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Items: 16

1.

Site-Directed Fragment-Based Screening for the Discovery of Protein-Protein Interaction Stabilizers.

Sijbesma E, Hallenbeck KK, Leysen S, de Vink PJ, Skóra L, Jahnke W, Brunsveld L, Arkin MR, Ottmann C.

J Am Chem Soc. 2019 Feb 27;141(8):3524-3531. doi: 10.1021/jacs.8b11658. Epub 2019 Feb 19.

PMID:
30707565
2.

Characterization of Coding/Noncoding Variants for SHROOM3 in Patients with CKD.

Prokop JW, Yeo NC, Ottmann C, Chhetri SB, Florus KL, Ross EJ, Sosonkina N, Link BA, Freedman BI, Coppola CJ, McDermott-Roe C, Leysen S, Milroy LG, Meijer FA, Geurts AM, Rauscher FJ 3rd, Ramaker R, Flister MJ, Jacob HJ, Mendenhall EM, Lazar J.

J Am Soc Nephrol. 2018 May;29(5):1525-1535. doi: 10.1681/ASN.2017080856. Epub 2018 Feb 23.

3.

Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening.

Sijbesma E, Skora L, Leysen S, Brunsveld L, Koch U, Nussbaumer P, Jahnke W, Ottmann C.

Biochemistry. 2017 Aug 1;56(30):3972-3982. doi: 10.1021/acs.biochem.7b00153. Epub 2017 Jul 21.

4.

Small-molecule stabilization of the p53 - 14-3-3 protein-protein interaction.

Doveston RG, Kuusk A, Andrei SA, Leysen S, Cao Q, Castaldi MP, Hendricks A, Brunsveld L, Chen H, Boyd H, Ottmann C.

FEBS Lett. 2017 Aug;591(16):2449-2457. doi: 10.1002/1873-3468.12723. Epub 2017 Aug 6.

5.

Designed Spiroketal Protein Modulation.

Scheepstra M, Andrei SA, Unver MY, Hirsch AKH, Leysen S, Ottmann C, Brunsveld L, Milroy LG.

Angew Chem Int Ed Engl. 2017 May 8;56(20):5480-5484. doi: 10.1002/anie.201612504. Epub 2017 Apr 13.

6.

Characterization and small-molecule stabilization of the multisite tandem binding between 14-3-3 and the R domain of CFTR.

Stevers LM, Lam CV, Leysen SF, Meijer FA, van Scheppingen DS, de Vries RM, Carlile GW, Milroy LG, Thomas DY, Brunsveld L, Ottmann C.

Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1152-61. doi: 10.1073/pnas.1516631113. Epub 2016 Feb 17.

7.

Chiral Dihydrobenzofuran Acids Show Potent Retinoid X Receptor-Nuclear Receptor Related 1 Protein Dimer Activation.

Sundén H, Schäfer A, Scheepstra M, Leysen S, Malo M, Ma JN, Burstein ES, Ottmann C, Brunsveld L, Olsson R.

J Med Chem. 2016 Feb 11;59(3):1232-8. doi: 10.1021/acs.jmedchem.5b01702. Epub 2016 Jan 28.

PMID:
26820900
8.

Identification of an allosteric binding site for RORγt inhibition.

Scheepstra M, Leysen S, van Almen GC, Miller JR, Piesvaux J, Kutilek V, van Eenennaam H, Zhang H, Barr K, Nagpal S, Soisson SM, Kornienko M, Wiley K, Elsen N, Sharma S, Correll CC, Trotter BW, van der Stelt M, Oubrie A, Ottmann C, Parthasarathy G, Brunsveld L.

Nat Commun. 2015 Dec 7;6:8833. doi: 10.1038/ncomms9833.

9.

Stabilizer-Guided Inhibition of Protein-Protein Interactions.

Milroy LG, Bartel M, Henen MA, Leysen S, Adriaans JM, Brunsveld L, Landrieu I, Ottmann C.

Angew Chem Int Ed Engl. 2015 Dec 21;54(52):15720-4. doi: 10.1002/anie.201507976. Epub 2015 Nov 5.

PMID:
26537010
10.

Accounting for observed small angle X-ray scattering profile in the protein-protein docking server ClusPro.

Xia B, Mamonov A, Leysen S, Allen KN, Strelkov SV, Paschalidis ICh, Vajda S, Kozakov D.

J Comput Chem. 2015 Jul 30;36(20):1568-72. doi: 10.1002/jcc.23952. Epub 2015 Jun 10.

11.

The structure of the proteinaceous inhibitor PliI from Aeromonas hydrophila in complex with its target lysozyme.

Leysen S, Van Herreweghe JM, Yoneda K, Ogata M, Usui T, Araki T, Michiels CW, Strelkov SV.

Acta Crystallogr D Biol Crystallogr. 2015 Feb;71(Pt 2):344-51. doi: 10.1107/S1399004714025863. Epub 2015 Jan 23.

PMID:
25664745
12.

A natural-product switch for a dynamic protein interface.

Scheepstra M, Nieto L, Hirsch AK, Fuchs S, Leysen S, Lam CV, in het Panhuis L, van Boeckel CA, Wienk H, Boelens R, Ottmann C, Milroy LG, Brunsveld L.

Angew Chem Int Ed Engl. 2014 Jun 16;53(25):6443-8. doi: 10.1002/anie.201403773. Epub 2014 May 12.

PMID:
24821627
13.

Structural basis of bacterial defense against g-type lysozyme-based innate immunity.

Leysen S, Vanderkelen L, Weeks SD, Michiels CW, Strelkov SV.

Cell Mol Life Sci. 2013 Mar;70(6):1113-22. doi: 10.1007/s00018-012-1184-1. Epub 2012 Oct 21.

PMID:
23086131
14.

Guards of the great wall: bacterial lysozyme inhibitors.

Callewaert L, Van Herreweghe JM, Vanderkelen L, Leysen S, Voet A, Michiels CW.

Trends Microbiol. 2012 Oct;20(10):501-10. doi: 10.1016/j.tim.2012.06.005. Epub 2012 Jul 27. Review.

PMID:
22840966
15.

Structural characterization of the PliG lysozyme inhibitor family.

Leysen S, Vanderkelen L, Van Asten K, Vanheuverzwijn S, Theuwis V, Michiels CW, Strelkov SV.

J Struct Biol. 2012 Oct;180(1):235-42. doi: 10.1016/j.jsb.2012.05.006. Epub 2012 May 24.

PMID:
22634186
16.

Molecular basis of bacterial defense against host lysozymes: X-ray structures of periplasmic lysozyme inhibitors PliI and PliC.

Leysen S, Van Herreweghe JM, Callewaert L, Heirbaut M, Buntinx P, Michiels CW, Strelkov SV.

J Mol Biol. 2011 Feb 4;405(5):1233-45. doi: 10.1016/j.jmb.2010.12.007. Epub 2010 Dec 10.

PMID:
21146533

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