Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 133


HIF2α-Targeted RNAi Therapeutic Inhibits Clear Cell Renal Cell Carcinoma.

Wong SC, Cheng W, Hamilton H, Nicholas AL, Wakefield DH, Almeida A, Blokhin AV, Carlson J, Neal ZC, Subbotin V, Zhang G, Hegge J, Bertin S, Trubetskoy VS, Rozema DB, Lewis DL, Kanner SB.

Mol Cancer Ther. 2018 Jan;17(1):140-149. doi: 10.1158/1535-7163.MCT-17-0471. Epub 2017 Oct 27.


RNAi-based treatment of chronically infected patients and chimpanzees reveals that integrated hepatitis B virus DNA is a source of HBsAg.

Wooddell CI, Yuen MF, Chan HL, Gish RG, Locarnini SA, Chavez D, Ferrari C, Given BD, Hamilton J, Kanner SB, Lai CL, Lau JYN, Schluep T, Xu Z, Lanford RE, Lewis DL.

Sci Transl Med. 2017 Sep 27;9(409). pii: eaan0241. doi: 10.1126/scitranslmed.aan0241.


Caldicellulosiruptor saccharolyticus transcriptomes reveal consequences of chemical pretreatment and genetic modification of lignocellulose.

Blumer-Schuette SE, Zurawski JV, Conway JM, Khatibi P, Lewis DL, Li Q, Chiang VL, Kelly RM.

Microb Biotechnol. 2017 Nov;10(6):1546-1557. doi: 10.1111/1751-7915.12494. Epub 2017 Mar 20.


Phosphorylation-specific status of RNAi triggers in pharmacokinetic and biodistribution analyses.

Trubetskoy VS, Griffin JB, Nicholas AL, Nord EM, Xu Z, Peterson RM, Wooddell CI, Rozema DB, Wakefield DH, Lewis DL, Kanner SB.

Nucleic Acids Res. 2017 Feb 17;45(3):1469-1478. doi: 10.1093/nar/gkw828.


Safety, Tolerability, and Pharmacokinetics of ARC-520 Injection, an RNA Interference-Based Therapeutic for the Treatment of Chronic Hepatitis B Virus Infection, in Healthy Volunteers.

Schluep T, Lickliter J, Hamilton J, Lewis DL, Lai CL, Lau JY, Locarnini SA, Gish RG, Given BD.

Clin Pharmacol Drug Dev. 2017 Jul;6(4):350-362. doi: 10.1002/cpdd.318. Epub 2016 Dec 12.


Investigations on the role of the salmon louse, Lepeophtheirus salmonis (Caligidae), as a vector in the transmission of Aeromonas salmonicida subsp. salmonicida.

Novak CW, Lewis DL, Collicutt B, Verkaik K, Barker DE.

J Fish Dis. 2016 Oct;39(10):1165-78. doi: 10.1111/jfd.12449. Epub 2016 Feb 5.


Synthetic RNAi triggers and their use in chronic hepatitis B therapies with curative intent.

Gish RG, Yuen MF, Chan HL, Given BD, Lai CL, Locarnini SA, Lau JY, Wooddell CI, Schluep T, Lewis DL.

Antiviral Res. 2015 Sep;121:97-108. doi: 10.1016/j.antiviral.2015.06.019. Epub 2015 Jun 27. Review.


Chronic hepatitis B: Virology, natural history, current management and a glimpse at future opportunities.

Gish RG, Given BD, Lai CL, Locarnini SA, Lau JY, Lewis DL, Schluep T.

Antiviral Res. 2015 Sep;121:47-58. doi: 10.1016/j.antiviral.2015.06.008. Epub 2015 Jun 16. Review.


Protease-triggered siRNA delivery vehicles.

Rozema DB, Blokhin AV, Wakefield DH, Benson JD, Carlson JC, Klein JJ, Almeida LJ, Nicholas AL, Hamilton HL, Chu Q, Hegge JO, Wong SC, Trubetskoy VS, Hagen CM, Kitas E, Wolff JA, Lewis DL.

J Control Release. 2015 Jul 10;209:57-66. doi: 10.1016/j.jconrel.2015.04.012. Epub 2015 Apr 14.


A mutant ('lab strain') of the hyperthermophilic archaeon Pyrococcus furiosus, lacking flagella, has unusual growth physiology.

Lewis DL, Notey JS, Chandrayan SK, Loder AJ, Lipscomb GL, Adams MW, Kelly RM.

Extremophiles. 2015 Mar;19(2):269-81. doi: 10.1007/s00792-014-0712-3. Epub 2014 Dec 4.


Targeted in vivo delivery of siRNA and an endosome-releasing agent to hepatocytes.

Sebestyén MG, Wong SC, Trubetskoy V, Lewis DL, Wooddell CI.

Methods Mol Biol. 2015;1218:163-86. doi: 10.1007/978-1-4939-1538-5_10.


Facing the danger zone: the use of ultrasound to distinguish cellulitis from abscess in facial infections.

Lewis DL, Butts CJ, Moreno-Walton L.

Case Rep Emerg Med. 2014;2014:935283. doi: 10.1155/2014/935283. Epub 2014 Jan 16.


Modulation of cellular innate immunity by Lepeophtheirus salmonis secretory products.

Lewis DL, Barker DE, McKinley RS.

Fish Shellfish Immunol. 2014 May;38(1):175-83. doi: 10.1016/j.fsi.2014.03.014. Epub 2014 Mar 20.


Stochasticity in natural forage production affects use of urban areas by black bears: implications to management of human-bear conflicts.

Baruch-Mordo S, Wilson KR, Lewis DL, Broderick J, Mao JS, Breck SW.

PLoS One. 2014 Jan 8;9(1):e85122. doi: 10.1371/journal.pone.0085122. eCollection 2014.


Hepatocyte-targeted RNAi therapeutics for the treatment of chronic hepatitis B virus infection.

Wooddell CI, Rozema DB, Hossbach M, John M, Hamilton HL, Chu Q, Hegge JO, Klein JJ, Wakefield DH, Oropeza CE, Deckert J, Roehl I, Jahn-Hofmann K, Hadwiger P, Vornlocher HP, McLachlan A, Lewis DL.

Mol Ther. 2013 May;21(5):973-85. doi: 10.1038/mt.2013.31. Epub 2013 Feb 26.


Co-injection of a targeted, reversibly masked endosomolytic polymer dramatically improves the efficacy of cholesterol-conjugated small interfering RNAs in vivo.

Wong SC, Klein JJ, Hamilton HL, Chu Q, Frey CL, Trubetskoy VS, Hegge J, Wakefield D, Rozema DB, Lewis DL.

Nucleic Acid Ther. 2012 Dec;22(6):380-90. doi: 10.1089/nat.2012.0389.


CRIP1a switches cannabinoid receptor agonist/antagonist-mediated protection from glutamate excitotoxicity.

Stauffer B, Wallis KT, Wilson SP, Egertová M, Elphick MR, Lewis DL, Hardy LR.

Neurosci Lett. 2011 Oct 10;503(3):224-8. doi: 10.1016/j.neulet.2011.08.041. Epub 2011 Aug 27.


Insights into plant biomass conversion from the genome of the anaerobic thermophilic bacterium Caldicellulosiruptor bescii DSM 6725.

Dam P, Kataeva I, Yang SJ, Zhou F, Yin Y, Chou W, Poole FL 2nd, Westpheling J, Hettich R, Giannone R, Lewis DL, Kelly R, Gilbert HJ, Henrissat B, Xu Y, Adams MW.

Nucleic Acids Res. 2011 Apr;39(8):3240-54. doi: 10.1093/nar/gkq1281. Epub 2011 Jan 11.


Phylogenetic, microbiological, and glycoside hydrolase diversities within the extremely thermophilic, plant biomass-degrading genus Caldicellulosiruptor.

Blumer-Schuette SE, Lewis DL, Kelly RM.

Appl Environ Microbiol. 2010 Dec;76(24):8084-92. doi: 10.1128/AEM.01400-10. Epub 2010 Oct 22.


Hydrogenomics of the extremely thermophilic bacterium Caldicellulosiruptor saccharolyticus.

van de Werken HJ, Verhaart MR, VanFossen AL, Willquist K, Lewis DL, Nichols JD, Goorissen HP, Mongodin EF, Nelson KE, van Niel EW, Stams AJ, Ward DE, de Vos WM, van der Oost J, Kelly RM, Kengen SW.

Appl Environ Microbiol. 2008 Nov;74(21):6720-9. doi: 10.1128/AEM.00968-08. Epub 2008 Sep 5.


Polysaccharide degradation and synthesis by extremely thermophilic anaerobes.

Vanfossen AL, Lewis DL, Nichols JD, Kelly RM.

Ann N Y Acad Sci. 2008 Mar;1125:322-37. doi: 10.1196/annals.1419.017. Review.


Body dysmorphic disorder.

Ende KH, Lewis DL, Kabaker SS.

Facial Plast Surg Clin North Am. 2008 May;16(2):217-23, vii. doi: 10.1016/j.fsc.2007.11.012.


CB1 cannabinoid receptor activity is modulated by the cannabinoid receptor interacting protein CRIP 1a.

Niehaus JL, Liu Y, Wallis KT, Egertová M, Bhartur SG, Mukhopadhyay S, Shi S, He H, Selley DE, Howlett AC, Elphick MR, Lewis DL.

Mol Pharmacol. 2007 Dec;72(6):1557-66. Epub 2007 Sep 25.


Impact of substrate glycoside linkage and elemental sulfur on bioenergetics of and hydrogen production by the hyperthermophilic archaeon Pyrococcus furiosus.

Chou CJ, Shockley KR, Conners SB, Lewis DL, Comfort DA, Adams MW, Kelly RM.

Appl Environ Microbiol. 2007 Nov;73(21):6842-53. Epub 2007 Sep 7.


Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes.

Rozema DB, Lewis DL, Wakefield DH, Wong SC, Klein JJ, Roesch PL, Bertin SL, Reppen TW, Chu Q, Blokhin AV, Hagstrom JE, Wolff JA.

Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):12982-7. Epub 2007 Jul 24.


Helix 8 Leu in the CB1 cannabinoid receptor contributes to selective signal transduction mechanisms.

Anavi-Goffer S, Fleischer D, Hurst DP, Lynch DL, Barnett-Norris J, Shi S, Lewis DL, Mukhopadhyay S, Howlett AC, Reggio PH, Abood ME.

J Biol Chem. 2007 Aug 24;282(34):25100-13. Epub 2007 Jun 26.


Systemic siRNA delivery via hydrodynamic intravascular injection.

Lewis DL, Wolff JA.

Adv Drug Deliv Rev. 2007 Mar 30;59(2-3):115-23. Epub 2007 Mar 15. Review.


Progress toward a nonviral gene therapy protocol for the treatment of anemia.

Sebestyén MG, Hegge JO, Noble MA, Lewis DL, Herweijer H, Wolff JA.

Hum Gene Ther. 2007 Mar;18(3):269-85.


PPARalpha siRNA-treated expression profiles uncover the causal sufficiency network for compound-induced liver hypertrophy.

Dai X, De Souza AT, Dai H, Lewis DL, Lee CK, Spencer AG, Herweijer H, Hagstrom JE, Linsley PS, Bassett DE, Ulrich RG, He YD.

PLoS Comput Biol. 2007 Mar 2;3(3):e30. Epub 2007 Jan 2.


Prospective study of cross-infection from upper-GI endoscopy in a hepatitis C-prevalent population.

Mikhail NN, Lewis DL, Omar N, Taha H, El-Badawy A, Abdel-Mawgoud N, Abdel-Hamid M, Strickland GT.

Gastrointest Endosc. 2007 Apr;65(4):584-8. Epub 2007 Jan 8.


Interactions of pathogens and irritant chemicals in land-applied sewage sludges (biosolids).

Lewis DL, Gattie DK, Novak ME, Sanchez S, Pumphrey C.

New Solut. 2002;12(4):409-23.


Do the ABCS 135 short cognitive screen and its subtests discriminate between normal cognition, mild cognitive impairment and dementia?

Standish TI, Molloy DW, Cunje A, Lewis DL.

Int J Geriatr Psychiatry. 2007 Mar;22(3):189-94.


Transcriptional and phenotypic comparisons of Ppara knockout and siRNA knockdown mice.

De Souza AT, Dai X, Spencer AG, Reppen T, Menzie A, Roesch PL, He Y, Caguyong MJ, Bloomer S, Herweijer H, Wolff JA, Hagstrom JE, Lewis DL, Linsley PS, Ulrich RG.

Nucleic Acids Res. 2006;34(16):4486-94. Epub 2006 Aug 31.


Hepatocyte targeting of nucleic acid complexes and liposomes by a T7 phage p17 peptide.

Wong SC, Wakefield D, Klein J, Monahan SD, Rozema DB, Lewis DL, Higgs L, Ludtke J, Sokoloff AV, Wolff JA.

Mol Pharm. 2006 Jul-Aug;3(4):386-97.


Mechanism of plasmid delivery by hydrodynamic tail vein injection. I. Hepatocyte uptake of various molecules.

Sebestyén MG, Budker VG, Budker T, Subbotin VM, Zhang G, Monahan SD, Lewis DL, Wong SC, Hagstrom JE, Wolff JA.

J Gene Med. 2006 Jul;8(7):852-73.


Alternate forms of logical memory and verbal fluency tasks for repeated testing in early cognitive changes.

Cunje A, Molloy DW, Standish TI, Lewis DL.

Int Psychogeriatr. 2007 Feb;19(1):65-75. Epub 2006 May 10.


Non-viral approaches for gene transfer.

Wolff J, Lewis DL, Herweijer H, Hegge J, Hagstrom J.

Acta Myol. 2005 Dec;24(3):202-8. Review.


Ectopic transgene expression in butterfly imaginal wing discs using vaccinia virus.

Lewis DL, Brunetti CR.

Biotechniques. 2006 Jan;40(1):48, 50, 52 passim. No abstract available.


Using duration of memory loss to improve differentiation of mild cognitive impairment from normal cognition.

Kupferschmidt AL, Lewis DL, Molloy DW, Standish TI, Babineau TR.

Int J Geriatr Psychiatry. 2006 Feb;21(2):189-90. No abstract available.


Translating evidence into practice: the case of dementia guidelines in specialized geriatric services.

Lewis DL, Jewell D, Turpie I, Patterson C, McCoy B, Baxter J.

Can J Aging. 2005 Fall;24(3):251-60.


Long-term RNA interference from optimized siRNA expression constructs in adult mice.

Wooddell CI, Van Hout CV, Reppen T, Lewis DL, Herweijer H.

Biochem Biophys Res Commun. 2005 Aug 19;334(1):117-27.


Screening for mild cognitive impairment: comparing the SMMSE and the ABCS.

Molloy DW, Standish TI, Lewis DL.

Can J Psychiatry. 2005 Jan;50(1):52-8.


Systolic blood pressure does not reliably identify vasoactive status in chronic heart failure.

Parrott CW, Quale C, Lewis DL, Ferguson S, Brunt R, Glass S.

Am J Hypertens. 2005 Feb;18(2 Pt 2):82S-86S.


A facile nonviral method for delivering genes and siRNAs to skeletal muscle of mammalian limbs.

Hagstrom JE, Hegge J, Zhang G, Noble M, Budker V, Lewis DL, Herweijer H, Wolff JA.

Mol Ther. 2004 Aug;10(2):386-98.


Use of noninvasive hemodynamics to aid decision making in the initiation and titration of neurohormonal agents.

Summers RL, Parrott CW, Quale C, Lewis DL.

Congest Heart Fail. 2004 Mar-Apr;10(2 Suppl 2):28-31.


Comparison of changes in ejection fraction to changes in impedance cardiography cardiac index and systolic time ratio.

Parrott CW, Burnham KM, Quale C, Lewis DL.

Congest Heart Fail. 2004 Mar-Apr;10(2 Suppl 2):11-3.


A high-level disinfection standard for land applying sewage sludges (biosolids).

Gattie DK, Lewis DL.

Environ Health Perspect. 2004 Feb;112(2):126-31.


Comment on "Evidence for the absence of Staphylococcus aureus in the land applied biosolids".

Lewis DL, Gattie DK.

Environ Sci Technol. 2003 Dec 15;37(24):5835; author reply 5836. No abstract available.


Supplemental Content

Loading ...
Support Center