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Items: 47

1.

PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism.

Jain SU, Do TJ, Lund PJ, Rashoff AQ, Diehl KL, Cieslik M, Bajic A, Juretic N, Deshmukh S, Venneti S, Muir TW, Garcia BA, Jabado N, Lewis PW.

Nat Commun. 2019 May 13;10(1):2146. doi: 10.1038/s41467-019-09981-6.

2.

Pervasive H3K27 Acetylation Leads to ERV Expression and a Therapeutic Vulnerability in H3K27M Gliomas.

Krug B, De Jay N, Harutyunyan AS, Deshmukh S, Marchione DM, Guilhamon P, Bertrand KC, Mikael LG, McConechy MK, Chen CCL, Khazaei S, Koncar RF, Agnihotri S, Faury D, Ellezam B, Weil AG, Ursini-Siegel J, De Carvalho DD, Dirks PB, Lewis PW, Salomoni P, Lupien M, Arrowsmith C, Lasko PF, Garcia BA, Kleinman CL, Jabado N, Mack SC.

Cancer Cell. 2019 May 13;35(5):782-797.e8. doi: 10.1016/j.ccell.2019.04.004.

PMID:
31085178
3.

Histone H3 tail binds a unique sensing pocket in EZH2 to activate the PRC2 methyltransferase.

Jani KS, Jain SU, Ge EJ, Diehl KL, Lundgren SM, Müller MM, Lewis PW, Muir TW.

Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8295-8300. doi: 10.1073/pnas.1819029116. Epub 2019 Apr 9.

PMID:
30967505
4.

H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis.

Harutyunyan AS, Krug B, Chen H, Papillon-Cavanagh S, Zeinieh M, De Jay N, Deshmukh S, Chen CCL, Belle J, Mikael LG, Marchione DM, Li R, Nikbakht H, Hu B, Cagnone G, Cheung WA, Mohammadnia A, Bechet D, Faury D, McConechy MK, Pathania M, Jain SU, Ellezam B, Weil AG, Montpetit A, Salomoni P, Pastinen T, Lu C, Lewis PW, Garcia BA, Kleinman CL, Jabado N, Majewski J.

Nat Commun. 2019 Mar 19;10(1):1262. doi: 10.1038/s41467-019-09140-x.

5.

Continued Activity of the Pioneer Factor Zelda Is Required to Drive Zygotic Genome Activation.

McDaniel SL, Gibson TJ, Schulz KN, Fernandez Garcia M, Nevil M, Jain SU, Lewis PW, Zaret KS, Harrison MM.

Mol Cell. 2019 Apr 4;74(1):185-195.e4. doi: 10.1016/j.molcel.2019.01.014. Epub 2019 Feb 20.

PMID:
30797686
6.

S-adenosylmethionine biosynthesis is a targetable metabolic vulnerability of cancer stem cells.

Strekalova E, Malin D, Weisenhorn EMM, Russell JD, Hoelper D, Jain A, Coon JJ, Lewis PW, Cryns VL.

Breast Cancer Res Treat. 2019 May;175(1):39-50. doi: 10.1007/s10549-019-05146-7. Epub 2019 Feb 2.

PMID:
30712196
7.

Anaphylaxis after vaccination reported to the Vaccine Adverse Event Reporting System, 1990-2016.

Su JR, Moro PL, Ng CS, Lewis PW, Said MA, Cano MV.

J Allergy Clin Immunol. 2019 Apr;143(4):1465-1473. doi: 10.1016/j.jaci.2018.12.1003. Epub 2019 Jan 14.

PMID:
30654049
8.

ATRX, DAXX or MEN1 mutant pancreatic neuroendocrine tumors are a distinct alpha-cell signature subgroup.

Chan CS, Laddha SV, Lewis PW, Koletsky MS, Robzyk K, Da Silva E, Torres PJ, Untch BR, Li J, Bose P, Chan TA, Klimstra DS, Allis CD, Tang LH.

Nat Commun. 2018 Oct 12;9(1):4158. doi: 10.1038/s41467-018-06498-2.

9.

Recognition of cancer mutations in histone H3K36 by epigenetic writers and readers.

Klein BJ, Krajewski K, Restrepo S, Lewis PW, Strahl BD, Kutateladze TG.

Epigenetics. 2018;13(7):683-692. doi: 10.1080/15592294.2018.1503491. Epub 2018 Aug 23. Review.

PMID:
30045670
10.

Adverse events after vaccination among HIV-positive persons, 1990-2016.

Su JR, Ng C, Lewis PW, Cano MV.

PLoS One. 2018 Jun 19;13(6):e0199229. doi: 10.1371/journal.pone.0199229. eCollection 2018.

11.

Safety of currently licensed hepatitis B surface antigen vaccines in the United States, Vaccine Adverse Event Reporting System (VAERS), 2005-2015.

Haber P, Moro PL, Ng C, Lewis PW, Hibbs B, Schillie SF, Nelson NP, Li R, Stewart B, Cano MV.

Vaccine. 2018 Jan 25;36(4):559-564. doi: 10.1016/j.vaccine.2017.11.079. Epub 2017 Dec 11.

PMID:
29241647
12.

Structural and mechanistic insights into ATRX-dependent and -independent functions of the histone chaperone DAXX.

Hoelper D, Huang H, Jain AY, Patel DJ, Lewis PW.

Nat Commun. 2017 Oct 30;8(1):1193. doi: 10.1038/s41467-017-01206-y.

13.

Adverse events following quadrivalent meningococcal CRM-conjugate vaccine (Menveo®) reported to the Vaccine Adverse Event Reporting system (VAERS), 2010-2015.

Myers TR, McNeil MM, Ng CS, Li R, Lewis PW, Cano MV.

Vaccine. 2017 Mar 27;35(14):1758-1763. doi: 10.1016/j.vaccine.2017.02.030. Epub 2017 Mar 3.

14.

Safety of Second-Dose Single-Antigen Varicella Vaccine.

Su JR, Leroy Z, Lewis PW, Haber P, Marin M, Leung J, Woo EJ, Shimabukuro TT.

Pediatrics. 2017 Mar;139(3). pii: e20162536. doi: 10.1542/peds.2016-2536. Epub 2017 Feb 7.

15.

Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas.

Papillon-Cavanagh S, Lu C, Gayden T, Mikael LG, Bechet D, Karamboulas C, Ailles L, Karamchandani J, Marchione DM, Garcia BA, Weinreb I, Goldstein D, Lewis PW, Dancu OM, Dhaliwal S, Stecho W, Howlett CJ, Mymryk JS, Barrett JW, Nichols AC, Allis CD, Majewski J, Jabado N.

Nat Genet. 2017 Feb;49(2):180-185. doi: 10.1038/ng.3757. Epub 2017 Jan 9.

16.

Lowered H3K27me3 and DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas.

Bayliss J, Mukherjee P, Lu C, Jain SU, Chung C, Martinez D, Sabari B, Margol AS, Panwalkar P, Parolia A, Pekmezci M, McEachin RC, Cieslik M, Tamrazi B, Garcia BA, La Rocca G, Santi M, Lewis PW, Hawkins C, Melnick A, David Allis C, Thompson CB, Chinnaiyan AM, Judkins AR, Venneti S.

Sci Transl Med. 2016 Nov 23;8(366):366ra161.

17.

Histone chaperone ASF1B promotes human β-cell proliferation via recruitment of histone H3.3.

Paul PK, Rabaglia ME, Wang CY, Stapleton DS, Leng N, Kendziorski C, Lewis PW, Keller MP, Attie AD.

Cell Cycle. 2016 Dec;15(23):3191-3202. Epub 2016 Oct 18.

18.

S-adenosyl methionine is necessary for inhibition of the methyltransferase G9a by the lysine 9 to methionine mutation on histone H3.

Jayaram H, Hoelper D, Jain SU, Cantone N, Lundgren SM, Poy F, Allis CD, Cummings R, Bellon S, Lewis PW.

Proc Natl Acad Sci U S A. 2016 May 31;113(22):6182-7. doi: 10.1073/pnas.1605523113. Epub 2016 May 16.

19.

Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape.

Lu C, Jain SU, Hoelper D, Bechet D, Molden RC, Ran L, Murphy D, Venneti S, Hameed M, Pawel BR, Wunder JS, Dickson BC, Lundgren SM, Jani KS, De Jay N, Papillon-Cavanagh S, Andrulis IL, Sawyer SL, Grynspan D, Turcotte RE, Nadaf J, Fahiminiyah S, Muir TW, Majewski J, Thompson CB, Chi P, Garcia BA, Allis CD, Jabado N, Lewis PW.

Science. 2016 May 13;352(6287):844-9. doi: 10.1126/science.aac7272.

20.

Targeted Histone Peptides: Insights into the Spatial Regulation of the Methyltransferase PRC2 by using a Surrogate of Heterotypic Chromatin.

Brown ZZ, Müller MM, Kong HE, Lewis PW, Muir TW.

Angew Chem Int Ed Engl. 2015 May 26;54(22):6457-61. doi: 10.1002/anie.201500085. Epub 2015 Apr 14.

21.

Adverse Events Following Measles, Mumps, and Rubella Vaccine in Adults Reported to the Vaccine Adverse Event Reporting System (VAERS), 2003-2013.

Sukumaran L, McNeil MM, Moro PL, Lewis PW, Winiecki SK, Shimabukuro TT.

Clin Infect Dis. 2015 May 15;60(10):e58-65. doi: 10.1093/cid/civ061. Epub 2015 Jan 30.

22.

ATRX tolerates activity-dependent histone H3 methyl/phos switching to maintain repetitive element silencing in neurons.

Noh KM, Maze I, Zhao D, Xiang B, Wenderski W, Lewis PW, Shen L, Li H, Allis CD.

Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):6820-7. doi: 10.1073/pnas.1411258112. Epub 2014 Dec 23. Erratum in: Proc Natl Acad Sci U S A. 2018 Jan 30;:.

23.

Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation.

Funato K, Major T, Lewis PW, Allis CD, Tabar V.

Science. 2014 Dec 19;346(6216):1529-33. doi: 10.1126/science.1253799. Epub 2014 Nov 20.

24.

A sensitive and specific histopathologic prognostic marker for H3F3A K27M mutant pediatric glioblastomas.

Venneti S, Santi M, Felicella MM, Yarilin D, Phillips JJ, Sullivan LM, Martinez D, Perry A, Lewis PW, Thompson CB, Judkins AR.

Acta Neuropathol. 2014 Nov;128(5):743-53. doi: 10.1007/s00401-014-1338-3. Epub 2014 Sep 9.

25.

Specific detection of methionine 27 mutation in histone 3 variants (H3K27M) in fixed tissue from high-grade astrocytomas.

Bechet D, Gielen GG, Korshunov A, Pfister SM, Rousso C, Faury D, Fiset PO, Benlimane N, Lewis PW, Lu C, David Allis C, Kieran MW, Ligon KL, Pietsch T, Ellezam B, Albrecht S, Jabado N.

Acta Neuropathol. 2014 Nov;128(5):733-41. doi: 10.1007/s00401-014-1337-4. Epub 2014 Sep 9.

26.

Strategy for "detoxification" of a cancer-derived histone mutant based on mapping its interaction with the methyltransferase PRC2.

Brown ZZ, Müller MM, Jain SU, Allis CD, Lewis PW, Muir TW.

J Am Chem Soc. 2014 Oct 1;136(39):13498-501. doi: 10.1021/ja5060934. Epub 2014 Sep 19.

27.

Poisoning the "histone code" in pediatric gliomagenesis.

Lewis PW, Allis CD.

Cell Cycle. 2013 Oct 15;12(20):3241-2. doi: 10.4161/cc.26356. Epub 2013 Sep 13. No abstract available.

28.

KDM4A lysine demethylase induces site-specific copy gain and rereplication of regions amplified in tumors.

Black JC, Manning AL, Van Rechem C, Kim J, Ladd B, Cho J, Pineda CM, Murphy N, Daniels DL, Montagna C, Lewis PW, Glass K, Allis CD, Dyson NJ, Getz G, Whetstine JR.

Cell. 2013 Aug 1;154(3):541-55. doi: 10.1016/j.cell.2013.06.051. Epub 2013 Jul 18.

29.

Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma.

Lewis PW, Müller MM, Koletsky MS, Cordero F, Lin S, Banaszynski LA, Garcia BA, Muir TW, Becher OJ, Allis CD.

Science. 2013 May 17;340(6134):857-61. doi: 10.1126/science.1232245. Epub 2013 Mar 28.

30.

DAXX envelops a histone H3.3-H4 dimer for H3.3-specific recognition.

Elsässer SJ, Huang H, Lewis PW, Chin JW, Allis CD, Patel DJ.

Nature. 2012 Nov 22;491(7425):560-5. doi: 10.1038/nature11608. Epub 2012 Oct 17.

31.

Adverse event reports after tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccines in pregnant women.

Zheteyeva YA, Moro PL, Tepper NK, Rasmussen SA, Barash FE, Revzina NV, Kissin D, Lewis PW, Yue X, Haber P, Tokars JI, Vellozzi C, Broder KR.

Am J Obstet Gynecol. 2012 Jul;207(1):59.e1-7. doi: 10.1016/j.ajog.2012.05.006. Epub 2012 May 14.

PMID:
22727350
32.

Drosophila lin-52 acts in opposition to repressive components of the Myb-MuvB/dREAM complex.

Lewis PW, Sahoo D, Geng C, Bell M, Lipsick JS, Botchan MR.

Mol Cell Biol. 2012 Aug;32(16):3218-27. doi: 10.1128/MCB.00432-12. Epub 2012 Jun 11.

33.

ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome.

Iwase S, Xiang B, Ghosh S, Ren T, Lewis PW, Cochrane JC, Allis CD, Picketts DJ, Patel DJ, Li H, Shi Y.

Nat Struct Mol Biol. 2011 Jun 12;18(7):769-76. doi: 10.1038/nsmb.2062.

34.

Cancer. New epigenetic drivers of cancers.

Elsässer SJ, Allis CD, Lewis PW.

Science. 2011 Mar 4;331(6021):1145-6. doi: 10.1126/science.1203280. No abstract available.

PMID:
21385704
35.

Histone variants in metazoan development.

Banaszynski LA, Allis CD, Lewis PW.

Dev Cell. 2010 Nov 16;19(5):662-74. doi: 10.1016/j.devcel.2010.10.014. Review.

36.

Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres.

Lewis PW, Elsaesser SJ, Noh KM, Stadler SC, Allis CD.

Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14075-80. doi: 10.1073/pnas.1008850107. Epub 2010 Jul 22.

37.

Distinct factors control histone variant H3.3 localization at specific genomic regions.

Goldberg AD, Banaszynski LA, Noh KM, Lewis PW, Elsaesser SJ, Stadler S, Dewell S, Law M, Guo X, Li X, Wen D, Chapgier A, DeKelver RC, Miller JC, Lee YL, Boydston EA, Holmes MC, Gregory PD, Greally JM, Rafii S, Yang C, Scambler PJ, Garrick D, Gibbons RJ, Higgs DR, Cristea IM, Urnov FD, Zheng D, Allis CD.

Cell. 2010 Mar 5;140(5):678-91. doi: 10.1016/j.cell.2010.01.003.

38.

Genomic profiling and expression studies reveal both positive and negative activities for the Drosophila Myb MuvB/dREAM complex in proliferating cells.

Georlette D, Ahn S, MacAlpine DM, Cheung E, Lewis PW, Beall EL, Bell SP, Speed T, Manak JR, Botchan MR.

Genes Dev. 2007 Nov 15;21(22):2880-96. Epub 2007 Oct 31.

39.

Discovery of tMAC: a Drosophila testis-specific meiotic arrest complex paralogous to Myb-Muv B.

Beall EL, Lewis PW, Bell M, Rocha M, Jones DL, Botchan MR.

Genes Dev. 2007 Apr 15;21(8):904-19. Epub 2007 Apr 2.

40.

Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase.

Moyer SE, Lewis PW, Botchan MR.

Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10236-10241. doi: 10.1073/pnas.0602400103. Epub 2006 Jun 23.

41.

Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex.

Lewis PW, Beall EL, Fleischer TC, Georlette D, Link AJ, Botchan MR.

Genes Dev. 2004 Dec 1;18(23):2929-40. Epub 2004 Nov 15.

42.

Adenovirus protein VII condenses DNA, represses transcription, and associates with transcriptional activator E1A.

Johnson JS, Osheim YN, Xue Y, Emanuel MR, Lewis PW, Bankovich A, Beyer AL, Engel DA.

J Virol. 2004 Jun;78(12):6459-68.

43.
44.

Myocardial infarct size and mortality in diabetic patients.

Gwilt DJ, Petri M, Lewis PW, Nattrass M, Pentecost BL.

Br Heart J. 1985 Nov;54(5):466-72.

45.

Informed consent: the three tests and a modest proposal for the reality of the patient as an individual.

Trichter JG, Lewis PW.

South Tex Law J. 1981;21(2):155-70. No abstract available.

PMID:
11658706
46.

Food coloring and allergy.

Lewis PW.

Pediatrics. 1979 Dec;64(6):975. No abstract available.

PMID:
514733
47.

Action limits for internal quality control.

Lewis PW, Dixon K.

Clin Chim Acta. 1971 Nov;35(1):21-32. No abstract available.

PMID:
5126996

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