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Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS-) vs. Alternatively Activated Macrophages.

Orecchioni M, Ghosheh Y, Pramod AB, Ley K.

Front Immunol. 2019 May 24;10:1084. doi: 10.3389/fimmu.2019.01084. eCollection 2019. Review.


Neutrophil Recruitment: From Model Systems to Tissue-Specific Patterns.

Margraf A, Ley K, Zarbock A.

Trends Immunol. 2019 Jun 4. pii: S1471-4906(19)30099-7. doi: 10.1016/ [Epub ahead of print] Review.


Rap1 binding and a lipid-dependent helix in talin F1 domain promote integrin activation in tandem.

Gingras AR, Lagarrigue F, Cuevas MN, Valadez AJ, Zorovich M, McLaughlin W, Lopez-Ramirez MA, Seban N, Ley K, Kiosses WB, Ginsberg MH.

J Cell Biol. 2019 Jun 3;218(6):1799-1809. doi: 10.1083/jcb.201810061. Epub 2019 Apr 15.


Vaccination against atherosclerosis.

Kobiyama K, Saigusa R, Ley K.

Curr Opin Immunol. 2019 Mar 28;59:15-24. doi: 10.1016/j.coi.2019.02.008. [Epub ahead of print] Review.


[Immunity and inflammation in atherosclerosis].

Wolf D, Ley K.

Herz. 2019 Apr;44(2):107-120. doi: 10.1007/s00059-019-4790-y. German.


The trafficking protein JFC1 regulates Rac1-GTP localization at the uropod controlling neutrophil chemotaxis and in vivo migration.

Ramadass M, Johnson JL, Marki A, Zhang J, Wolf D, Kiosses WB, Pestonjamasp K, Ley K, Catz SD.

J Leukoc Biol. 2019 Jun;105(6):1209-1224. doi: 10.1002/JLB.1VMA0818-320R. Epub 2019 Feb 12.


Immunity and Inflammation in Atherosclerosis.

Wolf D, Ley K.

Circ Res. 2019 Jan 18;124(2):315-327. doi: 10.1161/CIRCRESAHA.118.313591.


A Single-Step Chemoenzymatic Reaction for the Construction of Antibody-Cell Conjugates.

Li J, Chen M, Liu Z, Zhang L, Felding BH, Moremen KW, Lauvau G, Abadier M, Ley K, Wu P.

ACS Cent Sci. 2018 Dec 26;4(12):1633-1641. doi: 10.1021/acscentsci.8b00552. Epub 2018 Dec 7.


High-Affinity Bent β2-Integrin Molecules in Arresting Neutrophils Face Each Other through Binding to ICAMs In cis.

Fan Z, Kiosses WB, Sun H, Orecchioni M, Ghosheh Y, Zajonc DM, Arnaout MA, Gutierrez E, Groisman A, Ginsberg MH, Ley K.

Cell Rep. 2019 Jan 2;26(1):119-130.e5. doi: 10.1016/j.celrep.2018.12.038.


Myeloid-Specific Deletion of Epsins 1 and 2 Reduces Atherosclerosis by Preventing LRP-1 Downregulation.

Brophy ML, Dong Y, Tao H, Yancey PG, Song K, Zhang K, Wen A, Wu H, Lee Y, Malovichko MV, Sithu SD, Wong S, Yu L, Kocher O, Bischoff J, Srivastava S, Linton MF, Ley K, Chen H.

Circ Res. 2019 Feb 15;124(4):e6-e19. doi: 10.1161/CIRCRESAHA.118.313028.


Platelet Serotonin Aggravates Myocardial Ischemia/Reperfusion Injury via Neutrophil Degranulation.

Mauler M, Herr N, Schoenichen C, Witsch T, Marchini T, Härdtner C, Koentges C, Kienle K, Ollivier V, Schell M, Dorner L, Wippel C, Stallmann D, Normann C, Bugger H, Walther P, Wolf D, Ahrens I, Lämmermann T, Ho-Tin-Noé B, Ley K, Bode C, Hilgendorf I, Duerschmied D.

Circulation. 2019 Feb 12;139(7):918-931. doi: 10.1161/CIRCULATIONAHA.118.033942.


CX3CL1-Fc treatment prevents atherosclerosis in Ldlr KO mice.

Riopel M, Vassallo M, Ehinger E, Pattison J, Bowden K, Winkels H, Wilson M, de Jong R, Patel S, Balakrishna D, Bilakovics J, Fanjul A, Plonowski A, Larson CJ, Ley K, Cabrales P, Witztum JL, Olefsky JM, Lee YS.

Mol Metab. 2019 Feb;20:89-101. doi: 10.1016/j.molmet.2018.11.011. Epub 2018 Dec 2.


Neutrophils: New insights and open questions.

Ley K, Hoffman HM, Kubes P, Cassatella MA, Zychlinsky A, Hedrick CC, Catz SD.

Sci Immunol. 2018 Dec 7;3(30). pii: eaat4579. doi: 10.1126/sciimmunol.aat4579. Epub 2018 Dec 7. Review.


Loss of CXCR4 on non-classical monocytes in participants of the Women's Interagency HIV Study (WIHS) with subclinical atherosclerosis.

Mueller KAL, Hanna DB, Ehinger E, Xue X, Baas L, Gawaz MP, Geisler T, Anastos K, Cohen MH, Gange SJ, Heath SL, Lazar JM, Liu C, Mack WJ, Ofotokun I, Tien PC, Hodis HN, Landay AL, Kaplan RC, Ley K.

Cardiovasc Res. 2019 May 1;115(6):1029-1040. doi: 10.1093/cvr/cvy292.



Kobiyama K, Ley K.

Circ Res. 2018 Oct 26;123(10):1118-1120. doi: 10.1161/CIRCRESAHA.118.313816. No abstract available.


Deconvolution of pro- and antiviral genomic responses in Zika virus-infected and bystander macrophages.

Carlin AF, Vizcarra EA, Branche E, Viramontes KM, Suarez-Amaran L, Ley K, Heinz S, Benner C, Shresta S, Glass CK.

Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):E9172-E9181. doi: 10.1073/pnas.1807690115. Epub 2018 Sep 11.


Atherosclerosis in the single-cell era.

Winkels H, Ehinger E, Ghosheh Y, Wolf D, Ley K.

Curr Opin Lipidol. 2018 Oct;29(5):389-396. doi: 10.1097/MOL.0000000000000537.


Publisher Correction: Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice.

Que X, Hung MY, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Määttä A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Ylä-Herttuala S, Mellon PL, Hedrick CC, Ley K, Miller YI, Glass CK, Peterson KL, Binder CJ, Tsimikas S, Witztum JL.

Nature. 2018 Sep;561(7724):E43. doi: 10.1038/s41586-018-0313-x.


A clinically applicable adjuvant for an atherosclerosis vaccine in mice.

Kobiyama K, Vassallo M, Mitzi J, Winkels H, Pei H, Kimura T, Miller J, Wolf D, Ley K.

Eur J Immunol. 2018 Sep;48(9):1580-1587. doi: 10.1002/eji.201847584. Epub 2018 Aug 12.


Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice.

Que X, Hung MY, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Määttä A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Ylä-Herttuala S, Mellon PL, Hedrick CC, Ley K, Miller YI, Glass CK, Peterson KL, Binder CJ, Tsimikas S, Witztum JL.

Nature. 2018 Jun;558(7709):301-306. doi: 10.1038/s41586-018-0198-8. Epub 2018 Jun 6. Erratum in: Nature. 2018 Sep;561(7724):E43.


Regulatory CD4+ T Cells Recognize Major Histocompatibility Complex Class II Molecule-Restricted Peptide Epitopes of Apolipoprotein B.

Kimura T, Kobiyama K, Winkels H, Tse K, Miller J, Vassallo M, Wolf D, Ryden C, Orecchioni M, Dileepan T, Jenkins MK, James EA, Kwok WW, Hanna DB, Kaplan RC, Strickler HD, Durkin HG, Kassaye SG, Karim R, Tien PC, Landay AL, Gange SJ, Sidney J, Sette A, Ley K.

Circulation. 2018 Sep 11;138(11):1130-1143. doi: 10.1161/CIRCULATIONAHA.117.031420.


Atlas of the Immune Cell Repertoire in Mouse Atherosclerosis Defined by Single-Cell RNA-Sequencing and Mass Cytometry.

Winkels H, Ehinger E, Vassallo M, Buscher K, Dinh HQ, Kobiyama K, Hamers AAJ, Cochain C, Vafadarnejad E, Saliba AE, Zernecke A, Pramod AB, Ghosh AK, Anto Michel N, Hoppe N, Hilgendorf I, Zirlik A, Hedrick CC, Ley K, Wolf D.

Circ Res. 2018 Jun 8;122(12):1675-1688. doi: 10.1161/CIRCRESAHA.117.312513. Epub 2018 Mar 15.


Single-Cell RNA-Seq Reveals the Transcriptional Landscape and Heterogeneity of Aortic Macrophages in Murine Atherosclerosis.

Cochain C, Vafadarnejad E, Arampatzi P, Pelisek J, Winkels H, Ley K, Wolf D, Saliba AE, Zernecke A.

Circ Res. 2018 Jun 8;122(12):1661-1674. doi: 10.1161/CIRCRESAHA.117.312509. Epub 2018 Mar 15.


Transmission of integrin β7 transmembrane domain topology enables gut lymphoid tissue development.

Sun H, Lagarrigue F, Gingras AR, Fan Z, Ley K, Ginsberg MH.

J Cell Biol. 2018 Apr 2;217(4):1453-1465. doi: 10.1083/jcb.201707055. Epub 2018 Mar 13.


A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense.

Wolf D, Anto-Michel N, Blankenbach H, Wiedemann A, Buscher K, Hohmann JD, Lim B, Bäuml M, Marki A, Mauler M, Duerschmied D, Fan Z, Winkels H, Sidler D, Diehl P, Zajonc DM, Hilgendorf I, Stachon P, Marchini T, Willecke F, Schell M, Sommer B, von Zur Muhlen C, Reinöhl J, Gerhardt T, Plow EF, Yakubenko V, Libby P, Bode C, Ley K, Peter K, Zirlik A.

Nat Commun. 2018 Feb 6;9(1):525. doi: 10.1038/s41467-018-02896-8.


Inflammatory Pathways Regulated by Tumor Necrosis Receptor-Associated Factor 1 Protect From Metabolic Consequences in Diet-Induced Obesity.

Anto Michel N, Colberg C, Buscher K, Sommer B, Pramod AB, Ehinger E, Dufner B, Hoppe N, Pfeiffer K, Marchini T, Willecke F, Stachon P, Hilgendorf I, Heidt T, von Zur Muhlen C, von Elverfeldt D, Pfeifer D, Schüle R, Kintscher U, Brachs S, Ley K, Bode C, Zirlik A, Wolf D.

Circ Res. 2018 Mar 2;122(5):693-700. doi: 10.1161/CIRCRESAHA.117.312055. Epub 2018 Jan 22.


Patrolling Mechanics of Non-Classical Monocytes in Vascular Inflammation.

Buscher K, Marcovecchio P, Hedrick CC, Ley K.

Front Cardiovasc Med. 2017 Dec 19;4:80. doi: 10.3389/fcvm.2017.00080. eCollection 2017. Review.


Natural Killer Cells at Ease: Atherosclerosis Is Not Affected by Genetic Depletion or Hyperactivation of Natural Killer Cells.

Winkels H, Ley K.

Circ Res. 2018 Jan 5;122(1):6-7. doi: 10.1161/CIRCRESAHA.117.312289. No abstract available.


Effector and Regulatory T Cells Roll at High Shear Stress by Inducible Tether and Sling Formation.

Abadier M, Pramod AB, McArdle S, Marki A, Fan Z, Gutierrez E, Groisman A, Ley K.

Cell Rep. 2017 Dec 26;21(13):3885-3899. doi: 10.1016/j.celrep.2017.11.099.


Structure-function characterization of three human antibodies targeting the vaccinia virus adhesion molecule D8.

Matho MH, Schlossman A, Gilchuk IM, Miller G, Mikulski Z, Hupfer M, Wang J, Bitra A, Meng X, Xiang Y, Kaever T, Doukov T, Ley K, Crotty S, Peters B, Hsieh-Wilson LC, Crowe JE Jr, Zajonc DM.

J Biol Chem. 2018 Jan 5;293(1):390-401. doi: 10.1074/jbc.M117.814541. Epub 2017 Nov 9.


Scavenger Receptor CD36 Directs Nonclassical Monocyte Patrolling Along the Endothelium During Early Atherogenesis.

Marcovecchio PM, Thomas GD, Mikulski Z, Ehinger E, Mueller KAL, Blatchley A, Wu R, Miller YI, Nguyen AT, Taylor AM, McNamara CA, Ley K, Hedrick CC.

Arterioscler Thromb Vasc Biol. 2017 Nov;37(11):2043-2052. doi: 10.1161/ATVBAHA.117.309123. Epub 2017 Sep 21.


Developing Neutrophils Must Eat…Themselves!

Fan Z, Ley K.

Immunity. 2017 Sep 19;47(3):393-395. doi: 10.1016/j.immuni.2017.08.013.


M1 Means Kill; M2 Means Heal.

Ley K.

J Immunol. 2017 Oct 1;199(7):2191-2193. doi: 10.4049/jimmunol.1701135. No abstract available.


Rolling neutrophils form tethers and slings under physiologic conditions in vivo.

Marki A, Buscher K, Mikulski Z, Pries A, Ley K.

J Leukoc Biol. 2018 Jan;103(1):67-70. doi: 10.1189/jlb.1AB0617-230R. Epub 2017 Dec 28.


Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival.

Buscher K, Ehinger E, Gupta P, Pramod AB, Wolf D, Tweet G, Pan C, Mills CD, Lusis AJ, Ley K.

Nat Commun. 2017 Jul 24;8:16041. doi: 10.1038/ncomms16041.


IL-27R signaling controls myeloid cells accumulation and antigen-presentation in atherosclerosis.

Peshkova IO, Fatkhullina AR, Mikulski Z, Ley K, Koltsova EK.

Sci Rep. 2017 May 23;7(1):2255. doi: 10.1038/s41598-017-01828-8.


Differential DARC/ACKR1 expression distinguishes venular from non-venular endothelial cells in murine tissues.

Thiriot A, Perdomo C, Cheng G, Novitzky-Basso I, McArdle S, Kishimoto JK, Barreiro O, Mazo I, Triboulet R, Ley K, Rot A, von Andrian UH.

BMC Biol. 2017 May 19;15(1):45. doi: 10.1186/s12915-017-0381-7.


Defects in DNA replication hit NK cells and neutrophils.

Ley K.

J Clin Invest. 2017 May 1;127(5):1616-1617. doi: 10.1172/JCI93835. Epub 2017 Apr 17.


ATVB Distinguished Scientist Award: How Costimulatory and Coinhibitory Pathways Shape Atherosclerosis.

Ley K, Gerdes N, Winkels H.

Arterioscler Thromb Vasc Biol. 2017 May;37(5):764-777. doi: 10.1161/ATVBAHA.117.308611. Epub 2017 Mar 30. Review.


Breaking a Vicious Cycle.

Ley K.

N Engl J Med. 2017 Mar 23;376(12):1172-1174. doi: 10.1056/NEJMe1615654. No abstract available.


Endothelial Protective Monocyte Patrolling in Large Arteries Intensified by Western Diet and Atherosclerosis.

Quintar A, McArdle S, Wolf D, Marki A, Ehinger E, Vassallo M, Miller J, Mikulski Z, Ley K, Buscher K.

Circ Res. 2017 May 26;120(11):1789-1799. doi: 10.1161/CIRCRESAHA.117.310739. Epub 2017 Mar 16.


P-selectin glycoprotein ligand-1 in T cells.

Abadier M, Ley K.

Curr Opin Hematol. 2017 May;24(3):265-273. doi: 10.1097/MOH.0000000000000331. Review.


Atheroprotective vaccination with MHC-II-restricted ApoB peptides induces peritoneal IL-10-producing CD4 T cells.

Kimura T, Tse K, McArdle S, Gerhardt T, Miller J, Mikulski Z, Sidney J, Sette A, Wolf D, Ley K.

Am J Physiol Heart Circ Physiol. 2017 Apr 1;312(4):H781-H790. doi: 10.1152/ajpheart.00798.2016. Epub 2017 Jan 13.


Neutrophil recruitment limited by high-affinity bent β2 integrin binding ligand in cis.

Fan Z, McArdle S, Marki A, Mikulski Z, Gutierrez E, Engelhardt B, Deutsch U, Ginsberg M, Groisman A, Ley K.

Nat Commun. 2016 Aug 31;7:12658. doi: 10.1038/ncomms12658.


Surface heterogeneity: a friend or foe of protein adsorption - insights from theoretical simulations.

Penna M, Ley K, Maclaughlin S, Yarovsky I.

Faraday Discuss. 2016 Oct 6;191:435-464. Epub 2016 Jul 25.


Microfluidics-based side view flow chamber reveals tether-to-sling transition in rolling neutrophils.

Marki A, Gutierrez E, Mikulski Z, Groisman A, Ley K.

Sci Rep. 2016 Jun 30;6:28870. doi: 10.1038/srep28870.


How Mouse Macrophages Sense What Is Going On.

Ley K, Pramod AB, Croft M, Ravichandran KS, Ting JP.

Front Immunol. 2016 Jun 2;7:204. doi: 10.3389/fimmu.2016.00204. eCollection 2016. Review.


Live cell imaging to understand monocyte, macrophage, and dendritic cell function in atherosclerosis.

McArdle S, Mikulski Z, Ley K.

J Exp Med. 2016 Jun 27;213(7):1117-31. doi: 10.1084/jem.20151885. Epub 2016 Jun 6. Review.


Leukocyte Adhesion Deficiency IV. Monocyte Integrin Activation Deficiency in Cystic Fibrosis.

Fan Z, Ley K.

Am J Respir Crit Care Med. 2016 May 15;193(10):1075-7. doi: 10.1164/rccm.201512-2454ED. No abstract available.


CCR5+T-bet+FoxP3+ Effector CD4 T Cells Drive Atherosclerosis.

Li J, McArdle S, Gholami A, Kimura T, Wolf D, Gerhardt T, Miller J, Weber C, Ley K.

Circ Res. 2016 May 13;118(10):1540-52. doi: 10.1161/CIRCRESAHA.116.308648. Epub 2016 Mar 28.

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