.2016.10.009. Epub 2016 Oct 14.


miR-494 inhibits invasion and proliferation of gastric cancer by targeting IGF-1R.

Zhao XQ, Liang TJ, Fu JW.

Eur Rev Med Pharmacol Sci. 2016 Sep;20(18):3818-3824.


Infection of Hepatocytes With HCV Increases Cell Surface Levels of Heparan Sulfate Proteoglycans, Uptake of Cholesterol and Lipoprotein, and Virus Entry by Up-regulating SMAD6 and SMAD7.

Zhang F, Sodroski C, Cha H, Li Q, Liang TJ.

Gastroenterology. 2017 Jan;152(1):257-270.e7. doi: 10.1053/j.gastro.2016.09.033. Epub 2016 Sep 30.


Border Control in Hepatitis C Virus Infection: Inhibiting Viral Entry.

Schweitzer CJ, Liang TJ.

ACS Infect Dis. 2015 Sep 11;1(9):416-9. doi: 10.1021/acsinfecdis.5b00060. Epub 2015 Aug 11.


Spontaneous bleeding from a thyroid adenoma.

Liang TJ, Liu SI.

Ear Nose Throat J. 2016 Jul;95(7):268-73. No abstract available.


Hepatitis C virus depends on E-cadherin as an entry factor and regulates its expression in epithelial-to-mesenchymal transition.

Li Q, Sodroski C, Lowey B, Schweitzer CJ, Cha H, Zhang F, Liang TJ.

Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7620-5. doi: 10.1073/pnas.1602701113. Epub 2016 Jun 13.


Experimental models of hepatitis B and C - new insights and progress.

Thomas E, Liang TJ.

Nat Rev Gastroenterol Hepatol. 2016 Jun;13(6):362-74. doi: 10.1038/nrgastro.2016.37. Epub 2016 Apr 14. Review.


Hepatic differentiation of human pluripotent stem cells in miniaturized format suitable for high-throughput screen.

Carpentier A, Nimgaonkar I, Chu V, Xia Y, Hu Z, Liang TJ.

Stem Cell Res. 2016 May;16(3):640-50. doi: 10.1016/j.scr.2016.03.009. Epub 2016 Mar 29.


Evaluation of antiviral drug synergy in an infectious HCV system.

Lin B, He S, Yim HJ, Liang TJ, Hu Z.

Antivir Ther. 2016;21(7):595-603. doi: 10.3851/IMP3044. Epub 2016 Apr 1.


Analysis of Recurrence Management in Patients Who Underwent Nonsurgical Treatment for Acute Appendicitis.

Liang TJ, Liu SI, Tsai CY, Kang CH, Huang WC, Chang HT, Chen IS.

Medicine (Baltimore). 2016 Mar;95(12):e3159. doi: 10.1097/MD.0000000000003159.


Virology: The X-Files of hepatitis B.

Liang TJ.

Nature. 2016 Mar 17;531(7594):313-4. doi: 10.1038/531313a. No abstract available.


Associations of Volume and Thyroidectomy Outcomes: A Nationwide Study with Systematic Review and Meta-Analysis.

Liang TJ, Liu SI, Mok KT, Shi HY.

Otolaryngol Head Neck Surg. 2016 Jul;155(1):65-75. doi: 10.1177/0194599816634627. Epub 2016 Mar 1. Review.


Rapid decrease in hepatitis C viremia by direct acting antivirals improves the natural killer cell response to IFNα.

Serti E, Park H, Keane M, O'Keefe AC, Rivera E, Liang TJ, Ghany M, Rehermann B.

Gut. 2017 Apr;66(4):724-735. doi: 10.1136/gutjnl-2015-310033. Epub 2016 Jan 4.


Discovery, Optimization, and Characterization of Novel Chlorcyclizine Derivatives for the Treatment of Hepatitis C Virus Infection.

He S, Xiao J, Dulcey AE, Lin B, Rolt A, Hu Z, Hu X, Wang AQ, Xu X, Southall N, Ferrer M, Zheng W, Liang TJ, Marugan JJ.

J Med Chem. 2016 Feb 11;59(3):841-53. doi: 10.1021/acs.jmedchem.5b00752. Epub 2016 Feb 1.


Inguinal Hernia: Recurrences, Tailored Surgery & Pubic Inguinal Pain Syndrome (Sportsman Hernia).

Shapovalyants SG, Michalev AI, Timofeev ME, Polushkin VG, Volkov VV, Oettinger AP, Lorenz R, Koch A, Köckerling F, Burcharth J, Andresen K, Pommergaard HC, Bisgaard T, Rosenberg J, Friis-Andersen H, Li JW, Le F, Zheng MH, Roscio F, Combi F, Frattini P, Clerici F, Scandroglio I, Zhao X, Nie Y, Liu J, Wang M, Kuo L, Tsai CC, Mok KT, Liu SI, Chen IS, Chou NH, Wang BW, Chen YC, Chang BM, Liang TJ, Kang CH, Tsai CY, Dudai M, Zeng YJ, Liu TL, Shi CM, Sun L, Shu R, Kawaguchi M, Takahashi Y, Tochimoto M, Horiguchi Y, Kato H, Tawaraya K, Hosokawa O, Huang C, Sorge A, Masoni L, Maglio R, Di Marzo F, Mosconi C, Gallinella Muzi M, Kato J, Iuamoto L, Meyer A, Almehdi R, Alazri Y, Sahoo B, Ahmed R, Nasser M, Inaba T, Fukuhsima R, Yaguchi Y, Horikawa M, Ogawa E, Kumata Y, Pokorny H, Fischer I, Resinger C, Lorenz V, Podar S, Längue F, Etherson K, Atkinson K, Khan S, Pradeep R, Viswanath Y, Munipalle PC, Chung J, Schuricht A, Magalhães C, Marcos M, Flores A, Sekmen U, Paksoy M, Ceriani F, Cutaia S, Canziani M, Caravati F.

Hernia. 2015 Apr;19 Suppl 1:S167-75. doi: 10.1007/BF03355345. No abstract available.


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