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Tumor necrosis factor receptor signaling is a driver of chronic lymphocytic leukemia that can be therapeutically targeted by the flavonoid wogonin.

Dürr C, Hanna BS, Schulz A, Lucas F, Zucknick M, Benner A, Clear A, Ohl S, Öztürk S, Zenz T, Stilgenbauer S, Li-Weber M, Krammer PH, Gribben JG, Lichter P, Seiffert M.

Haematologica. 2018 Apr;103(4):688-697. doi: 10.3324/haematol.2017.177808. Epub 2018 Jan 11.


Rocaglamide breaks TRAIL-resistance in human multiple myeloma and acute T-cell leukemia in vivo in a mouse xenogtraft model.

Wu Y, Giaisi M, Köhler R, Chen WM, Krammer PH, Li-Weber M.

Cancer Lett. 2017 Mar 28;389:70-77. doi: 10.1016/j.canlet.2016.12.010. Epub 2016 Dec 18.


The anticancer phytochemical rocaglamide inhibits Rho GTPase activity and cancer cell migration.

Becker MS, Müller PM, Bajorat J, Schroeder A, Giaisi M, Amin E, Ahmadian MR, Rocks O, Köhler R, Krammer PH, Li-Weber M.

Oncotarget. 2016 Aug 9;7(32):51908-51921. doi: 10.18632/oncotarget.10188.


HTLV-1-associated adult T cell leukemia is highly susceptible to Navitoclax due to enhanced Bax expression.

Witzens-Harig M, Giaisi M, Köhler R, Krammer PH, Li-Weber M.

Int J Cancer. 2016 Jan 15;138(2):507-14. doi: 10.1002/ijc.29726. Epub 2015 Aug 27.


Mangrove dolabrane-type of diterpenes tagalsins suppresses tumor growth via ROS-mediated apoptosis and ATM/ATR-Chk1/Chk2-regulated cell cycle arrest.

Neumann J, Yang Y, Köhler R, Giaisi M, Witzens-Harig M, Liu D, Krammer PH, Lin W, Li-Weber M.

Int J Cancer. 2015 Dec 1;137(11):2739-48. doi: 10.1002/ijc.29629. Epub 2015 Jun 30.


Dolabrane-type diterpenes from the mangrove plant Ceriops tagal with antitumor activities.

Yang Y, Zhang Y, Liu D, Li-Weber M, Shao B, Lin W.

Fitoterapia. 2015 Jun;103:277-82. doi: 10.1016/j.fitote.2015.04.016. Epub 2015 Apr 30.


Tax contributes apoptosis resistance to HTLV-1-infected T cells via suppression of Bid and Bim expression.

Mühleisen A, Giaisi M, Köhler R, Krammer PH, Li-Weber M.

Cell Death Dis. 2014 Dec 18;5:e1575. doi: 10.1038/cddis.2014.536.


Molecular mechanisms and anti-cancer aspects of the medicinal phytochemicals rocaglamides (=flavaglines).

Li-Weber M.

Int J Cancer. 2015 Oct 15;137(8):1791-9. doi: 10.1002/ijc.29013. Epub 2014 Jun 11. Review.


Targeting CDK9 by wogonin and related natural flavones potentiates the anti-cancer efficacy of the Bcl-2 family inhibitor ABT-263.

Polier G, Giaisi M, Köhler R, Müller WW, Lutz C, Buss EC, Krammer PH, Li-Weber M.

Int J Cancer. 2015 Feb 1;136(3):688-98. doi: 10.1002/ijc.29009. Epub 2014 Jun 13.


The traditional Chinese medical compound Rocaglamide protects nonmalignant primary cells from DNA damage-induced toxicity by inhibition of p53 expression.

Becker MS, Schmezer P, Breuer R, Haas SF, Essers MA, Krammer PH, Li-Weber M.

Cell Death Dis. 2014 Jan 16;5:e1000. doi: 10.1038/cddis.2013.528.


The natural anticancer compound rocaglamide selectively inhibits the G1-S-phase transition in cancer cells through the ATM/ATR-mediated Chk1/2 cell cycle checkpoints.

Neumann J, Boerries M, Köhler R, Giaisi M, Krammer PH, Busch H, Li-Weber M.

Int J Cancer. 2014 Apr 15;134(8):1991-2002. doi: 10.1002/ijc.28521. Epub 2013 Oct 21.


The Wilms' tumor suppressor WT1 enhances CD95L expression and promotes activation-induced cell death in leukemic T cells.

Bourkoula K, Englert C, Giaisi M, Köhler R, Krammer PH, Li-Weber M.

Int J Cancer. 2014 Jan 15;134(2):291-300. doi: 10.1002/ijc.28379. Epub 2013 Aug 9.


Targeting the IL-4/IL-13 signaling pathway sensitizes Hodgkin lymphoma cells to chemotherapeutic drugs.

Natoli A, Lüpertz R, Merz C, Müller WW, Köhler R, Krammer PH, Li-Weber M.

Int J Cancer. 2013 Oct 15;133(8):1945-54. doi: 10.1002/ijc.28189. Epub 2013 Apr 25.


The natural anticancer compounds rocaglamides inhibit the Raf-MEK-ERK pathway by targeting prohibitin 1 and 2.

Polier G, Neumann J, Thuaud F, Ribeiro N, Gelhaus C, Schmidt H, Giaisi M, Köhler R, Müller WW, Proksch P, Leippe M, Janssen O, Désaubry L, Krammer PH, Li-Weber M.

Chem Biol. 2012 Sep 21;19(9):1093-104. doi: 10.1016/j.chembiol.2012.07.012.


Curcumin suppresses T cell activation by blocking Ca2+ mobilization and nuclear factor of activated T cells (NFAT) activation.

Kliem C, Merling A, Giaisi M, Köhler R, Krammer PH, Li-Weber M.

J Biol Chem. 2012 Mar 23;287(13):10200-9. doi: 10.1074/jbc.M111.318733. Epub 2012 Feb 2.


Rocaglamide and a XIAP inhibitor cooperatively sensitize TRAIL-mediated apoptosis in Hodgkin's lymphomas.

Giaisi M, Köhler R, Fulda S, Krammer PH, Li-Weber M.

Int J Cancer. 2012 Aug 15;131(4):1003-8. doi: 10.1002/ijc.26458. Epub 2011 Nov 8.


Chemistry and biology of rocaglamides (= flavaglines) and related derivatives from aglaia species (meliaceae).

Ebada SS, Lajkiewicz N, Porco JA Jr, Li-Weber M, Proksch P.

Prog Chem Org Nat Prod. 2011;94:1-58. doi: 10.1007/978-3-7091-0748-5_1. Review. No abstract available.


Wogonin and related natural flavones are inhibitors of CDK9 that induce apoptosis in cancer cells by transcriptional suppression of Mcl-1.

Polier G, Ding J, Konkimalla BV, Eick D, Ribeiro N, Köhler R, Giaisi M, Efferth T, Desaubry L, Krammer PH, Li-Weber M.

Cell Death Dis. 2011 Jul 21;2:e182. doi: 10.1038/cddis.2011.66.


Rocaglamide breaks TRAIL resistance in HTLV-1-associated adult T-cell leukemia/lymphoma by translational suppression of c-FLIP expression.

Bleumink M, Köhler R, Giaisi M, Proksch P, Krammer PH, Li-Weber M.

Cell Death Differ. 2011 Feb;18(2):362-70. doi: 10.1038/cdd.2010.99. Epub 2010 Aug 13.


Targeting apoptosis pathways in cancer by Chinese medicine.

Li-Weber M.

Cancer Lett. 2013 May 28;332(2):304-12. doi: 10.1016/j.canlet.2010.07.015. Epub 2010 Aug 3. Review.


Early growth response protein-1 (Egr-1) is preferentially expressed in T helper type 2 (Th2) cells and is involved in acute transcription of the Th2 cytokine interleukin-4.

Lohoff M, Giaisi M, Köhler R, Casper B, Krammer PH, Li-Weber M.

J Biol Chem. 2010 Jan 15;285(3):1643-52. doi: 10.1074/jbc.M109.011585. Epub 2009 Nov 13.


Rocaglamide sensitizes leukemic T cells to activation-induced cell death by differential regulation of CD95L and c-FLIP expression.

Zhu JY, Giaisi M, Köhler R, Müller WW, Mühleisen A, Proksch P, Krammer PH, Li-Weber M.

Cell Death Differ. 2009 Sep;16(9):1289-99. doi: 10.1038/cdd.2009.42. Epub 2009 Apr 17.


New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin.

Li-Weber M.

Cancer Treat Rev. 2009 Feb;35(1):57-68. doi: 10.1016/j.ctrv.2008.09.005. Epub 2008 Nov 11. Review.


LEF-1 negatively controls interleukin-4 expression through a proximal promoter regulatory element.

Hebenstreit D, Giaisi M, Treiber MK, Zhang XB, Mi HF, Horejs-Hoeck J, Andersen KG, Krammer PH, Duschl A, Li-Weber M.

J Biol Chem. 2008 Aug 15;283(33):22490-7. doi: 10.1074/jbc.M804096200. Epub 2008 Jun 25.


Wogonin preferentially kills malignant lymphocytes and suppresses T-cell tumor growth by inducing PLCgamma1- and Ca2+-dependent apoptosis.

Baumann S, Fas SC, Giaisi M, Müller WW, Merling A, Gülow K, Edler L, Krammer PH, Li-Weber M.

Blood. 2008 Feb 15;111(4):2354-63. Epub 2007 Dec 10.


Artesunate induces ROS-mediated apoptosis in doxorubicin-resistant T leukemia cells.

Efferth T, Giaisi M, Merling A, Krammer PH, Li-Weber M.

PLoS One. 2007 Aug 1;2(8):e693.


The traditional Chinese herbal compound rocaglamide preferentially induces apoptosis in leukemia cells by modulation of mitogen-activated protein kinase activities.

Zhu JY, Lavrik IN, Mahlknecht U, Giaisi M, Proksch P, Krammer PH, Li-Weber M.

Int J Cancer. 2007 Oct 15;121(8):1839-46.


Wogonin sensitizes resistant malignant cells to TNFalpha- and TRAIL-induced apoptosis.

Fas SC, Baumann S, Zhu JY, Giaisi M, Treiber MK, Mahlknecht U, Krammer PH, Li-Weber M.

Blood. 2006 Dec 1;108(12):3700-6. Epub 2006 Aug 24.


HTLV-1 Tax protects against CD95-mediated apoptosis by induction of the cellular FLICE-inhibitory protein (c-FLIP).

Krueger A, Fas SC, Giaisi M, Bleumink M, Merling A, Stumpf C, Baumann S, Holtkotte D, Bosch V, Krammer PH, Li-Weber M.

Blood. 2006 May 15;107(10):3933-9. Epub 2006 Jan 10.


Ultraviolet irradiation suppresses T cell activation via blocking TCR-mediated ERK and NF-kappa B signaling pathways.

Li-Weber M, Treiber MK, Giaisi M, Palfi K, Stephan N, Parg S, Krammer PH.

J Immunol. 2005 Aug 15;175(4):2132-43.


Proteasome inhibition sensitizes hepatocellular carcinoma cells, but not human hepatocytes, to TRAIL.

Ganten TM, Koschny R, Haas TL, Sykora J, Li-Weber M, Herzer K, Walczak H.

Hepatology. 2005 Sep;42(3):588-97.


Rocaglamide derivatives are immunosuppressive phytochemicals that target NF-AT activity in T cells.

Proksch P, Giaisi M, Treiber MK, Palfi K, Merling A, Spring H, Krammer PH, Li-Weber M.

J Immunol. 2005 Jun 1;174(11):7075-84.


HIV-1 trans-activator of transcription substitutes for oxidative signaling in activation-induced T cell death.

Gülow K, Kaminski M, Darvas K, Süss D, Li-Weber M, Krammer PH.

J Immunol. 2005 May 1;174(9):5249-60.


Dual role of the anti-inflammatory sesquiterpene lactone: regulation of life and death by parthenolide.

Li-Weber M, Palfi K, Giaisi M, Krammer PH.

Cell Death Differ. 2005 Apr;12(4):408-9. No abstract available.


Helicobacter pylori activates the early growth response 1 protein in gastric epithelial cells.

Abdel-Latif MM, Windle HJ, Fitzgerald KA, Ang YS, Eidhin DN, Li-Weber M, Sabra K, Kelleher D.

Infect Immun. 2004 Jun;72(6):3549-60.


NF-kappa B synergizes with NF-AT and NF-IL6 in activation of the IL-4 gene in T cells.

Li-Weber M, Giaisi M, Baumann S, Pálfi K, Krammer PH.

Eur J Immunol. 2004 Apr;34(4):1111-8.


Activation of intrinsic and extrinsic proapoptotic signaling pathways in interleukin-18-mediated human cardiac endothelial cell death.

Chandrasekar B, Vemula K, Surabhi RM, Li-Weber M, Owen-Schaub LB, Jensen LE, Mummidi S.

J Biol Chem. 2004 May 7;279(19):20221-33. Epub 2004 Feb 11.


Function and regulation of the CD95 (APO-1/Fas) ligand in the immune system.

Li-Weber M, Krammer PH.

Semin Immunol. 2003 Jun;15(3):145-57. Review.


Regulation of IL4 gene expression by T cells and therapeutic perspectives.

Li-Weber M, Krammer PH.

Nat Rev Immunol. 2003 Jul;3(7):534-43. Review.


The anti-inflammatory sesquiterpene lactone parthenolide suppresses IL-4 gene expression in peripheral blood T.

Li-Weber M, Giaisi M, Treiber MK, Krammer PH.

Eur J Immunol. 2002 Dec;32(12):3587-97.


IFN-gamma represses IL-4 expression via IRF-1 and IRF-2.

Elser B, Lohoff M, Kock S, Giaisi M, Kirchhoff S, Krammer PH, Li-Weber M.

Immunity. 2002 Dec;17(6):703-12.


The anti-inflammatory sesquiterpene lactone parthenolide suppresses CD95-mediated activation-induced-cell-death in T-cells.

Li-Weber M, Giaisi M, Baumann S, Treiber MK, Krammer PH.

Cell Death Differ. 2002 Nov;9(11):1256-65.


Vitamin E inhibits IL-4 gene expression in peripheral blood T cells.

Li-Weber M, Giaisi M, Treiber MK, Krammer PH.

Eur J Immunol. 2002 Sep;32(9):2401-8.


Vitamin E inhibits CD95 ligand expression and protects T cells from activation-induced cell death.

Li-Weber M, Weigand MA, Giaisi M, Süss D, Treiber MK, Baumann S, Ritsou E, Breitkreutz R, Krammer PH.

J Clin Invest. 2002 Sep;110(5):681-90.


The death of a T-cell: expression of the CD95 ligand.

Li-Weber M, Krammer PH.

Cell Death Differ. 2002 Feb;9(2):101-3. No abstract available.


Viral IFN-regulatory factors inhibit activation-induced cell death via two positive regulatory IFN-regulatory factor 1-dependent domains in the CD95 ligand promoter.

Kirchhoff S, Sebens T, Baumann S, Krueger A, Zawatzky R, Li-Weber M, Meinl E, Neipel F, Fleckenstein B, Krammer PH.

J Immunol. 2002 Feb 1;168(3):1226-34.


Roles of CCAAT/enhancer-binding protein in transcriptional regulation of the human IL-5 gene.

Li-Weber M, Giaisi M, Krammer PH.

Eur J Immunol. 2001 Dec;31(12):3694-703.


Human T cell leukemia virus type I Tax enhances IL-4 gene expression in T cells.

Li-Weber M, Giaisi M, Chlichlia K, Khazaie K, Krammer PH.

Eur J Immunol. 2001 Sep;31(9):2623-32.


The effect of HIV-1 regulatory proteins on cellular genes: derepression of the IL-2 promoter by Tat.

Ehret A, Li-Weber M, Frank R, Krammer PH.

Eur J Immunol. 2001 Jun;31(6):1790-9.

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