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Items: 1 to 50 of 52

1.

The genome sequence of Streptomyces rochei 7434AN4, which carries a linear chromosome and three characteristic linear plasmids.

Nindita Y, Cao Z, Fauzi AA, Teshima A, Misaki Y, Muslimin R, Yang Y, Shiwa Y, Yoshikawa H, Tagami M, Lezhava A, Ishikawa J, Kuroda M, Sekizuka T, Inada K, Kinashi H, Arakawa K.

Sci Rep. 2019 Jul 29;9(1):10973. doi: 10.1038/s41598-019-47406-y.

2.

Genomics-driven discovery of a biosynthetic gene cluster required for the synthesis of BII-Rafflesfungin from the fungus Phoma sp. F3723.

Sinha S, Nge CE, Leong CY, Ng V, Crasta S, Alfatah M, Goh F, Low KN, Zhang H, Arumugam P, Lezhava A, Chen SL, Kanagasundaram Y, Ng SB, Eisenhaber F, Eisenhaber B.

BMC Genomics. 2019 May 14;20(1):374. doi: 10.1186/s12864-019-5762-6.

3.

Genome-wide identification of natural RNA aptamers in prokaryotes and eukaryotes.

Tapsin S, Sun M, Shen Y, Zhang H, Lim XN, Susanto TT, Yang SL, Zeng GS, Lee J, Lezhava A, Ang EL, Zhang LH, Wang Y, Zhao H, Nagarajan N, Wan Y.

Nat Commun. 2018 Mar 29;9(1):1289. doi: 10.1038/s41467-018-03675-1.

4.

Chromosome 1q21.3 amplification is a trackable biomarker and actionable target for breast cancer recurrence.

Goh JY, Feng M, Wang W, Oguz G, Yatim SMJM, Lee PL, Bao Y, Lim TH, Wang P, Tam WL, Kodahl AR, Lyng MB, Sarma S, Lin SY, Lezhava A, Yap YS, Lim AST, Hoon DSB, Ditzel HJ, Lee SC, Tan EY, Yu Q.

Nat Med. 2017 Nov;23(11):1319-1330. doi: 10.1038/nm.4405. Epub 2017 Sep 25.

PMID:
28967919
5.

VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma.

Yao X, Tan J, Lim KJ, Koh J, Ooi WF, Li Z, Huang D, Xing M, Chan YS, Qu JZ, Tay ST, Wijaya G, Lam YN, Hong JH, Lee-Lim AP, Guan P, Ng MSW, He CZ, Lin JS, Nandi T, Qamra A, Xu C, Myint SS, Davies JOJ, Goh JY, Loh G, Tan BC, Rozen SG, Yu Q, Tan IBH, Cheng CWS, Li S, Chang KTE, Tan PH, Silver DL, Lezhava A, Steger G, Hughes JR, Teh BT, Tan P.

Cancer Discov. 2017 Nov;7(11):1284-1305. doi: 10.1158/2159-8290.CD-17-0375. Epub 2017 Sep 11.

6.

Phenotype-driven precision oncology as a guide for clinical decisions one patient at a time.

Chia S, Low JL, Zhang X, Kwang XL, Chong FT, Sharma A, Bertrand D, Toh SY, Leong HS, Thangavelu MT, Hwang JSG, Lim KH, Skanthakumar T, Tan HK, Su Y, Hui Choo S, Hentze H, Tan IBH, Lezhava A, Tan P, Tan DSW, Periyasamy G, Koh JLY, Gopalakrishna Iyer N, DasGupta R.

Nat Commun. 2017 Sep 5;8(1):435. doi: 10.1038/s41467-017-00451-5.

7.

Multiregion ultra-deep sequencing reveals early intermixing and variable levels of intratumoral heterogeneity in colorectal cancer.

Suzuki Y, Ng SB, Chua C, Leow WQ, Chng J, Liu SY, Ramnarayanan K, Gan A, Ho DL, Ten R, Su Y, Lezhava A, Lai JH, Koh D, Lim KH, Tan P, Rozen SG, Tan IB.

Mol Oncol. 2017 Feb;11(2):124-139. doi: 10.1002/1878-0261.12012. Epub 2016 Oct 20.

8.

Technical Validation of a Next-Generation Sequencing Assay for Detecting Actionable Mutations in Patients with Gastrointestinal Cancer.

Wang SR, Malik S, Tan IB, Chan YS, Hoi Q, Ow JL, He CZ, Ching CE, Poh DYS, Seah HM, Cheung KHT, Perumal D, Devasia AG, Pan L, Ang S, Lee SE, Ten R, Chua C, Tan DSW, Qu JZZ, Bylstra YM, Lim L, Lezhava A, Ng PC, Wong CW, Lim T, Tan P.

J Mol Diagn. 2016 May;18(3):416-424. doi: 10.1016/j.jmoldx.2016.01.006. Epub 2016 Mar 9.

9.

The tap-tpg gene pair on the linear plasmid functions to maintain a linear topology of the chromosome in Streptomyces rochei.

Nindita Y, Cao Z, Yang Y, Arakawa K, Shiwa Y, Yoshikawa H, Tagami M, Lezhava A, Kinashi H.

Mol Microbiol. 2015 Mar;95(5):846-58. doi: 10.1111/mmi.12904. Epub 2015 Jan 24.

10.

Single-nucleotide polymorphism (c.309T>G) in the MDM2 gene and lung cancer risk.

Enokida Y, Shimizu K, Kakegawa S, Atsumi J, Takase Y, Miyamae Y, Nagashima T, Ohtaki Y, Kaira K, Sunaga N, Yanagitani N, Yoshino R, Tsunekawa K, Igai H, Kamiyoshihara M, Usui K, Lezhava A, Tomizawa Y, Ishikawa T, Murakami M, Hayashizaki Y, Takeyoshi I.

Biomed Rep. 2014 Sep;2(5):719-724. Epub 2014 Jun 26.

11.

SNP (-617C>A) in ARE-like loci of the NRF2 gene: a new biomarker for prognosis of lung adenocarcinoma in Japanese non-smoking women.

Okano Y, Nezu U, Enokida Y, Lee MT, Kinoshita H, Lezhava A, Hayashizaki Y, Morita S, Taguri M, Ichikawa Y, Kaneko T, Natsumeda Y, Yokose T, Nakayama H, Miyagi Y, Ishikawa T.

PLoS One. 2013 Sep 11;8(9):e73794. doi: 10.1371/journal.pone.0073794. eCollection 2013.

12.

Rapid detection of SNP (c.309T>G) in the MDM2 gene by the Duplex SmartAmp method.

Enokida Y, Shimizu K, Atsumi J, Lezhava A, Tanaka Y, Kimura Y, Soma T, Hanami T, Kawai Y, Usui K, Okano Y, Kakegawa S, Ogawa H, Miyamae Y, Miyagi Y, Nakayama H, Ishikawa T, Hayashizaki Y, Takeyoshi I.

PLoS One. 2013;8(4):e60151. doi: 10.1371/journal.pone.0060151. Epub 2013 Apr 2.

13.

Direct and rapid genotyping of SLCO1B1 388A>G and 521T>C in human blood specimens using the SmartAmp-2 method.

Yoshida K, Takano J, Ishizu Y, Lezhava A, Ieiri I, Maeda K, Hayashizaki Y, Sugiyama Y.

AAPS J. 2013 Apr;15(2):618-22. doi: 10.1208/s12248-013-9471-9. Epub 2013 Mar 8.

14.

Effect of thiazole orange doubly labeled thymidine on DNA duplex formation.

Kimura Y, Hanami T, Tanaka Y, de Hoon MJ, Soma T, Harbers M, Lezhava A, Hayashizaki Y, Usui K.

Biochemistry. 2012 Aug 7;51(31):6056-67. Epub 2012 Jul 25.

PMID:
22765348
15.

The SmartAmp method: rapid detection of SNPs in thiopurine S-methyltransferase and ABC transporters ABCC4 and ABCG2.

Aw W, Lezhava A, Andoh A, Tanaka H, Hayashizaki Y, Ishikawa T.

Curr Drug Metab. 2012 Sep 1;13(7):968-77.

PMID:
22591349
16.

Institutional Profile: Golden Helix Institute of Biomedical Research: interdisciplinary research and educational activities in pharmacogenomics and personalized medicine.

Mitropoulos K, Innocenti F, van Schaik RH, Lezhava A, Tzimas G, Kollia P, Macek M Jr, Fortina P, Patrinos GP.

Pharmacogenomics. 2012 Mar;13(4):387-92. doi: 10.2217/pgs.12.7.

17.

One-step detection of the 2009 pandemic influenza A(H1N1) virus by the RT-SmartAmp assay and its clinical validation.

Kawai Y, Kimura Y, Lezhava A, Kanamori H, Usui K, Hanami T, Soma T, Morlighem JÉ, Saga S, Ishizu Y, Aoki S, Endo R, Oguchi-Katayama A, Kogo Y, Mitani Y, Ishidao T, Kawakami C, Kurata H, Furuya Y, Saito T, Okazaki N, Chikahira M, Hayashi E, Tsuruoka S, Toguchi T, Saito Y, Ban T, Izumi S, Uryu H, Kudo K, Sakai-Tagawa Y, Kawaoka Y, Hirai A, Hayashizaki Y, Ishikawa T.

PLoS One. 2012;7(1):e30236. doi: 10.1371/journal.pone.0030236. Epub 2012 Jan 25.

18.

Association between accumulation of visceral fat and the combination of β3 adrenergic receptor Trp64Arg, β2 adrenergic receptor Arg16Gly and uncoupling protein 1 -3826A>G polymorphisms detected by Smart Amplification Process 2.

Tsunekawa K, Yanagawa Y, Aoki T, Morimura T, Araki O, Ogiwara T, Kawai Y, Mitani Y, Lezhava A, Yanagawa M, Hayashizaki Y, Murakami M.

Endocr J. 2011;58(12):1079-86. Epub 2011 Sep 30.

19.

Clinical screening assay for EGFR exon 19 mutations using PNA-clamp smart amplification process version 2 in lung adenocarcinoma.

Araki T, Shimizu K, Nakamura T, Baba M, Kawai Y, Nakamura K, Mitani Y, Obayashi K, Aomori T, Fujita Y, Miyamae Y, Kakegawa S, Kaira K, Lezhava A, Hayashizaki Y, Takeyoshi I, Yamamoto K.

Oncol Rep. 2011 Nov;26(5):1213-9. doi: 10.3892/or.2011.1391. Epub 2011 Jul 15.

PMID:
21769434
20.

DNA amplification techniques in pharmacogenomics.

Morlighem JÉ, Harbers M, Traeger-Synodinos J, Lezhava A.

Pharmacogenomics. 2011 Jun;12(6):845-60. doi: 10.2217/pgs.11.10. Review.

PMID:
21692615
21.

Direct genotyping of Cytochrome P450 2A6 whole gene deletion from human blood samples by the SmartAmp method.

Azuma K, Lezhava A, Shimizu M, Kimura Y, Ishizu Y, Ishikawa T, Kamataki T, Hayashizaki Y, Yamazaki H.

Clin Chim Acta. 2011 Jun 11;412(13-14):1249-51. doi: 10.1016/j.cca.2011.03.017. Epub 2011 Mar 21.

PMID:
21420395
22.

A new trend in personalized medicine: rapid detection of SNPs in drug transporter genes by the SmartAmp method.

Aw W, Lezhava A, Hayashizaki Y, Ishikawa T.

Clin Pharmacol Ther. 2011 Apr;89(4):617-20. doi: 10.1038/clpt.2011.13. Epub 2011 Feb 23. No abstract available. Erratum in: Clin Pharmacol Ther. 2011 Jun;89(6):928. Hyashizaki, Y [corrected to Hayashizaki, Y].

PMID:
21346755
23.

Optimization of turn-back primers in isothermal amplification.

Kimura Y, de Hoon MJ, Aoki S, Ishizu Y, Kawai Y, Kogo Y, Daub CO, Lezhava A, Arner E, Hayashizaki Y.

Nucleic Acids Res. 2011 May;39(9):e59. doi: 10.1093/nar/gkr041. Epub 2011 Feb 9.

24.

A large inversion in the linear chromosome of Streptomyces griseus caused by replicative transposition of a new Tn3 family transposon.

Murata M, Uchida T, Yang Y, Lezhava A, Kinashi H.

Arch Microbiol. 2011 Apr;193(4):299-306. doi: 10.1007/s00203-010-0674-5. Epub 2011 Jan 15.

PMID:
21234748
25.

Association between breast cancer risk and the wild-type allele of human ABC transporter ABCC11.

Ota I, Sakurai A, Toyoda Y, Morita S, Sasaki T, Chishima T, Yamakado M, Kawai Y, Ishidao T, Lezhava A, Yoshiura K, Togo S, Hayashizaki Y, Ishikawa T, Ishikawa T, Endo I, Shimada H.

Anticancer Res. 2010 Dec;30(12):5189-94.

PMID:
21187511
26.

Effects of the turn-back primer on intermediate product generation in isothermal DNA amplification.

Tanaka Y, Kimura Y, Mitani Y, Kawai Y, Lezhava A, Noma S, Tagami M, Kawai J, Hayashizaki Y, Usui K.

Biotechniques. 2010 Dec;49(6):888-92. doi: 10.2144/000113566.

27.

Pharmacogenomics of human ABC transporters: detection of clinically important SNPs by SmartAmp2 method.

Aw W, Ota I, Toyoda Y, Lezhava A, Sakai Y, Gomi T, Hayashizaki Y, Ishikawa T.

Curr Pharm Biotechnol. 2011 Apr;12(4):693-704. Review.

PMID:
21118085
28.

Direct and rapid genotyping of glutathione-S-transferase M1 and T1 from human blood specimens using the SmartAmp2 method.

Okada R, Ishizu Y, Endo R, Lezhava A, Ieiri I, Kusuhara H, Sugiyama Y, Hayashizaki Y.

Drug Metab Dispos. 2010 Oct;38(10):1636-9. doi: 10.1124/dmd.110.034652. Epub 2010 Jul 7.

PMID:
20610557
29.

[To promise personalized medicine: development of world's fastest SNP detection method to circumvent drug-induced adverse reactions].

Ishikawa T, Aw W, Lezhava A, Hayashizaki Y.

Arerugi. 2010 Feb;59(2):98-108. Review. Japanese. No abstract available.

PMID:
20212351
30.

Emerging new technologies in Pharmacogenomics: rapid SNP detection, molecular dynamic simulation, and QSAR analysis methods to validate clinically important genetic variants of human ABC Transporter ABCB1 (P-gp/MDR1).

Ishikawa T, Sakurai A, Hirano H, Lezhava A, Sakurai M, Hayashizaki Y.

Pharmacol Ther. 2010 Apr;126(1):69-81. doi: 10.1016/j.pharmthera.2010.01.005. Epub 2010 Feb 4. Review.

PMID:
20138191
31.

Mutation detection of epidermal growth factor receptor and KRAS genes using the smart amplification process version 2 from formalin-fixed, paraffin-embedded lung cancer tissue.

Miyamae Y, Shimizu K, Mitani Y, Araki T, Kawai Y, Baba M, Kakegawa S, Sugano M, Kaira K, Lezhava A, Hayashizaki Y, Yamamoto K, Takeyoshi I.

J Mol Diagn. 2010 Mar;12(2):257-64. doi: 10.2353/jmoldx.2010.090105. Epub 2010 Jan 21.

32.

Exciton Primer-mediated SNP detection in SmartAmp2 reactions.

Lezhava A, Ishidao T, Ishizu Y, Naito K, Hanami T, Katayama A, Kogo Y, Soma T, Ikeda S, Murakami K, Nogawa C, Itoh M, Mitani Y, Harbers M, Okamoto A, Hayashizaki Y.

Hum Mutat. 2010 Feb;31(2):208-17. doi: 10.1002/humu.21177.

PMID:
20052755
33.

Usefulness of peptide nucleic acid (PNA)-clamp smart amplification process version 2 (SmartAmp2) for clinical diagnosis of KRAS codon 12 mutations in lung adenocarcinoma: comparison of PNA-clamp SmartAmp2 and PCR-related methods.

Araki T, Shimizu K, Nakamura K, Nakamura T, Mitani Y, Obayashi K, Fujita Y, Kakegawa S, Miyamae Y, Kaira K, Ishidao T, Lezhava A, Hayashizaki Y, Takeyoshi I, Yamamoto K.

J Mol Diagn. 2010 Jan;12(1):118-24. doi: 10.2353/jmoldx.2010.090081. Epub 2009 Dec 10.

34.

Isothermal single nucleotide polymorphism genotyping and direct PCR from whole blood using a novel whole-blood lysis buffer.

Victor ST, Lezhava A, Ishidao T, Endo R, Mitani Y, Kawaoka Y, Hayashizaki Y.

Mol Diagn Ther. 2009 Dec 1;13(6):383-7. doi: 10.2165/11317520-000000000-00000.

PMID:
19925036
35.

Detection of SNP by the isothermal smart amplification method.

Lezhava A, Hayashizaki Y.

Methods Mol Biol. 2009;578:437-51. doi: 10.1007/978-1-60327-411-1_28.

PMID:
19768611
36.

Rapid and cost-effective SNP detection method: application of SmartAmp2 to pharmacogenomics research.

Mitani Y, Lezhava A, Sakurai A, Horikawa A, Nagakura M, Hayashizaki Y, Ishikawa T.

Pharmacogenomics. 2009 Jul;10(7):1187-97. doi: 10.2217/pgs.09.39.

PMID:
19604094
37.

Earwax, osmidrosis, and breast cancer: why does one SNP (538G>A) in the human ABC transporter ABCC11 gene determine earwax type?

Toyoda Y, Sakurai A, Mitani Y, Nakashima M, Yoshiura K, Nakagawa H, Sakai Y, Ota I, Lezhava A, Hayashizaki Y, Niikawa N, Ishikawa T.

FASEB J. 2009 Jun;23(6):2001-13. doi: 10.1096/fj.09-129098. Epub 2009 Apr 21.

PMID:
19383836
38.

Tail variation of the folding primer affects the SmartAmp2 process differently.

Kimura Y, Oguchi-Katayama A, Kawai Y, Naito K, Mitani Y, Morlighem JE, Hayashizaki Y, Lezhava A.

Biochem Biophys Res Commun. 2009 Jun 12;383(4):455-9. doi: 10.1016/j.bbrc.2009.04.033. Epub 2009 Apr 14.

PMID:
19371726
39.

Rapid single-nucleotide polymorphism detection of cytochrome P450 (CYP2C9) and vitamin K epoxide reductase (VKORC1) genes for the warfarin dose adjustment by the SMart-amplification process version 2.

Aomori T, Yamamoto K, Oguchi-Katayama A, Kawai Y, Ishidao T, Mitani Y, Kogo Y, Lezhava A, Fujita Y, Obayashi K, Nakamura K, Kohnke H, Wadelius M, Ekström L, Skogastierna C, Rane A, Kurabayashi M, Murakami M, Cizdziel PE, Hayashizaki Y, Horiuchi R.

Clin Chem. 2009 Apr;55(4):804-12. doi: 10.1373/clinchem.2008.115295. Epub 2009 Jan 30.

40.

Rapid screening assay for KRAS mutations by the modified smart amplification process.

Tatsumi K, Mitani Y, Watanabe J, Takakura H, Hoshi K, Kawai Y, Kikuchi T, Kogo Y, Oguchi-Katayama A, Tomaru Y, Kanamori H, Baba M, Ishidao T, Usui K, Itoh M, Cizdziel PE, Lezhava A, Ueda M, Ichikawa Y, Endo I, Togo S, Shimada H, Hayashizaki Y.

J Mol Diagn. 2008 Nov;10(6):520-6. doi: 10.2353/jmoldx.2008.080024. Epub 2008 Oct 2.

41.

Use of a competitive probe in assay design for genotyping of the UGT1A1 *28 microsatellite polymorphism by the smart amplification process.

Watanabe J, Mitani Y, Kawai Y, Kikuchi T, Kogo Y, Oguchi-Katayama A, Kanamori H, Usui K, Itoh M, Cizdziel PE, Lezhava A, Tatsumi K, Ichikawa Y, Togo S, Shimada H, Hayashizaki Y.

Biotechniques. 2007 Oct;43(4):479-84.

42.

Rapid detection of epidermal growth factor receptor mutations in lung cancer by the SMart-Amplification Process.

Hoshi K, Takakura H, Mitani Y, Tatsumi K, Momiyama N, Ichikawa Y, Togo S, Miyagi T, Kawai Y, Kogo Y, Kikuchi T, Kato C, Arakawa T, Uno S, Cizdziel PE, Lezhava A, Ogawa N, Hayashizaki Y, Shimada H.

Clin Cancer Res. 2007 Sep 1;13(17):4974-83.

43.

Rapid SNP diagnostics using asymmetric isothermal amplification and a new mismatch-suppression technology.

Mitani Y, Lezhava A, Kawai Y, Kikuchi T, Oguchi-Katayama A, Kogo Y, Itoh M, Miyagi T, Takakura H, Hoshi K, Kato C, Arakawa T, Shibata K, Fukui K, Masui R, Kuramitsu S, Kiyotani K, Chalk A, Tsunekawa K, Murakami M, Kamataki T, Oka T, Shimada H, Cizdziel PE, Hayashizaki Y.

Nat Methods. 2007 Mar;4(3):257-62. Epub 2007 Feb 18.

PMID:
17322893
44.

Possible involvement of ActVI-ORFA in transcriptional regulation of actVI tailoring-step genes for actinorhodin biosynthesis.

Taguchi T, Okamoto S, Lezhava A, Li A, Ochi K, Ebizuka Y, Ichinose K.

FEMS Microbiol Lett. 2007 Apr;269(2):234-9. Epub 2007 Jan 15.

45.

Enhanced expression of S-adenosylmethionine synthetase causes overproduction of actinorhodin in Streptomyces coelicolor A3(2).

Okamoto S, Lezhava A, Hosaka T, Okamoto-Hosoya Y, Ochi K.

J Bacteriol. 2003 Jan;185(2):601-9.

46.

Cloning and analysis of the telomere and terminal inverted repeat of the linear chromosome of Streptomyces griseus.

Goshi K, Uchida T, Lezhava A, Yamasaki M, Hiratsu K, Shinkawa H, Kinashi H.

J Bacteriol. 2002 Jun;184(12):3411-5.

47.

Analysis of fusion junctions of circularized chromosomes in Streptomyces griseus.

Kameoka D, Lezhava A, Zenitani H, Hiratsu K, Kawamoto M, Goshi K, Inada K, Shinkawa H, Kinashi H.

J Bacteriol. 1999 Sep;181(18):5711-7.

48.

Chromosomal deletions in Streptomyces griseus that remove the afsA locus.

Lezhava A, Kameoka D, Sugino H, Goshi K, Shinkawa H, Nimi O, Horinouchi S, Beppu T, Kinashi H.

Mol Gen Genet. 1997 Jan 27;253(4):478-83.

PMID:
9037108
49.

The location and deletion of the genes which code for SSI-like protease inhibitors in Streptomyces species.

Kuramoto A, Lezhava A, Taguchi S, Momose H, Kinashi H.

FEMS Microbiol Lett. 1996 May 15;139(1):37-42.

PMID:
8647372
50.

Physical map of the linear chromosome of Streptomyces griseus.

Lezhava A, Mizukami T, Kajitani T, Kameoka D, Redenbach M, Shinkawa H, Nimi O, Kinashi H.

J Bacteriol. 1995 Nov;177(22):6492-8.

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