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Items: 1 to 50 of 81

1.

ABIN2 Function Is Required To Suppress DSS-Induced Colitis by a Tpl2-Independent Mechanism.

Nanda SK, Nagamori T, Windheim M, Amu S, Aviello G, Patterson-Kane J, Arthur JSC, Ley SC, Fallon P, Cohen P.

J Immunol. 2018 Oct 24. pii: ji1700614. doi: 10.4049/jimmunol.1700614. [Epub ahead of print]

PMID:
30355787
2.

A20-binding inhibitor of NF-κB (ABIN) 2 negatively regulates allergic airway inflammation.

Ventura S, Cano F, Kannan Y, Breyer F, Pattison MJ, Wilson MS, Ley SC.

J Exp Med. 2018 Nov 5;215(11):2737-2747. doi: 10.1084/jem.20170852. Epub 2018 Oct 18.

PMID:
30337469
3.

Assaying kinase activity of the TPL-2/NF-κB1 p105/ABIN-2 complex using an optimal peptide substrate.

Kümper S, Gantke T, Chen CS, Soneji Y, Pattison MJ, Chakravarty P, Kjær S, Thomas D, Haslam C, Leavens BJ, House D, Powell DJ, Ley SC.

Biochem J. 2018 Jan 11;475(1):329-340. doi: 10.1042/BCJ20170579.

4.

Protein CoAlation: a redox-linked post-translational modification.

Ley SC, de Carvalho LPS.

Biochem J. 2017 Aug 10;474(16):2897-2899. doi: 10.1042/BCJ20170168.

PMID:
28798160
5.

TPL-2 restricts Ccl24-dependent immunity to Heligmosomoides polygyrus.

Kannan Y, Entwistle LJ, Pelly VS, Perez-Lloret J, Walker AW, Ley SC, Wilson MS.

PLoS Pathog. 2017 Jul 31;13(7):e1006536. doi: 10.1371/journal.ppat.1006536. eCollection 2017 Jul.

6.

TPL-2 Regulates Macrophage Lipid Metabolism and M2 Differentiation to Control TH2-Mediated Immunopathology.

Kannan Y, Perez-Lloret J, Li Y, Entwistle LJ, Khoury H, Papoutsopoulou S, Mahmood R, Mansour NR, Ching-Cheng Huang S, Pearce EJ, Pedro S de Carvalho L, Ley SC, Wilson MS.

PLoS Pathog. 2016 Aug 3;12(8):e1005783. doi: 10.1371/journal.ppat.1005783. eCollection 2016 Aug.

7.

Tumor progression locus 2 reduces severe allergic airway inflammation by inhibiting Ccl24 production in dendritic cells.

Kannan Y, Li Y, Coomes SM, Okoye IS, Pelly VS, Sriskantharajah S, Gückel E, Webb L, Czieso S, Nikolov N, MacDonald AS, Ley SC, Wilson MS.

J Allergy Clin Immunol. 2017 Feb;139(2):655-666.e7. doi: 10.1016/j.jaci.2016.05.031. Epub 2016 Jul 5.

8.

TNF activation of NF-κB is essential for development of single-positive thymocytes.

Webb LV, Ley SC, Seddon B.

J Exp Med. 2016 Jul 25;213(8):1399-407. doi: 10.1084/jem.20151604. Epub 2016 Jul 18.

9.

TLR and TNF-R1 activation of the MKK3/MKK6-p38α axis in macrophages is mediated by TPL-2 kinase.

Pattison MJ, Mitchell O, Flynn HR, Chen CS, Yang HT, Ben-Addi H, Boeing S, Snijders AP, Ley SC.

Biochem J. 2016 Sep 15;473(18):2845-61. doi: 10.1042/BCJ20160502. Epub 2016 Jul 11.

10.

Psoriasis mutations disrupt CARD14 autoinhibition promoting BCL10-MALT1-dependent NF-κB activation.

Howes A, O'Sullivan PA, Breyer F, Ghose A, Cao L, Krappmann D, Bowcock AM, Ley SC.

Biochem J. 2016 Jun 15;473(12):1759-68. doi: 10.1042/BCJ20160270. Epub 2016 Apr 12.

11.

BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival.

Jacque E, Schweighoffer E, Tybulewicz VL, Ley SC.

J Exp Med. 2015 Jun 1;212(6):883-92. doi: 10.1084/jem.20142127. Epub 2015 May 18.

12.

IKK-induced NF-κB1 p105 proteolysis is critical for B cell antibody responses to T cell-dependent antigen.

Jacque E, Schweighoffer E, Visekruna A, Papoutsopoulou S, Janzen J, Zillwood R, Tarlinton DM, Tybulewicz VL, Ley SC.

J Exp Med. 2014 Sep 22;211(10):2085-101. doi: 10.1084/jem.20132019. Epub 2014 Sep 15.

13.

Priming IKKβ kinase for action.

Ley SC, Beyaert R.

Biochem J. 2014 Oct 1;463(1):e1-2. doi: 10.1042/BJ20140989.

PMID:
25195736
14.

IκB kinase-induced interaction of TPL-2 kinase with 14-3-3 is essential for Toll-like receptor activation of ERK-1 and -2 MAP kinases.

Ben-Addi A, Mambole-Dema A, Brender C, Martin SR, Janzen J, Kjaer S, Smerdon SJ, Ley SC.

Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):E2394-403. doi: 10.1073/pnas.1320440111. Epub 2014 May 27.

15.

Regulation of experimental autoimmune encephalomyelitis by TPL-2 kinase.

Sriskantharajah S, Gückel E, Tsakiri N, Kierdorf K, Brender C, Ben-Addi A, Veldhoen M, Tsichlis PN, Stockinger B, O'Garra A, Prinz M, Kollias G, Ley SC.

J Immunol. 2014 Apr 15;192(8):3518-3529. doi: 10.4049/jimmunol.1300172. Epub 2014 Mar 17.

16.

NF-κB signaling mediates homeostatic maturation of new T cells.

Silva A, Cornish G, Ley SC, Seddon B.

Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):E846-55. doi: 10.1073/pnas.1319397111. Epub 2014 Feb 18.

17.

Mitogen-activated protein kinases in innate immunity.

Arthur JS, Ley SC.

Nat Rev Immunol. 2013 Sep;13(9):679-92. doi: 10.1038/nri3495. Epub 2013 Aug 19. Review.

PMID:
23954936
18.

TPL-2-ERK1/2 signaling promotes host resistance against intracellular bacterial infection by negative regulation of type I IFN production.

McNab FW, Ewbank J, Rajsbaum R, Stavropoulos E, Martirosyan A, Redford PS, Wu X, Graham CM, Saraiva M, Tsichlis P, Chaussabel D, Ley SC, O'Garra A.

J Immunol. 2013 Aug 15;191(4):1732-43. doi: 10.4049/jimmunol.1300146. Epub 2013 Jul 10.

19.

Ebola virus VP35 induces high-level production of recombinant TPL-2-ABIN-2-NF-κB1 p105 complex in co-transfected HEK-293 cells.

Gantke T, Boussouf S, Janzen J, Morrice NA, Howell S, Mühlberger E, Ley SC.

Biochem J. 2013 Jun 1;452(2):359-65. doi: 10.1042/BJ20121873.

20.

IκB kinase 2 regulates TPL-2 activation of extracellular signal-regulated kinases 1 and 2 by direct phosphorylation of TPL-2 serine 400.

Roget K, Ben-Addi A, Mambole-Dema A, Gantke T, Yang HT, Janzen J, Morrice N, Abbott D, Ley SC.

Mol Cell Biol. 2012 Nov;32(22):4684-90. doi: 10.1128/MCB.01065-12. Epub 2012 Sep 17.

21.

Coordinate regulation of TPL-2 and NF-κB signaling in macrophages by NF-κB1 p105.

Yang HT, Papoutsopoulou S, Belich M, Brender C, Janzen J, Gantke T, Handley M, Ley SC.

Mol Cell Biol. 2012 Sep;32(17):3438-51. doi: 10.1128/MCB.00564-12. Epub 2012 Jun 25.

22.

p38γ and p38δ kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation.

Risco A, del Fresno C, Mambol A, Alsina-Beauchamp D, MacKenzie KF, Yang HT, Barber DF, Morcelle C, Arthur JS, Ley SC, Ardavin C, Cuenda A.

Proc Natl Acad Sci U S A. 2012 Jul 10;109(28):11200-5. doi: 10.1073/pnas.1207290109. Epub 2012 Jun 25.

23.

IκB kinase regulation of the TPL-2/ERK MAPK pathway.

Gantke T, Sriskantharajah S, Sadowski M, Ley SC.

Immunol Rev. 2012 Mar;246(1):168-82. doi: 10.1111/j.1600-065X.2012.01104.x. Review.

PMID:
22435554
24.

A20 inactivation in ocular adnexal MALT lymphoma.

Bi Y, Zeng N, Chanudet E, Huang Y, Hamoudi RA, Liu H, Dong G, Watkins AJ, Ley SC, Zou L, Chen R, Zhu X, Du MQ.

Haematologica. 2012 Jun;97(6):926-30. doi: 10.3324/haematol.2010.036798. Epub 2011 Dec 29.

25.

ABIN1 protein cooperates with TAX1BP1 and A20 proteins to inhibit antiviral signaling.

Gao L, Coope H, Grant S, Ma A, Ley SC, Harhaj EW.

J Biol Chem. 2011 Oct 21;286(42):36592-602. doi: 10.1074/jbc.M111.283762. Epub 2011 Sep 1.

26.

NF-κB1 inhibits TLR-induced IFN-β production in macrophages through TPL-2-dependent ERK activation.

Yang HT, Wang Y, Zhao X, Demissie E, Papoutsopoulou S, Mambole A, O'Garra A, Tomczak MF, Erdman SE, Fox JG, Ley SC, Horwitz BH.

J Immunol. 2011 Feb 15;186(4):1989-96. doi: 10.4049/jimmunol.1001003. Epub 2011 Jan 7.

27.

Regulation and function of TPL-2, an IκB kinase-regulated MAP kinase kinase kinase.

Gantke T, Sriskantharajah S, Ley SC.

Cell Res. 2011 Jan;21(1):131-45. doi: 10.1038/cr.2010.173. Epub 2010 Dec 7. Review. Erratum in: Cell Res. 2011 Apr;21(4):704.

28.

TPL-2-mediated activation of MAPK downstream of TLR4 signaling is coupled to arginine availability.

Mieulet V, Yan L, Choisy C, Sully K, Procter J, Kouroumalis A, Krywawych S, Pende M, Ley SC, Moinard C, Lamb RF.

Sci Signal. 2010 Aug 17;3(135):ra61. doi: 10.1126/scisignal.2000934.

29.

Expression, biological activities and mechanisms of action of A20 (TNFAIP3).

Verstrepen L, Verhelst K, van Loo G, Carpentier I, Ley SC, Beyaert R.

Biochem Pharmacol. 2010 Dec 15;80(12):2009-20. doi: 10.1016/j.bcp.2010.06.044. Epub 2010 Jul 3. Review.

PMID:
20599425
30.

Cell biology. Turning off inflammation signaling.

Sriskantharajah S, Ley SC.

Science. 2010 Feb 26;327(5969):1093-4. doi: 10.1126/science.1187271. No abstract available.

PMID:
20185718
31.

TPL-2 negatively regulates interferon-beta production in macrophages and myeloid dendritic cells.

Kaiser F, Cook D, Papoutsopoulou S, Rajsbaum R, Wu X, Yang HT, Grant S, Ricciardi-Castagnoli P, Tsichlis PN, Ley SC, O'Garra A.

J Exp Med. 2009 Aug 31;206(9):1863-71. doi: 10.1084/jem.20091059. Epub 2009 Aug 10.

32.

RNF11, a new piece in the A20 puzzle.

Jacque E, Ley SC.

EMBO J. 2009 Mar 4;28(5):455-6. doi: 10.1038/emboj.2009.18. No abstract available.

33.

Proteolysis of NF-kappaB1 p105 is essential for T cell antigen receptor-induced proliferation.

Sriskantharajah S, Belich MP, Papoutsopoulou S, Janzen J, Tybulewicz V, Seddon B, Ley SC.

Nat Immunol. 2009 Jan;10(1):38-47. doi: 10.1038/ni.1685. Epub 2008 Dec 7.

PMID:
19060899
34.

New insights into NF-kappaB regulation and function.

Sun SC, Ley SC.

Trends Immunol. 2008 Oct;29(10):469-78. doi: 10.1016/j.it.2008.07.003. Epub 2008 Sep 3.

35.

TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF alpha in LPS-stimulated macrophages.

Rousseau S, Papoutsopoulou M, Symons A, Cook D, Lucocq JM, Prescott AR, O'Garra A, Ley SC, Cohen P.

J Cell Sci. 2008 Jan 15;121(Pt 2):149-54. doi: 10.1242/jcs.018671.

36.

Phosphorylation of TPL-2 on serine 400 is essential for lipopolysaccharide activation of extracellular signal-regulated kinase in macrophages.

Robinson MJ, Beinke S, Kouroumalis A, Tsichlis PN, Ley SC.

Mol Cell Biol. 2007 Nov;27(21):7355-64. Epub 2007 Aug 20.

37.

[Variability of blood glucose concentration and short-term mortality in critically ill patient].

Ley SC, Kindgen-Milles D.

Anaesthesist. 2007 Aug;56(8):820-1. German. No abstract available.

PMID:
17639283
38.

TPL-2 MEK kinase is not targeted by mutation in diffuse large B cell lymphoma and myeloid leukemia.

Shirali S, Hamoudi RA, Bench A, Scott M, Ley SC, Du MQ.

Leuk Res. 2007 Nov;31(11):1604-7. Epub 2007 Feb 26. No abstract available.

PMID:
17324460
39.

Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH).

Cockman ME, Lancaster DE, Stolze IP, Hewitson KS, McDonough MA, Coleman ML, Coles CH, Yu X, Hay RT, Ley SC, Pugh CW, Oldham NJ, Masson N, Schofield CJ, Ratcliffe PJ.

Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14767-72. Epub 2006 Sep 26.

40.

Arrestin-2 and G protein-coupled receptor kinase 5 interact with NFkappaB1 p105 and negatively regulate lipopolysaccharide-stimulated ERK1/2 activation in macrophages.

Parameswaran N, Pao CS, Leonhard KS, Kang DS, Kratz M, Ley SC, Benovic JL.

J Biol Chem. 2006 Nov 10;281(45):34159-70. Epub 2006 Sep 15.

41.

ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses.

Papoutsopoulou S, Symons A, Tharmalingham T, Belich MP, Kaiser F, Kioussis D, O'Garra A, Tybulewicz V, Ley SC.

Nat Immunol. 2006 Jun;7(6):606-15. Epub 2006 Apr 23.

PMID:
16633345
42.

MAP kinase kinase kinases and innate immunity.

Symons A, Beinke S, Ley SC.

Trends Immunol. 2006 Jan;27(1):40-8. Epub 2005 Dec 13. Review.

PMID:
16356769
43.

Identification of a macrophage-specific chromatin signature in the IL-10 locus.

Saraiva M, Christensen JR, Tsytsykova AV, Goldfeld AE, Ley SC, Kioussis D, O'Garra A.

J Immunol. 2005 Jul 15;175(2):1041-6.

44.

[Perioperative treatment of patients with Diabetes mellitus].

Ley SC, Preckel B, Schlack W.

Anasthesiol Intensivmed Notfallmed Schmerzther. 2005 Apr;40(4):230-46; quiz 247-9. Review. German. No abstract available. Erratum in: Anasthesiol Intensivmed Notfallmed Schmerzther. 2005 May;40(5):326. dosage error in text.

PMID:
15832243
46.

Functions of NF-kappaB1 and NF-kappaB2 in immune cell biology.

Beinke S, Ley SC.

Biochem J. 2004 Sep 1;382(Pt 2):393-409. Review.

47.

ABIN-2 forms a ternary complex with TPL-2 and NF-kappa B1 p105 and is essential for TPL-2 protein stability.

Lang V, Symons A, Watton SJ, Janzen J, Soneji Y, Beinke S, Howell S, Ley SC.

Mol Cell Biol. 2004 Jun;24(12):5235-48.

48.

Latent membrane protein 1 of Epstein-Barr virus stimulates processing of NF-kappa B2 p100 to p52.

Atkinson PG, Coope HJ, Rowe M, Ley SC.

J Biol Chem. 2003 Dec 19;278(51):51134-42. Epub 2003 Oct 7.

49.

NF-kappaB1 p105 negatively regulates TPL-2 MEK kinase activity.

Beinke S, Deka J, Lang V, Belich MP, Walker PA, Howell S, Smerdon SJ, Gamblin SJ, Ley SC.

Mol Cell Biol. 2003 Jul;23(14):4739-52.

50.

betaTrCP-mediated proteolysis of NF-kappaB1 p105 requires phosphorylation of p105 serines 927 and 932.

Lang V, Janzen J, Fischer GZ, Soneji Y, Beinke S, Salmeron A, Allen H, Hay RT, Ben-Neriah Y, Ley SC.

Mol Cell Biol. 2003 Jan;23(1):402-13.

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