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Items: 28


Single-molecule probing of the conformational homogeneity of the ABC transporter BtuCD.

Yang M, Livnat Levanon N, Acar B, Aykac Fas B, Masrati G, Rose J, Ben-Tal N, Haliloglu T, Zhao Y, Lewinson O.

Nat Chem Biol. 2018 Jul;14(7):715-722. doi: 10.1038/s41589-018-0088-2. Epub 2018 Jun 18.


Dimerization of the adaptor Gads facilitates antigen receptor signaling by promoting the cooperative binding of Gads to the adaptor LAT.

Sukenik S, Frushicheva MP, Waknin-Lellouche C, Hallumi E, Ifrach T, Shalah R, Beach D, Avidan R, Oz I, Libman E, Aronheim A, Lewinson O, Yablonski D.

Sci Signal. 2017 Sep 26;10(498). pii: eaal1482. doi: 10.1126/scisignal.aal1482.


ATP binding and hydrolysis disrupt the high-affinity interaction between the heme ABC transporter HmuUV and its cognate substrate-binding protein.

Qasem-Abdullah H, Perach M, Livnat-Levanon N, Lewinson O.

J Biol Chem. 2017 Sep 1;292(35):14617-14624. doi: 10.1074/jbc.M117.779975. Epub 2017 Jul 14.


The highly synergistic, broad spectrum, antibacterial activity of organic acids and transition metals.

Zhitnitsky D, Rose J, Lewinson O.

Sci Rep. 2017 Mar 15;7:44554. doi: 10.1038/srep44554.


L-glutamine Induces Expression of Listeria monocytogenes Virulence Genes.

Haber A, Friedman S, Lobel L, Burg-Golani T, Sigal N, Rose J, Livnat-Levanon N, Lewinson O, Herskovits AA.

PLoS Pathog. 2017 Jan 23;13(1):e1006161. doi: 10.1371/journal.ppat.1006161. eCollection 2017 Jan.


Mechanism of Action of ABC Importers: Conservation, Divergence, and Physiological Adaptations.

Lewinson O, Livnat-Levanon N.

J Mol Biol. 2017 Mar 10;429(5):606-619. doi: 10.1016/j.jmb.2017.01.010. Epub 2017 Jan 16. Review.


Metal binding spectrum and model structure of the Bacillus anthracis virulence determinant MntA.

Vigonsky E, Fish I, Livnat-Levanon N, Ovcharenko E, Ben-Tal N, Lewinson O.

Metallomics. 2015 Oct;7(10):1407-19. doi: 10.1039/c5mt00100e. Epub 2015 Jun 24.


Real time measurements of membrane protein:receptor interactions using Surface Plasmon Resonance (SPR).

Livnat Levanon N, Vigonsky E, Lewinson O.

J Vis Exp. 2014 Nov 29;(93):e51937. doi: 10.3791/51937.


A relay network of extracellular heme-binding proteins drives C. albicans iron acquisition from hemoglobin.

Kuznets G, Vigonsky E, Weissman Z, Lalli D, Gildor T, Kauffman SJ, Turano P, Becker J, Lewinson O, Kornitzer D.

PLoS Pathog. 2014 Oct 2;10(10):e1004407. doi: 10.1371/journal.ppat.1004407. eCollection 2014 Oct.


Structural basis for heavy metal detoxification by an Atm1-type ABC exporter.

Lee JY, Yang JG, Zhitnitsky D, Lewinson O, Rees DC.

Science. 2014 Mar 7;343(6175):1133-6. doi: 10.1126/science.1246489.


Identification of functionally important conserved trans-membrane residues of bacterial PIB -type ATPases.

Zhitnitsky D, Lewinson O.

Mol Microbiol. 2014 Feb;91(4):777-89. doi: 10.1111/mmi.12495. Epub 2014 Jan 14.


A single intact ATPase site of the ABC transporter BtuCD drives 5% transport activity yet supports full in vivo vitamin B12 utilization.

Tal N, Ovcharenko E, Lewinson O.

Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5434-9. doi: 10.1073/pnas.1209644110. Epub 2013 Mar 19.


Two molybdate/tungstate ABC transporters that interact very differently with their substrate binding proteins.

Vigonsky E, Ovcharenko E, Lewinson O.

Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5440-5. doi: 10.1073/pnas.1213598110. Epub 2013 Mar 19.


The size of the proteasomal substrate determines whether its degradation will be mediated by mono- or polyubiquitylation.

Shabek N, Herman-Bachinsky Y, Buchsbaum S, Lewinson O, Haj-Yahya M, Hejjaoui M, Lashuel HA, Sommer T, Brik A, Ciechanover A.

Mol Cell. 2012 Oct 12;48(1):87-97. doi: 10.1016/j.molcel.2012.07.011. Epub 2012 Aug 16.


Bacterial ATP-driven transporters of transition metals: physiological roles, mechanisms of action, and roles in bacterial virulence.

Klein JS, Lewinson O.

Metallomics. 2011 Nov;3(11):1098-108. doi: 10.1039/c1mt00073j. Epub 2011 Sep 7. Review.


A distinct mechanism for the ABC transporter BtuCD-BtuF revealed by the dynamics of complex formation.

Lewinson O, Lee AT, Locher KP, Rees DC.

Nat Struct Mol Biol. 2010 Mar;17(3):332-8. doi: 10.1038/nsmb.1770. Epub 2010 Feb 21.


A P-type ATPase importer that discriminates between essential and toxic transition metals.

Lewinson O, Lee AT, Rees DC.

Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4677-82. doi: 10.1073/pnas.0900666106. Epub 2009 Mar 5.


ABC transporters: the power to change.

Rees DC, Johnson E, Lewinson O.

Nat Rev Mol Cell Biol. 2009 Mar;10(3):218-27. doi: 10.1038/nrm2646. Review.


The funnel approach to the precrystallization production of membrane proteins.

Lewinson O, Lee AT, Rees DC.

J Mol Biol. 2008 Mar 14;377(1):62-73. doi: 10.1016/j.jmb.2007.12.059. Epub 2008 Jan 4.


E. coli multidrug transporter MdfA is a monomer.

Sigal N, Lewinson O, Wolf SG, Bibi E.

Biochemistry. 2007 May 1;46(17):5200-8. Epub 2007 Apr 4.


Promiscuity in multidrug recognition and transport: the bacterial MFS Mdr transporters.

Lewinson O, Adler J, Sigal N, Bibi E.

Mol Microbiol. 2006 Jul;61(2):277-84. Review.


Do physiological roles foster persistence of drug/multidrug-efflux transporters? A case study.

Krulwich TA, Lewinson O, Padan E, Bibi E.

Nat Rev Microbiol. 2005 Jul;3(7):566-72. Review.


Alkalitolerance: a biological function for a multidrug transporter in pH homeostasis.

Lewinson O, Padan E, Bibi E.

Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):14073-8. Epub 2004 Sep 15.


Role of a conserved membrane-embedded acidic residue in the multidrug transporter MdfA.

Adler J, Lewinson O, Bibi E.

Biochemistry. 2004 Jan 20;43(2):518-25.


The Escherichia coli multidrug transporter MdfA catalyzes both electrogenic and electroneutral transport reactions.

Lewinson O, Adler J, Poelarends GJ, Mazurkiewicz P, Driessen AJ, Bibi E.

Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1667-72. Epub 2003 Feb 10.


MdfA, an interesting model protein for studying multidrug transport.

Bibi E, Adler J, Lewinson O, Edgar R.

J Mol Microbiol Biotechnol. 2001 Apr;3(2):171-7. Review.


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