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Items: 44

1.

4-Phenylbutyrate protects against atherosclerotic lesion growth by increasing the expression of HSP25 in macrophages and in the circulation of Apoe-/- mice.

Lynn EG, Lhoták Š, Lebeau P, Byun JH, Chen J, Platko K, Shi C, O'Brien ER, Austin RC.

FASEB J. 2019 Jul;33(7):8406-8422. doi: 10.1096/fj.201802293RR. Epub 2019 Apr 9.

PMID:
30964709
2.

Anti-GRP78 autoantibodies induce endothelial cell activation and accelerate the development of atherosclerotic lesions.

Crane ED, Al-Hashimi AA, Chen J, Lynn EG, Won KD, Lhoták Š, Naeim M, Platko K, Lebeau P, Byun JH, Shayegan B, Krepinsky JC, Rayner KJ, Marchiò S, Pasqualini R, Arap W, Austin RC.

JCI Insight. 2018 Dec 20;3(24). pii: 99363. doi: 10.1172/jci.insight.99363.

3.

IL-6 mediates ER expansion during hyperpolarization of alternatively activated macrophages.

Ayaub EA, Tandon K, Padwal M, Imani J, Patel H, Dubey A, Mekhael O, Upagupta C, Ayoub A, Dvorkin-Gheva A, Murphy J, Kolb PS, Lhotak S, Dickhout JG, Austin RC, Kolb MRJ, Richards CD, Ask K.

Immunol Cell Biol. 2019 Feb;97(2):203-217. doi: 10.1111/imcb.12212. Epub 2018 Nov 14.

PMID:
30298952
4.

Sialidase down-regulation reduces non-HDL cholesterol, inhibits leukocyte transmigration, and attenuates atherosclerosis in ApoE knockout mice.

White EJ, Gyulay G, Lhoták Š, Szewczyk MM, Chong T, Fuller MT, Dadoo O, Fox-Robichaud AE, Austin RC, Trigatti BL, Igdoura SA.

J Biol Chem. 2018 Sep 21;293(38):14689-14706. doi: 10.1074/jbc.RA118.004589. Epub 2018 Aug 10.

5.

Loss-of-function PCSK9 mutants evade the unfolded protein response sensor GRP78 and fail to induce endoplasmic reticulum stress when retained.

Lebeau P, Platko K, Al-Hashimi AA, Byun JH, Lhoták Š, Holzapfel N, Gyulay G, Igdoura SA, Cool DR, Trigatti B, Seidah NG, Austin RC.

J Biol Chem. 2018 May 11;293(19):7329-7343. doi: 10.1074/jbc.RA117.001049. Epub 2018 Mar 28.

6.

Autoantibodies against the cell surface-associated chaperone GRP78 stimulate tumor growth via tissue factor.

Al-Hashimi AA, Lebeau P, Majeed F, Polena E, Lhotak Š, Collins CAF, Pinthus JH, Gonzalez-Gronow M, Hoogenes J, Pizzo SV, Crowther M, Kapoor A, Rak J, Gyulay G, D'Angelo S, Marchiò S, Pasqualini R, Arap W, Shayegan B, Austin RC.

J Biol Chem. 2017 Dec 22;292(51):21180-21192. doi: 10.1074/jbc.M117.799908. Epub 2017 Oct 24.

7.

Endoplasmic Reticulum Stress and Ca2+ Depletion Differentially Modulate the Sterol Regulatory Protein PCSK9 to Control Lipid Metabolism.

Lebeau P, Al-Hashimi A, Sood S, Lhoták Š, Yu P, Gyulay G, Paré G, Chen SR, Trigatti B, Prat A, Seidah NG, Austin RC.

J Biol Chem. 2017 Jan 27;292(4):1510-1523. doi: 10.1074/jbc.M116.744235. Epub 2016 Dec 1.

8.

Liver-specific ATP-citrate lyase inhibition by bempedoic acid decreases LDL-C and attenuates atherosclerosis.

Pinkosky SL, Newton RS, Day EA, Ford RJ, Lhotak S, Austin RC, Birch CM, Smith BK, Filippov S, Groot PHE, Steinberg GR, Lalwani ND.

Nat Commun. 2016 Nov 28;7:13457. doi: 10.1038/ncomms13457.

9.

Characterization of Proliferating Lesion-Resident Cells During All Stages of Atherosclerotic Growth.

Lhoták Š, Gyulay G, Cutz JC, Al-Hashimi A, Trigatti BL, Richards CD, Igdoura SA, Steinberg GR, Bramson J, Ask K, Austin RC.

J Am Heart Assoc. 2016 Aug 15;5(8). pii: e003945. doi: 10.1161/JAHA.116.003945.

10.

GRP78 and CHOP modulate macrophage apoptosis and the development of bleomycin-induced pulmonary fibrosis.

Ayaub EA, Kolb PS, Mohammed-Ali Z, Tat V, Murphy J, Bellaye PS, Shimbori C, Boivin FJ, Lai R, Lynn EG, Lhoták Š, Bridgewater D, Kolb MR, Inman MD, Dickhout JG, Austin RC, Ask K.

J Pathol. 2016 Aug;239(4):411-25. doi: 10.1002/path.4738. Epub 2016 Jun 7.

PMID:
27135434
11.

Salicylate improves macrophage cholesterol homeostasis via activation of Ampk.

Fullerton MD, Ford RJ, McGregor CP, LeBlond ND, Snider SA, Stypa SA, Day EA, Lhoták Š, Schertzer JD, Austin RC, Kemp BE, Steinberg GR.

J Lipid Res. 2015 May;56(5):1025-33. doi: 10.1194/jlr.M058875. Epub 2015 Mar 15.

12.

Novel function of Oncostatin M as a potent tumour-promoting agent in lung.

Lauber S, Wong S, Cutz JC, Tanaka M, Barra N, Lhoták S, Ashkar A, Richards CD.

Int J Cancer. 2015 Feb 15;136(4):831-43. doi: 10.1002/ijc.29055. Epub 2014 Jul 7.

13.

Underactivation of the adiponectin-adiponectin receptor 1 axis in clear cell renal cell carcinoma: implications for progression.

Kleinmann N, Duivenvoorden WC, Hopmans SN, Beatty LK, Qiao S, Gallino D, Lhotak S, Daya D, Paschos A, Austin RC, Pinthus JH.

Clin Exp Metastasis. 2014 Feb;31(2):169-83. doi: 10.1007/s10585-013-9618-1. Epub 2013 Oct 5.

PMID:
24096711
14.

Decreased endogenous production of hydrogen sulfide accelerates atherosclerosis.

Mani S, Li H, Untereiner A, Wu L, Yang G, Austin RC, Dickhout JG, Lhoták Š, Meng QH, Wang R.

Circulation. 2013 Jun 25;127(25):2523-34. doi: 10.1161/CIRCULATIONAHA.113.002208. Epub 2013 May 23.

PMID:
23704252
15.

Deficiency of TDAG51 protects against atherosclerosis by modulating apoptosis, cholesterol efflux, and peroxiredoxin-1 expression.

Hossain GS, Lynn EG, Maclean KN, Zhou J, Dickhout JG, Lhoták S, Trigatti B, Capone J, Rho J, Tang D, McCulloch CA, Al-Bondokji I, Malloy MJ, Pullinger CR, Kane JP, Li Y, Shiffman D, Austin RC.

J Am Heart Assoc. 2013 May 17;2(3):e000134. doi: 10.1161/JAHA.113.000134.

16.

Prenatal stress enhances severity of atherosclerosis in the adult apolipoprotein E-deficient mouse offspring via inflammatory pathways.

Ho H, Lhotak S, Solano ME, Karimi K, Pincus MK, Austin RC, Arck P.

J Dev Orig Health Dis. 2013 Feb;4(1):90-7. doi: 10.1017/S2040174412000608.

PMID:
25080185
17.

Underexpression of tumour suppressor LKB1 in clear cell renal cell carcinoma is common and confers growth advantage in vitro and in vivo.

Duivenvoorden WC, Beatty LK, Lhotak S, Hill B, Mak I, Paulin G, Gallino D, Popovic S, Austin RC, Pinthus JH.

Br J Cancer. 2013 Feb 5;108(2):327-33. doi: 10.1038/bjc.2012.574. Epub 2013 Jan 15.

18.

Loss of TDAG51 results in mature-onset obesity, hepatic steatosis, and insulin resistance by regulating lipogenesis.

Basseri S, Lhoták S, Fullerton MD, Palanivel R, Jiang H, Lynn EG, Ford RJ, Maclean KN, Steinberg GR, Austin RC.

Diabetes. 2013 Jan;62(1):158-69. doi: 10.2337/db12-0256. Epub 2012 Sep 6.

19.

Cystathionine protects against endoplasmic reticulum stress-induced lipid accumulation, tissue injury, and apoptotic cell death.

Maclean KN, Greiner LS, Evans JR, Sood SK, Lhotak S, Markham NE, Stabler SP, Allen RH, Austin RC, Balasubramaniam V, Jiang H.

J Biol Chem. 2012 Sep 14;287(38):31994-2005. doi: 10.1074/jbc.M112.355172. Epub 2012 Aug 1.

20.

ER stress contributes to renal proximal tubule injury by increasing SREBP-2-mediated lipid accumulation and apoptotic cell death.

Lhoták S, Sood S, Brimble E, Carlisle RE, Colgan SM, Mazzetti A, Dickhout JG, Ingram AJ, Austin RC.

Am J Physiol Renal Physiol. 2012 Jul 15;303(2):F266-78. doi: 10.1152/ajprenal.00482.2011. Epub 2012 May 9.

21.

Immunohistochemical detection of the unfolded protein response in atherosclerotic plaques.

Lhoták S, Zhou J, Austin RC.

Methods Enzymol. 2011;489:23-46. doi: 10.1016/B978-0-12-385116-1.00002-9.

PMID:
21266222
22.

Induction of the unfolded protein response after monocyte to macrophage differentiation augments cell survival in early atherosclerotic lesions.

Dickhout JG, Lhoták Š, Hilditch BA, Basseri S, Colgan SM, Lynn EG, Carlisle RE, Zhou J, Sood SK, Ingram AJ, Austin RC.

FASEB J. 2011 Feb;25(2):576-89. doi: 10.1096/fj.10-159319. Epub 2010 Oct 21.

PMID:
20966213
23.

The chemical chaperone 4-phenylbutyrate inhibits adipogenesis by modulating the unfolded protein response.

Basseri S, Lhoták S, Sharma AM, Austin RC.

J Lipid Res. 2009 Dec;50(12):2486-501. doi: 10.1194/jlr.M900216-JLR200.

24.

Mouse models of cystathionine beta-synthase deficiency reveal significant threshold effects of hyperhomocysteinemia.

Gupta S, Kühnisch J, Mustafa A, Lhotak S, Schlachterman A, Slifker MJ, Klein-Szanto A, High KA, Austin RC, Kruger WD.

FASEB J. 2009 Mar;23(3):883-93. doi: 10.1096/fj.08-120584. Epub 2008 Nov 5.

25.

Immunohistochemical detection of N-homocysteinylated proteins in humans and mice.

Perła-Kaján J, Stanger O, Luczak M, Ziółkowska A, Malendowicz LK, Twardowski T, Lhotak S, Austin RC, Jakubowski H.

Biomed Pharmacother. 2008 Sep;62(7):473-9. doi: 10.1016/j.biopha.2008.04.001. Epub 2008 May 2.

PMID:
18501553
26.

Hyperhomocysteinemia induced by methionine supplementation does not independently cause atherosclerosis in C57BL/6J mice.

Zhou J, Werstuck GH, Lhoták S, Shi YY, Tedesco V, Trigatti B, Dickhout J, Majors AK, DiBello PM, Jacobsen DW, Austin RC.

FASEB J. 2008 Jul;22(7):2569-78. doi: 10.1096/fj.07-105353. Epub 2008 Mar 25.

27.

Increased endoplasmic reticulum stress in atherosclerotic plaques associated with acute coronary syndrome: a balancing act between plaque stability and rupture.

Dickhout JG, Colgan SM, Lhoták S, Austin RC.

Circulation. 2007 Sep 11;116(11):1214-6. No abstract available.

PMID:
17846339
28.

Prothrombotic effects of hyperhomocysteinemia and hypercholesterolemia in ApoE-deficient mice.

Wilson KM, McCaw RB, Leo L, Arning E, Lhoták S, Bottiglieri T, Austin RC, Lentz SR.

Arterioscler Thromb Vasc Biol. 2007 Jan;27(1):233-40. Epub 2006 Nov 2.

PMID:
17082485
29.

Peroxynitrite causes endoplasmic reticulum stress and apoptosis in human vascular endothelium: implications in atherogenesis.

Dickhout JG, Hossain GS, Pozza LM, Zhou J, Lhoták S, Austin RC.

Arterioscler Thromb Vasc Biol. 2005 Dec;25(12):2623-9. Epub 2005 Oct 6.

PMID:
16210571
30.

Activation of the unfolded protein response occurs at all stages of atherosclerotic lesion development in apolipoprotein E-deficient mice.

Zhou J, Lhoták S, Hilditch BA, Austin RC.

Circulation. 2005 Apr 12;111(14):1814-21. Epub 2005 Apr 4.

PMID:
15809369
31.

Association of multiple cellular stress pathways with accelerated atherosclerosis in hyperhomocysteinemic apolipoprotein E-deficient mice.

Zhou J, Werstuck GH, Lhoták S, de Koning AB, Sood SK, Hossain GS, Møller J, Ritskes-Hoitinga M, Falk E, Dayal S, Lentz SR, Austin RC.

Circulation. 2004 Jul 13;110(2):207-13. Epub 2004 Jun 21.

PMID:
15210586
32.

Morphological, histomorphometric, and microstructural alterations in human bone metastasis from breast carcinoma.

Vukmirovic-Popovic S, Colterjohn N, Lhoták S, Duivenvoorden WC, Orr FW, Singh G.

Bone. 2002 Oct;31(4):529-35.

PMID:
12398951
33.

Doxycycline decreases tumor burden in a bone metastasis model of human breast cancer.

Duivenvoorden WC, Popović SV, Lhoták S, Seidlitz E, Hirte HW, Tozer RG, Singh G.

Cancer Res. 2002 Mar 15;62(6):1588-91.

34.

Immunolocalization of matrix metalloproteinases and their inhibitors in clinical specimens of bone metastasis from breast carcinoma.

Lhoták S, Elavathil LJ, Vukmirović-Popović S, Duivenvoorden WC, Tozer RG, Singh G.

Clin Exp Metastasis. 2000;18(6):463-70.

PMID:
11592303
35.

A mouse homologue of the Drosophila tumor suppressor l(2)tid gene defines a novel Ras GTPase-activating protein (RasGAP)-binding protein.

Trentin GA, Yin X, Tahir S, Lhotak S, Farhang-Fallah J, Li Y, Rozakis-Adcock M.

J Biol Chem. 2001 Apr 20;276(16):13087-95. Epub 2000 Dec 14.

37.

Evidence that colitis is initiated by environmental stress and sustained by fecal factors in the cotton-top tamarin (Saguinus oedipus).

Wood JD, Peck OC, Tefend KS, Stonerook MJ, Caniano DA, Mutabagani KH, Lhoták S, Sharma HM.

Dig Dis Sci. 2000 Feb;45(2):385-93.

PMID:
10711456
38.

Taxol involution of collagen-induced arthritis: ultrastructural correlation with the inhibition of synovitis and neovascularization.

Arsenault AL, Lhoták S, Hunter WL, Banquerigo ML, Brahn E.

Clin Immunol Immunopathol. 1998 Mar;86(3):280-9.

PMID:
9557161
39.

Effect of truncal vagotomy and capsaicin on mast cells and IgA-positive plasma cells in rat jejunal mucosa.

Gottwald T, Lhoták S, Stead RH.

Neurogastroenterol Motil. 1997 Mar;9(1):25-32.

PMID:
9058389
40.

Electrical stimulation of the vagus nerve modulates the histamine content of mast cells in the rat jejunal mucosa.

Gottwald TP, Hewlett BR, Lhoták S, Stead RH.

Neuroreport. 1995 Dec 29;7(1):313-7.

PMID:
8742478
41.

Ultrastructural examination of B-50(GAP-43) immunoreactivity in rat jejunal villi.

Lhoták S, Oestreicher AB, Stead RH.

Histochem J. 1995 Apr;27(4):272-9.

PMID:
7635759
42.

Effects of subdiaphragmatic vagotomy on mucosal mast cell densities in stomach and jejunum of rats.

Gottwald TP, Lhotak S, Stead RH.

Adv Exp Med Biol. 1995;371A:303-6. No abstract available.

PMID:
8525930
43.

Endothelial injury causes degradation of adjacent basement membranes and promotes their invasion by A549 carcinoma cells.

Missirlis E, Whaley M, Lhotak S, Orr FW.

Invasion Metastasis. 1992;12(1):35-46.

PMID:
1512135
44.

Immunoelectron microscopic diagnosis in nephropathology.

Simon GT, Lhoták S, Alexopoulou I.

Am J Kidney Dis. 1989 Nov;14(5):369-76.

PMID:
2683755

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