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Items: 17


A Quantitative Systems Pharmacology Approach to Infer Pathways Involved in Complex Disease Phenotypes.

Schurdak ME, Pei F, Lezon TR, Carlisle D, Friedlander R, Taylor DL, Stern AM.

Methods Mol Biol. 2018;1787:207-222. doi: 10.1007/978-1-4939-7847-2_16.


Connecting Neuronal Cell Protective Pathways and Drug Combinations in a Huntington's Disease Model through the Application of Quantitative Systems Pharmacology.

Pei F, Li H, Henderson MJ, Titus SA, Jadhav A, Simeonov A, Cobanoglu MC, Mousavi SH, Shun T, McDermott L, Iyer P, Fioravanti M, Carlisle D, Friedlander RM, Bahar I, Taylor DL, Lezon TR, Stern AM, Schurdak ME.

Sci Rep. 2017 Dec 19;7(1):17803. doi: 10.1038/s41598-017-17378-y.


Platform for Quantitative Evaluation of Spatial Intratumoral Heterogeneity in Multiplexed Fluorescence Images.

Spagnolo DM, Al-Kofahi Y, Zhu P, Lezon TR, Gough A, Stern AM, Lee AV, Ginty F, Sarachan B, Taylor DL, Chennubhotla SC.

Cancer Res. 2017 Nov 1;77(21):e71-e74. doi: 10.1158/0008-5472.CAN-17-0676.


Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release.

Suofu Y, Li W, Jean-Alphonse FG, Jia J, Khattar NK, Li J, Baranov SV, Leronni D, Mihalik AC, He Y, Cecon E, Wehbi VL, Kim J, Heath BE, Baranova OV, Wang X, Gable MJ, Kretz ES, Di Benedetto G, Lezon TR, Ferrando LM, Larkin TM, Sullivan M, Yablonska S, Wang J, Minnigh MB, Guillaumet G, Suzenet F, Richardson RM, Poloyac SM, Stolz DB, Jockers R, Witt-Enderby PA, Carlisle DL, Vilardaga JP, Friedlander RM.

Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):E7997-E8006. doi: 10.1073/pnas.1705768114. Epub 2017 Sep 5.


Pointwise mutual information quantifies intratumor heterogeneity in tissue sections labeled with multiple fluorescent biomarkers.

Spagnolo DM, Gyanchandani R, Al-Kofahi Y, Stern AM, Lezon TR, Gough A, Meyer DE, Ginty F, Sarachan B, Fine J, Lee AV, Taylor DL, Chennubhotla SC.

J Pathol Inform. 2016 Nov 29;7:47. eCollection 2016.


Modeling global changes induced by local perturbations to the HIV-1 capsid.

Bergman S, Lezon TR.

J Mol Graph Model. 2017 Jan;71:218-226. doi: 10.1016/j.jmgm.2016.12.003. Epub 2016 Dec 5.


Proteomic Screening and Lasso Regression Reveal Differential Signaling in Insulin and Insulin-like Growth Factor I (IGF1) Pathways.

Erdem C, Nagle AM, Casa AJ, Litzenburger BC, Wang YF, Taylor DL, Lee AV, Lezon TR.

Mol Cell Proteomics. 2016 Sep;15(9):3045-57. doi: 10.1074/mcp.M115.057729. Epub 2016 Jun 30.


Identifying and quantifying heterogeneity in high content analysis: application of heterogeneity indices to drug discovery.

Gough AH, Chen N, Shun TY, Lezon TR, Boltz RC, Reese CE, Wagner J, Vernetti LA, Grandis JR, Lee AV, Stern AM, Schurdak ME, Taylor DL.

PLoS One. 2014 Jul 18;9(7):e102678. doi: 10.1371/journal.pone.0102678. eCollection 2014. Erratum in: PLoS One. 2015;10(3):e0120468.


Evol and ProDy for bridging protein sequence evolution and structural dynamics.

Bakan A, Dutta A, Mao W, Liu Y, Chennubhotla C, Lezon TR, Bahar I.

Bioinformatics. 2014 Sep 15;30(18):2681-3. doi: 10.1093/bioinformatics/btu336. Epub 2014 May 21.


Constraints imposed by the membrane selectively guide the alternating access dynamics of the glutamate transporter GltPh.

Lezon TR, Bahar I.

Biophys J. 2012 Mar 21;102(6):1331-40. doi: 10.1016/j.bpj.2012.02.028. Epub 2012 Mar 20.


The effects of rigid motions on elastic network model force constants.

Lezon TR.

Proteins. 2012 Apr;80(4):1133-42. doi: 10.1002/prot.24014. Epub 2012 Jan 7.


Using entropy maximization to understand the determinants of structural dynamics beyond native contact topology.

Lezon TR, Bahar I.

PLoS Comput Biol. 2010 Jun 17;6(6):e1000816. doi: 10.1371/journal.pcbi.1000816.


Global dynamics of proteins: bridging between structure and function.

Bahar I, Lezon TR, Yang LW, Eyal E.

Annu Rev Biophys. 2010;39:23-42. doi: 10.1146/annurev.biophys.093008.131258. Review.


Normal mode analysis of biomolecular structures: functional mechanisms of membrane proteins.

Bahar I, Lezon TR, Bakan A, Shrivastava IH.

Chem Rev. 2010 Mar 10;110(3):1463-97. doi: 10.1021/cr900095e. Review. No abstract available.


Global motions of the nuclear pore complex: insights from elastic network models.

Lezon TR, Sali A, Bahar I.

PLoS Comput Biol. 2009 Sep;5(9):e1000496. doi: 10.1371/journal.pcbi.1000496. Epub 2009 Sep 4.


Using the principle of entropy maximization to infer genetic interaction networks from gene expression patterns.

Lezon TR, Banavar JR, Cieplak M, Maritan A, Fedoroff NV.

Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19033-8. Epub 2006 Nov 30.


What determines the spectrum of protein native state structures?

Lezon TR, Banavar JR, Lesk AM, Maritan A.

Proteins. 2006 May 1;63(2):273-7.


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