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Antipsychotic use is inversely associated with gastric cancer risk: A nationwide population-based nested case-control study.

Hsieh YH, Chan HL, Lin CF, Liang SH, Lu ML, McIntyre RS, Lee Y, Lin TC, Chiu WC, Chen VC.

Cancer Med. 2019 Jun 10. doi: 10.1002/cam4.2329. [Epub ahead of print]


Allergic rhinitis increases the risk of incident panic disorder among young individuals: A nationwide population-based cohort study in Taiwan.

Hsieh MT, Liang SH, Yang YH, Kuo TY, Lin TY, Wang TN, Chen VC, Wu MH.

J Affect Disord. 2019 Jun 1;252:60-67. doi: 10.1016/j.jad.2019.04.037. Epub 2019 Apr 9.


Facile 18F labeling of non-activated arenes via a spirocyclic iodonium(III) ylide method and its application in the synthesis of the mGluR5 PET radiopharmaceutical [18F]FPEB.

Liang SH, Wang L, Stephenson NA, Rotstein BH, Vasdev N.

Nat Protoc. 2019 May;14(5):1530-1545. doi: 10.1038/s41596-019-0149-3. Epub 2019 Apr 12.


[18 F]Ethenesulfonyl Fluoride as a Practical Radiofluoride Relay Reagent.

Zhang B, Fraser BH, Klenner MA, Chen Z, Liang SH, Massi M, Robinson AJ, Pascali G.

Chemistry. 2019 Jun 7;25(32):7613-7617. doi: 10.1002/chem.201900930. Epub 2019 May 9.


Self-Reported and Parent-Reported School Bullying in Adolescents with High Functioning Autism Spectrum Disorder: The Roles of Autistic Social Impairment, Attention-Deficit/Hyperactivity and Oppositional Defiant Disorder Symptoms.

Chou WJ, Hsiao RC, Ni HC, Liang SH, Lin CF, Chan HL, Hsieh YH, Wang LJ, Lee MJ, Hu HF, Yen CF.

Int J Environ Res Public Health. 2019 Mar 28;16(7). pii: E1117. doi: 10.3390/ijerph16071117.


Half-curcumin analogues as PET imaging probes for amyloid beta species.

Yang J, Cheng R, Fu H, Yang J, Kumar M, Lu J, Xu Y, Liang SH, Cui M, Ran C.

Chem Commun (Camb). 2019 Mar 21;55(25):3630-3633. doi: 10.1039/c8cc10166c.


Design, Synthesis, and Evaluation of Reversible and Irreversible Monoacylglycerol Lipase Positron Emission Tomography (PET) Tracers Using a "Tail Switching" Strategy on a Piperazinyl Azetidine Skeleton.

Chen Z, Mori W, Deng X, Cheng R, Ogasawara D, Zhang G, Schafroth MA, Dahl K, Fu H, Hatori A, Shao T, Zhang Y, Yamasaki T, Zhang X, Rong J, Yu Q, Hu K, Fujinaga M, Xie L, Kumata K, Gou Y, Chen J, Gu S, Bao L, Wang L, Collier TL, Vasdev N, Shao Y, Ma JA, Cravatt BF, Fowler C, Josephson L, Zhang MR, Liang SH.

J Med Chem. 2019 Apr 11;62(7):3336-3353. doi: 10.1021/acs.jmedchem.8b01778. Epub 2019 Mar 21.


Hemizygosity Enables a Mutational Transition Governing Fungal Virulence and Commensalism.

Liang SH, Anderson MZ, Hirakawa MP, Wang JM, Frazer C, Alaalm LM, Thomson GJ, Ene IV, Bennett RJ.

Cell Host Microbe. 2019 Mar 13;25(3):418-431.e6. doi: 10.1016/j.chom.2019.01.005. Epub 2019 Feb 26.


Copper promotes E. coli laccase-mediated TNT biotransformation and alters the toxicity of TNT metabolites toward Tigriopus japonicus.

Hsu DW, Wang TI, Huang DJ, Pao YJ, Lin YA, Cheng TW, Liang SH, Chen CY, Kao CM, Sheu YT, Chen CC.

Ecotoxicol Environ Saf. 2019 May 30;173:452-460. doi: 10.1016/j.ecoenv.2019.02.056. Epub 2019 Feb 21.


Exploring the Variability in Reaction Times of Preschoolers at Risk of Attention-Deficit/Hyperactivity Disorder: an ex-Gaussian Analysis.

Hwang-Gu SL, Chen YC, Liang SH, Ni HC, Lin HY, Lin CF, Gau SS.

J Abnorm Child Psychol. 2019 Feb 1. doi: 10.1007/s10802-018-00508-z. [Epub ahead of print]


Synthesis and Preliminary Evaluations of a Triazole-Cored Antagonist as a PET Imaging Probe ([18F]N2B-0518) for GluN2B Subunit in the Brain.

Fu H, Tang W, Chen Z, Belov VV, Zhang G, Shao T, Zhang X, Yu Q, Rong J, Deng X, Han W, Myers SJ, Giffenig P, Wang L, Josephson L, Shao Y, Davenport AT, Daunais JB, Papisov M, Yuan H, Li Z, Traynelis SF, Liang SH.

ACS Chem Neurosci. 2019 May 15;10(5):2263-2275. doi: 10.1021/acschemneuro.8b00591. Epub 2019 Feb 27.


Recent applications of a single quadrupole mass spectrometer in 11C, 18F and radiometal chemistry.

Collier TL, Dahl K, Stephenson NA, Holland JP, Riley A, Liang SH, Vasdev N.

J Fluor Chem. 2018 Jun;210:46-55. doi: 10.1016/j.jfluchem.2018.02.009. Epub 2018 Mar 5.


The antimicrobial photodynamic inactivation resistance of Candida albicans is modulated by the Hog1 pathway and the Cap1 transcription factor.

Chien CT, Chen YC, Liu YC, Liang SH, Lin HH, Lin CH.

Med Mycol. 2018 Oct 4. doi: 10.1093/mmy/myy079. [Epub ahead of print]


Siblings' experiences of growing up with children with autism in Taiwan and the United Kingdom.

Tsai HJ, Cebula K, Liang SH, Fletcher-Watson S.

Res Dev Disabil. 2018 Dec;83:206-216. doi: 10.1016/j.ridd.2018.09.001. Epub 2018 Sep 22.


The Binding of BF-227-Like Benzoxazoles to Human α-Synuclein and Amyloid β Peptide Fibrils.

Josephson L, Stratman N, Liu Y, Qian F, Liang SH, Vasdev N, Patel S.

Mol Imaging. 2018 Jan-Dec;17:1536012118796297. doi: 10.1177/1536012118796297.


[Quality control of Dandeng Tongnao Ruanjiaonang based on UPLC fingerprint combined with chemical pattern recognition].

Zhou L, Sun Z, Xue WH, Liang SH, Zuo LH, Ding J, Zhao LL, Jiang XF, Jia QQ, Wei H, Liu KF, Hu YH, Zhao J.

Zhongguo Zhong Yao Za Zhi. 2018 Aug;43(16):3279-3284. doi: 10.19540/j.cnki.cjcmm.20180611.006. Chinese.


Correction to: PET imaging of EGFR expression using an 18F-labeled RNA aptamer.

Cheng S, Jacobson O, Zhu G, Chen Z, Liang SH, Tian R, Yang Z, Niu G, Zhu X, Chen X.

Eur J Nucl Med Mol Imaging. 2018 Nov;45(12):2245. doi: 10.1007/s00259-018-4145-6.


Synthesis, pharmacology and preclinical evaluation of 11C-labeled 1,3-dihydro-2H-benzo[d]imidazole-2-ones for imaging γ8-dependent transmembrane AMPA receptor regulatory protein.

Chen Z, Mori W, Zhang X, Yamasaki T, Dunn PJ, Zhang G, Fu H, Shao T, Zhang Y, Hatori A, Ma L, Fujinaga M, Xie L, Deng X, Li H, Yu Q, Rong J, Josephson L, Ma JA, Shao Y, Tomita S, Zhang MR, Liang SH.

Eur J Med Chem. 2018 Sep 5;157:898-908. doi: 10.1016/j.ejmech.2018.08.019. Epub 2018 Aug 9.


Multiplanar reconstruction technique for difficult computed tomography-guided lung biopsy: Improved accuracy and safety.

Huang WM, Chen CH, Liang SH, Huang CY, Cheng SM, Sheu CY, Huang CC.

Thorac Cancer. 2018 Oct;9(10):1333-1337. doi: 10.1111/1759-7714.12835. Epub 2018 Aug 9.


Ru-Photoredox-Catalyzed Decarboxylative Oxygenation of Aliphatic Carboxylic Acids through N-(acyloxy)phthalimide.

Zheng C, Wang Y, Xu Y, Chen Z, Chen G, Liang SH.

Org Lett. 2018 Aug 17;20(16):4824-4827. doi: 10.1021/acs.orglett.8b01885. Epub 2018 Aug 2.


PET imaging of EGFR expression using an 18F-labeled RNA aptamer.

Cheng S, Jacobson O, Zhu G, Chen Z, Liang SH, Tian R, Yang Z, Niu G, Zhu X, Chen X.

Eur J Nucl Med Mol Imaging. 2019 Apr;46(4):948-956. doi: 10.1007/s00259-018-4105-1. Epub 2018 Aug 1. Erratum in: Eur J Nucl Med Mol Imaging. 2018 Nov;45(12):2245.


Chemistry for Positron Emission Tomography: Recent Advances in 11 C-, 18 F-, 13 N-, and 15 O-Labeling Reactions.

Deng X, Rong J, Wang L, Vasdev N, Zhang L, Josephson L, Liang SH.

Angew Chem Int Ed Engl. 2019 Feb 25;58(9):2580-2605. doi: 10.1002/anie.201805501. Epub 2019 Jan 14. Review.


First demonstration of in vivo mapping for regional brain monoacylglycerol lipase using PET with [11C]SAR127303.

Yamasaki T, Mori W, Zhang Y, Hatori A, Fujinaga M, Wakizaka H, Kurihara Y, Wang L, Nengaki N, Ohya T, Liang SH, Zhang MR.

Neuroimage. 2018 Aug 1;176:313-320. doi: 10.1016/j.neuroimage.2018.05.015. Epub 2018 May 5.


Microfluidic radiosynthesis of [18F]FEMPT, a high affinity PET radiotracer for imaging serotonin receptors.

Collier TL, Liang SH, Mann JJ, Vasdev N, Kumar JSD.

Beilstein J Org Chem. 2017 Dec 29;13:2922-2927. doi: 10.3762/bjoc.13.285. eCollection 2017.


In Vitro and in Vivo Evaluation of 11C-Labeled Azetidinecarboxylates for Imaging Monoacylglycerol Lipase by PET Imaging Studies.

Cheng R, Mori W, Ma L, Alhouayek M, Hatori A, Zhang Y, Ogasawara D, Yuan G, Chen Z, Zhang X, Shi H, Yamasaki T, Xie L, Kumata K, Fujinaga M, Nagai Y, Minamimoto T, Svensson M, Wang L, Du Y, Ondrechen MJ, Vasdev N, Cravatt BF, Fowler C, Zhang MR, Liang SH.

J Med Chem. 2018 Mar 22;61(6):2278-2291. doi: 10.1021/acs.jmedchem.7b01400. Epub 2018 Mar 9.


Does biopsy needle traversing through central portion of lesion increase the risk of hemoptysis during percutaneous transthoracic needle biopsy?

Chen CH, Huang WM, Liang SH, Jhou ZY, Chen CW, Chien YC, Lin HC, Wang CH, Huang CC, Liao WN, Huang CY.

Jpn J Radiol. 2018 Mar;36(3):231-237. doi: 10.1007/s11604-018-0719-2. Epub 2018 Jan 19.


Metal Protein-Attenuating Compound for PET Neuroimaging: Synthesis and Preclinical Evaluation of [11C]PBT2.

Krishnan HS, Bernard-Gauthier V, Placzek MS, Dahl K, Narayanaswami V, Livni E, Chen Z, Yang J, Collier TL, Ran C, Hooker JM, Liang SH, Vasdev N.

Mol Pharm. 2018 Feb 5;15(2):695-702. doi: 10.1021/acs.molpharmaceut.7b00936. Epub 2018 Jan 22.


Recent Advances in 18F Radiochemistry: A Focus on B-18F, Si-18F, Al-18F, and C-18F Radiofluorination via Spirocyclic Iodonium Ylides.

Bernard-Gauthier V, Lepage ML, Waengler B, Bailey JJ, Liang SH, Perrin DM, Vasdev N, Schirrmacher R.

J Nucl Med. 2018 Apr;59(4):568-572. doi: 10.2967/jnumed.117.197095. Epub 2017 Dec 28. Review.


Discovery of PET radiopharmaceuticals at the academia-industry interface.

Bernard-Gauthier V, Collier TL, Liang SH, Vasdev N.

Drug Discov Today Technol. 2017 Nov;25:19-26. doi: 10.1016/j.ddtec.2017.09.001. Epub 2017 Oct 23. Review.


Fluorinated Adenosine A2A Receptor Antagonists Inspired by Preladenant as Potential Cancer Immunotherapeutics.

Yuan G, Jankins TC, Patrick CG Jr, Philbrook P, Sears O, Hatfield S, Sitkovsky M, Vasdev N, Liang SH, Ondrechen MJ, Pollastri MP, Jones GB.

Int J Med Chem. 2017;2017:4852537. doi: 10.1155/2017/4852537. Epub 2017 Oct 19.


Multimodality Imaging of Angiogenesis in a Rabbit Atherosclerotic Model by GEBP11 Peptide Targeted Nanoparticles.

Su T, Wang YB, Han D, Wang J, Qi S, Gao L, Shao YH, Qiao HY, Chen JW, Liang SH, Nie YZ, Li JY, Cao F.

Theranostics. 2017 Oct 17;7(19):4791-4804. doi: 10.7150/thno.20767. eCollection 2017.


Assessment of brain functional connectome alternations and correlation with depression and anxiety in major depressive disorders.

Chen VC, Shen CY, Liang SH, Li ZH, Hsieh MH, Tyan YS, Lu ML, Lee Y, McIntyre RS, Weng JC.

PeerJ. 2017 Nov 22;5:e3147. doi: 10.7717/peerj.3147. eCollection 2017.


Suicide risk reduction in youths with attention-deficit/hyperactivity disorder prescribed methylphenidate: A Taiwan nationwide population-based cohort study.

Liang SH, Yang YH, Kuo TY, Liao YT, Lin TC, Lee Y, McIntyre RS, Kelsen BA, Wang TN, Chen VC.

Res Dev Disabil. 2018 Jan;72:96-105. doi: 10.1016/j.ridd.2017.10.023. Epub 2017 Nov 6.


Brain Penetration of the ROS1/ALK Inhibitor Lorlatinib Confirmed by PET.

Collier TL, Maresca KP, Normandin MD, Richardson P, McCarthy TJ, Liang SH, Waterhouse RN, Vasdev N.

Mol Imaging. 2017 Jan-Dec;16:1536012117736669. doi: 10.1177/1536012117736669.


Relationship between parenting stress and informant discrepancies on symptoms of ADHD/ODD and internalizing behaviors in preschool children.

Chen YC, Hwang-Gu SL, Ni HC, Liang SH, Lin HY, Lin CF, Tseng YH, Gau SS.

PLoS One. 2017 Oct 10;12(10):e0183467. doi: 10.1371/journal.pone.0183467. eCollection 2017.


PET Imaging of Human Brown Adipose Tissue with the TSPO Tracer [11C]PBR28.

Ran C, Albrecht DS, Bredella MA, Yang J, Yang J, Liang SH, Cypess AM, Loggia ML, Atassi N, Moore A.

Mol Imaging Biol. 2018 Apr;20(2):188-193. doi: 10.1007/s11307-017-1129-z.


[miR-218 Promoted the Apoptosis of Human Ovarian Carcinoma Cells via Suppression of the WNT/β-Catenin Signaling Pathway].

Huang Y, Liang SH, Xiang LB, Han XT, Zhang W, Tang J, Wu XH, Zhang MQ.

Mol Biol (Mosk). 2017 Jul-Aug;51(4):629-636. doi: 10.7868/S0026898417030065. Russian.


Synthesis-free PET imaging of brown adipose tissue and TSPO via combination of disulfiram and 64CuCl2.

Yang J, Yang J, Wang L, Moore A, Liang SH, Ran C.

Sci Rep. 2017 Aug 15;7(1):8298. doi: 10.1038/s41598-017-09018-2.


18 F-Labeling of Sensitive Biomolecules for Positron Emission Tomography.

Krishnan HS, Ma L, Vasdev N, Liang SH.

Chemistry. 2017 Nov 7;23(62):15553-15577. doi: 10.1002/chem.201701581. Epub 2017 Sep 1. Review.


"In-loop" [11 C]CO2 fixation: Prototype and proof of concept.

Dahl K, Collier TL, Cheng R, Zhang X, Sadovski O, Liang SH, Vasdev N.

J Labelled Comp Radiopharm. 2018 Mar;61(3):252-262. doi: 10.1002/jlcr.3528. Epub 2017 Jul 25.


Synthesis and preliminary PET imaging of 11C and 18F isotopologues of the ROS1/ALK inhibitor lorlatinib.

Collier TL, Normandin MD, Stephenson NA, Livni E, Liang SH, Wooten DW, Esfahani SA, Stabin MG, Mahmood U, Chen J, Wang W, Maresca K, Waterhouse RN, El Fakhri G, Richardson P, Vasdev N.

Nat Commun. 2017 Jun 8;8:15761. doi: 10.1038/ncomms15761.


[11C]Cyanation of arylboronic acids in aqueous solutions.

Ma L, Placzek MS, Hooker JM, Vasdev N, Liang SH.

Chem Commun (Camb). 2017 Jun 21;53(49):6597-6600. doi: 10.1039/c7cc02886e. Epub 2017 Jun 5.


Synthesis and Preliminary Studies of a Novel Negative Allosteric Modulator, 7-((2,5-Dioxopyrrolidin-1-yl)methyl)-4-(2-fluoro-4-[11C]methoxyphenyl) quinoline-2-carboxamide, for Imaging of Metabotropic Glutamate Receptor 2.

Zhang X, Kumata K, Yamasaki T, Cheng R, Hatori A, Ma L, Zhang Y, Xie L, Wang L, Kang HJ, Sheffler DJ, Cosford NDP, Zhang MR, Liang SH.

ACS Chem Neurosci. 2017 Sep 20;8(9):1937-1948. doi: 10.1021/acschemneuro.7b00098. Epub 2017 Jun 13.


A Facile Radiolabeling of [18F]FDPA via Spirocyclic Iodonium Ylides: Preliminary PET Imaging Studies in Preclinical Models of Neuroinflammation.

Wang L, Cheng R, Fujinaga M, Yang J, Zhang Y, Hatori A, Kumata K, Yang J, Vasdev N, Du Y, Ran C, Zhang MR, Liang SH.

J Med Chem. 2017 Jun 22;60(12):5222-5227. doi: 10.1021/acs.jmedchem.7b00432. Epub 2017 Jun 5.


[A pilot study to explore a registry method for acute cardiovascular events].

Hou L, Han W, Tang Y, Xue F, Liang SH, Wang WZ, Zhang B, Pang HY, Wang YY, Wang ZX, Hu YD, Wang L, Zhang MT, Jiang JM.

Zhonghua Yi Xue Za Zhi. 2017 Apr 4;97(13):1024-1029. doi: 10.3760/cma.j.issn.0376-2491.2017.13.013. Chinese.


Development of [18F]Maleimide-Based Glycogen Synthase Kinase-3β Ligands for Positron Emission Tomography Imaging.

Hu K, Patnaik D, Collier TL, Lee KN, Gao H, Swoyer MR, Rotstein BH, Krishnan HS, Liang SH, Wang J, Yan Z, Hooker JM, Vasdev N, Haggarty SJ, Ngai MY.

ACS Med Chem Lett. 2017 Feb 2;8(3):287-292. doi: 10.1021/acsmedchemlett.6b00405. eCollection 2017 Mar 9.


Contrasting determinants for the introduction and establishment success of exotic birds in Taiwan using decision trees models.

Liang SH, Walther BA, Shieh BS.

PeerJ. 2017 Mar 14;5:e3092. doi: 10.7717/peerj.3092. eCollection 2017.


An Unconventional Mechanistic Insight into SCF3 Formation from Difluorocarbene: Preparation of 18 F-Labeled α-SCF3 Carbonyl Compounds.

Zheng J, Cheng R, Lin JH, Yu DH, Ma L, Jia L, Zhang L, Wang L, Xiao JC, Liang SH.

Angew Chem Int Ed Engl. 2017 Mar 13;56(12):3196-3200. doi: 10.1002/anie.201611761. Epub 2017 Feb 14.


The TORC1-Sch9-Rim15 signaling pathway represses yeast-to-hypha transition in response to glycerol availability in the oleaginous yeast Yarrowia lipolytica.

Liang SH, Wu H, Wang RR, Wang Q, Shu T, Gao XD.

Mol Microbiol. 2017 May;104(4):553-567. doi: 10.1111/mmi.13645. Epub 2017 Mar 2.

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