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Pharmacogenomic Polygenic Response Score Predicts Ischemic Events and Cardiovascular Mortality in Clopidogrel-Treated Patients.

Lewis JP, Backman JD, Reny JL, Bergmeijer TO, Mitchell BD, Ritchie MD, Déry JP, Pakyz RE, Gong L, Ryan K, Kim EY, Aradi D, Fernandez-Cadenas I, Lee MTM, Whaley RM, Montaner J, Gensini GF, Cleator JH, Chang K, Holmvang L, Hochholzer W, Roden DM, Winter S, Altman R, Alexopoulos D, Kim HS, Gawaz M, Bliden K, Valgimigli M, Marcucci R, Campo G, Schaeffeler E, Dridi NP, Wen MS, Shin JG, Fontana P, Giusti B, Geisler T, Kubo M, Trenk D, Siller-Matula JM, Ten Berg JM, Gurbel PA, Schwab M, Klein TE, Shuldiner AR.

Eur Heart J Cardiovasc Pharmacother. 2019 Sep 3. pii: pvz045. doi: 10.1093/ehjcvp/pvz045. [Epub ahead of print]


Boosting Photocatalytic Hydrogen Production by Modulating Recombination Modes and Proton Adsorption Energy.

Dai Y, Bu Q, Sooriyagoda R, Tavadze P, Pavlic O, Lim T, Shen Y, Mamakhel A, Wang X, Li Y, Niemantsverdriet H, Iversen BB, Besenbacher F, Xie T, Lewis JP, Bristow AD, Lock N, Su R.

J Phys Chem Lett. 2019 Aug 29:5381-5386. doi: 10.1021/acs.jpclett.9b01460. [Epub ahead of print]


Alaska Native Elders' Perspectives on Physical Activity and Successful Aging.

Brooks-Cleator LA, Lewis JP.

Can J Aging. 2019 Jul 16:1-11. doi: 10.1017/S0714980819000400. [Epub ahead of print]


Nitrosative stress sensing in Porphyromonas gingivalis: structure of and heme binding by the transcriptional regulator HcpR.

Belvin BR, Musayev FN, Burgner J, Scarsdale JN, Escalante CR, Lewis JP.

Acta Crystallogr D Struct Biol. 2019 Apr 1;75(Pt 4):437-450. doi: 10.1107/S205979831900264X. Epub 2019 Apr 5.


Solid Base Bi24 O31 Br10 (OH)δ with Active Lattice Oxygen for the Efficient Photo-Oxidation of Primary Alcohols to Aldehydes.

Dai Y, Ren P, Li Y, Lv D, Shen Y, Li Y, Niemantsverdriet H, Besenbacher F, Xiang H, Hao W, Lock N, Wen X, Lewis JP, Su R.

Angew Chem Int Ed Engl. 2019 May 6;58(19):6265-6270. doi: 10.1002/anie.201900773. Epub 2019 Feb 27.


The Porphyromonas gingivalis Hybrid Cluster Protein Hcp Is Required for Growth with Nitrite and Survival with Host Cells.

Belvin BR, Gui Q, Hutcherson JA, Lewis JP.

Infect Immun. 2019 Mar 25;87(4). pii: e00572-18. doi: 10.1128/IAI.00572-18. Print 2019 Apr.


Efficient Variant Set Mixed Model Association Tests for Continuous and Binary Traits in Large-Scale Whole-Genome Sequencing Studies.

Chen H, Huffman JE, Brody JA, Wang C, Lee S, Li Z, Gogarten SM, Sofer T, Bielak LF, Bis JC, Blangero J, Bowler RP, Cade BE, Cho MH, Correa A, Curran JE, de Vries PS, Glahn DC, Guo X, Johnson AD, Kardia S, Kooperberg C, Lewis JP, Liu X, Mathias RA, Mitchell BD, O'Connell JR, Peyser PA, Post WS, Reiner AP, Rich SS, Rotter JI, Silverman EK, Smith JA, Vasan RS, Wilson JG, Yanek LR; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; TOPMed Hematology and Hemostasis Working Group, Redline S, Smith NL, Boerwinkle E, Borecki IB, Cupples LA, Laurie CC, Morrison AC, Rice KM, Lin X.

Am J Hum Genet. 2019 Feb 7;104(2):260-274. doi: 10.1016/j.ajhg.2018.12.012. Epub 2019 Jan 10.


Increased usual physical activity is associated with a blunting of the triglyceride response to a high-fat meal.

Mitchell BD, Kalra G, Ryan KA, Zhang M, Sztalryd C, Steinle NI, Taylor SI, Snitker S, Lewis JP, Miller M, Shuldiner AR, Xu H.

J Clin Lipidol. 2019 Jan - Feb;13(1):109-114. doi: 10.1016/j.jacl.2018.11.006. Epub 2018 Nov 20.


Machine-Learning Prediction of CO Adsorption in Thiolated, Ag-Alloyed Au Nanoclusters.

Panapitiya G, Avendaño-Franco G, Ren P, Wen X, Li Y, Lewis JP.

J Am Chem Soc. 2018 Dec 19;140(50):17508-17514. doi: 10.1021/jacs.8b08800. Epub 2018 Nov 26.


"We Raise our Grandchildren as our Own:" Alaska Native Grandparents Raising Grandchildren in Southwest Alaska.

Lewis JP, Boyd K, Allen J, Rasmus S, Henderson T.

J Cross Cult Gerontol. 2018 Sep;33(3):265-286. doi: 10.1007/s10823-018-9350-z.


Structural and catalytic properties of the Au25-xAgx(SCH3)18 (x = 6, 7, 8) nanocluster.

Panapitiya G, Wang H, Chen Y, Hussain E, Jin R, Lewis JP.

Phys Chem Chem Phys. 2018 May 23;20(20):13747-13756. doi: 10.1039/c7cp07295c.


Genome-wide and candidate gene approaches of clopidogrel efficacy using pharmacodynamic and clinical end points-Rationale and design of the International Clopidogrel Pharmacogenomics Consortium (ICPC).

Bergmeijer TO, Reny JL, Pakyz RE, Gong L, Lewis JP, Kim EY, Aradi D, Fernandez-Cadenas I, Horenstein RB, Lee MTM, Whaley RM, Montaner J, Gensini GF, Cleator JH, Chang K, Holmvang L, Hochholzer W, Roden DM, Winter S, Altman RB, Alexopoulos D, Kim HS, Déry JP, Gawaz M, Bliden K, Valgimigli M, Marcucci R, Campo G, Schaeffeler E, Dridi NP, Wen MS, Shin JG, Simon T, Fontana P, Giusti B, Geisler T, Kubo M, Trenk D, Siller-Matula JM, Ten Berg JM, Gurbel PA, Hulot JS, Mitchell BD, Schwab M, Ritchie MD, Klein TE, Shuldiner AR; ICPC Investigators.

Am Heart J. 2018 Apr;198:152-159. doi: 10.1016/j.ahj.2017.12.010. Epub 2017 Dec 17. Review.


Implementation of Genotype-Guided Antiplatelet Therapy: Feasible but Not Without Obstacles.

Lewis JP.

Circ Genom Precis Med. 2018 Apr;11(4):e002118. doi: 10.1161/CIRCGEN.118.002118. No abstract available.


A Machine-Driven Hunt for Global Reaction Coordinates of Azobenzene Photoisomerization.

Tavadze P, Avendaño Franco G, Ren P, Wen X, Li Y, Lewis JP.

J Am Chem Soc. 2018 Jan 10;140(1):285-290. doi: 10.1021/jacs.7b10030. Epub 2017 Dec 27.


Controlling Ag-doping in [AgxAu25-x(SC6H11)18]- nanoclusters: cryogenic optical, electronic and electrocatalytic properties.

Jin R, Zhao S, Liu C, Zhou M, Panapitiya G, Xing Y, Rosi NL, Lewis JP, Jin R.

Nanoscale. 2017 Dec 14;9(48):19183-19190. doi: 10.1039/c7nr05871c.


Exome-chip meta-analysis identifies association between variation in ANKRD26 and platelet aggregation.

Chen MH, Yanek LR, Backman JD, Eicher JD, Huffman JE, Ben-Shlomo Y, Beswick AD, Yerges-Armstrong LM, Shuldiner AR, O'Connell JR, Mathias RA, Becker DM, Becker LC, Lewis JP, Johnson AD, Faraday N.

Platelets. 2019;30(2):164-173. doi: 10.1080/09537104.2017.1384538. Epub 2017 Nov 29.


Analysis commons, a team approach to discovery in a big-data environment for genetic epidemiology.

Brody JA, Morrison AC, Bis JC, O'Connell JR, Brown MR, Huffman JE, Ames DC, Carroll A, Conomos MP, Gabriel S, Gibbs RA, Gogarten SM, Gupta N, Jaquish CE, Johnson AD, Lewis JP, Liu X, Manning AK, Papanicolaou GJ, Pitsillides AN, Rice KM, Salerno W, Sitlani CM, Smith NL; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium; TOPMed Hematology and Hemostasis Working Group; CHARGE Analysis and Bioinformatics Working Group, Heckbert SR, Laurie CC, Mitchell BD, Vasan RS, Rich SS, Rotter JI, Wilson JG, Boerwinkle E, Psaty BM, Cupples LA.

Nat Genet. 2017 Oct 27;49(11):1560-1563. doi: 10.1038/ng.3968. No abstract available.


Natural variability and effects of cleaning and storage procedures on vertebral chemistry of the blacktip shark Carcharhinus limbatus.

Lewis JP, Patterson WF 3rd, Carlson JK.

J Fish Biol. 2017 Nov;91(5):1284-1300. doi: 10.1111/jfb.13462. Epub 2017 Oct 10.


Amixicile, a novel strategy for targeting oral anaerobic pathogens.

Hutcherson JA, Sinclair KM, Belvin BR, Gui Q, Hoffman PS, Lewis JP.

Sci Rep. 2017 Sep 5;7(1):10474. doi: 10.1038/s41598-017-09616-0.


Genetic Variants of PEAR1 are Associated with Platelet Function and Antiplatelet Drug Efficacy: A Systematic Review and Meta-Analysis.

Xiang Q, Zhou S, Lewis JP, Shuldiner AR, Ren G, Cui Y.

Curr Pharm Des. 2017;23(44):6815-6827. doi: 10.2174/1381612823666170817122043.


A comparative study of different methods for automatic identification of clopidogrel-induced bleedings in electronic health records.

Lee HJ, Jiang M, Wu Y, Shaffer CM, Cleator JH, Friedman EA, Lewis JP, Roden DM, Denny J, Xu H.

AMIA Jt Summits Transl Sci Proc. 2017 Jul 26;2017:185-192. eCollection 2017.


Alaska Native Elders in Recovery: Linkages between Indigenous Cultural Generativity and Sobriety to Promote Successful Aging.

Lewis JP, Allen J.

J Cross Cult Gerontol. 2017 Jun;32(2):209-222. doi: 10.1007/s10823-017-9314-8.


Genome-wide analysis of clopidogrel active metabolite levels identifies novel variants that influence antiplatelet response.

Backman JD, O'Connell JR, Tanner K, Peer CJ, Figg WD, Spencer SD, Mitchell BD, Shuldiner AR, Yerges-Armstrong LM, Horenstein RB, Lewis JP.

Pharmacogenet Genomics. 2017 Apr;27(4):159-163. doi: 10.1097/FPC.0000000000000272.


Prospective Evaluation of Genetic Variation in Platelet Endothelial Aggregation Receptor 1 Reveals Aspirin-Dependent Effects on Platelet Aggregation Pathways.

Backman JD, Yerges-Armstrong LM, Horenstein RB, Newcomer S, Shaub S, Morrisey M, Donnelly P, Drolet M, Tanner K, Pavlovich MA, O'Connell JR, Mitchell BD, Lewis JP.

Clin Transl Sci. 2017 Mar;10(2):102-109. doi: 10.1111/cts.12438. Epub 2017 Jan 11.


Quantum Mechanics/Molecular Mechanics Free Energy Maps and Nonadiabatic Simulations for a Photochemical Reaction in DNA: Cyclobutane Thymine Dimer.

Mendieta-Moreno JI, Trabada DG, Mendieta J, Lewis JP, Gómez-Puertas P, Ortega J.

J Phys Chem Lett. 2016 Nov 3;7(21):4391-4397. Epub 2016 Oct 25.


Clopidogrel Improves Skin Microcirculatory Endothelial Function in Persons With Heightened Platelet Aggregation.

Salimi S, Lewis JP, Yerges-Armstrong LM, Mitchell BD, Saeed F, O'Connell JR, Perry JA, Ryan KA, Shuldiner AR, Parsa A.

J Am Heart Assoc. 2016 Oct 31;5(11). pii: e003751. Erratum in: J Am Heart Assoc. 2017 Feb 14;6(2):.


Correction to "Product Selectivity Controlled by Zeolite Crystals in Biomass Hydrogenation over a Palladium Catalyst".

Wang C, Wang L, Zhang J, Wang H, Lewis JP, Xiao FS.

J Am Chem Soc. 2016 Oct 19;138(41):13756. doi: 10.1021/jacs.6b08468. Epub 2016 Oct 7. No abstract available.


Clopidogrel pharmacogenetics: Beyond candidate genes and genome-wide association studies.

Lewis JP, Shuldiner AR.

Clin Pharmacol Ther. 2017 Mar;101(3):323-325. doi: 10.1002/cpt.519. Epub 2016 Nov 22.


Effect of Two Lipoprotein (a)-Associated Genetic Variants on Plasminogen Levels and Fibrinolysis.

Wang H, Hong CE, Lewis JP, Zhu Y, Wang X, Chu X, Backman J, Hu Z, Yang P, Still CD, Gerhard GS, Fu M.

G3 (Bethesda). 2016 Nov 8;6(11):3525-3532. doi: 10.1534/g3.116.034702.


Identifying clinically relevant sources of variability: The clopidogrel challenge.

Samant S, Jiang XL, Peletier LA, Shuldiner AR, Horenstein RB, Lewis JP, Lesko LJ, Schmidt S.

Clin Pharmacol Ther. 2017 Feb;101(2):264-273. doi: 10.1002/cpt.459. Epub 2016 Oct 11.


Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci.

Walford GA, Gustafsson S, Rybin D, Stančáková A, Chen H, Liu CT, Hong J, Jensen RA, Rice K, Morris AP, Mägi R, Tönjes A, Prokopenko I, Kleber ME, Delgado G, Silbernagel G, Jackson AU, Appel EV, Grarup N, Lewis JP, Montasser ME, Landenvall C, Staiger H, Luan J, Frayling TM, Weedon MN, Xie W, Morcillo S, Martínez-Larrad MT, Biggs ML, Chen YD, Corbaton-Anchuelo A, Færch K, Gómez-Zumaquero JM, Goodarzi MO, Kizer JR, Koistinen HA, Leong A, Lind L, Lindgren C, Machicao F, Manning AK, Martín-Núñez GM, Rojo-Martínez G, Rotter JI, Siscovick DS, Zmuda JM, Zhang Z, Serrano-Rios M, Smith U, Soriguer F, Hansen T, Jørgensen TJ, Linnenberg A, Pedersen O, Walker M, Langenberg C, Scott RA, Wareham NJ, Fritsche A, Häring HU, Stefan N, Groop L, O'Connell JR, Boehnke M, Bergman RN, Collins FS, Mohlke KL, Tuomilehto J, März W, Kovacs P, Stumvoll M, Psaty BM, Kuusisto J, Laakso M, Meigs JB, Dupuis J, Ingelsson E, Florez JC.

Diabetes. 2016 Oct;65(10):3200-11. doi: 10.2337/db16-0199. Epub 2016 Jul 14.


From Genotype to Phenotype: Nonsense Variants in SLC13A1 Are Associated with Decreased Serum Sulfate and Increased Serum Aminotransferases.

Tise CG, Perry JA, Anforth LE, Pavlovich MA, Backman JD, Ryan KA, Lewis JP, O'Connell JR, Yerges-Armstrong LM, Shuldiner AR.

G3 (Bethesda). 2016 Sep 8;6(9):2909-18. doi: 10.1534/g3.116.032979.


Product Selectivity Controlled by Zeolite Crystals in Biomass Hydrogenation over a Palladium Catalyst.

Wang C, Wang L, Zhang J, Wang H, Lewis JP, Xiao FS.

J Am Chem Soc. 2016 Jun 29;138(25):7880-3. doi: 10.1021/jacs.6b04951. Epub 2016 Jun 20. Erratum in: J Am Chem Soc. 2016 Oct 19;138(41):13756.


American Indian/Alaska Native Elders: A Growing Demographic that Is Changing How We View Aging.

Lewis JP.

J Gerontol Soc Work. 2016 May-Jun;59(4):277-280. Epub 2016 Jun 7.


Non-adiabatic molecular dynamic simulations of opening reaction of molecular junctions.

Zobač V, Lewis JP, Jelínek P.

Nanotechnology. 2016 Jul 15;27(28):285202. doi: 10.1088/0957-4484/27/28/285202. Epub 2016 Jun 3.


"I'm in this world for a reason": Resilience and recovery among American Indian and Alaska Native two-spirit women.

Elm JH, Lewis JP, Walters KL, Self JM.

J Lesbian Stud. 2016 Jul-Dec;20(3-4):352-71. doi: 10.1080/10894160.2016.1152813.


Slow Relaxation of Surface Plasmon Excitations in Au55: The Key to Efficient Plasmonic Heating in Au/TiO2.

Ranasingha O, Wang H, Zobač V, Jelínek P, Panapitiya G, Neukirch AJ, Prezhdo OV, Lewis JP.

J Phys Chem Lett. 2016 Apr 21;7(8):1563-9. doi: 10.1021/acs.jpclett.6b00283. Epub 2016 Apr 13.


Sobriety and alcohol use among rural Alaska Native elders.

Skewes MC, Lewis JP.

Int J Circumpolar Health. 2016 Feb 4;75:30476. doi: 10.3402/ijch.v75.30476. eCollection 2016.


Batrachochytrium salamandrivorans: The North American Response and a Call for Action.

Gray MJ, Lewis JP, Nanjappa P, Klocke B, Pasmans F, Martel A, Stephen C, Parra Olea G, Smith SA, Sacerdote-Velat A, Christman MR, Williams JM, Olson DH.

PLoS Pathog. 2015 Dec 10;11(12):e1005251. doi: 10.1371/journal.ppat.1005251. eCollection 2015 Dec. Review. No abstract available.


Development of a physiology-directed population pharmacokinetic and pharmacodynamic model for characterizing the impact of genetic and demographic factors on clopidogrel response in healthy adults.

Jiang XL, Samant S, Lewis JP, Horenstein RB, Shuldiner AR, Yerges-Armstrong LM, Peletier LA, Lesko LJ, Schmidt S.

Eur J Pharm Sci. 2016 Jan 20;82:64-78. doi: 10.1016/j.ejps.2015.10.024. Epub 2015 Oct 30.


Oxylipid Profile of Low-Dose Aspirin Exposure: A Pharmacometabolomics Study.

Ellero-Simatos S, Beitelshees AL, Lewis JP, Yerges-Armstrong LM, Georgiades A, Dane A, Harms AC, Strassburg K, Guled F, Hendriks MM, Horenstein RB, Shuldiner AR, Hankemeier T, Kaddurah-Daouk R; Pharmacometabolomics Research Network.

J Am Heart Assoc. 2015 Oct 26;4(10):e002203. doi: 10.1161/JAHA.115.002203.


Genetic Variation in the Platelet Endothelial Aggregation Receptor 1 Gene Results in Endothelial Dysfunction.

Fisch AS, Yerges-Armstrong LM, Backman JD, Wang H, Donnelly P, Ryan KA, Parihar A, Pavlovich MA, Mitchell BD, O'Connell JR, Herzog W, Harman CR, Wren JD, Lewis JP.

PLoS One. 2015 Sep 25;10(9):e0138795. doi: 10.1371/journal.pone.0138795. eCollection 2015.


The Pharmacogenomics of Anti-Platelet Intervention (PAPI) Study: Variation in Platelet Response to Clopidogrel and Aspirin.

Bozzi LM, Mitchell BD, Lewis JP, Ryan KA, Herzog WR, O'Connell JR, Horenstein RB, Shuldiner AR, Yerges-Armstrong LM.

Curr Vasc Pharmacol. 2016;14(1):116-24.


Tripeptides on Gold Nanoparticles: Structural Differences between Two Reverse Sequences as Determined by Solid-State NMR and DFT Calculations.

Karki I, Wang H, Geise NR, Wilson BW, Lewis JP, Gullion T.

J Phys Chem B. 2015 Sep 10;119(36):11998-2006. doi: 10.1021/acs.jpcb.5b04299. Epub 2015 Aug 31.


Design and Preparation of Supported Au Catalyst with Enhanced Catalytic Activities by Rationally Positioning Au Nanoparticles on Anatase.

Wang L, Wang H, Rice AE, Zhang W, Li X, Chen M, Meng X, Lewis JP, Xiao FS.

J Phys Chem Lett. 2015 Jun 18;6(12):2345-9. doi: 10.1021/acs.jpclett.5b00655. Epub 2015 Jun 8.


The pharmacogenetic control of antiplatelet response: candidate genes and CYP2C19.

Yang Y, Lewis JP, Hulot JS, Scott SA.

Expert Opin Drug Metab Toxicol. 2015;11(10):1599-617. doi: 10.1517/17425255.2015.1068757. Epub 2015 Jul 14. Review.


CYP2C19 metabolizer status and clopidogrel efficacy in the Secondary Prevention of Small Subcortical Strokes (SPS3) study.

McDonough CW, McClure LA, Mitchell BD, Gong Y, Horenstein RB, Lewis JP, Field TS, Talbert RL, Benavente OR, Johnson JA, Shuldiner AR.

J Am Heart Assoc. 2015 May 27;4(6):e001652. doi: 10.1161/JAHA.114.001652.


Personalized antiplatelet and anticoagulation therapy: applications and significance of pharmacogenomics.

Beitelshees AL, Voora D, Lewis JP.

Pharmgenomics Pers Med. 2015 Feb 9;8:43-61. doi: 10.2147/PGPM.S52900. eCollection 2015. Review.


Photo-induced reactions from efficient molecular dynamics with electronic transitions using the FIREBALL local-orbital density functional theory formalism.

Zobač V, Lewis JP, Abad E, Mendieta-Moreno JI, Hapala P, Jelínek P, Ortega J.

J Phys Condens Matter. 2015 May 8;27(17):175002. doi: 10.1088/0953-8984/27/17/175002. Epub 2015 Mar 20.


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