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Correlation between frataxin expression and contractility revealed by in vitro Friedreich's ataxia cardiac tissue models engineered from human pluripotent stem cells.

Wong AO, Wong G, Shen M, Chow MZ, Tse WW, Gurung B, Mak SY, Lieu DK, Costa KD, Chan CW, Martelli A, Nabhan JF, Li RA.

Stem Cell Res Ther. 2019 Jul 8;10(1):203. doi: 10.1186/s13287-019-1305-y.

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Five-year Longitudinal Cohort Study of Reinterventions After Sleeve Gastrectomy and Roux-en-Y Gastric Bypass.

Li RA, Liu L, Arterburn D, Coleman KJ, Courcoulas AP, Fisher D, Haneuse S, Johnson E, Theis MK, Yoon TK, Fisher H, Fraser JR, Herrinton LJ.

Ann Surg. 2019 Jun 7. doi: 10.1097/SLA.0000000000003401. [Epub ahead of print]


Modulation of chromatin remodeling proteins SMYD1 and SMARCD1 promotes contractile function of human pluripotent stem cell-derived ventricular cardiomyocyte in 3D-engineered cardiac tissues.

Chow MZ, Sadrian SN, Keung W, Geng L, Ren L, Kong CW, Wong AO, Hulot JS, Chen CS, Costa KD, Hajjar RJ, Li RA.

Sci Rep. 2019 May 16;9(1):7502. doi: 10.1038/s41598-019-42953-w.


Structural and Mechanistic Bases of Nuclear Calcium Signaling in Human Pluripotent Stem Cell-Derived Ventricular Cardiomyocytes.

Li S, Keung W, Cheng H, Li RA.

Stem Cells Int. 2019 Apr 1;2019:8765752. doi: 10.1155/2019/8765752. eCollection 2019.


Disinfectant residual stability leading to disinfectant decay and by-product formation in drinking water distribution systems: A systematic review.

Li RA, McDonald JA, Sathasivan A, Khan SJ.

Water Res. 2019 Apr 15;153:335-348. doi: 10.1016/j.watres.2019.01.020. Epub 2019 Jan 24. Review.


Human Cardiac Ventricular-Like Organoid Chambers and Tissue Strips From Pluripotent Stem Cells as a Two-Tiered Assay for Inotropic Responses.

Keung W, Chan PKW, Backeris PC, Lee EK, Wong N, Wong AOT, Wong GKY, Chan CWY, Fermini B, Costa KD, Li RA.

Clin Pharmacol Ther. 2019 Feb 5. doi: 10.1002/cpt.1385. [Epub ahead of print]


Probing flecainide block of INa using human pluripotent stem cell-derived ventricular cardiomyocytes adapted to automated patch-clamping and 2D monolayers.

Geng L, Kong CW, Wong AOT, Shum AM, Chow MZY, Che H, Zhang C, Yau KL, Chan CW, Keung W, Li RA.

Toxicol Lett. 2018 Sep 15;294:61-72. doi: 10.1016/j.toxlet.2018.05.006. Epub 2018 May 21.


TRPV6 protects ER stress-induced apoptosis via ATF6α-TRPV6-JNK pathway in human embryonic stem cell-derived cardiomyocytes.

Li Z, Meng Z, Lu J, Chen FM, Wong WT, Tse G, Zheng C, Keung W, Tse K, Li RA, Jiang L, Yao X.

J Mol Cell Cardiol. 2018 Jul;120:1-11. doi: 10.1016/j.yjmcc.2018.05.008. Epub 2018 May 16.


Functional and transcriptomic insights into pathogenesis of R9C phospholamban mutation using human induced pluripotent stem cell-derived cardiomyocytes.

Ceholski DK, Turnbull IC, Kong CW, Koplev S, Mayourian J, Gorski PA, Stillitano F, Skodras AA, Nonnenmacher M, Cohen N, Björkegren JLM, Stroik DR, Cornea RL, Thomas DD, Li RA, Costa KD, Hajjar RJ.

J Mol Cell Cardiol. 2018 Jun;119:147-154. doi: 10.1016/j.yjmcc.2018.05.007. Epub 2018 May 9.


Human ISL1+ Ventricular Progenitors Self-Assemble into an In Vivo Functional Heart Patch and Preserve Cardiac Function Post Infarction.

Foo KS, Lehtinen ML, Leung CY, Lian X, Xu J, Keung W, Geng L, Kolstad TRS, Thams S, Wong AO, Wong N, Bylund K, Zhou C, He X, Jin SB, Clarke J, Lendahl U, Li RA, Louch WE, Chien KR.

Mol Ther. 2018 Jul 5;26(7):1644-1659. doi: 10.1016/j.ymthe.2018.02.012. Epub 2018 Feb 17.


Industrial brewing yeast engineered for the production of primary flavor determinants in hopped beer.

Denby CM, Li RA, Vu VT, Costello Z, Lin W, Chan LJG, Williams J, Donaldson B, Bamforth CW, Petzold CJ, Scheller HV, Martin HG, Keasling JD.

Nat Commun. 2018 Mar 20;9(1):965. doi: 10.1038/s41467-018-03293-x.


Bioengineering an electro-mechanically functional miniature ventricular heart chamber from human pluripotent stem cells.

Li RA, Keung W, Cashman TJ, Backeris PC, Johnson BV, Bardot ES, Wong AOT, Chan PKW, Chan CWY, Costa KD.

Biomaterials. 2018 May;163:116-127. doi: 10.1016/j.biomaterials.2018.02.024. Epub 2018 Feb 10.


Polycystin-2 Plays an Essential Role in Glucose Starvation-Induced Autophagy in Human Embryonic Stem Cell-Derived Cardiomyocytes.

Lu J, Boheler KR, Jiang L, Chan CW, Tse WW, Keung W, Poon EN, Li RA, Yao X.

Stem Cells. 2018 Apr;36(4):501-513. doi: 10.1002/stem.2764. Epub 2018 Jan 3.


High-Content Electrophysiological Analysis of Human Pluripotent Stem Cell-Derived Cardiomyocytes (hPSC-CMs).

Kong CW, Geng L, Li RA.

Methods Mol Biol. 2018;1722:185-194. doi: 10.1007/978-1-4939-7553-2_12.


Effects of pharmacological gap junction and sodium channel blockade on S1S2 restitution properties in Langendorff-perfused mouse hearts.

Tse G, Liu T, Li G, Keung W, Yeo JM, Fiona Chan YW, Yan BP, Chan YS, Wong SH, Li RA, Zhao J, Wu WKK, Wong WT.

Oncotarget. 2017 Jul 28;8(49):85341-85352. doi: 10.18632/oncotarget.19675. eCollection 2017 Oct 17.


Machine Learning of Human Pluripotent Stem Cell-Derived Engineered Cardiac Tissue Contractility for Automated Drug Classification.

Lee EK, Tran DD, Keung W, Chan P, Wong G, Chan CW, Costa KD, Li RA, Khine M.

Stem Cell Reports. 2017 Nov 14;9(5):1560-1572. doi: 10.1016/j.stemcr.2017.09.008. Epub 2017 Oct 12.


AAV-mediated conversion of human pluripotent stem cell-derived pacemaker.

Chan PKW, Geng L, Gao Y, Keung W, Li RA.

Biochem Biophys Res Commun. 2017 Dec 9;494(1-2):346-351. doi: 10.1016/j.bbrc.2017.10.023. Epub 2017 Oct 6.


An abnormal TRPV4-related cytosolic Ca2+ rise in response to uniaxial stretch in induced pluripotent stem cells-derived cardiomyocytes from dilated cardiomyopathy patients.

Lu J, Lee YK, Ran X, Lai WH, Li RA, Keung W, Tse K, Tse HF, Yao X.

Biochim Biophys Acta Mol Basis Dis. 2017 Nov;1863(11):2964-2972. doi: 10.1016/j.bbadis.2017.07.021. Epub 2017 Jul 25.


A Singular Role of IK1 Promoting the Development of Cardiac Automaticity during Cardiomyocyte Differentiation by IK1 -Induced Activation of Pacemaker Current.

Sun Y, Timofeyev V, Dennis A, Bektik E, Wan X, Laurita KR, Deschênes I, Li RA, Fu JD.

Stem Cell Rev. 2017 Oct;13(5):631-643. doi: 10.1007/s12015-017-9745-1.


Tachycardia-bradycardia syndrome: Electrophysiological mechanisms and future therapeutic approaches (Review).

Tse G, Liu T, Li KH, Laxton V, Wong AO, Chan YW, Keung W, Chan CW, Li RA.

Int J Mol Med. 2017 Mar;39(3):519-526. doi: 10.3892/ijmm.2017.2877. Epub 2017 Feb 6. Review.


Increasing the physical size and nucleation status of human pluripotent stem cell-derived ventricular cardiomyocytes by cell fusion.

Kong CW, Chen S, Geng L, Shum AM, Sun D, Li RA.

Stem Cell Res. 2017 Mar;19:76-81. doi: 10.1016/j.scr.2017.01.003. Epub 2017 Jan 6.


Gene Delivery for the Generation of Bioartificial Pacemaker.

Chan PK, Li RA.

Methods Mol Biol. 2017;1521:293-306.


A Cas9-based toolkit to program gene expression in Saccharomyces cerevisiae.

Reider Apel A, d'Espaux L, Wehrs M, Sachs D, Li RA, Tong GJ, Garber M, Nnadi O, Zhuang W, Hillson NJ, Keasling JD, Mukhopadhyay A.

Nucleic Acids Res. 2017 Jan 9;45(1):496-508. doi: 10.1093/nar/gkw1023. Epub 2016 Nov 28.


Maturation of human embryonic stem cell-derived cardiomyocytes (hESC-CMs) in 3D collagen matrix: Effects of niche cell supplementation and mechanical stimulation.

Zhang W, Kong CW, Tong MH, Chooi WH, Huang N, Li RA, Chan BP.

Acta Biomater. 2017 Feb;49:204-217. doi: 10.1016/j.actbio.2016.11.058. Epub 2016 Nov 24.


Ndrg1b and fam49ab modulate the PTEN pathway to control T-cell lymphopoiesis in the zebrafish.

Li RA, Traver D, Matthes T, Bertrand JY.

Blood. 2016 Dec 29;128(26):3052-3060. doi: 10.1182/blood-2016-09-742502. Epub 2016 Nov 8.


A Micropatterned Human Pluripotent Stem Cell-Based Ventricular Cardiac Anisotropic Sheet for Visualizing Drug-Induced Arrhythmogenicity.

Shum AM, Che H, Wong AO, Zhang C, Wu H, Chan CW, Costa K, Khine M, Kong CW, Li RA.

Adv Mater. 2017 Jan;29(1). doi: 10.1002/adma.201602448. Epub 2016 Nov 2.


Electrophysiological Mechanisms of Brugada Syndrome: Insights from Pre-clinical and Clinical Studies.

Tse G, Liu T, Li KH, Laxton V, Chan YW, Keung W, Li RA, Yan BP.

Front Physiol. 2016 Oct 18;7:467. eCollection 2016. Review.


Non-cell autonomous cues for enhanced functionality of human embryonic stem cell-derived cardiomyocytes via maturation of sarcolemmal and mitochondrial KATP channels.

Keung W, Ren L, Sen Li, Wong AO, Chopra A, Kong CW, Tomaselli GF, Chen CS, Li RA.

Sci Rep. 2016 Sep 28;6:34154. doi: 10.1038/srep34154.


Aptamer-Based Microfluidic Electrochemical Biosensor for Monitoring Cell-Secreted Trace Cardiac Biomarkers.

Shin SR, Zhang YS, Kim DJ, Manbohi A, Avci H, Silvestri A, Aleman J, Hu N, Kilic T, Keung W, Righi M, Assawes P, Alhadrami HA, Li RA, Dokmeci MR, Khademhosseini A.

Anal Chem. 2016 Oct 18;88(20):10019-10027. doi: 10.1021/acs.analchem.6b02028. Epub 2016 Oct 4.


Corrigendum: Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells.

Soh BS, Ng SY, Wu H, Buac K, Park JH, Lian X, Xu J, Foo KS, Felldin U, He X, Nichane M, Yang H, Bu L, Li RA, Lim B, Chien KR.

Nat Commun. 2016 Jul 19;7:12118. doi: 10.1038/ncomms12118. No abstract available.


Single Cell Transfection through Precise Microinjection with Quantitatively Controlled Injection Volumes.

Chow YT, Chen S, Wang R, Liu C, Kong CW, Li RA, Cheng SH, Sun D.

Sci Rep. 2016 Apr 12;6:24127. doi: 10.1038/srep24127.


Construction of Defined Human Engineered Cardiac Tissues to Study Mechanisms of Cardiac Cell Therapy.

Cashman TJ, Josowitz R, Gelb BD, Li RA, Dubois NC, Costa KD.

J Vis Exp. 2016 Mar 1;(109):e53447. doi: 10.3791/53447.


Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells.

Soh BS, Ng SY, Wu H, Buac K, Park JH, Lian X, Xu J, Foo KS, Felldin U, He X, Nichane M, Yang H, Bu L, Li RA, Lim B, Chien KR.

Nat Commun. 2016 Mar 8;7:10774. doi: 10.1038/ncomms10774. Erratum in: Nat Commun. 2016 Jul 19;7:12118.


Fusion with stem cell makes the hepatocellular carcinoma cells similar to liver tumor-initiating cells.

Wang R, Chen S, Li C, Ng KT, Kong CW, Cheng J, Cheng SH, Li RA, Lo CM, Man K, Sun D.

BMC Cancer. 2016 Feb 4;16:56. doi: 10.1186/s12885-016-2094-7.


Nitric Oxide-cGMP-PKG Pathway Acts on Orai1 to Inhibit the Hypertrophy of Human Embryonic Stem Cell-Derived Cardiomyocytes.

Wang Y, Li ZC, Zhang P, Poon E, Kong CW, Boheler KR, Huang Y, Li RA, Yao X.

Stem Cells. 2015 Oct;33(10):2973-84. doi: 10.1002/stem.2118. Epub 2015 Aug 12.


Uniaxial cyclic stretch stimulates TRPV4 to induce realignment of human embryonic stem cell-derived cardiomyocytes.

Qi Y, Li Z, Kong CW, Tang NL, Huang Y, Li RA, Yao X.

J Mol Cell Cardiol. 2015 Oct;87:65-73. doi: 10.1016/j.yjmcc.2015.08.005. Epub 2015 Aug 7.


Bariatric surgery results: reporting clinical characteristics and adverse outcomes from an integrated healthcare delivery system.

Li RA, Fisher DP, Dutta S, O'Brien RM, Ackerson LM, Sorel ME, Sidney S.

Surg Obes Relat Dis. 2015 Sep-Oct;11(5):1119-25. doi: 10.1016/j.soard.2015.03.002. Epub 2015 Mar 9.


Consensus comparative analysis of human embryonic stem cell-derived cardiomyocytes.

Zhang S, Poon E, Xie D, Boheler KR, Li RA, Wong HS.

PLoS One. 2015 May 4;10(5):e0125442. doi: 10.1371/journal.pone.0125442. eCollection 2015.


Correction of human phospholamban R14del mutation associated with cardiomyopathy using targeted nucleases and combination therapy.

Karakikes I, Stillitano F, Nonnenmacher M, Tzimas C, Sanoudou D, Termglinchan V, Kong CW, Rushing S, Hansen J, Ceholski D, Kolokathis F, Kremastinos D, Katoulis A, Ren L, Cohen N, Gho JMIH, Tsiapras D, Vink A, Wu JC, Asselbergs FW, Li RA, Hulot JS, Kranias EG, Hajjar RJ.

Nat Commun. 2015 Apr 29;6:6955. doi: 10.1038/ncomms7955.


Proteomic Analysis of Human Pluripotent Stem Cell-Derived, Fetal, and Adult Ventricular Cardiomyocytes Reveals Pathways Crucial for Cardiac Metabolism and Maturation.

Poon E, Keung W, Liang Y, Ramalingam R, Yan B, Zhang S, Chopra A, Moore J, Herren A, Lieu DK, Wong HS, Weng Z, Wong OT, Lam YW, Tomaselli GF, Chen C, Boheler KR, Li RA.

Circ Cardiovasc Genet. 2015 Jun;8(3):427-36. doi: 10.1161/CIRCGENETICS.114.000918. Epub 2015 Mar 10.


Cardiovascular regeneration.

Li RA.

Stem Cell Res Ther. 2014 Dec 17;5(6):141. doi: 10.1186/scrt531.


Phospholamban as a crucial determinant of the inotropic response of human pluripotent stem cell-derived ventricular cardiomyocytes and engineered 3-dimensional tissue constructs.

Chen G, Li S, Karakikes I, Ren L, Chow MZ, Chopra A, Keung W, Yan B, Chan CW, Costa KD, Kong CW, Hajjar RJ, Chen CS, Li RA.

Circ Arrhythm Electrophysiol. 2015 Feb;8(1):193-202. doi: 10.1161/CIRCEP.114.002049. Epub 2014 Dec 10.


Engineering a freestanding biomimetic cardiac patch using biodegradable poly(lactic-co-glycolic acid) (PLGA) and human embryonic stem cell-derived ventricular cardiomyocytes (hESC-VCMs).

Chen Y, Wang J, Shen B, Chan CW, Wang C, Zhao Y, Chan HN, Tian Q, Chen Y, Yao C, Hsing IM, Li RA, Wu H.

Macromol Biosci. 2015 Mar;15(3):426-36. doi: 10.1002/mabi.201400448. Epub 2014 Nov 25.


N-cadherin prevents the premature differentiation of anterior heart field progenitors in the pharyngeal mesodermal microenvironment.

Soh BS, Buac K, Xu H, Li E, Ng SY, Wu H, Chmielowiec J, Jiang X, Bu L, Li RA, Cowan C, Chien KR.

Cell Res. 2014 Dec;24(12):1420-32. doi: 10.1038/cr.2014.142. Epub 2014 Nov 4.


Cytoprotection of baicalein against oxidative stress-induced cardiomyocytes injury through the Nrf2/Keap1 pathway.

Cui G, Luk SC, Li RA, Chan KK, Lei SW, Wang L, Shen H, Leung GP, Lee SM.

J Cardiovasc Pharmacol. 2015 Jan;65(1):39-46. doi: 10.1097/FJC.0000000000000161.


Nitric oxide and protein kinase G act on TRPC1 to inhibit 11,12-EET-induced vascular relaxation.

Zhang P, Ma Y, Wang Y, Ma X, Huang Y, Li RA, Wan S, Yao X.

Cardiovasc Res. 2014 Oct 1;104(1):138-46. doi: 10.1093/cvr/cvu190. Epub 2014 Aug 18.


Major transcriptome re-organisation and abrupt changes in signalling, cell cycle and chromatin regulation at neural differentiation in vivo.

Olivera-Martinez I, Schurch N, Li RA, Song J, Halley PA, Das RM, Burt DW, Barton GJ, Storey KG.

Development. 2014 Aug;141(16):3266-76. doi: 10.1242/dev.112623. Epub 2014 Jul 25.


Bariatric surgery prior to total joint arthroplasty may not provide dramatic improvements in post-arthroplasty surgical outcomes.

Inacio MC, Paxton EW, Fisher D, Li RA, Barber TC, Singh JA.

J Arthroplasty. 2014 Jul;29(7):1359-64. doi: 10.1016/j.arth.2014.02.021. Epub 2014 Feb 26.


A simple, cost-effective but highly efficient system for deriving ventricular cardiomyocytes from human pluripotent stem cells.

Weng Z, Kong CW, Ren L, Karakikes I, Geng L, He J, Chow MZ, Mok CF, Chan HYS, Webb SE, Keung W, Chow H, Miller AL, Leung AY, Hajjar RJ, Li RA, Chan CW.

Stem Cells Dev. 2014 Jul 15;23(14):1704-16. doi: 10.1089/scd.2013.0509. Epub 2014 Apr 22. Erratum in: Stem Cells Dev. 2016 Jun 1;25(11):882.

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