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Items: 1 to 50 of 277

1.

Enabling synthesis in fragment-based drug discovery by reactivity mapping: photoredox-mediated cross-dehydrogenative heteroarylation of cyclic amines.

Grainger R, Heightman TD, Ley SV, Lima F, Johnson CN.

Chem Sci. 2018 Dec 21;10(8):2264-2271. doi: 10.1039/c8sc04789h. eCollection 2019 Feb 28.

2.

Direct Oxidation of Csp3 -H bonds using in Situ Generated Trifluoromethylated Dioxirane in Flow.

Lesieur M, Battilocchio C, Labes R, Jacq J, Genicot C, Ley SV, Pasau P.

Chemistry. 2019 Jan 24;25(5):1203-1207. doi: 10.1002/chem.201805657. Epub 2018 Dec 14.

PMID:
30485562
3.

Photochemical Homologation for the Preparation of Aliphatic Aldehydes in Flow.

Chen Y, Leonardi M, Dingwall P, Labes R, Pasau P, Blakemore DC, Ley SV.

J Org Chem. 2018 Dec 21;83(24):15558-15568. doi: 10.1021/acs.joc.8b02721. Epub 2018 Nov 29.

4.

Across-the-World Automated Optimization and Continuous-Flow Synthesis of Pharmaceutical Agents Operating Through a Cloud-Based Server.

Fitzpatrick DE, Maujean T, Evans AC, Ley SV.

Angew Chem Int Ed Engl. 2018 Nov 12;57(46):15128-15132. doi: 10.1002/anie.201809080. Epub 2018 Oct 24.

5.

Three-Component Assembly of Multiply Substituted Homoallylic Alcohols and Amines Using a Flow Chemistry Photoreactor.

Chen Y, Blakemore DC, Pasau P, Ley SV.

Org Lett. 2018 Oct 19;20(20):6569-6572. doi: 10.1021/acs.orglett.8b02907. Epub 2018 Oct 1.

PMID:
30270627
6.

C-H functionalisation of aldehydes using light generated, non-stabilised diazo compounds in flow.

Dingwall P, Greb A, Crespin LNS, Labes R, Musio B, Poh JS, Pasau P, Blakemore DC, Ley SV.

Chem Commun (Camb). 2018 Oct 16;54(83):11685-11688. doi: 10.1039/c8cc06202a.

PMID:
30203830
7.

Preparation of homoallylic amines via a three-component coupling process.

Ou X, Labes R, Battilocchio C, Ley SV.

Org Biomol Chem. 2018 Sep 19;16(36):6652-6654. doi: 10.1039/c8ob01831f.

PMID:
30183047
8.

Organic photocatalysis for the radical couplings of boronic acid derivatives in batch and flow.

Lima F, Grunenberg L, Rahman HBA, Labes R, Sedelmeier J, Ley SV.

Chem Commun (Camb). 2018 May 29;54(44):5606-5609. doi: 10.1039/c8cc02169d.

PMID:
29767201
9.

Mimicking the surface and prebiotic chemistry of early Earth using flow chemistry.

Ritson DJ, Battilocchio C, Ley SV, Sutherland JD.

Nat Commun. 2018 May 8;9(1):1821. doi: 10.1038/s41467-018-04147-2.

10.

Unveiling the role of boroxines in metal-free carbon-carbon homologations using diazo compounds and boronic acids.

Bomio C, Kabeshov MA, Lit AR, Lau SH, Ehlert J, Battilocchio C, Ley SV.

Chem Sci. 2017 Sep 1;8(9):6071-6075. doi: 10.1039/c7sc02264f. Epub 2017 Jun 15.

11.

The Engineering of Chemical Synthesis: Humans and Machines Working in Harmony.

Ley SV.

Angew Chem Int Ed Engl. 2018 May 4;57(19):5182-5183. doi: 10.1002/anie.201802383. Epub 2018 Mar 30.

PMID:
29603525
12.

Visible-Light-Mediated Annulation of Electron-Rich Alkenes and Nitrogen-Centered Radicals from N-Sulfonylallylamines: Construction of Chloromethylated Pyrrolidine Derivatives.

Crespin LNS, Greb A, Blakemore DC, Ley SV.

J Org Chem. 2017 Dec 15;82(24):13093-13108. doi: 10.1021/acs.joc.7b02146. Epub 2017 Nov 22.

PMID:
29121471
13.

A Versatile Route to Unstable Diazo Compounds via Oxadiazolines and their Use in Aryl-Alkyl Cross-Coupling Reactions.

Greb A, Poh JS, Greed S, Battilocchio C, Pasau P, Blakemore DC, Ley SV.

Angew Chem Int Ed Engl. 2017 Dec 22;56(52):16602-16605. doi: 10.1002/anie.201710445. Epub 2017 Dec 5.

14.

A Lewis Base Catalysis Approach for the Photoredox Activation of Boronic Acids and Esters.

Lima F, Sharma UK, Grunenberg L, Saha D, Johannsen S, Sedelmeier J, Van der Eycken EV, Ley SV.

Angew Chem Int Ed Engl. 2017 Nov 20;56(47):15136-15140. doi: 10.1002/anie.201709690. Epub 2017 Oct 24.

15.

A New Methodology for Incorporating Chiral Linkers into Stapled Peptides.

Serrano JC, Sipthorp J, Xu W, Itzhaki LS, Ley SV.

Chembiochem. 2017 Jun 19;18(12):1066-1071. doi: 10.1002/cbic.201700075. Epub 2017 May 18.

16.

One-Pot Acid-Catalyzed Ring-Opening/Cyclization/Oxidation of Aziridines with N-Tosylhydrazones: Access to 1,2,4-Triazines.

Crespin L, Biancalana L, Morack T, Blakemore DC, Ley SV.

Org Lett. 2017 Mar 3;19(5):1084-1087. doi: 10.1021/acs.orglett.7b00101. Epub 2017 Feb 15.

17.

Rapid Asymmetric Synthesis of Disubstituted Allenes by Coupling of Flow-Generated Diazo Compounds and Propargylated Amines.

Poh JS, Makai S, von Keutz T, Tran DN, Battilocchio C, Pasau P, Ley SV.

Angew Chem Int Ed Engl. 2017 Feb 6;56(7):1864-1868. doi: 10.1002/anie.201611067. Epub 2017 Jan 11.

18.

A multicomponent approach for the preparation of homoallylic alcohols.

Poh JS, Lau SH, Dykes IG, Tran DN, Battilocchio C, Ley SV.

Chem Sci. 2016 Nov 18;7(11):6803-6807. doi: 10.1039/c6sc02581a. Epub 2016 Jul 8.

19.

Visible Light Activation of Boronic Esters Enables Efficient Photoredox C(sp2 )-C(sp3 ) Cross-Couplings in Flow.

Lima F, Kabeshov MA, Tran DN, Battilocchio C, Sedelmeier J, Sedelmeier G, Schenkel B, Ley SV.

Angew Chem Int Ed Engl. 2016 Nov 2;55(45):14085-14089. doi: 10.1002/anie.201605548. Epub 2016 Oct 6.

20.

Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.

Picaud S, Leonards K, Lambert JP, Dovey O, Wells C, Fedorov O, Monteiro O, Fujisawa T, Wang CY, Lingard H, Tallant C, Nikbin N, Guetzoyan L, Ingham R, Ley SV, Brennan P, Muller S, Samsonova A, Gingras AC, Schwaller J, Vassiliou G, Knapp S, Filippakopoulos P.

Sci Adv. 2016 Oct 12;2(10):e1600760. eCollection 2016 Oct.

21.

The Total Synthesis of the Bioactive Natural Product Plantazolicin A and Its Biosynthetic Precursor Plantazolicin B.

Fenner S, Wilson ZE, Ley SV.

Chemistry. 2016 Oct 24;22(44):15902-15912. doi: 10.1002/chem.201603157. Epub 2016 Sep 13.

PMID:
27619732
22.

Taming hazardous chemistry by continuous flow technology.

Movsisyan M, Delbeke EI, Berton JK, Battilocchio C, Ley SV, Stevens CV.

Chem Soc Rev. 2016 Sep 21;45(18):4892-928. doi: 10.1039/c5cs00902b. Epub 2016 Jul 25.

PMID:
27453961
23.

A multistep continuous flow synthesis machine for the preparation of pyrazoles via a metal-free amine-redox process.

Poh JS, Browne DL, Ley SV.

React Chem Eng. 2016 Feb 3;1(1):101-105. Epub 2016 Jan 7.

24.

Synthesis of trifluoromethylated isoxazoles and their elaboration through inter- and intra-molecular C-H arylation.

Poh JS, García-Ruiz C, Zúñiga A, Meroni F, Blakemore DC, Browne DL, Ley SV.

Org Biomol Chem. 2016 Jul 7;14(25):5983-91. doi: 10.1039/c6ob00970k. Epub 2016 May 26.

PMID:
27225313
25.

Enabling Technologies for the Future of Chemical Synthesis.

Fitzpatrick DE, Battilocchio C, Ley SV.

ACS Cent Sci. 2016 Mar 23;2(3):131-8. doi: 10.1021/acscentsci.6b00015. Epub 2016 Feb 24. Review.

26.

Identification and Development of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex.

Sutherell CL, Tallant C, Monteiro OP, Yapp C, Fuchs JE, Fedorov O, Siejka P, Müller S, Knapp S, Brenton JD, Brennan PE, Ley SV.

J Med Chem. 2016 May 26;59(10):5095-101. doi: 10.1021/acs.jmedchem.5b01997. Epub 2016 May 11.

27.

Iterative reactions of transient boronic acids enable sequential C-C bond formation.

Battilocchio C, Feist F, Hafner A, Simon M, Tran DN, Allwood DM, Blakemore DC, Ley SV.

Nat Chem. 2016 Apr;8(4):360-7. doi: 10.1038/nchem.2439. Epub 2016 Feb 8.

PMID:
27001732
28.

Synthesis of Natural and Unnatural Cyclooligomeric Depsipeptides Enabled by Flow Chemistry.

Lücke D, Dalton T, Ley SV, Wilson ZE.

Chemistry. 2016 Mar 14;22(12):4206-17. doi: 10.1002/chem.201504457. Epub 2016 Feb 4.

29.

Synthesis of a Precursor to Sacubitril Using Enabling Technologies.

Lau SH, Bourne SL, Martin B, Schenkel B, Penn G, Ley SV.

Org Lett. 2015 Nov 6;17(21):5436-9. doi: 10.1021/acs.orglett.5b02806. Epub 2015 Oct 28.

PMID:
26509957
30.

Dynamic flow synthesis of porous organic cages.

Briggs ME, Slater AG, Lunt N, Jiang S, Little MA, Greenaway RL, Hasell T, Battilocchio C, Ley SV, Cooper AI.

Chem Commun (Camb). 2015 Dec 21;51(98):17390-3. doi: 10.1039/c5cc07447a. Epub 2015 Oct 14.

PMID:
26463103
31.

Continuous Flow Metathesis for Direct Valorization of Food Waste: An Example of Cocoa Butter Triglyceride.

Schotten C, Plaza D, Manzini S, Nolan SP, Ley SV, Browne DL, Lapkin A.

ACS Sustain Chem Eng. 2015 Jul 6;3(7):1453-1459. Epub 2015 May 26.

32.

Callipeltosides A, B and C: Total Syntheses and Structural Confirmation.

Frost JR, Pearson CM, Snaddon TN, Booth RA, Turner RM, Gold J, Shaw DM, Gaunt MJ, Ley SV.

Chemistry. 2015 Sep 14;21(38):13261-77. doi: 10.1002/chem.201501877. Epub 2015 Jul 31.

33.

Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors.

De Lucia D, Lucio OM, Musio B, Bender A, Listing M, Dennhardt S, Koeberle A, Garscha U, Rizzo R, Manfredini S, Werz O, Ley SV.

Eur J Med Chem. 2015 Aug 28;101:573-83. doi: 10.1016/j.ejmech.2015.07.011. Epub 2015 Jul 15. Erratum in: Eur J Med Chem. 2015 Oct 20;103:223-5.

PMID:
26197161
34.

Machine-Assisted Organic Synthesis.

Ley SV, Fitzpatrick DE, Myers RM, Battilocchio C, Ingham RJ.

Angew Chem Int Ed Engl. 2015 Aug 24;54(35):10122-36. doi: 10.1002/anie.201501618. Epub 2015 Jul 16. Review.

35.

Machines vs Malaria: A Flow-Based Preparation of the Drug Candidate OZ439.

Lau SH, Galván A, Merchant RR, Battilocchio C, Souto JA, Berry MB, Ley SV.

Org Lett. 2015 Jul 2;17(13):3218-21. doi: 10.1021/acs.orglett.5b01307. Epub 2015 Jun 16.

PMID:
26079282
36.

A Versatile Room-Temperature Route to Di- and Trisubstituted Allenes Using Flow-Generated Diazo Compounds.

Poh JS, Tran DN, Battilocchio C, Hawkins JM, Ley SV.

Angew Chem Int Ed Engl. 2015 Jun 26;54(27):7920-3. doi: 10.1002/anie.201501538. Epub 2015 May 26.

37.

A practical deca-gram scale ring expansion of (R)-(-)-carvone to (R)-(+)-3-methyl-6-isopropenyl-cyclohept-3-enone-1.

Alves Lde C, Desiderá AL, de Oliveira KT, Newton S, Ley SV, Brocksom TJ.

Org Biomol Chem. 2015 Jul 28;13(28):7633-42. doi: 10.1039/c5ob00525f. Epub 2015 May 22.

PMID:
25997609
38.

Design, Synthesis, and Evaluation of Tetrasubstituted Pyridines as Potent 5-HT2C Receptor Agonists.

Rouquet G, Moore DE, Spain M, Allwood DM, Battilocchio C, Blakemore DC, Fish PV, Jenkinson S, Jessiman AS, Ley SV, McMurray G, Storer RI.

ACS Med Chem Lett. 2015 Jan 20;6(3):329-33. doi: 10.1021/ml500507v. eCollection 2015 Mar 12.

39.

Development of a web-based platform for studying lithiation reactions in silico.

Kabeshov MA, Sliwiński É, Fitzpatrick DE, Musio B, Newby JA, Blaylock WD, Ley SV.

Chem Commun (Camb). 2015 Apr 28;51(33):7172-5. doi: 10.1039/c5cc00782h.

PMID:
25811168
40.

Development of a flow method for the hydroboration/oxidation of olefins.

Souto JA, Stockman RA, Ley SV.

Org Biomol Chem. 2015 Apr 7;13(13):3871-7. doi: 10.1039/c5ob00170f.

PMID:
25714697
41.

Flow chemistry as a discovery tool to access sp2-sp3 cross-coupling reactions via diazo compounds.

Tran DN, Battilocchio C, Lou SB, Hawkins JM, Ley SV.

Chem Sci. 2015 Feb 1;6(2):1120-1125. doi: 10.1039/c4sc03072a. Epub 2014 Nov 7.

42.

Flow chemistry: intelligent processing of gas-liquid transformations using a tube-in-tube reactor.

Brzozowski M, O'Brien M, Ley SV, Polyzos A.

Acc Chem Res. 2015 Feb 17;48(2):349-62. doi: 10.1021/ar500359m. Epub 2015 Jan 22. Review.

PMID:
25611216
43.

Cyclopropanation using flow-generated diazo compounds.

Roda NM, Tran DN, Battilocchio C, Labes R, Ingham RJ, Hawkins JM, Ley SV.

Org Biomol Chem. 2015 Mar 7;13(9):2550-4. doi: 10.1039/c5ob00019j.

PMID:
25600950
44.

Organic synthesis: march of the machines.

Ley SV, Fitzpatrick DE, Ingham RJ, Myers RM.

Angew Chem Int Ed Engl. 2015 Mar 9;54(11):3449-64. doi: 10.1002/anie.201410744. Epub 2015 Jan 13.

PMID:
25586940
45.

Total syntheses of linear polythiazole/oxazole plantazolicin A and its biosynthetic precursor plantazolicin B.

Wilson ZE, Fenner S, Ley SV.

Angew Chem Int Ed Engl. 2015 Jan 19;54(4):1284-8. doi: 10.1002/anie.201410063. Epub 2014 Nov 25.

46.

A systems approach towards an intelligent and self-controlling platform for integrated continuous reaction sequences.

Ingham RJ, Battilocchio C, Fitzpatrick DE, Sliwinski E, Hawkins JM, Ley SV.

Angew Chem Int Ed Engl. 2015 Jan 2;54(1):144-8. doi: 10.1002/anie.201409356. Epub 2014 Nov 5.

47.

The rapid synthesis of oxazolines and their heterogeneous oxidation to oxazoles under flow conditions.

Glöckner S, Tran DN, Ingham RJ, Fenner S, Wilson ZE, Battilocchio C, Ley SV.

Org Biomol Chem. 2015 Jan 7;13(1):207-14. doi: 10.1039/c4ob02105c.

PMID:
25370905
48.

Flow chemistry meets advanced functional materials.

Myers RM, Fitzpatrick DE, Turner RM, Ley SV.

Chemistry. 2014 Sep 22;20(39):12348-66. doi: 10.1002/chem.201402801. Epub 2014 Aug 25.

PMID:
25156609
49.

Regioselective preparation of saturated spirocyclic and ring-expanded fused pyrazoles.

Merchant RR, Allwood DM, Blakemore DC, Ley SV.

J Org Chem. 2014 Sep 19;79(18):8800-11. doi: 10.1021/jo501624t. Epub 2014 Aug 28.

PMID:
25148419
50.

Expedient preparation of nazlinine and a small library of indole alkaloids using flow electrochemistry as an enabling technology.

Kabeshov MA, Musio B, Murray PR, Browne DL, Ley SV.

Org Lett. 2014 Sep 5;16(17):4618-21. doi: 10.1021/ol502201d. Epub 2014 Aug 22.

PMID:
25147957

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