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Allosteres to regulate neurotransmitter sulfonation.

Darrah K, Wang T, Cook I, Cacace M, Deiters A, Leyh TS.

J Biol Chem. 2019 Feb 15;294(7):2293-2301. doi: 10.1074/jbc.RA118.006511. Epub 2018 Dec 13.


Isoform-specific therapeutic control of sulfonation in humans.

Cook I, Wang T, Leyh TS.

Biochem Pharmacol. 2019 Jan;159:25-31. doi: 10.1016/j.bcp.2018.11.010. Epub 2018 Nov 10.


STRENDA DB: enabling the validation and sharing of enzyme kinetics data.

Swainston N, Baici A, Bakker BM, Cornish-Bowden A, Fitzpatrick PF, Halling P, Leyh TS, O'Donovan C, Raushel FM, Reschel U, Rohwer JM, Schnell S, Schomburg D, Tipton KF, Tsai MD, Westerhoff HV, Wittig U, Wohlgemuth R, Kettner C.

FEBS J. 2018 Jun;285(12):2193-2204. doi: 10.1111/febs.14427. Epub 2018 Mar 23.


The NSAID allosteric site of human cytosolic sulfotransferases.

Wang T, Cook I, Leyh TS.

J Biol Chem. 2017 Dec 8;292(49):20305-20312. doi: 10.1074/jbc.M117.817387. Epub 2017 Oct 16.


Tetrahydrobiopterin regulates monoamine neurotransmitter sulfonation.

Cook I, Wang T, Leyh TS.

Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):E5317-E5324. doi: 10.1073/pnas.1704500114. Epub 2017 Jun 19.


The structure of the catechin-binding site of human sulfotransferase 1A1.

Cook I, Wang T, Girvin M, Leyh TS.

Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):14312-14317. Epub 2016 Nov 23.


Isozyme Specific Allosteric Regulation of Human Sulfotransferase 1A1.

Wang T, Cook I, Leyh TS.

Biochemistry. 2016 Jul 26;55(29):4036-46. doi: 10.1021/acs.biochem.6b00401. Epub 2016 Jul 13.


Controlling Sulfuryl-Transfer Biology.

Cook I, Wang T, Wang W, Kopp F, Wu P, Leyh TS.

Cell Chem Biol. 2016 May 19;23(5):579-586. doi: 10.1016/j.chembiol.2016.04.009.


Design and Interpretation of Human Sulfotransferase 1A1 Assays.

Wang T, Cook I, Leyh TS.

Drug Metab Dispos. 2016 Apr;44(4):481-4. doi: 10.1124/dmd.115.068205. Epub 2015 Dec 9. Review. Erratum in: Drug Metab Dispos. 2016 Apr;44(4):616. Drug Metab Dispos. 2016 Apr;44(4):616.


Sulfotransferase 1A1 Substrate Selectivity: A Molecular Clamp Mechanism.

Cook I, Wang T, Leyh TS.

Biochemistry. 2015 Oct 6;54(39):6114-22. doi: 10.1021/acs.biochem.5b00406.


The ribosome can discriminate the chirality of amino acids within its peptidyl-transferase center.

Englander MT, Avins JL, Fleisher RC, Liu B, Effraim PR, Wang J, Schulten K, Leyh TS, Gonzalez RL Jr, Cornish VW.

Proc Natl Acad Sci U S A. 2015 May 12;112(19):6038-43. doi: 10.1073/pnas.1424712112. Epub 2015 Apr 27.


The allosteric binding sites of sulfotransferase 1A1.

Cook I, Wang T, Falany CN, Leyh TS.

Drug Metab Dispos. 2015 Mar;43(3):418-23. doi: 10.1124/dmd.114.061887. Epub 2014 Dec 22.


Synthesis of mevalonate- and fluorinated mevalonate prodrugs and their in vitro human plasma stability.

Kang S, Watanabe M, Jacobs JC, Yamaguchi M, Dahesh S, Nizet V, Leyh TS, Silverman RB.

Eur J Med Chem. 2015 Jan 27;90:448-61. doi: 10.1016/j.ejmech.2014.11.040. Epub 2014 Nov 22.


3'-Phosphoadenosine 5'-phosphosulfate allosterically regulates sulfotransferase turnover.

Wang T, Cook I, Leyh TS.

Biochemistry. 2014 Nov 11;53(44):6893-900. doi: 10.1021/bi501120p. Epub 2014 Oct 27.


An enzymatic platform for the synthesis of isoprenoid precursors.

Rodriguez SB, Leyh TS.

PLoS One. 2014 Aug 25;9(8):e105594. doi: 10.1371/journal.pone.0105594. eCollection 2014.


Paradigms of sulfotransferase catalysis: the mechanism of SULT2A1.

Wang T, Cook I, Falany CN, Leyh TS.

J Biol Chem. 2014 Sep 19;289(38):26474-80. doi: 10.1074/jbc.M114.573501. Epub 2014 Jul 23.


High accuracy in silico sulfotransferase models.

Cook I, Wang T, Falany CN, Leyh TS.

J Biol Chem. 2013 Nov 29;288(48):34494-501. doi: 10.1074/jbc.M113.510974. Epub 2013 Oct 15.


Structure, dynamics and selectivity in the sulfotransferase family.

Leyh TS, Cook I, Wang T.

Drug Metab Rev. 2013 Nov;45(4):423-30. doi: 10.3109/03602532.2013.835625. Epub 2013 Sep 11. Review.


Testing the sulfotransferase molecular pore hypothesis.

Cook I, Wang T, Almo SC, Kim J, Falany CN, Leyh TS.

J Biol Chem. 2013 Mar 22;288(12):8619-26. doi: 10.1074/jbc.M112.445015. Epub 2013 Jan 28.


The gate that governs sulfotransferase selectivity.

Cook I, Wang T, Almo SC, Kim J, Falany CN, Leyh TS.

Biochemistry. 2013 Jan 15;52(2):415-24. doi: 10.1021/bi301492j. Epub 2012 Dec 28.


Host cell-induced components of the sulfate assimilation pathway are major protective antigens of Mycobacterium tuberculosis.

Pinto R, Leotta L, Shanahan ER, West NP, Leyh TS, Britton W, Triccas JA.

J Infect Dis. 2013 Mar 1;207(5):778-85. doi: 10.1093/infdis/jis751. Epub 2012 Dec 7.


A nucleotide-gated molecular pore selects sulfotransferase substrates.

Cook I, Wang T, Falany CN, Leyh TS.

Biochemistry. 2012 Jul 17;51(28):5674-83. Epub 2012 Jun 29.


Potent inhibition of human sulfotransferase 1A1 by 17α-ethinylestradiol: role of 3'-phosphoadenosine 5'-phosphosulfate binding and structural rearrangements in regulating inhibition and activity.

Rohn KJ, Cook IT, Leyh TS, Kadlubar SA, Falany CN.

Drug Metab Dispos. 2012 Aug;40(8):1588-95. doi: 10.1124/dmd.112.045583. Epub 2012 May 16.


Analytical expressions for the homotropic binding of ligand to protein dimers and trimers.

Lefurgy ST, Leyh TS.

Anal Biochem. 2012 Feb 15;421(2):433-8. doi: 10.1016/j.ab.2011.12.016. Epub 2011 Dec 16.


Three-stage assembly of the cysteine synthase complex from Escherichia coli.

Wang T, Leyh TS.

J Biol Chem. 2012 Feb 3;287(6):4360-7. doi: 10.1074/jbc.M111.288423. Epub 2011 Dec 16.


Lack of substrate inhibition in a monomeric form of human cytosolic SULT2A1.

Cook IT, Leyh TS, Kadlubar SA, Falany CN.

Horm Mol Biol Clin Investig. 2010 Dec;3(1):357-366.


Lack of substrate inhibition in a monomeric form of human cytosolic SULT2A1.

Cook IT, Leyh TS, Kadlubar SA, Falany CN.

Horm Mol Biol Clin Investig. 2010 Dec 1;3(1):367-74. doi: 10.1515/HMBCI.2010.041.


A large-scale protein-function database.

Apweiler R, Armstrong R, Bairoch A, Cornish-Bowden A, Halling PJ, Hofmeyr JH, Kettner C, Leyh TS, Rohwer J, Schomburg D, Steinbeck C, Tipton K.

Nat Chem Biol. 2010 Nov;6(11):785. doi: 10.1038/nchembio.460. No abstract available.


Backbone 1H, 13C, 15N NMR assignments of the unliganded and substrate ternary complex forms of mevalonate diphosphate decarboxylase from Streptococcus pneumoniae.

Reuther G, Harris R, Girvin M, Leyh TS.

Biomol NMR Assign. 2011 Apr;5(1):11-4. doi: 10.1007/s12104-010-9255-4. Epub 2010 Aug 25.


Precise, facile initial rate measurements.

Tang Q, Leyh TS.

J Phys Chem B. 2010 Dec 16;114(49):16131-6. doi: 10.1021/jp1055528. Epub 2010 Aug 24.


The human estrogen sulfotransferase: a half-site reactive enzyme.

Sun M, Leyh TS.

Biochemistry. 2010 Jun 15;49(23):4779-85. doi: 10.1021/bi902190r.


Probing ligand-binding pockets of the mevalonate pathway enzymes from Streptococcus pneumoniae.

Lefurgy ST, Rodriguez SB, Park CS, Cahill S, Silverman RB, Leyh TS.

J Biol Chem. 2010 Jul 2;285(27):20654-63. doi: 10.1074/jbc.M109.098350. Epub 2010 Apr 19.


Mevalonate analogues as substrates of enzymes in the isoprenoid biosynthetic pathway of Streptococcus pneumoniae.

Kudoh T, Park CS, Lefurgy ST, Sun M, Michels T, Leyh TS, Silverman RB.

Bioorg Med Chem. 2010 Feb;18(3):1124-34. doi: 10.1016/j.bmc.2009.12.050. Epub 2009 Dec 24.


Structural rearrangement of SULT2A1: effects on dehydroepiandrosterone and raloxifene sulfation.

Cook IT, Leyh TS, Kadlubar SA, Falany CN.

Horm Mol Biol Clin Investig. 2010;1(2):81-87.


Natural amino acids do not require their native tRNAs for efficient selection by the ribosome.

Effraim PR, Wang J, Englander MT, Avins J, Leyh TS, Gonzalez RL Jr, Cornish VW.

Nat Chem Biol. 2009 Dec;5(12):947-53. doi: 10.1038/nchembio.255. Epub 2009 Oct 25.


Structure of the ternary complex of phosphomevalonate kinase: the enzyme and its family.

Andreassi JL 2nd, Vetting MW, Bilder PW, Roderick SL, Leyh TS.

Biochemistry. 2009 Jul 14;48(27):6461-8. doi: 10.1021/bi900537u.


Mycobacterium tuberculosis universal stress protein Rv2623 regulates bacillary growth by ATP-Binding: requirement for establishing chronic persistent infection.

Drumm JE, Mi K, Bilder P, Sun M, Lim J, Bielefeldt-Ohmann H, Basaraba R, So M, Zhu G, Tufariello JM, Izzo AA, Orme IM, Almo SC, Leyh TS, Chan J.

PLoS Pathog. 2009 May;5(5):e1000460. doi: 10.1371/journal.ppat.1000460. Epub 2009 May 29. Erratum in: PLoS Pathog. 2009 Sep;5(9). doi: 10.1371/annotation/2b1a4b06-9558-448b-a8e8-5e2d407816a0.


Diffusional channeling in the sulfate-activating complex: combined continuum modeling and coarse-grained brownian dynamics studies.

Cheng Y, Chang CE, Yu Z, Zhang Y, Sun M, Leyh TS, Holst MJ, McCammon JA.

Biophys J. 2008 Nov 15;95(10):4659-67. doi: 10.1529/biophysj.108.140038. Epub 2008 Aug 8.


Sulfite reduction in mycobacteria.

Pinto R, Harrison JS, Hsu T, Jacobs WR Jr, Leyh TS.

J Bacteriol. 2007 Sep;189(18):6714-22. Epub 2007 Jul 20.


Crystal structure of the Streptococcus pneumoniae mevalonate kinase in complex with diphosphomevalonate.

Andreassi JL 2nd, Bilder PW, Vetting MW, Roderick SL, Leyh TS.

Protein Sci. 2007 May;16(5):983-9. Epub 2007 Mar 30.


Channeling in sulfate activating complexes.

Sun M, Leyh TS.

Biochemistry. 2006 Sep 26;45(38):11304-11.


Transition state of the sulfuryl transfer reaction of estrogen sulfotransferase.

Hoff RH, Czyryca PG, Sun M, Leyh TS, Hengge AC.

J Biol Chem. 2006 Oct 13;281(41):30645-9. Epub 2006 Aug 9.


Sulfation of raloxifene and 4-hydroxytamoxifen by human cytosolic sulfotransferases.

Falany JL, Pilloff DE, Leyh TS, Falany CN.

Drug Metab Dispos. 2006 Mar;34(3):361-8. Epub 2005 Dec 28.


The importance of uniformity in reporting protein-function data.

Apweiler R, Cornish-Bowden A, Hofmeyr JH, Kettner C, Leyh TS, Schomburg D, Tipton K.

Trends Biochem Sci. 2005 Jan;30(1):11-2. No abstract available.


The trifunctional sulfate-activating complex (SAC) of Mycobacterium tuberculosis.

Sun M, Andreassi JL 2nd, Liu S, Pinto R, Triccas JA, Leyh TS.

J Biol Chem. 2005 Mar 4;280(9):7861-6. Epub 2004 Dec 22.


Streptococcus pneumoniae isoprenoid biosynthesis is downregulated by diphosphomevalonate: an antimicrobial target.

Andreassi JL 2nd, Dabovic K, Leyh TS.

Biochemistry. 2004 Dec 28;43(51):16461-6.


Molecular functions of conserved aspects of the GHMP kinase family.

Andreassi JL 2nd, Leyh TS.

Biochemistry. 2004 Nov 23;43(46):14594-601.


The Mycobacterium tuberculosis cysD and cysNC genes form a stress-induced operon that encodes a tri-functional sulfate-activating complex.

Pinto R, Tang QX, Britton WJ, Leyh TS, Triccas JA.

Microbiology. 2004 Jun;150(Pt 6):1681-6.


Structural and functional analysis of a truncated form of Saccharomyces cerevisiae ATP sulfurylase: C-terminal domain essential for oligomer formation but not for activity.

Lalor DJ, Schnyder T, Saridakis V, Pilloff DE, Dong A, Tang H, Leyh TS, Pai EF.

Protein Eng. 2003 Dec;16(12):1071-9.


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