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Items: 1 to 50 of 173

1.

Connexin43 Hemichannel Targeting With TAT-Gap19 Alleviates Radiation-Induced Endothelial Cell Damage.

Ramadan R, Vromans E, Anang DC, Goetschalckx I, Hoorelbeke D, Decrock E, Baatout S, Leybaert L, Aerts A.

Front Pharmacol. 2020 Mar 5;11:212. doi: 10.3389/fphar.2020.00212. eCollection 2020.

PMID:
32210810
2.

Cx43 channels and signaling via IP3/Ca2+, ATP, and ROS/NO propagate radiation-induced DNA damage to non-irradiated brain microvascular endothelial cells.

Hoorelbeke D, Decrock E, De Smet M, De Bock M, Descamps B, Van Haver V, Delvaeye T, Krysko DV, Vanhove C, Bultynck G, Leybaert L.

Cell Death Dis. 2020 Mar 18;11(3):194. doi: 10.1038/s41419-020-2392-5.

3.

RyR2 regulates Cx43 hemichannel intracellular Ca2+-dependent activation in cardiomyocytes.

Lissoni A, Hulpiau P, Martins-Marques T, Wang N, Bultynck G, Schulz R, Witschas K, Girao H, De Smet M, Leybaert L.

Cardiovasc Res. 2019 Dec 16. pii: cvz340. doi: 10.1093/cvr/cvz340. [Epub ahead of print]

PMID:
31841141
4.

Vitrification negatively affects the Ca2+-releasing and activation potential of mouse oocytes, but vitrified oocytes are potentially useful for diagnostic purposes.

Bonte D, Thys V, De Sutter P, Boel A, Leybaert L, Heindryckx B.

Reprod Biomed Online. 2019 Sep 28. pii: S1472-6483(19)30749-7. doi: 10.1016/j.rbmo.2019.09.012. [Epub ahead of print]

PMID:
31740224
5.

Blocking connexin43 hemichannels protects mice against tumour necrosis factor-induced inflammatory shock.

Delvaeye T, De Smet MAJ, Verwaerde S, Decrock E, Czekaj A, Vandenbroucke RE, Lemeire K, Gonçalves A, Declercq W, Vandenabeele P, Krysko DV, Leybaert L.

Sci Rep. 2019 Nov 12;9(1):16623. doi: 10.1038/s41598-019-52900-4.

6.

Adjuvant therapeutic potential of tonabersat in the standard treatment of glioblastoma: A preclinical F98 glioblastoma rat model study.

De Meulenaere V, Bonte E, Verhoeven J, Kalala Okito JP, Pieters L, Vral A, De Wever O, Leybaert L, Goethals I, Vanhove C, Descamps B, Deblaere K.

PLoS One. 2019 Oct 21;14(10):e0224130. doi: 10.1371/journal.pone.0224130. eCollection 2019.

7.

Single and fractionated ionizing radiation induce alterations in endothelial connexin expression and channel function.

Ramadan R, Vromans E, Anang DC, Decrock E, Mysara M, Monsieurs P, Baatout S, Leybaert L, Aerts A.

Sci Rep. 2019 Jun 20;9(1):4643. doi: 10.1038/s41598-019-39317-9.

8.

Targeting MAPK phosphorylation of Connexin43 provides neuroprotection in stroke.

Freitas-Andrade M, Wang N, Bechberger JF, De Bock M, Lampe PD, Leybaert L, Naus CC.

J Exp Med. 2019 Apr 1;216(4):916-935. doi: 10.1084/jem.20171452. Epub 2019 Mar 14.

9.

Articulated Instruments and 3D Visualization: A Synergy? Evaluation of Execution Time, Errors, and Visual Fatigue.

Dewaele F, De Pauw T, Lumen N, Van Daele E, Hamerlynck T, Weyers S, Strubbe I, Van den Broeck F, Van Zele T, Van Roost D, Leybaert L, Kalmar AF, Van Nieuwenhove Y.

Surg Innov. 2019 Aug;26(4):456-463. doi: 10.1177/1553350618822077. Epub 2019 Jan 22.

PMID:
30667302
10.

Species-dependent extracranial manifestations of a brain seeking breast cancer cell line.

De Meulenaere V, Neyt S, Vandeghinste B, Mollet P, De Wever O, Decrock E, Leybaert L, Goethals I, Vanhove C, Descamps B, Deblaere K.

PLoS One. 2018 Dec 10;13(12):e0208340. doi: 10.1371/journal.pone.0208340. eCollection 2018.

11.

Therapeutic Targeting of Connexin Channels: New Views and Challenges.

Delvaeye T, Vandenabeele P, Bultynck G, Leybaert L, Krysko DV.

Trends Mol Med. 2018 Dec;24(12):1036-1053. doi: 10.1016/j.molmed.2018.10.005. Epub 2018 Nov 10. Review.

PMID:
30424929
12.

Connexin hemichannels and cell death as measures of bovine COC vitrification success.

Szymańska KJ, Ortiz-Escribano N, Van den Abbeel E, Van Soom A, Leybaert L.

Reproduction. 2019 Jan;157(1):87-99. doi: 10.1530/REP-18-0387.

PMID:
30390612
13.

Blocking connexin channels during vitrification of immature cat oocytes improves maturation capacity after warming.

Snoeck F, Szymanska KJ, Sarrazin S, Ortiz-Escribano N, Leybaert L, Van Soom A.

Theriogenology. 2018 Dec;122:144-149. doi: 10.1016/j.theriogenology.2018.09.011. Epub 2018 Sep 14.

PMID:
30268031
14.

Calcium, a pivotal player in photodynamic therapy?

Hoorelbeke D, Decrock E, Van Haver V, De Bock M, Leybaert L.

Biochim Biophys Acta Mol Cell Res. 2018 Nov;1865(11 Pt B):1805-1814. doi: 10.1016/j.bbamcr.2018.07.022. Epub 2018 Aug 1. Review.

15.

Glucocorticoid receptor in astrocytes regulates midbrain dopamine neurodegeneration through connexin hemichannel activity.

Maatouk L, Yi C, Carrillo-de Sauvage MA, Compagnion AC, Hunot S, Ezan P, Hirsch EC, Koulakoff A, Pfrieger FW, Tronche F, Leybaert L, Giaume C, Vyas S.

Cell Death Differ. 2019 Mar;26(3):580-596. doi: 10.1038/s41418-018-0150-3. Epub 2018 Jul 13.

16.

Inhibition of astroglial connexin43 hemichannels with TAT-Gap19 exerts anticonvulsant effects in rodents.

Walrave L, Pierre A, Albertini G, Aourz N, De Bundel D, Van Eeckhaut A, Vinken M, Giaume C, Leybaert L, Smolders I.

Glia. 2018 Aug;66(8):1788-1804. doi: 10.1002/glia.23341. Epub 2018 Apr 23.

PMID:
29683209
17.

TAT-Gap19 and Carbenoxolone Alleviate Liver Fibrosis in Mice.

Crespo Yanguas S, da Silva TC, Pereira IVA, Willebrords J, Maes M, Sayuri Nogueira M, Alves de Castro I, Leclercq I, Romualdo GR, Barbisan LF, Leybaert L, Cogliati B, Vinken M.

Int J Mol Sci. 2018 Mar 12;19(3). pii: E817. doi: 10.3390/ijms19030817.

18.

Noninvasive Whole-Body Imaging of Phosphatidylethanolamine as a Cell Death Marker Using 99mTc-Duramycin During TNF-Induced SIRS.

Delvaeye T, Wyffels L, Deleye S, Lemeire K, Gonçalves A, Decrock E, Staelens S, Leybaert L, Vandenabeele P, Krysko DV.

J Nucl Med. 2018 Jul;59(7):1140-1145. doi: 10.2967/jnumed.117.205815. Epub 2018 Feb 1.

19.

Human oocyte calcium analysis predicts the response to assisted oocyte activation in patients experiencing fertilization failure after ICSI.

Ferrer-Buitrago M, Dhaenens L, Lu Y, Bonte D, Vanden Meerschaut F, De Sutter P, Leybaert L, Heindryckx B.

Hum Reprod. 2018 Mar 1;33(3):416-425. doi: 10.1093/humrep/dex376.

PMID:
29329390
20.

Culture conditions affect Ca2+ release in artificially activated mouse and human oocytes.

Lu Y, Bonte D, Ferrer-Buitrago M, Popovic M, Neupane J, Van der Jeught M, Leybaert L, De Sutter P, Heindryckx B.

Reprod Fertil Dev. 2018 Jun;30(7):991-1001. doi: 10.1071/RD17145.

PMID:
29325603
21.

The SH3-binding domain of Cx43 participates in loop/tail interactions critical for Cx43-hemichannel activity.

Iyyathurai J, Wang N, D'hondt C, Jiang JX, Leybaert L, Bultynck G.

Cell Mol Life Sci. 2018 Jun;75(11):2059-2073. doi: 10.1007/s00018-017-2722-7. Epub 2017 Dec 7.

22.

Single Ca2+ transients vs oscillatory Ca2+ signaling for assisted oocyte activation: limitations and benefits.

Ferrer-Buitrago M, Bonte D, De Sutter P, Leybaert L, Heindryckx B.

Reproduction. 2018 Feb;155(2):R105-R119. doi: 10.1530/REP-17-0098. Epub 2017 Nov 9. Review.

PMID:
29122969
23.

Necroptotic cell death in anti-cancer therapy.

Krysko O, Aaes TL, Kagan VE, D'Herde K, Bachert C, Leybaert L, Vandenabeele P, Krysko DV.

Immunol Rev. 2017 Nov;280(1):207-219. doi: 10.1111/imr.12583. Review.

PMID:
29027225
24.

Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications.

Leybaert L, Lampe PD, Dhein S, Kwak BR, Ferdinandy P, Beyer EC, Laird DW, Naus CC, Green CR, Schulz R.

Pharmacol Rev. 2017 Oct;69(4):396-478. doi: 10.1124/pr.115.012062. Review.

25.

Connexins and pannexins in Alzheimer's disease.

Giaume C, Sáez JC, Song W, Leybaert L, Naus CC.

Neurosci Lett. 2019 Mar 16;695:100-105. doi: 10.1016/j.neulet.2017.09.006. Epub 2017 Sep 8. Review.

PMID:
28893592
26.

Contribution of Astroglial Cx43 Hemichannels to the Modulation of Glutamatergic Currents by D-Serine in the Mouse Prefrontal Cortex.

Meunier C, Wang N, Yi C, Dallerac G, Ezan P, Koulakoff A, Leybaert L, Giaume C.

J Neurosci. 2017 Sep 13;37(37):9064-9075. doi: 10.1523/JNEUROSCI.2204-16.2017. Epub 2017 Aug 11.

27.

Inhibition of connexin hemichannels alleviates non-alcoholic steatohepatitis in mice.

Willebrords J, Cogliati B, Pereira IVA, da Silva TC, Crespo Yanguas S, Maes M, Govoni VM, Lima A, Felisbino DA, Decrock E, Nogueira MS, de Castro IA, Leclercq I, Leybaert L, Rodrigues RM, Vinken M.

Sci Rep. 2017 Aug 15;7(1):8268. doi: 10.1038/s41598-017-08583-w.

28.

Connexin-Dependent Neuroglial Networking as a New Therapeutic Target.

Charvériat M, Naus CC, Leybaert L, Sáez JC, Giaume C.

Front Cell Neurosci. 2017 Jun 26;11:174. doi: 10.3389/fncel.2017.00174. eCollection 2017. Review.

29.

Connexin hemichannel inhibition reduces acetaminophen-induced liver injury in mice.

Maes M, Crespo Yanguas S, Willebrords J, Weemhoff JL, da Silva TC, Decrock E, Lebofsky M, Pereira IVA, Leybaert L, Farhood A, Jaeschke H, Cogliati B, Vinken M.

Toxicol Lett. 2017 Aug 15;278:30-37. doi: 10.1016/j.toxlet.2017.07.007. Epub 2017 Jul 4.

30.

Connexin Channels at the Glio-Vascular Interface: Gatekeepers of the Brain.

De Bock M, Leybaert L, Giaume C.

Neurochem Res. 2017 Sep;42(9):2519-2536. doi: 10.1007/s11064-017-2313-x. Epub 2017 Jun 20. Review.

PMID:
28634726
31.

Mitochondrial Cx43 hemichannels contribute to mitochondrial calcium entry and cell death in the heart.

Gadicherla AK, Wang N, Bulic M, Agullo-Pascual E, Lissoni A, De Smet M, Delmar M, Bultynck G, Krysko DV, Camara A, Schlüter KD, Schulz R, Kwok WM, Leybaert L.

Basic Res Cardiol. 2017 May;112(3):27. doi: 10.1007/s00395-017-0618-1. Epub 2017 Mar 31.

PMID:
28364353
32.

Blocking connexin channels improves embryo development of vitrified bovine blastocysts.

Ortiz-Escribano N, Szymanska KJ, Bol M, Vandenberghe L, Decrock E, Van Poucke M, Peelman L, Van den Abbeel E, Van Soom A, Leybaert L.

Biol Reprod. 2017 Feb 1;96(2):288-301. doi: 10.1095/biolreprod.116.144121.

PMID:
28203704
33.

Calcium, oxidative stress and connexin channels, a harmonious orchestra directing the response to radiotherapy treatment?

Decrock E, Hoorelbeke D, Ramadan R, Delvaeye T, De Bock M, Wang N, Krysko DV, Baatout S, Bultynck G, Aerts A, Vinken M, Leybaert L.

Biochim Biophys Acta Mol Cell Res. 2017 Jun;1864(6):1099-1120. doi: 10.1016/j.bbamcr.2017.02.007. Epub 2017 Feb 11. Review.

34.

The BH4 domain of Bcl-2 orthologues from different classes of vertebrates can act as an evolutionary conserved inhibitor of IP3 receptor channels.

Ivanova H, Luyten T, Decrock E, Vervliet T, Leybaert L, Parys JB, Bultynck G.

Cell Calcium. 2017 Mar;62:41-46. doi: 10.1016/j.ceca.2017.01.010. Epub 2017 Jan 25.

PMID:
28179071
35.

Inhibition of Connexin43 Hemichannels Impairs Spatial Short-Term Memory without Affecting Spatial Working Memory.

Walrave L, Vinken M, Albertini G, De Bundel D, Leybaert L, Smolders IJ.

Front Cell Neurosci. 2016 Dec 20;10:288. doi: 10.3389/fncel.2016.00288. eCollection 2016.

36.

Astrocytic gap junction blockade markedly increases extracellular potassium without causing seizures in the mouse neocortex.

Bazzigaluppi P, Weisspapir I, Stefanovic B, Leybaert L, Carlen PL.

Neurobiol Dis. 2017 May;101:1-7. doi: 10.1016/j.nbd.2016.12.017. Epub 2016 Dec 20.

PMID:
28007587
37.

IP3, still on the move but now in the slow lane.

Leybaert L.

Sci Signal. 2016 Nov 8;9(453):fs17. Review.

PMID:
27919025
38.

Pannexin1 as mediator of inflammation and cell death.

Crespo Yanguas S, Willebrords J, Johnstone SR, Maes M, Decrock E, De Bock M, Leybaert L, Cogliati B, Vinken M.

Biochim Biophys Acta Mol Cell Res. 2017 Jan;1864(1):51-61. doi: 10.1016/j.bbamcr.2016.10.006. Epub 2016 Oct 11. Review.

39.

At the cross-point of connexins, calcium, and ATP: blocking hemichannels inhibits vasoconstriction of rat small mesenteric arteries.

Bol M, Wang N, De Bock M, Wacquier B, Decrock E, Gadicherla A, Decaluwé K, Vanheel B, van Rijen HV, Krysko DV, Bultynck G, Dupont G, Van de Voorde J, Leybaert L.

Cardiovasc Res. 2017 Feb;113(2):195-206. doi: 10.1093/cvr/cvw215. Epub 2016 Sep 27.

PMID:
27677282
40.

Connexins and their channels in inflammation.

Willebrords J, Crespo Yanguas S, Maes M, Decrock E, Wang N, Leybaert L, Kwak BR, Green CR, Cogliati B, Vinken M.

Crit Rev Biochem Mol Biol. 2016 Nov/Dec;51(6):413-439. doi: 10.1080/10409238.2016.1204980. Epub 2016 Jul 7. Review.

41.

Connexins: substrates and regulators of autophagy.

Iyyathurai J, Decuypere JP, Leybaert L, D'hondt C, Bultynck G.

BMC Cell Biol. 2016 May 24;17 Suppl 1:20. doi: 10.1186/s12860-016-0093-9. Review.

42.

Electroporation Loading and Dye Transfer: A Safe and Robust Method to Probe Gap Junctional Coupling.

Decrock E, De Bock M, De Baere D, Hoorelbeke D, Wang N, Leybaert L.

Methods Mol Biol. 2016;1437:155-69. doi: 10.1007/978-1-4939-3664-9_11.

PMID:
27207293
43.

Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity.

Aaes TL, Kaczmarek A, Delvaeye T, De Craene B, De Koker S, Heyndrickx L, Delrue I, Taminau J, Wiernicki B, De Groote P, Garg AD, Leybaert L, Grooten J, Bertrand MJ, Agostinis P, Berx G, Declercq W, Vandenabeele P, Krysko DV.

Cell Rep. 2016 Apr 12;15(2):274-87. doi: 10.1016/j.celrep.2016.03.037. Epub 2016 Mar 31.

44.

Structure, Regulation and Function of Gap Junctions in Liver.

Willebrords J, Crespo Yanguas S, Maes M, Decrock E, Wang N, Leybaert L, da Silva TC, Veloso Alves Pereira I, Jaeschke H, Cogliati B, Vinken M.

Cell Commun Adhes. 2015 Apr - Dec;22(2-6):29-37. doi: 10.3109/15419061.2016.1151875. Epub 2016 Mar 22. Review.

45.

Nutrient Starvation Decreases Cx43 Levels and Limits Intercellular Communication in Primary Bovine Corneal Endothelial Cells.

D'hondt C, Iyyathurai J, Welkenhuyzen K, Himpens B, Leybaert L, Bultynck G.

J Membr Biol. 2016 Jun;249(3):363-73. doi: 10.1007/s00232-016-9874-5. Epub 2016 Feb 12.

PMID:
26873723
46.

Into rather unexplored terrain-transcellular transport across the blood-brain barrier.

De Bock M, Van Haver V, Vandenbroucke RE, Decrock E, Wang N, Leybaert L.

Glia. 2016 Jul;64(7):1097-123. doi: 10.1002/glia.22960. Epub 2016 Feb 8. Review.

PMID:
26852907
47.

Intracellular Cleavage of the Cx43 C-Terminal Domain by Matrix-Metalloproteases: A Novel Contributor to Inflammation?

De Bock M, Wang N, Decrock E, Bultynck G, Leybaert L.

Mediators Inflamm. 2015;2015:257471. doi: 10.1155/2015/257471. Epub 2015 Sep 3. Review.

48.

Connexin and pannexin signaling pathways, an architectural blueprint for CNS physiology and pathology?

Decrock E, De Bock M, Wang N, Bultynck G, Giaume C, Naus CC, Green CR, Leybaert L.

Cell Mol Life Sci. 2015 Aug;72(15):2823-51. doi: 10.1007/s00018-015-1962-7. Epub 2015 Jun 29. Review.

PMID:
26118660
49.

Fluoxetine suppresses calcium signaling in human T lymphocytes through depletion of intracellular calcium stores.

Gobin V, De Bock M, Broeckx BJ, Kiselinova M, De Spiegelaere W, Vandekerckhove L, Van Steendam K, Leybaert L, Deforce D.

Cell Calcium. 2015 Sep;58(3):254-63. doi: 10.1016/j.ceca.2015.06.003. Epub 2015 Jun 10.

50.

Connexin 43 is an emerging therapeutic target in ischemia/reperfusion injury, cardioprotection and neuroprotection.

Schulz R, Görge PM, Görbe A, Ferdinandy P, Lampe PD, Leybaert L.

Pharmacol Ther. 2015 Sep;153:90-106. doi: 10.1016/j.pharmthera.2015.06.005. Epub 2015 Jun 11. Review.

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