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Bone mineral density in patients with longstanding type 1 diabetes: Results from the Canadian Study of Longevity in Type 1 Diabetes.

Alhuzaim ON, Lewis EJH, Lovblom LE, Cardinez M, Scarr D, Boulet G, Weisman A, Lovshin JA, Lytvyn Y, Keenan HA, Brent MH, Paul N, Bril V, Cherney DZI, Perkins BA.

J Diabetes Complications. 2019 Nov;33(11):107324. doi: 10.1016/j.jdiacomp.2018.12.009. Epub 2018 Dec 22.


Ethical Reasoning Debriefing in Disaster Simulations.

Greco S, Lewis EJ, Sanford J, Sawin EM, Ames A.

J Prof Nurs. 2019 Mar - Apr;35(2):124-132. doi: 10.1016/j.profnurs.2018.09.004. Epub 2018 Sep 14.


Student ethical reasoning confidence pre/post an innovative makerspace course: A survey of ethical reasoning.

Lewis EJ, Ludwig PM, Nagel J, Ames A.

Nurse Educ Today. 2019 Apr;75:75-79. doi: 10.1016/j.nedt.2019.01.011. Epub 2019 Jan 29.


Does repetitive negative thinking affect attention? Differential effects of worry and rumination on attention to emotional stimuli.

Lewis EJ, Blanco I, Raila H, Joormann J.

Emotion. 2019 Feb 4. doi: 10.1037/emo0000535. [Epub ahead of print]


Establishing Surrogate Kidney End Points for Lupus Nephritis Clinical Trials: Development and Validation of a Novel Approach to Predict Future Kidney Outcomes.

Mackay M, Dall'Era M, Fishbein J, Kalunian K, Lesser M, Sanchez-Guerrero J, Levy DM, Silverman E, Petri M, Arriens C, Lewis EJ, Korbet SM, Conti F, Tesar V, Hruskova Z, Borba EF, Bonfa E, Chan TM, Rathi M, Gupta KL, Jha V, Hasni S, West MR, Solomons N, Houssiau FA, Romero-Diaz J, Mejia-Vilet J, Rovin BH.

Arthritis Rheumatol. 2019 Mar;71(3):411-419. doi: 10.1002/art.40724. Epub 2019 Feb 1.


A Fragment-Derived Clinical Candidate for Antagonism of X-Linked and Cellular Inhibitor of Apoptosis Proteins: 1-(6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-1 H,2 H,3 H-pyrrolo[3,2- b]pyridin-1-yl)-2-[(2 R,5 R)-5-methyl-2-([(3R)-3-methylmorpholin-4-yl]methyl)piperazin-1-yl]ethan-1-one (ASTX660).

Johnson CN, Ahn JS, Buck IM, Chiarparin E, Day JEH, Hopkins A, Howard S, Lewis EJ, Martins V, Millemaggi A, Munck JM, Page LW, Peakman T, Reader M, Rich SJ, Saxty G, Smyth T, Thompson NT, Ward GA, Williams PA, Wilsher NE, Chessari G.

J Med Chem. 2018 Aug 23;61(16):7314-7329. doi: 10.1021/acs.jmedchem.8b00900. Epub 2018 Aug 9.


ASTX660, a Novel Non-peptidomimetic Antagonist of cIAP1/2 and XIAP, Potently Induces TNFα-Dependent Apoptosis in Cancer Cell Lines and Inhibits Tumor Growth.

Ward GA, Lewis EJ, Ahn JS, Johnson CN, Lyons JF, Martins V, Munck JM, Rich SJ, Smyth T, Thompson NT, Williams PA, Wilsher NE, Wallis NG, Chessari G.

Mol Cancer Ther. 2018 Jul;17(7):1381-1391. doi: 10.1158/1535-7163.MCT-17-0848. Epub 2018 Apr 25.


Design thinking: Opportunities for application in nursing education.

Beaird G, Geist M, Lewis EJ.

Nurse Educ Today. 2018 May;64:115-118. doi: 10.1016/j.nedt.2018.02.007. Epub 2018 Feb 9. No abstract available.


Effect of omega-3 supplementation on neuropathy in type 1 diabetes: A 12-month pilot trial.

Lewis EJH, Perkins BA, Lovblom LE, Bazinet RP, Wolever TMS, Bril V.

Neurology. 2017 Jun 13;88(24):2294-2301. doi: 10.1212/WNL.0000000000004033. Epub 2017 May 17.


Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP).

Tamanini E, Buck IM, Chessari G, Chiarparin E, Day JEH, Frederickson M, Griffiths-Jones CM, Hearn K, Heightman TD, Iqbal A, Johnson CN, Lewis EJ, Martins V, Peakman T, Reader M, Rich SJ, Ward GA, Williams PA, Wilsher NE.

J Med Chem. 2017 Jun 8;60(11):4611-4625. doi: 10.1021/acs.jmedchem.6b01877. Epub 2017 May 24.


Emotion regulation and biological stress responding: associations with worry, rumination, and reappraisal.

Lewis EJ, Yoon KL, Joormann J.

Cogn Emot. 2018 Nov;32(7):1487-1498. doi: 10.1080/02699931.2017.1310088. Epub 2017 Apr 11.


Using in vivo corneal confocal microscopy to identify diabetic sensorimotor polyneuropathy risk profiles in patients with type 1 diabetes.

Lewis EJ, Perkins BA, Lovblom LE, Bazinet RP, Wolever TM, Bril V.

BMJ Open Diabetes Res Care. 2017 Feb 16;5(1):e000251. doi: 10.1136/bmjdrc-2016-000251. eCollection 2017.


Neuromuscular adaptations to sprint interval training and the effect of mammalian omega-3 fatty acid supplementation.

Lewis EJH, Stucky F, Radonic PW, Metherel AH, Wolever TMS, Wells GD.

Eur J Appl Physiol. 2017 Mar;117(3):469-482. doi: 10.1007/s00421-017-3539-7. Epub 2017 Feb 3.


Student learning outcomes from a pilot medical innovations course with nursing, engineering, and biology undergraduate students.

Ludwig PM, Nagel JK, Lewis EJ.

Int J STEM Educ. 2017;4(1):33. doi: 10.1186/s40594-017-0095-y. Epub 2017 Nov 27.


The Impact of Baseline Serum Creatinine on Complete Remission Rate and Long-Term Outcome in Patients with Severe Lupus Nephritis.

Collaborative Study Group, Korbet SM, Whittier WL, Lewis EJ.

Nephron Extra. 2016 Aug 18;6(2):12-21. eCollection 2016 May-Aug.


Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP.

Chessari G, Buck IM, Day JE, Day PJ, Iqbal A, Johnson CN, Lewis EJ, Martins V, Miller D, Reader M, Rees DC, Rich SJ, Tamanini E, Vitorino M, Ward GA, Williams PA, Williams G, Wilsher NE, Woolford AJ.

J Med Chem. 2015 Aug 27;58(16):6574-88. doi: 10.1021/acs.jmedchem.5b00706. Epub 2015 Aug 7.


21 days of mammalian omega-3 fatty acid supplementation improves aspects of neuromuscular function and performance in male athletes compared to olive oil placebo.

Lewis EJ, Radonic PW, Wolever TM, Wells GD.

J Int Soc Sports Nutr. 2015 Jun 18;12:28. doi: 10.1186/s12970-015-0089-4. eCollection 2015.


Efficiency of energy transfer during exercise: what are the limiting factors?

Banks L, Thompson S, Lewis EJ.

J Physiol. 2015 May 1;593(9):2113-4. doi: 10.1113/JP270261. No abstract available.


A prospective randomized blister prevention trial assessing paper tape in endurance distances (Pre-TAPED).

Lipman GS, Ellis MA, Lewis EJ, Waite BL, Lissoway J, Chan GK, Krabak BJ.

Wilderness Environ Med. 2014 Dec;25(4):457-61. doi: 10.1016/j.wem.2014.06.013. Epub 2014 Oct 31.


Relationship of adverse events and support to RN burnout.

Lewis EJ, Baernholdt MB, Yan G, Guterbock TG.

J Nurs Care Qual. 2015 Apr-Jun;30(2):144-52. doi: 10.1097/NCQ.0000000000000084.


A pilot study of staff nurses' perceptions of factors that influence quality of care in critical access hospitals.

Baernholdt M, Jennings BM, Lewis EJ.

J Nurs Care Qual. 2013 Oct-Dec;28(4):352-9. doi: 10.1097/NCQ.0b013e31829fad73.


Severe lupus nephritis: the predictive value of a ≥ 50% reduction in proteinuria at 6 months.

Korbet SM, Lewis EJ; Collaborative Study Group.

Nephrol Dial Transplant. 2013 Sep;28(9):2313-8. doi: 10.1093/ndt/gft201. Epub 2013 Jun 19.


Mild eccentric exercise increases Hsp72 content in skeletal muscles from adult and late middle-aged rats.

Lewis EJ, Ramsook AH, Locke M, Amara CE.

Cell Stress Chaperones. 2013 Sep;18(5):667-73. doi: 10.1007/s12192-013-0412-4. Epub 2013 Feb 27.


Changes in hydration status of elite Olympic class sailors in different climates and the effects of different fluid replacement beverages.

Lewis EJ, Fraser SJ, Thomas SG, Wells GD.

J Int Soc Sports Nutr. 2013 Feb 21;10(1):11. doi: 10.1186/1550-2783-10-11.


Proteinuria in membranous lupus nephritis: the pathology is in the podocyte.

Desai N, Cimbaluk D, Lewis EJ, Whittier WL.

Lupus. 2013 Apr;22(5):461-8. doi: 10.1177/0961203313477225. Epub 2013 Feb 21.


Omega-3 fatty acid supplementation and cardiovascular disease events.

Lewis EJ.

JAMA. 2013 Jan 2;309(1):27. doi: 10.1001/jama.2012.116654. No abstract available.


Nurses' experience of medical errors: an integrative literature review.

Lewis EJ, Baernholdt M, Hamric AB.

J Nurs Care Qual. 2013 Apr-Jun;28(2):153-61. doi: 10.1097/NCQ.0b013e31827e05d1. Review.


The Morganroth hypothesis revisited: endurance exercise elicits eccentric hypertrophy of the heart.

Lewis EJ, McKillop A, Banks L.

J Physiol. 2012 Jun 15;590(12):2833-4. doi: 10.1113/jphysiol.2011.226217. No abstract available.


Impact of glycaemic control on the effect of direct renin inhibition in the AVOID study.

Persson F, Lewis JB, Lewis EJ, Rossing P, Hollenberg NK, Parving HH.

J Renin Angiotensin Aldosterone Syst. 2012 Jun;13(2):250-3. doi: 10.1177/1470320312437068. Epub 2012 Feb 16.


Complete remission in severe lupus nephritis: assessing the rate of loss in proteinuria.

Korbet SM, Lewis EJ; Collaborative Study Group.

Nephrol Dial Transplant. 2012 Jul;27(7):2813-9. doi: 10.1093/ndt/gfr741. Epub 2011 Dec 23.


Pyridorin in type 2 diabetic nephropathy.

Lewis EJ, Greene T, Spitalewiz S, Blumenthal S, Berl T, Hunsicker LG, Pohl MA, Rohde RD, Raz I, Yerushalmy Y, Yagil Y, Herskovits T, Atkins RC, Reutens AT, Packham DK, Lewis JB; Collaborative Study Group.

J Am Soc Nephrol. 2012 Jan;23(1):131-6. doi: 10.1681/ASN.2011030272. Epub 2011 Oct 27.


Sulodexide fails to demonstrate renoprotection in overt type 2 diabetic nephropathy.

Packham DK, Wolfe R, Reutens AT, Berl T, Heerspink HL, Rohde R, Ivory S, Lewis J, Raz I, Wiegmann TB, Chan JC, de Zeeuw D, Lewis EJ, Atkins RC; Collaborative Study Group.

J Am Soc Nephrol. 2012 Jan;23(1):123-30. doi: 10.1681/ASN.2011040378. Epub 2011 Oct 27.


Sulodexide for kidney protection in type 2 diabetes patients with microalbuminuria: a randomized controlled trial.

Lewis EJ, Lewis JB, Greene T, Hunsicker LG, Berl T, Pohl MA, de Zeeuw D, Heerspink HL, Rohde RD, Atkins RC, Reutens AT, Packham DK, Raz I; Collaborative Study Group.

Am J Kidney Dis. 2011 Nov;58(5):729-36. doi: 10.1053/j.ajkd.2011.06.020. Epub 2011 Aug 26. Erratum in: Am J Kidney Dis. 2012 Feb;59(2):318.


Impact of aliskiren treatment on urinary aldosterone levels in patients with type 2 diabetes and nephropathy: an AVOID substudy.

Persson F, Lewis JB, Lewis EJ, Rossing P, Hollenberg NK, Hans-Henrik P.

J Renin Angiotensin Aldosterone Syst. 2012 Mar;13(1):118-21. doi: 10.1177/1470320311417272. Epub 2011 Aug 8.


Potent, selective inhibitors of fibroblast growth factor receptor define fibroblast growth factor dependence in preclinical cancer models.

Squires M, Ward G, Saxty G, Berdini V, Cleasby A, King P, Angibaud P, Perera T, Fazal L, Ross D, Jones CG, Madin A, Benning RK, Vickerstaffe E, O'Brien A, Frederickson M, Reader M, Hamlett C, Batey MA, Rich S, Carr M, Miller D, Feltell R, Thiru A, Bethell S, Devine LA, Graham BL, Pike A, Cosme J, Lewis EJ, Freyne E, Lyons J, Irving J, Murray C, Newell DR, Thompson NT.

Mol Cancer Ther. 2011 Sep;10(9):1542-52. doi: 10.1158/1535-7163.MCT-11-0426. Epub 2011 Jul 15.


Insect anaphylaxis: addressing clinical challenges.

Tracy JM, Lewis EJ, Demain JG.

Curr Opin Allergy Clin Immunol. 2011 Aug;11(4):332-6. doi: 10.1097/ACI.0b013e32834877ab. Review.


Reactive oxygen species mediate high glucose-induced heparanase-1 production and heparan sulphate proteoglycan degradation in human and rat endothelial cells: a potential role in the pathogenesis of atherosclerosis.

Rao G, Ding HG, Huang W, Le D, Maxhimer JB, Oosterhof A, van Kuppevelt T, Lum H, Lewis EJ, Reddy V, Prinz RA, Xu X.

Diabetologia. 2011 Jun;54(6):1527-38. doi: 10.1007/s00125-011-2110-z. Epub 2011 Mar 20.


Aliskiren in combination with losartan reduces albuminuria independent of baseline blood pressure in patients with type 2 diabetes and nephropathy.

Persson F, Lewis JB, Lewis EJ, Rossing P, Hollenberg NK, Parving HH.

Clin J Am Soc Nephrol. 2011 May;6(5):1025-31. doi: 10.2215/CJN.07590810. Epub 2011 Feb 24.


The prognosis of severe lupus nephritis based on the Modification of Diet in Renal Disease (MDRD) study estimated glomerular filtration rate.

Patel SB, Korbet SM, Lewis EJ.

Lupus. 2011 Mar;20(3):256-64. doi: 10.1177/0961203310385267. Epub 2010 Dec 7.


Impact of baseline renal function on the efficacy and safety of aliskiren added to losartan in patients with type 2 diabetes and nephropathy.

Persson F, Lewis JB, Lewis EJ, Rossing P, Hollenberg NK, Parving HH; AVOID Study Investigators.

Diabetes Care. 2010 Nov;33(11):2304-9. doi: 10.2337/dc10-0833. Epub 2010 Aug 6.


AT7519, a cyclin-dependent kinase inhibitor, exerts its effects by transcriptional inhibition in leukemia cell lines and patient samples.

Squires MS, Cooke L, Lock V, Qi W, Lewis EJ, Thompson NT, Lyons JF, Mahadevan D.

Mol Cancer Ther. 2010 Apr;9(4):920-8. doi: 10.1158/1535-7163.MCT-09-1071. Epub 2010 Mar 30.


Effects of the HEET garment in the prevention of hypothermia in a porcine model.

Johnson D, Gegel B, Burgert J, Duncklee GW, Robison RR, Lewis EJ, Crum PM, Kuhns W, Moore D, O'Brien S, Elliott J, Washington J, Boyle J, Seigler D.

J Surg Res. 2010 Nov;164(1):126-30. doi: 10.1016/j.jss.2009.07.038. Epub 2009 Aug 26.


Pathogenetic features of severe segmental lupus nephritis.

Behara VY, Whittier WL, Korbet SM, Schwartz MM, Martens M, Lewis EJ.

Nephrol Dial Transplant. 2010 Jan;25(1):153-9. doi: 10.1093/ndt/gfp424. Epub 2009 Aug 23.


The enigma of cellular immunity in glomerulonephritis: lupus nephritis is not necessarily a prototype of immune complex-mediated glomerulonephritis.

Lewis EJ.

Nephron Physiol. 2009;112(1):p6-10. doi: 10.1159/000212067. Epub 2009 May 6. Review. No abstract available.


Detection of Toxoplasma gondii oocysts in water sample concentrates by real-time PCR.

Yang W, Lindquist HD, Cama V, Schaefer FW 3rd, Villegas E, Fayer R, Lewis EJ, Feng Y, Xiao L.

Appl Environ Microbiol. 2009 Jun;75(11):3477-83. doi: 10.1128/AEM.00285-09. Epub 2009 Apr 10.


[Aliskiren combined with losartan in type 2-diabetes and nephropathy - secondary publication].

Parving HH, Persson F, Lewis JB, Lewis EJ, Hollenberg NK.

Ugeskr Laeger. 2009 Mar 9;171(11):881-4. Danish.


The value of post-biopsy ultrasound in predicting complications after percutaneous renal biopsy of native kidneys.

Waldo B, Korbet SM, Freimanis MG, Lewis EJ.

Nephrol Dial Transplant. 2009 Aug;24(8):2433-9. doi: 10.1093/ndt/gfp073. Epub 2009 Feb 25.


Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines.

Squires MS, Feltell RE, Wallis NG, Lewis EJ, Smith DM, Cross DM, Lyons JF, Thompson NT.

Mol Cancer Ther. 2009 Feb;8(2):324-32. doi: 10.1158/1535-7163.MCT-08-0890. Epub 2009 Jan 27.


Evidence of concurrent immunopathological mechanisms determining the pathology of severe lupus nephritis.

Schwartz MM, Korbet SM, Katz RS, Lewis EJ.

Lupus. 2009 Feb;18(2):149-58. doi: 10.1177/0961203308095947.


Identification of N-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1H-pyrazole-3-carboxamide (AT7519), a novel cyclin dependent kinase inhibitor using fragment-based X-ray crystallography and structure based drug design.

Wyatt PG, Woodhead AJ, Berdini V, Boulstridge JA, Carr MG, Cross DM, Davis DJ, Devine LA, Early TR, Feltell RE, Lewis EJ, McMenamin RL, Navarro EF, O'Brien MA, O'Reilly M, Reule M, Saxty G, Seavers LC, Smith DM, Squires MS, Trewartha G, Walker MT, Woolford AJ.

J Med Chem. 2008 Aug 28;51(16):4986-99. doi: 10.1021/jm800382h. Epub 2008 Jul 26.


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