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Neutrophils: New insights and open questions.

Ley K, Hoffman HM, Kubes P, Cassatella MA, Zychlinsky A, Hedrick CC, Catz SD.

Sci Immunol. 2018 Dec 7;3(30). pii: eaat4579. doi: 10.1126/sciimmunol.aat4579. Epub 2018 Dec 7. Review.


Loss of CXCR4 on non-classical monocytes in participants of the Women's Interagency HIV Study (WIHS) with subclinical atherosclerosis.

Mueller KAL, Hanna DB, Ehinger E, Xue X, Baas L, Gawaz MP, Geisler T, Anastos K, Cohen MH, Gange SJ, Heath SL, Lazar JM, Liu C, Mack WJ, Ofotokun I, Tien PC, Hodis HN, Landay AL, Kaplan RC, Ley K.

Cardiovasc Res. 2018 Dec 5. doi: 10.1093/cvr/cvy292. [Epub ahead of print]



Kobiyama K, Ley K.

Circ Res. 2018 Oct 26;123(10):1118-1120. doi: 10.1161/CIRCRESAHA.118.313816. No abstract available.


Deconvolution of pro- and antiviral genomic responses in Zika virus-infected and bystander macrophages.

Carlin AF, Vizcarra EA, Branche E, Viramontes KM, Suarez-Amaran L, Ley K, Heinz S, Benner C, Shresta S, Glass CK.

Proc Natl Acad Sci U S A. 2018 Sep 25;115(39):E9172-E9181. doi: 10.1073/pnas.1807690115. Epub 2018 Sep 11.


Atherosclerosis in the single-cell era.

Winkels H, Ehinger E, Ghosheh Y, Wolf D, Ley K.

Curr Opin Lipidol. 2018 Oct;29(5):389-396. doi: 10.1097/MOL.0000000000000537.


Publisher Correction: Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice.

Que X, Hung MY, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Määttä A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Ylä-Herttuala S, Mellon PL, Hedrick CC, Ley K, Miller YI, Glass CK, Peterson KL, Binder CJ, Tsimikas S, Witztum JL.

Nature. 2018 Sep;561(7724):E43. doi: 10.1038/s41586-018-0313-x.


A clinically applicable adjuvant for an atherosclerosis vaccine in mice.

Kobiyama K, Vassallo M, Mitzi J, Winkels H, Pei H, Kimura T, Miller J, Wolf D, Ley K.

Eur J Immunol. 2018 Sep;48(9):1580-1587. doi: 10.1002/eji.201847584. Epub 2018 Aug 12.


Oxidized phospholipids are proinflammatory and proatherogenic in hypercholesterolaemic mice.

Que X, Hung MY, Yeang C, Gonen A, Prohaska TA, Sun X, Diehl C, Määttä A, Gaddis DE, Bowden K, Pattison J, MacDonald JG, Ylä-Herttuala S, Mellon PL, Hedrick CC, Ley K, Miller YI, Glass CK, Peterson KL, Binder CJ, Tsimikas S, Witztum JL.

Nature. 2018 Jun;558(7709):301-306. doi: 10.1038/s41586-018-0198-8. Epub 2018 Jun 6. Erratum in: Nature. 2018 Sep;561(7724):E43.


Regulatory CD4+ T Cells Recognize Major Histocompatibility Complex Class II Molecule-Restricted Peptide Epitopes of Apolipoprotein B.

Kimura T, Kobiyama K, Winkels H, Tse K, Miller J, Vassallo M, Wolf D, Ryden C, Orecchioni M, Dileepan T, Jenkins MK, James EA, Kwok WW, Hanna DB, Kaplan RC, Strickler HD, Durkin HG, Kassaye SG, Karim R, Tien PC, Landay AL, Gange SJ, Sidney J, Sette A, Ley K.

Circulation. 2018 Sep 11;138(11):1130-1143. doi: 10.1161/CIRCULATIONAHA.117.031420.


Atlas of the Immune Cell Repertoire in Mouse Atherosclerosis Defined by Single-Cell RNA-Sequencing and Mass Cytometry.

Winkels H, Ehinger E, Vassallo M, Buscher K, Dinh HQ, Kobiyama K, Hamers AAJ, Cochain C, Vafadarnejad E, Saliba AE, Zernecke A, Pramod AB, Ghosh AK, Anto Michel N, Hoppe N, Hilgendorf I, Zirlik A, Hedrick CC, Ley K, Wolf D.

Circ Res. 2018 Jun 8;122(12):1675-1688. doi: 10.1161/CIRCRESAHA.117.312513. Epub 2018 Mar 15.


Single-Cell RNA-Seq Reveals the Transcriptional Landscape and Heterogeneity of Aortic Macrophages in Murine Atherosclerosis.

Cochain C, Vafadarnejad E, Arampatzi P, Pelisek J, Winkels H, Ley K, Wolf D, Saliba AE, Zernecke A.

Circ Res. 2018 Jun 8;122(12):1661-1674. doi: 10.1161/CIRCRESAHA.117.312509. Epub 2018 Mar 15.


Transmission of integrin β7 transmembrane domain topology enables gut lymphoid tissue development.

Sun H, Lagarrigue F, Gingras AR, Fan Z, Ley K, Ginsberg MH.

J Cell Biol. 2018 Apr 2;217(4):1453-1465. doi: 10.1083/jcb.201707055. Epub 2018 Mar 13.


A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense.

Wolf D, Anto-Michel N, Blankenbach H, Wiedemann A, Buscher K, Hohmann JD, Lim B, Bäuml M, Marki A, Mauler M, Duerschmied D, Fan Z, Winkels H, Sidler D, Diehl P, Zajonc DM, Hilgendorf I, Stachon P, Marchini T, Willecke F, Schell M, Sommer B, von Zur Muhlen C, Reinöhl J, Gerhardt T, Plow EF, Yakubenko V, Libby P, Bode C, Ley K, Peter K, Zirlik A.

Nat Commun. 2018 Feb 6;9(1):525. doi: 10.1038/s41467-018-02896-8.


Inflammatory Pathways Regulated by Tumor Necrosis Receptor-Associated Factor 1 Protect From Metabolic Consequences in Diet-Induced Obesity.

Anto Michel N, Colberg C, Buscher K, Sommer B, Pramod AB, Ehinger E, Dufner B, Hoppe N, Pfeiffer K, Marchini T, Willecke F, Stachon P, Hilgendorf I, Heidt T, von Zur Muhlen C, von Elverfeldt D, Pfeifer D, Schüle R, Kintscher U, Brachs S, Ley K, Bode C, Zirlik A, Wolf D.

Circ Res. 2018 Mar 2;122(5):693-700. doi: 10.1161/CIRCRESAHA.117.312055. Epub 2018 Jan 22.


Patrolling Mechanics of Non-Classical Monocytes in Vascular Inflammation.

Buscher K, Marcovecchio P, Hedrick CC, Ley K.

Front Cardiovasc Med. 2017 Dec 19;4:80. doi: 10.3389/fcvm.2017.00080. eCollection 2017. Review.


Natural Killer Cells at Ease: Atherosclerosis Is Not Affected by Genetic Depletion or Hyperactivation of Natural Killer Cells.

Winkels H, Ley K.

Circ Res. 2018 Jan 5;122(1):6-7. doi: 10.1161/CIRCRESAHA.117.312289. No abstract available.


Effector and Regulatory T Cells Roll at High Shear Stress by Inducible Tether and Sling Formation.

Abadier M, Pramod AB, McArdle S, Marki A, Fan Z, Gutierrez E, Groisman A, Ley K.

Cell Rep. 2017 Dec 26;21(13):3885-3899. doi: 10.1016/j.celrep.2017.11.099.


Structure-function characterization of three human antibodies targeting the vaccinia virus adhesion molecule D8.

Matho MH, Schlossman A, Gilchuk IM, Miller G, Mikulski Z, Hupfer M, Wang J, Bitra A, Meng X, Xiang Y, Kaever T, Doukov T, Ley K, Crotty S, Peters B, Hsieh-Wilson LC, Crowe JE Jr, Zajonc DM.

J Biol Chem. 2018 Jan 5;293(1):390-401. doi: 10.1074/jbc.M117.814541. Epub 2017 Nov 9.


Scavenger Receptor CD36 Directs Nonclassical Monocyte Patrolling Along the Endothelium During Early Atherogenesis.

Marcovecchio PM, Thomas GD, Mikulski Z, Ehinger E, Mueller KAL, Blatchley A, Wu R, Miller YI, Nguyen AT, Taylor AM, McNamara CA, Ley K, Hedrick CC.

Arterioscler Thromb Vasc Biol. 2017 Nov;37(11):2043-2052. doi: 10.1161/ATVBAHA.117.309123. Epub 2017 Sep 21.


Developing Neutrophils Must Eat…Themselves!

Fan Z, Ley K.

Immunity. 2017 Sep 19;47(3):393-395. doi: 10.1016/j.immuni.2017.08.013.


M1 Means Kill; M2 Means Heal.

Ley K.

J Immunol. 2017 Oct 1;199(7):2191-2193. doi: 10.4049/jimmunol.1701135. No abstract available.


Rolling neutrophils form tethers and slings under physiologic conditions in vivo.

Marki A, Buscher K, Mikulski Z, Pries A, Ley K.

J Leukoc Biol. 2018 Jan;103(1):67-70. doi: 10.1189/jlb.1AB0617-230R. Epub 2017 Dec 28.


Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival.

Buscher K, Ehinger E, Gupta P, Pramod AB, Wolf D, Tweet G, Pan C, Mills CD, Lusis AJ, Ley K.

Nat Commun. 2017 Jul 24;8:16041. doi: 10.1038/ncomms16041.


IL-27R signaling controls myeloid cells accumulation and antigen-presentation in atherosclerosis.

Peshkova IO, Fatkhullina AR, Mikulski Z, Ley K, Koltsova EK.

Sci Rep. 2017 May 23;7(1):2255. doi: 10.1038/s41598-017-01828-8.


Differential DARC/ACKR1 expression distinguishes venular from non-venular endothelial cells in murine tissues.

Thiriot A, Perdomo C, Cheng G, Novitzky-Basso I, McArdle S, Kishimoto JK, Barreiro O, Mazo I, Triboulet R, Ley K, Rot A, von Andrian UH.

BMC Biol. 2017 May 19;15(1):45. doi: 10.1186/s12915-017-0381-7.


Defects in DNA replication hit NK cells and neutrophils.

Ley K.

J Clin Invest. 2017 May 1;127(5):1616-1617. doi: 10.1172/JCI93835. Epub 2017 Apr 17.


ATVB Distinguished Scientist Award: How Costimulatory and Coinhibitory Pathways Shape Atherosclerosis.

Ley K, Gerdes N, Winkels H.

Arterioscler Thromb Vasc Biol. 2017 May;37(5):764-777. doi: 10.1161/ATVBAHA.117.308611. Epub 2017 Mar 30. Review.


Breaking a Vicious Cycle.

Ley K.

N Engl J Med. 2017 Mar 23;376(12):1172-1174. doi: 10.1056/NEJMe1615654. No abstract available.


Endothelial Protective Monocyte Patrolling in Large Arteries Intensified by Western Diet and Atherosclerosis.

Quintar A, McArdle S, Wolf D, Marki A, Ehinger E, Vassallo M, Miller J, Mikulski Z, Ley K, Buscher K.

Circ Res. 2017 May 26;120(11):1789-1799. doi: 10.1161/CIRCRESAHA.117.310739. Epub 2017 Mar 16.


P-selectin glycoprotein ligand-1 in T cells.

Abadier M, Ley K.

Curr Opin Hematol. 2017 May;24(3):265-273. doi: 10.1097/MOH.0000000000000331. Review.


Atheroprotective vaccination with MHC-II-restricted ApoB peptides induces peritoneal IL-10-producing CD4 T cells.

Kimura T, Tse K, McArdle S, Gerhardt T, Miller J, Mikulski Z, Sidney J, Sette A, Wolf D, Ley K.

Am J Physiol Heart Circ Physiol. 2017 Apr 1;312(4):H781-H790. doi: 10.1152/ajpheart.00798.2016. Epub 2017 Jan 13.


Neutrophil recruitment limited by high-affinity bent β2 integrin binding ligand in cis.

Fan Z, McArdle S, Marki A, Mikulski Z, Gutierrez E, Engelhardt B, Deutsch U, Ginsberg M, Groisman A, Ley K.

Nat Commun. 2016 Aug 31;7:12658. doi: 10.1038/ncomms12658.


Surface heterogeneity: a friend or foe of protein adsorption - insights from theoretical simulations.

Penna M, Ley K, Maclaughlin S, Yarovsky I.

Faraday Discuss. 2016 Oct 6;191:435-464. Epub 2016 Jul 25.


Microfluidics-based side view flow chamber reveals tether-to-sling transition in rolling neutrophils.

Marki A, Gutierrez E, Mikulski Z, Groisman A, Ley K.

Sci Rep. 2016 Jun 30;6:28870. doi: 10.1038/srep28870.


How Mouse Macrophages Sense What Is Going On.

Ley K, Pramod AB, Croft M, Ravichandran KS, Ting JP.

Front Immunol. 2016 Jun 2;7:204. doi: 10.3389/fimmu.2016.00204. eCollection 2016. Review.


Live cell imaging to understand monocyte, macrophage, and dendritic cell function in atherosclerosis.

McArdle S, Mikulski Z, Ley K.

J Exp Med. 2016 Jun 27;213(7):1117-31. doi: 10.1084/jem.20151885. Epub 2016 Jun 6. Review.


Leukocyte Adhesion Deficiency IV. Monocyte Integrin Activation Deficiency in Cystic Fibrosis.

Fan Z, Ley K.

Am J Respir Crit Care Med. 2016 May 15;193(10):1075-7. doi: 10.1164/rccm.201512-2454ED. No abstract available.


CCR5+T-bet+FoxP3+ Effector CD4 T Cells Drive Atherosclerosis.

Li J, McArdle S, Gholami A, Kimura T, Wolf D, Gerhardt T, Miller J, Weber C, Ley K.

Circ Res. 2016 May 13;118(10):1540-52. doi: 10.1161/CIRCRESAHA.116.308648. Epub 2016 Mar 28.


Gαi2 and Gαi3 Differentially Regulate Arrest from Flow and Chemotaxis in Mouse Neutrophils.

Kuwano Y, Adler M, Zhang H, Groisman A, Ley K.

J Immunol. 2016 May 1;196(9):3828-33. doi: 10.4049/jimmunol.1500532. Epub 2016 Mar 14.


Macrophage Polarization: Decisions That Affect Health.

Mills CD, Harris RA, Ley K.

J Clin Cell Immunol. 2015 Oct;6(5). pii: 364. Epub 2015 Oct 30. No abstract available.


Protection from septic peritonitis by rapid neutrophil recruitment through omental high endothelial venules.

Buscher K, Wang H, Zhang X, Striewski P, Wirth B, Saggu G, Lütke-Enking S, Mayadas TN, Ley K, Sorokin L, Song J.

Nat Commun. 2016 Mar 4;7:10828. doi: 10.1038/ncomms10828.


Integrin-based therapeutics: biological basis, clinical use and new drugs.

Ley K, Rivera-Nieves J, Sandborn WJ, Shattil S.

Nat Rev Drug Discov. 2016 Mar;15(3):173-83. doi: 10.1038/nrd.2015.10. Epub 2016 Jan 29. Review.


2015 Russell Ross Memorial Lecture in Vascular Biology: Protective Autoimmunity in Atherosclerosis.

Ley K.

Arterioscler Thromb Vasc Biol. 2016 Mar;36(3):429-38. doi: 10.1161/ATVBAHA.115.306009. Epub 2016 Jan 28.


Leukocyte arrest: Biomechanics and molecular mechanisms of β2 integrin activation.

Fan Z, Ley K.

Biorheology. 2015;52(5-6):353-77. doi: 10.3233/BIR-15085. Review.


Surface-water Interface Induces Conformational Changes Critical for Protein Adsorption: Implications for Monolayer Formation of EAS Hydrophobin.

Ley K, Christofferson A, Penna M, Winkler D, Maclaughlin S, Yarovsky I.

Front Mol Biosci. 2015 Nov 16;2:64. doi: 10.3389/fmolb.2015.00064. eCollection 2015.


SLAT promotes TCR-mediated, Rap1-dependent LFA-1 activation and adhesion through interaction of its PH domain with Rap1.

Côte M, Fos C, Canonigo-Balancio AJ, Ley K, Bécart S, Altman A.

J Cell Sci. 2015 Dec 1;128(23):4341-52. doi: 10.1242/jcs.172742. Epub 2015 Oct 19.


Gnb isoforms control a signaling pathway comprising Rac1, Plcβ2, and Plcβ3 leading to LFA-1 activation and neutrophil arrest in vivo.

Block H, Stadtmann A, Riad D, Rossaint J, Sohlbach C, Germena G, Wu D, Simon SI, Ley K, Zarbock A.

Blood. 2016 Jan 21;127(3):314-24. doi: 10.1182/blood-2015-06-651034. Epub 2015 Oct 14.


MISTICA: Minimum Spanning Tree-Based Coarse Image Alignment for Microscopy Image Sequences.

Ray N, McArdle S, Ley K, Acton ST.

IEEE J Biomed Health Inform. 2016 Nov;20(6):1575-1584. doi: 10.1109/JBHI.2015.2480712. Epub 2015 Sep 21.


Beyond vascular inflammation--recent advances in understanding atherosclerosis.

Wolf D, Zirlik A, Ley K.

Cell Mol Life Sci. 2015 Oct;72(20):3853-69. doi: 10.1007/s00018-015-1971-6. Epub 2015 Jun 23. Review.


HGF Guides T Cells into the Heart.

Wolf D, Li J, Ley K.

Immunity. 2015 Jun 16;42(6):979-81. doi: 10.1016/j.immuni.2015.06.001.

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