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Items: 12


Inhibition of IL-23 mediated inflammation with a novel small molecule inverse agonist of RORgt.

Gauld S, Jacquet S, Gauvin D, Wallace C, Wang Y, McCarthy R, Goess C, Leys L, Huang S, Su Z, Edelmayer R, Wetter J, Salte K, McGaraughty S, Argiriadi M, Honore P, Luccarini JM, Bressac D, Desino K, Breinlinger E, Cusack K, Potin D, Kort M, Masson P.

J Pharmacol Exp Ther. 2019 Aug 2. pii: jpet.119.258046. doi: 10.1124/jpet.119.258046. [Epub ahead of print]


Characterization of psoriasiform dermatitis induced by systemic injection of interleukin-23 minicircles in mice.

Leys L, Wang Y, Paulsboe S, Edelmayer R, Salte K, Wetter J, Namovic M, Phillips L, Dunstan R, Gauvin D, Donnelly-Roberts D, Su Z, Honore P, McGaraughty S.

J Dermatol. 2019 Jun;46(6):482-497. doi: 10.1111/1346-8138.14899. Epub 2019 May 7.


Monocytes/Macrophages play a pathogenic role in IL-23 mediated psoriasis-like skin inflammation.

Wang Y, Edelmayer R, Wetter J, Salte K, Gauvin D, Leys L, Paulsboe S, Su Z, Weinberg I, Namovic M, Gauld SB, Honore P, Scott VE, McGaraughty S.

Sci Rep. 2019 Mar 29;9(1):5310. doi: 10.1038/s41598-019-41655-7.


IL-36 receptor antagonistic antibodies inhibit inflammatory responses in preclinical models of psoriasiform dermatitis.

Su Z, Paulsboe S, Wetter J, Salte K, Kannan A, Mathew S, Horowitz A, Gerstein C, Namovic M, Todorović V, Seagal J, Edelmayer RM, Viner M, Rinaldi L, Zhou L, Leys L, Huang S, Wang L, Sadhukhan R, Honore P, McGaraughty S, Scott VE.

Exp Dermatol. 2019 Feb;28(2):113-120. doi: 10.1111/exd.13841. Epub 2018 Dec 21.


Mechanistic and pharmacological assessment of murine IL-23 mediated psoriasiform dermatitis; implications for drug discovery.

Gauld SB, Gauvin D, Olson L, Leys L, Paulsboe S, Liu Z, Edelmayer RM, Wetter J, Salte K, Wang Y, Huang S, Honore P, McGaraughty S.

J Dermatol Sci. 2018 Oct;92(1):45-53. doi: 10.1016/j.jdermsci.2018.08.001. Epub 2018 Aug 7.


Losartan improves renal function and pathology in obese ZSF-1 rats.

Su Z, Widomski D, Nikkel A, Leys L, Namovic M, Donnelly-Roberts D, Gopalakrishnan M, McGaraughty S.

J Basic Clin Physiol Pharmacol. 2018 Jun 27;29(3):281-290. doi: 10.1515/jbcpp-2017-0157.


TRPV3 modulates nociceptive signaling through peripheral and supraspinal sites in rats.

McGaraughty S, Chu KL, Xu J, Leys L, Radek RJ, Dart MJ, Gomtsyan A, Schmidt RG, Kym PR, Brederson JD.

J Neurophysiol. 2017 Aug 1;118(2):904-916. doi: 10.1152/jn.00104.2017. Epub 2017 May 3.


Longitudinal Changes in Measured Glomerular Filtration Rate, Renal Fibrosis and Biomarkers in a Rat Model of Type 2 Diabetic Nephropathy.

Su Z, Widomski D, Ma J, Namovic M, Nikkel A, Leys L, Olson L, Salte K, Donnelly-Roberts D, Esbenshade T, McGaraughty S.

Am J Nephrol. 2016;44(5):339-353. Epub 2016 Oct 14.


A-306989, an inhibitor of adenosine kinase, is renoprotective in rodent models of podocyte, basement membrane, and obstructive injury.

Zhu CZ, Gopalakrishnan S, Doyle K, Nikkel AL, Olson L, Abraham VC, Leys L, Widomski D, Salte K, Putman B, Pratt S, Ma J, Su Z, Gopalakrishnan M, Lee CH, McGaraughty SP.

Eur J Pharmacol. 2016 Oct 5;788:1-11. doi: 10.1016/j.ejphar.2016.06.012. Epub 2016 Jun 8.


Disturbances in slow-wave sleep are induced by models of bilateral inflammation, neuropathic, and postoperative pain, but not osteoarthritic pain in rats.

Leys LJ, Chu KL, Xu J, Pai M, Yang HS, Robb HM, Jarvis MF, Radek RJ, McGaraughty S.

Pain. 2013 Jul;154(7):1092-102. doi: 10.1016/j.pain.2013.03.019. Epub 2013 Mar 15.


Rats housed on corncob bedding show less slow-wave sleep.

Leys LJ, McGaraughty S, Radek RJ.

J Am Assoc Lab Anim Sci. 2012 Nov;51(6):764-8.


Emptying commodes and washing patients are vital.

Leys L.

Nurs Stand. 2006 Sep 20;21(2):31. doi: 10.7748/ns.21.2.31.s43.


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