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Items: 1 to 50 of 70

1.

Gold nanoparticles as tracking devices to shed light on the role of caveolin-1 in early stages of melanoma metastasis.

Guerrero S, Díaz-García VM, Contreras-Orellana P, Lara P, Palma S, Guzman F, Lobos-Gonzalez L, Cárdenas A, Rojas-Silva X, Muñoz L, Leyton L, Kogan MJ, Quest AF.

Nanomedicine (Lond). 2018 Jun;13(12):1447-1462. doi: 10.2217/nnm-2017-0390. Epub 2018 Jul 4.

PMID:
29972676
2.

Encapsulation of Gold Nanostructures and Oil-in-Water Nanocarriers in Microgels with Biomedical Potential.

Inostroza-Riquelme M, Vivanco A, Lara P, Guerrero S, Salas-Huenuleo E, Chamorro A, Leyton L, Bolaños K, Araya E, Quest AFG, Kogan MJ, Oyarzun-Ampuero F.

Molecules. 2018 May 18;23(5). pii: E1208. doi: 10.3390/molecules23051208.

3.

Anti-neoplastic drugs increase caveolin-1-dependent migration, invasion and metastasis of cancer cells.

Díaz-Valdivia NI, Calderón CC, Díaz JE, Lobos-González L, Sepulveda H, Ortíz RJ, Martinez S, Silva V, Maldonado HJ, Silva P, Wehinger S, Burzio VA, Torres VA, Montecino M, Leyton L, Quest AFG.

Oncotarget. 2017 Dec 5;8(67):111943-111965. doi: 10.18632/oncotarget.22955. eCollection 2017 Dec 19.

4.

Single-molecule measurements of the effect of force on Thy-1/αvβ3-integrin interaction using nonpurified proteins.

Burgos-Bravo F, Figueroa NL, Casanova-Morales N, Quest AFG, Wilson CAM, Leyton L.

Mol Biol Cell. 2018 Feb 1;29(3):326-338. doi: 10.1091/mbc.E17-03-0133. Epub 2017 Dec 6.

5.

αVβ3 Integrin regulates astrocyte reactivity.

Lagos-Cabré R, Alvarez A, Kong M, Burgos-Bravo F, Cárdenas A, Rojas-Mancilla E, Pérez-Nuñez R, Herrera-Molina R, Rojas F, Schneider P, Herrera-Marschitz M, Quest AFG, van Zundert B, Leyton L.

J Neuroinflammation. 2017 Sep 29;14(1):194. doi: 10.1186/s12974-017-0968-5.

6.

Herpes Simplex Virus Type 1 Neuronal Infection Perturbs Golgi Apparatus Integrity through Activation of Src Tyrosine Kinase and Dyn-2 GTPase.

Martin C, Leyton L, Hott M, Arancibia Y, Spichiger C, McNiven MA, Court FA, Concha MI, Burgos PV, Otth C.

Front Cell Infect Microbiol. 2017 Aug 22;7:371. doi: 10.3389/fcimb.2017.00371. eCollection 2017.

7.

Astrocyte-to-neuron communication through integrin-engaged Thy-1/CBP/Csk/Src complex triggers neurite retraction via the RhoA/ROCK pathway.

Maldonado H, Calderon C, Burgos-Bravo F, Kobler O, Zuschratter W, Ramirez O, Härtel S, Schneider P, Quest AF, Herrera-Molina R, Leyton L.

Biochim Biophys Acta. 2017 Feb;1864(2):243-254. doi: 10.1016/j.bbamcr.2016.11.006. Epub 2016 Nov 12.

8.

Extracellular matrix-specific Caveolin-1 phosphorylation on tyrosine 14 is linked to augmented melanoma metastasis but not tumorigenesis.

Ortiz R, Díaz J, Díaz N, Lobos-Gonzalez L, Cárdenas A, Contreras P, Díaz MI, Otte E, Cooper-White J, Torres V, Leyton L, Quest AF.

Oncotarget. 2016 Jun 28;7(26):40571-40593. doi: 10.18632/oncotarget.9738.

9.

[Correlation between clinical and laboratory criteria of suspected Hantavirus cases and the results of the reference diagnostic technique].

Navarrete M, Hott M, Caroca J, Leyton L, Venegas N, Ismail K, Saavedra F, Otth C.

Rev Chilena Infectol. 2016 Jun;33(3):275-81. doi: 10.4067/S0716-10182016000300004. Spanish.

10.

Integrin-mediated transactivation of P2X7R via hemichannel-dependent ATP release stimulates astrocyte migration.

Alvarez A, Lagos-Cabré R, Kong M, Cárdenas A, Burgos-Bravo F, Schneider P, Quest AF, Leyton L.

Biochim Biophys Acta. 2016 Sep;1863(9):2175-88. doi: 10.1016/j.bbamcr.2016.05.018. Epub 2016 May 25.

11.

Enhanced caveolin-1 expression increases migration, anchorage-independent growth and invasion of endometrial adenocarcinoma cells.

Diaz-Valdivia N, Bravo D, Huerta H, Henriquez S, Gabler F, Vega M, Romero C, Calderon C, Owen GI, Leyton L, Quest AF.

BMC Cancer. 2015 Jun 10;15:463. doi: 10.1186/s12885-015-1477-5.

12.

Nutraceutical activators of AMPK/Sirt1 axis inhibit viral production and protect neurons from neurodegenerative events triggered during HSV-1 infection.

Leyton L, Hott M, Acuña F, Caroca J, Nuñez M, Martin C, Zambrano A, Concha MI, Otth C.

Virus Res. 2015 Jul 2;205:63-72. doi: 10.1016/j.virusres.2015.05.015. Epub 2015 May 30.

PMID:
26031763
13.

Phosphorylation of caveolin-1 on tyrosine-14 induced by ROS enhances palmitate-induced death of beta-pancreatic cells.

Wehinger S, Ortiz R, Díaz MI, Aguirre A, Valenzuela M, Llanos P, Mc Master C, Leyton L, Quest AF.

Biochim Biophys Acta. 2015 May;1852(5):693-708. doi: 10.1016/j.bbadis.2014.12.021. Epub 2015 Jan 5.

14.
15.

Short- and long-term consequences of perinatal asphyxia: looking for neuroprotective strategies.

Herrera-Marschitz M, Neira-Peña T, Rojas-Mancilla E, Morales P, Bustamante D, Leyton L, Gebicke-Haerter P.

Adv Neurobiol. 2015;10:169-98. doi: 10.1007/978-1-4939-1372-5_9.

PMID:
25287541
16.

General trends in selectively driven codon usage biases in the domain archaea.

Iriarte A, Jara E, Leytón L, Diana L, Musto H.

J Mol Evol. 2014 Oct;79(3-4):105-10. doi: 10.1007/s00239-014-9647-7. Epub 2014 Sep 20.

PMID:
25239794
17.

Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced β-catenin/Tcf-Lef dependent transcription.

Fernández JG, Rodríguez DA, Valenzuela M, Calderon C, Urzúa U, Munroe D, Rosas C, Lemus D, Díaz N, Wright MC, Leyton L, Tapia JC, Quest AF.

Mol Cancer. 2014 Sep 9;13:209. doi: 10.1186/1476-4598-13-209.

18.

Modulation of the AMPK/Sirt1 axis during neuronal infection by herpes simplex virus type 1.

Martin C, Leyton L, Arancibia Y, Cuevas A, Zambrano A, Concha MI, Otth C.

J Alzheimers Dis. 2014;42(1):301-12. doi: 10.3233/JAD-140237.

PMID:
24858404
19.

Human survivin and Trypanosoma cruzi calreticulin act in synergy against a murine melanoma in vivo.

Aguilar-Guzmán L, Lobos-González L, Rosas C, Vallejos G, Falcón C, Sosoniuk E, Coddou F, Leyton L, Lemus D, Quest AF, Ferreira A.

PLoS One. 2014 Apr 22;9(4):e95457. doi: 10.1371/journal.pone.0095457. eCollection 2014.

20.

Rab5 is required in metastatic cancer cells for Caveolin-1-enhanced Rac1 activation, migration and invasion.

Díaz J, Mendoza P, Ortiz R, Díaz N, Leyton L, Stupack D, Quest AF, Torres VA.

J Cell Sci. 2014 Jun 1;127(Pt 11):2401-6. doi: 10.1242/jcs.141689. Epub 2014 Mar 21.

21.

Caveolin-1 is a risk factor for postsurgery metastasis in preclinical melanoma models.

Lobos-Gonzalez L, Aguilar-Guzmán L, Fernandez JG, Muñoz N, Hossain M, Bieneck S, Silva V, Burzio V, Sviderskaya EV, Bennett DC, Leyton L, Quest AF.

Melanoma Res. 2014 Apr;24(2):108-19. doi: 10.1097/CMR.0000000000000046.

22.

Editorial: Signaling in cell migration and disease.

Leyton L, Torres VA, Quest AF.

Curr Mol Med. 2014 Feb;14(2):197-8. No abstract available.

PMID:
24467209
23.

Signaling pathways involved in neuron-astrocyte adhesion and migration.

Cárdenas A, Kong M, Alvarez A, Maldonado H, Leyton L.

Curr Mol Med. 2014 Feb;14(2):275-90. Review.

PMID:
24467202
24.

Thy-1-interacting molecules and cellular signaling in cis and trans.

Herrera-Molina R, Valdivia A, Kong M, Alvarez A, Cárdenas A, Quest AF, Leyton L.

Int Rev Cell Mol Biol. 2013;305:163-216. doi: 10.1016/B978-0-12-407695-2.00004-4. Review.

PMID:
23890382
25.

Rab5 activation promotes focal adhesion disassembly, migration and invasiveness in tumor cells.

Mendoza P, Ortiz R, Díaz J, Quest AF, Leyton L, Stupack D, Torres VA.

J Cell Sci. 2013 Sep 1;126(Pt 17):3835-47. doi: 10.1242/jcs.119727. Epub 2013 Jun 26.

26.

Focal adhesion dynamics are altered in schizophrenia.

Fan Y, Abrahamsen G, Mills R, Calderón CC, Tee JY, Leyton L, Murrell W, Cooper-White J, McGrath JJ, Mackay-Sim A.

Biol Psychiatry. 2013 Sep 15;74(6):418-26. doi: 10.1016/j.biopsych.2013.01.020. Epub 2013 Mar 5.

PMID:
23482246
27.

Thy-1-mediated cell-cell contact induces astrocyte migration through the engagement of αVβ3 integrin and syndecan-4.

Kong M, Muñoz N, Valdivia A, Alvarez A, Herrera-Molina R, Cárdenas A, Schneider P, Burridge K, Quest AF, Leyton L.

Biochim Biophys Acta. 2013 Jun;1833(6):1409-20. doi: 10.1016/j.bbamcr.2013.02.013. Epub 2013 Feb 26.

28.

E-cadherin determines Caveolin-1 tumor suppression or metastasis enhancing function in melanoma cells.

Lobos-González L, Aguilar L, Diaz J, Diaz N, Urra H, Torres VA, Silva V, Fitzpatrick C, Lladser A, Hoek KS, Leyton L, Quest AF.

Pigment Cell Melanoma Res. 2013 Jul;26(4):555-70. doi: 10.1111/pcmr.12085. Epub 2013 Apr 11.

29.

The caveolin-1 connection to cell death and survival.

Quest AF, Lobos-González L, Nuñez S, Sanhueza C, Fernández JG, Aguirre A, Rodríguez D, Leyton L, Torres V.

Curr Mol Med. 2013 Feb;13(2):266-81. Review.

PMID:
23228128
30.

Progesterone promotes focal adhesion formation and migration in breast cancer cells through induction of protease-activated receptor-1.

Diaz J, Aranda E, Henriquez S, Quezada M, Espinoza E, Bravo ML, Oliva B, Lange S, Villalon M, Jones M, Brosens JJ, Kato S, Cuello MA, Knutson TP, Lange CA, Leyton L, Owen GI.

J Endocrinol. 2012 Aug;214(2):165-75. doi: 10.1530/JOE-11-0310. Epub 2012 May 16.

31.

Caveolin-1-enhanced motility and focal adhesion turnover require tyrosine-14 but not accumulation to the rear in metastatic cancer cells.

Urra H, Torres VA, Ortiz RJ, Lobos L, Díaz MI, Díaz N, Härtel S, Leyton L, Quest AF.

PLoS One. 2012;7(4):e33085. doi: 10.1371/journal.pone.0033085. Epub 2012 Apr 10.

32.

Astrocytic αVβ3 integrin inhibits neurite outgrowth and promotes retraction of neuronal processes by clustering Thy-1.

Herrera-Molina R, Frischknecht R, Maldonado H, Seidenbecher CI, Gundelfinger ED, Hetz C, Aylwin Mde L, Schneider P, Quest AF, Leyton L.

PLoS One. 2012;7(3):e34295. doi: 10.1371/journal.pone.0034295. Epub 2012 Mar 30.

33.

Simvastatin disrupts cytoskeleton and decreases cardiac fibroblast adhesion, migration and viability.

Copaja M, Venegas D, Aranguiz P, Canales J, Vivar R, Avalos Y, Garcia L, Chiong M, Olmedo I, Catalán M, Leyton L, Lavandero S, Díaz-Araya G.

Toxicology. 2012 Mar 29;294(1):42-9. doi: 10.1016/j.tox.2012.01.011. Epub 2012 Jan 28.

PMID:
22306966
34.

Type IV(B) pili are required for invasion but not for adhesion of Salmonella enterica serovar Typhi into BHK epithelial cells in a cystic fibrosis transmembrane conductance regulator-independent manner.

Bravo D, Blondel CJ, Hoare A, Leyton L, Valvano MA, Contreras I.

Microb Pathog. 2011 Nov;51(5):373-7. doi: 10.1016/j.micpath.2011.07.005. Epub 2011 Jul 18.

PMID:
21782926
35.

Simvastatin induces apoptosis by a Rho-dependent mechanism in cultured cardiac fibroblasts and myofibroblasts.

Copaja M, Venegas D, Aránguiz P, Canales J, Vivar R, Catalán M, Olmedo I, Rodríguez AE, Chiong M, Leyton L, Lavandero S, Díaz-Araya G.

Toxicol Appl Pharmacol. 2011 Aug 15;255(1):57-64. doi: 10.1016/j.taap.2011.05.016. Epub 2011 May 30.

PMID:
21651924
36.

ATP release due to Thy-1-integrin binding induces P2X7-mediated calcium entry required for focal adhesion formation.

Henríquez M, Herrera-Molina R, Valdivia A, Alvarez A, Kong M, Muñoz N, Eisner V, Jaimovich E, Schneider P, Quest AF, Leyton L.

J Cell Sci. 2011 May 1;124(Pt 9):1581-8. doi: 10.1242/jcs.073171.

37.

Perinatal asphyxia: current status and approaches towards neuroprotective strategies, with focus on sentinel proteins.

Herrera-Marschitz M, Morales P, Leyton L, Bustamante D, Klawitter V, Espina-Marchant P, Allende C, Lisboa F, Cunich G, Jara-Cavieres A, Neira T, Gutierrez-Hernandez MA, Gonzalez-Lira V, Simola N, Schmitt A, Morelli M, Andrew Tasker R, Gebicke-Haerter PJ.

Neurotox Res. 2011 May;19(4):603-27. doi: 10.1007/s12640-010-9208-9. Epub 2010 Jul 20. Review.

38.

Neuronal Thy-1 induces astrocyte adhesion by engaging syndecan-4 in a cooperative interaction with alphavbeta3 integrin that activates PKCalpha and RhoA.

Avalos AM, Valdivia AD, Muñoz N, Herrera-Molina R, Tapia JC, Lavandero S, Chiong M, Burridge K, Schneider P, Quest AF, Leyton L.

J Cell Sci. 2009 Oct 1;122(Pt 19):3462-71. doi: 10.1242/jcs.034827. Epub 2009 Sep 1.

39.

Caveolin-1-mediated suppression of cyclooxygenase-2 via a beta-catenin-Tcf/Lef-dependent transcriptional mechanism reduced prostaglandin E2 production and survivin expression.

Rodriguez DA, Tapia JC, Fernandez JG, Torres VA, Muñoz N, Galleguillos D, Leyton L, Quest AF.

Mol Biol Cell. 2009 Apr;20(8):2297-310. doi: 10.1091/mbc.E08-09-0939. Epub 2009 Feb 25.

40.

Severe alterations in expression and localisation of {alpha}6{beta}4 integrin in salivary gland acini from patients with Sjogren syndrome.

Velozo J, Aguilera S, Alliende C, Ewert P, Molina C, Pérez P, Leyton L, Quest A, Brito M, González S, Leyton C, Hermoso M, Romo R, González MJ.

Ann Rheum Dis. 2009 Jun;68(6):991-6. doi: 10.1136/ard.2008.089607. Epub 2008 Jul 14.

PMID:
18625620
41.

Direct Thy-1/alphaVbeta3 integrin interaction mediates neuron to astrocyte communication.

Hermosilla T, Muñoz D, Herrera-Molina R, Valdivia A, Muñoz N, Nham SU, Schneider P, Burridge K, Quest AF, Leyton L.

Biochim Biophys Acta. 2008 Jun;1783(6):1111-20. doi: 10.1016/j.bbamcr.2008.01.034. Epub 2008 Feb 20.

42.

Reduced sulfation of muc5b is linked to xerostomia in patients with Sjögren syndrome.

Alliende C, Kwon YJ, Brito M, Molina C, Aguilera S, Pérez P, Leyton L, Quest AF, Mandel U, Veerman E, Espinosa M, Clausen H, Leyton C, Romo R, González MJ.

Ann Rheum Dis. 2008 Oct;67(10):1480-7. Epub 2007 Nov 12.

PMID:
17998215
43.

E-cadherin is required for caveolin-1-mediated down-regulation of the inhibitor of apoptosis protein survivin via reduced beta-catenin-Tcf/Lef-dependent transcription.

Torres VA, Tapia JC, Rodriguez DA, Lladser A, Arredondo C, Leyton L, Quest AF.

Mol Cell Biol. 2007 Nov;27(21):7703-17. Epub 2007 Sep 4.

44.

Involvement of specific laminins and nidogens in the active remodeling of the basal lamina of labial salivary glands from patients with Sjögren's syndrome.

Kwon YJ, Pérez P, Aguilera S, Molina C, Leyton L, Alliende C, Leyton C, Brito M, Romo R, González MJ.

Arthritis Rheum. 2006 Nov;54(11):3465-75.

45.

Casein kinase 2 (CK2) increases survivin expression via enhanced beta-catenin-T cell factor/lymphoid enhancer binding factor-dependent transcription.

Tapia JC, Torres VA, Rodriguez DA, Leyton L, Quest AF.

Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15079-84. Epub 2006 Sep 27.

46.

Caveolin-1 controls cell proliferation and cell death by suppressing expression of the inhibitor of apoptosis protein survivin.

Torres VA, Tapia JC, Rodríguez DA, Párraga M, Lisboa P, Montoya M, Leyton L, Quest AF.

J Cell Sci. 2006 May 1;119(Pt 9):1812-23. Epub 2006 Apr 11.

48.

Basal lamina disorganisation of the acini and ducts of labial salivary glands from patients with Sjogren's syndrome: association with mononuclear cell infiltration.

Molina C, Alliende C, Aguilera S, Kwon YJ, Leyton L, Martínez B, Leyton C, Pérez P, González MJ.

Ann Rheum Dis. 2006 Feb;65(2):178-83. Epub 2005 Jul 13.

49.

Characterization of alphaX I-domain binding to Thy-1.

Choi J, Leyton L, Nham SU.

Biochem Biophys Res Commun. 2005 Jun 3;331(2):557-61.

PMID:
15850796
50.

Aggregation of integrins and RhoA activation are required for Thy-1-induced morphological changes in astrocytes.

Avalos AM, Arthur WT, Schneider P, Quest AF, Burridge K, Leyton L.

J Biol Chem. 2004 Sep 10;279(37):39139-45. Epub 2004 Jun 25.

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