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Items: 1 to 50 of 112

1.

New hope for tuberculosis vaccines.

Olesen OF, Abdullah F, Coppens R, Gardner PJ, Ginsberg AM, Hanekom WA, Laang H, Lewinsohn DM, Loots G, Schmidt A, Vekemans J, Voss GH.

Lancet Infect Dis. 2019 Jul;19(7):687-688. doi: 10.1016/S1473-3099(19)30280-4. No abstract available.

PMID:
31250810
2.

TRAV1-2+ CD8+ T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis.

Wong EB, Gold MC, Meermeier EW, Xulu BZ, Khuzwayo S, Sullivan ZA, Mahyari E, Rogers Z, Kløverpris H, Sharma PK, Worley AH, Lalloo U, Baijnath P, Ambaram A, Naidoo L, Suleman M, Madansein R, McLaren JE, Ladell K, Miners KL, Price DA, Behar SM, Nielsen M, Kasprowicz VO, Leslie A, Bishai WR, Ndung'u T, Lewinsohn DM.

Commun Biol. 2019 Jun 5;2:203. doi: 10.1038/s42003-019-0442-2. eCollection 2019.

3.

Tuberculosis Screening, Testing, and Treatment of U.S. Health Care Personnel: Recommendations from the National Tuberculosis Controllers Association and CDC, 2019.

Sosa LE, Njie GJ, Lobato MN, Bamrah Morris S, Buchta W, Casey ML, Goswami ND, Gruden M, Hurst BJ, Khan AR, Kuhar DT, Lewinsohn DM, Mathew TA, Mazurek GH, Reves R, Paulos L, Thanassi W, Will L, Belknap R.

MMWR Morb Mortal Wkly Rep. 2019 May 17;68(19):439-443. doi: 10.15585/mmwr.mm6819a3.

4.

Harnessing donor unrestricted T-cells for new vaccines against tuberculosis.

Joosten SA, Ottenhoff THM, Lewinsohn DM, Hoft DF, Moody DB, Seshadri C; Collaboration for Tuberculosis Vaccine Discovery - Donor-Unrestricted T-cells Working Group, Bill and Melinda Gates Foundation.

Vaccine. 2019 May 21;37(23):3022-3030. doi: 10.1016/j.vaccine.2019.04.050. Epub 2019 Apr 27. Review.

5.

Recognition of CD8+ T-cell epitopes to identify adults with pulmonary tuberculosis.

Lancioni C, Swarbrick GM, Park B, Nyendak M, Nsereko M, Mayanja-Kizza H, Null MD, Cansler ME, Duncan RB, Baseke J, Chervenak K, Malone L, Heaphy EG, Boom WH, Lewinsohn DM, Lewinsohn DA.

Eur Respir J. 2019 May 30;53(5). pii: 1802053. doi: 10.1183/13993003.02053-2018. Print 2019 May. No abstract available.

PMID:
30923183
6.
7.

Casting a wider net: Immunosurveillance by nonclassical MHC molecules.

D'Souza MP, Adams E, Altman JD, Birnbaum ME, Boggiano C, Casorati G, Chien YH, Conley A, Eckle SBG, Früh K, Gondré-Lewis T, Hassan N, Huang H, Jayashankar L, Kasmar AG, Kunwar N, Lavelle J, Lewinsohn DM, Moody B, Picker L, Ramachandra L, Shastri N, Parham P, McMichael AJ, Yewdell JW.

PLoS Pathog. 2019 Feb 21;15(2):e1007567. doi: 10.1371/journal.ppat.1007567. eCollection 2019 Feb. Review.

8.

MR1-dependent antigen presentation.

Karamooz E, Harriff MJ, Lewinsohn DM.

Semin Cell Dev Biol. 2018 Dec;84:58-64. doi: 10.1016/j.semcdb.2017.11.028. Review.

PMID:
30449535
9.

Moving toward Tuberculosis Elimination. Critical Issues for Research in Diagnostics and Therapeutics for Tuberculosis Infection.

Keshavjee S, Amanullah F, Cattamanchi A, Chaisson R, Dobos KM, Fox GJ, Gendelman HE, Gordon R, Hesseling A, Le Van H, Kampmann B, Kana B, Khuller G, Lewinsohn DM, Lewinsohn DA, Lin PL, Lu LL, Maartens G, Owen A, Protopopova M, Rengarajan J, Rubin E, Salgame P, Schurr E, Seddon JA, Swindells S, Tobin DM, Udwadia Z, Walzl G, Srinivasan S, Rustomjee R, Nahid P.

Am J Respir Crit Care Med. 2019 Mar 1;199(5):564-571. doi: 10.1164/rccm.201806-1053PP. No abstract available.

10.

Application of multiplexed ion mobility spectrometry towards the identification of host protein signatures of treatment effect in pulmonary tuberculosis.

Kedia K, Wendler JP, Baker ES, Burnum-Johnson KE, Jarsberg LG, Stratton KG, Wright AT, Piehowski PD, Gritsenko MA, Lewinsohn DM, Sigal GB, Weiner MH, Smith RD, Jacobs JM, Nahid P.

Tuberculosis (Edinb). 2018 Sep;112:52-61. doi: 10.1016/j.tube.2018.07.005. Epub 2018 Jul 18.

11.

Diagnostic Challenge of Tuberculosis Heterogeneity.

Nemes E, Meermeier EW, Scriba TJ, Walzl G, Malherbe ST, Lewinsohn DM.

Semin Respir Crit Care Med. 2018 Jun;39(3):286-296. doi: 10.1055/s-0038-1660471. Epub 2018 Aug 2. Review.

PMID:
30071544
12.

Incipient and Subclinical Tuberculosis: a Clinical Review of Early Stages and Progression of Infection.

Drain PK, Bajema KL, Dowdy D, Dheda K, Naidoo K, Schumacher SG, Ma S, Meermeier E, Lewinsohn DM, Sherman DR.

Clin Microbiol Rev. 2018 Jul 18;31(4). pii: e00021-18. doi: 10.1128/CMR.00021-18. Print 2018 Oct. Review.

PMID:
30021818
13.

MR1 displays the microbial metabolome driving selective MR1-restricted T cell receptor usage.

Harriff MJ, McMurtrey C, Froyd CA, Jin H, Cansler M, Null M, Worley A, Meermeier EW, Swarbrick G, Nilsen A, Lewinsohn DA, Hildebrand W, Adams EJ, Lewinsohn DM.

Sci Immunol. 2018 Jul 13;3(25). pii: eaao2556. doi: 10.1126/sciimmunol.aao2556.

PMID:
30006464
14.

Role of MAIT cells in pulmonary bacterial infection.

Hartmann N, Harriff MJ, McMurtrey CP, Hildebrand WH, Lewinsohn DM, Kronenberg M.

Mol Immunol. 2018 Sep;101:155-159. doi: 10.1016/j.molimm.2018.06.270. Epub 2018 Jun 26. Review.

PMID:
29940408
15.

Early clearance versus control: what is the meaning of a negative tuberculin skin test or interferon-gamma release assay following exposure to Mycobacterium tuberculosis?

Meermeier EW, Lewinsohn DM.

F1000Res. 2018 May 25;7. pii: F1000 Faculty Rev-664. doi: 10.12688/f1000research.13224.1. eCollection 2018. Review.

16.

Interplay of strain and race/ethnicity in the innate immune response to M. tuberculosis.

Nahid P, Jarlsberg LG, Kato-Maeda M, Segal MR, Osmond DH, Gagneux S, Dobos K, Gold M, Hopewell PC, Lewinsohn DM.

PLoS One. 2018 May 22;13(5):e0195392. doi: 10.1371/journal.pone.0195392. eCollection 2018.

17.

Identification and Evaluation of Novel Protective Antigens for the Development of a Candidate Tuberculosis Subunit Vaccine.

Stylianou E, Harrington-Kandt R, Beglov J, Bull N, Pinpathomrat N, Swarbrick GM, Lewinsohn DA, Lewinsohn DM, McShane H.

Infect Immun. 2018 Jun 21;86(7). pii: e00014-18. doi: 10.1128/IAI.00014-18. Print 2018 Jul.

18.

MAIT cells and microbial immunity.

Meermeier EW, Harriff MJ, Karamooz E, Lewinsohn DM.

Immunol Cell Biol. 2018 Jul;96(6):607-617. doi: 10.1111/imcb.12022. Epub 2018 Mar 9. Review.

19.

Riboflavin Metabolism Variation among Clinical Isolates of Streptococcus pneumoniae Results in Differential Activation of Mucosal-associated Invariant T Cells.

Hartmann N, McMurtrey C, Sorensen ML, Huber ME, Kurapova R, Coleman FT, Mizgerd JP, Hildebrand W, Kronenberg M, Lewinsohn DM, Harriff MJ.

Am J Respir Cell Mol Biol. 2018 Jun;58(6):767-776. doi: 10.1165/rcmb.2017-0290OC.

20.

T cell recognition of Mycobacterium tuberculosis peptides presented by HLA-E derived from infected human cells.

McMurtrey C, Harriff MJ, Swarbrick GM, Duncan A, Cansler M, Null M, Bardet W, Jackson KW, Lewinsohn DA, Hildebrand W, Lewinsohn DM.

PLoS One. 2017 Nov 27;12(11):e0188288. doi: 10.1371/journal.pone.0188288. eCollection 2017.

21.

Tuberculosis Infectiousness and Host Susceptibility.

Turner RD, Chiu C, Churchyard GJ, Esmail H, Lewinsohn DM, Gandhi NR, Fennelly KP.

J Infect Dis. 2017 Nov 3;216(suppl_6):S636-S643. doi: 10.1093/infdis/jix361. Review.

22.

Biomarkers of Tuberculosis Severity and Treatment Effect: A Directed Screen of 70 Host Markers in a Randomized Clinical Trial.

Sigal GB, Segal MR, Mathew A, Jarlsberg L, Wang M, Barbero S, Small N, Haynesworth K, Davis JL, Weiner M, Whitworth WC, Jacobs J, Schorey J, Lewinsohn DM, Nahid P.

EBioMedicine. 2017 Nov;25:112-121. doi: 10.1016/j.ebiom.2017.10.018. Epub 2017 Oct 24.

23.

IL-17 Production from T Helper 17, Mucosal-Associated Invariant T, and γδ Cells in Tuberculosis Infection and Disease.

Coulter F, Parrish A, Manning D, Kampmann B, Mendy J, Garand M, Lewinsohn DM, Riley EM, Sutherland JS.

Front Immunol. 2017 Oct 11;8:1252. doi: 10.3389/fimmu.2017.01252. eCollection 2017.

24.

Polyfunctional CD4+ T Cells As Targets for Tuberculosis Vaccination.

Lewinsohn DA, Lewinsohn DM, Scriba TJ.

Front Immunol. 2017 Oct 5;8:1262. doi: 10.3389/fimmu.2017.01262. eCollection 2017. Review.

25.

An Expanding Role for Environmental Microbes in Shaping the Immune Response to Infection with Mycobacterium tuberculosis.

Lewinsohn DM.

Am J Respir Crit Care Med. 2017 Sep 15;196(6):677-679. doi: 10.1164/rccm.201708-1599ED. No abstract available.

26.

Comprehensive definition of human immunodominant CD8 antigens in tuberculosis.

Lewinsohn DA, Swarbrick GM, Park B, Cansler ME, Null MD, Toren KG, Baseke J, Zalwango S, Mayanja-Kizza H, Malone LL, Nyendak M, Wu G, Guinn K, McWeeney S, Mori T, Chervenak KA, Sherman DR, Boom WH, Lewinsohn DM.

NPJ Vaccines. 2017;2. pii: 8. doi: 10.1038/s41541-017-0008-6. Epub 2017 Apr 3.

27.

HLA-E Presents Glycopeptides from the Mycobacterium tuberculosis Protein MPT32 to Human CD8+ T cells.

Harriff MJ, Wolfe LM, Swarbrick G, Null M, Cansler ME, Canfield ET, Vogt T, Toren KG, Li W, Jackson M, Lewinsohn DA, Dobos KM, Lewinsohn DM.

Sci Rep. 2017 Jul 4;7(1):4622. doi: 10.1038/s41598-017-04894-0.

28.

The Mycobacterium tuberculosis MmpL11 Cell Wall Lipid Transporter Is Important for Biofilm Formation, Intracellular Growth, and Nonreplicating Persistence.

Wright CC, Hsu FF, Arnett E, Dunaj JL, Davidson PM, Pacheco SA, Harriff MJ, Lewinsohn DM, Schlesinger LS, Purdy GE.

Infect Immun. 2017 Jul 19;85(8). pii: e00131-17. doi: 10.1128/IAI.00131-17. Print 2017 Aug.

29.

Diagnosis of Tuberculosis in Adults and Children.

Jamil SM, Oren E, Garrison GW, Srikanth S, Lewinsohn DM, Wilson KC, Thomson CC.

Ann Am Thorac Soc. 2017 Feb;14(2):275-278. doi: 10.1513/AnnalsATS.201608-636CME. Review. No abstract available.

PMID:
28146376
30.

Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of Tuberculosis in Adults and Children.

Lewinsohn DM, Leonard MK, LoBue PA, Cohn DL, Daley CL, Desmond E, Keane J, Lewinsohn DA, Loeffler AM, Mazurek GH, O'Brien RJ, Pai M, Richeldi L, Salfinger M, Shinnick TM, Sterling TR, Warshauer DM, Woods GL.

Clin Infect Dis. 2017 Jan 15;64(2):111-115. doi: 10.1093/cid/ciw778.

31.

Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of Tuberculosis in Adults and Children.

Lewinsohn DM, Leonard MK, LoBue PA, Cohn DL, Daley CL, Desmond E, Keane J, Lewinsohn DA, Loeffler AM, Mazurek GH, O'Brien RJ, Pai M, Richeldi L, Salfinger M, Shinnick TM, Sterling TR, Warshauer DM, Woods GL.

Clin Infect Dis. 2017 Jan 15;64(2):e1-e33. doi: 10.1093/cid/ciw694. Epub 2016 Dec 8.

PMID:
27932390
32.

A polymorphism in human MR1 is associated with mRNA expression and susceptibility to tuberculosis.

Seshadri C, Thuong NT, Mai NT, Bang ND, Chau TT, Lewinsohn DM, Thwaites GE, Dunstan SJ, Hawn TR.

Genes Immun. 2017 Jan;18(1):8-14. doi: 10.1038/gene.2016.41. Epub 2016 Nov 24.

33.

Adenovirally-Induced Polyfunctional T Cells Do Not Necessarily Recognize the Infected Target: Lessons from a Phase I Trial of the AERAS-402 Vaccine.

Nyendak M, Swarbrick GM, Duncan A, Cansler M, Huff EW, Hokey D, Evans T, Barker L, Blatner G, Sadoff J, Douoguih M, Pau MG, Lewinsohn DA, Lewinsohn DM.

Sci Rep. 2016 Nov 2;6:36355. doi: 10.1038/srep36355.

34.

MR1-restricted mucosal-associated invariant T (MAIT) cells respond to mycobacterial vaccination and infection in nonhuman primates.

Greene JM, Dash P, Roy S, McMurtrey C, Awad W, Reed JS, Hammond KB, Abdulhaqq S, Wu HL, Burwitz BJ, Roth BF, Morrow DW, Ford JC, Xu G, Bae JY, Crank H, Legasse AW, Dang TH, Greenaway HY, Kurniawan M, Gold MC, Harriff MJ, Lewinsohn DA, Park BS, Axthelm MK, Stanton JJ, Hansen SG, Picker LJ, Venturi V, Hildebrand W, Thomas PG, Lewinsohn DM, Adams EJ, Sacha JB.

Mucosal Immunol. 2017 May;10(3):802-813. doi: 10.1038/mi.2016.91. Epub 2016 Oct 19.

35.

Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens.

Meermeier EW, Laugel BF, Sewell AK, Corbett AJ, Rossjohn J, McCluskey J, Harriff MJ, Franks T, Gold MC, Lewinsohn DM.

Nat Commun. 2016 Aug 16;7:12506. doi: 10.1038/ncomms12506.

36.

Engineering of Isogenic Cells Deficient for MR1 with a CRISPR/Cas9 Lentiviral System: Tools To Study Microbial Antigen Processing and Presentation to Human MR1-Restricted T Cells.

Laugel B, Lloyd A, Meermeier EW, Crowther MD, Connor TR, Dolton G, Miles JJ, Burrows SR, Gold MC, Lewinsohn DM, Sewell AK.

J Immunol. 2016 Aug 1;197(3):971-82. doi: 10.4049/jimmunol.1501402. Epub 2016 Jun 15.

37.

Endosomal MR1 Trafficking Plays a Key Role in Presentation of Mycobacterium tuberculosis Ligands to MAIT Cells.

Harriff MJ, Karamooz E, Burr A, Grant WF, Canfield ET, Sorensen ML, Moita LF, Lewinsohn DM.

PLoS Pathog. 2016 Mar 31;12(3):e1005524. doi: 10.1371/journal.ppat.1005524. eCollection 2016 Mar.

38.

The Role of Mucosal Associated Invariant T Cells in Antimicrobial Immunity.

Napier RJ, Adams EJ, Gold MC, Lewinsohn DM.

Front Immunol. 2015 Jul 6;6:344. doi: 10.3389/fimmu.2015.00344. eCollection 2015. Review.

39.

High expression of CD26 accurately identifies human bacteria-reactive MR1-restricted MAIT cells.

Sharma PK, Wong EB, Napier RJ, Bishai WR, Ndung'u T, Kasprowicz VO, Lewinsohn DA, Lewinsohn DM, Gold MC.

Immunology. 2015 Jul;145(3):443-53. doi: 10.1111/imm.12461. Epub 2015 Mar 29.

40.

MR1-restricted mucosal associated invariant T (MAIT) cells in the immune response to Mycobacterium tuberculosis.

Gold MC, Napier RJ, Lewinsohn DM.

Immunol Rev. 2015 Mar;264(1):154-66. doi: 10.1111/imr.12271. Review.

41.

ATS Core Curriculum 2014: part I. Adult pulmonary medicine.

Nyendak MR, Lewinsohn DM, Shah RD, Wunderink RG, Koch CD, Morris A, McDade KE, Michaud GC, Mahajan AK, Channick CL, Argento AC, Wahidi MM, Beckett WS, George G, Thomson CC.

Ann Am Thorac Soc. 2014 Sep;11(7):1136-44. doi: 10.1513/AnnalsATS.201406-262CME. No abstract available.

42.

MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage.

Gold MC, McLaren JE, Reistetter JA, Smyk-Pearson S, Ladell K, Swarbrick GM, Yu YY, Hansen TH, Lund O, Nielsen M, Gerritsen B, Kesmir C, Miles JJ, Lewinsohn DA, Price DA, Lewinsohn DM.

J Exp Med. 2014 Jul 28;211(8):1601-10. doi: 10.1084/jem.20140507. Epub 2014 Jul 21.

43.

T cell inactivation by poxviral B22 family proteins increases viral virulence.

Alzhanova D, Hammarlund E, Reed J, Meermeier E, Rawlings S, Ray CA, Edwards DM, Bimber B, Legasse A, Planer S, Sprague J, Axthelm MK, Pickup DJ, Lewinsohn DM, Gold MC, Wong SW, Sacha JB, Slifka MK, Früh K.

PLoS Pathog. 2014 May 15;10(5):e1004123. doi: 10.1371/journal.ppat.1004123. eCollection 2014 May.

44.

Human lung epithelial cells contain Mycobacterium tuberculosis in a late endosomal vacuole and are efficiently recognized by CD8⁺ T cells.

Harriff MJ, Cansler ME, Toren KG, Canfield ET, Kwak S, Gold MC, Lewinsohn DM.

PLoS One. 2014 May 14;9(5):e97515. doi: 10.1371/journal.pone.0097515. eCollection 2014.

45.

Low levels of peripheral CD161++CD8+ mucosal associated invariant T (MAIT) cells are found in HIV and HIV/TB co-infection.

Wong EB, Akilimali NA, Govender P, Sullivan ZA, Cosgrove C, Pillay M, Lewinsohn DM, Bishai WR, Walker BD, Ndung'u T, Klenerman P, Kasprowicz VO.

PLoS One. 2013 Dec 31;8(12):e83474. doi: 10.1371/journal.pone.0083474. eCollection 2013. Erratum in: PLoS One. 2014;9(4):e95115.

46.

Mycobacterium tuberculosis specific CD8(+) T cells rapidly decline with antituberculosis treatment.

Nyendak MR, Park B, Null MD, Baseke J, Swarbrick G, Mayanja-Kizza H, Nsereko M, Johnson DF, Gitta P, Okwera A, Goldberg S, Bozeman L, Johnson JL, Boom WH, Lewinsohn DA, Lewinsohn DM; Tuberculosis Research Unit and the Tuberculosis Trials Consortium.

PLoS One. 2013 Dec 4;8(12):e81564. doi: 10.1371/journal.pone.0081564. eCollection 2013.

47.

TAP mediates import of Mycobacterium tuberculosis-derived peptides into phagosomes and facilitates loading onto HLA-I.

Harriff MJ, Burgdorf S, Kurts C, Wiertz EJ, Lewinsohn DA, Lewinsohn DM.

PLoS One. 2013 Nov 11;8(11):e79571. doi: 10.1371/journal.pone.0079571. eCollection 2013.

48.

Human Mycobacterium tuberculosis CD8 T Cell Antigens/Epitopes Identified by a Proteomic Peptide Library.

Lewinsohn DM, Swarbrick GM, Cansler ME, Null MD, Rajaraman V, Frieder MM, Sherman DR, McWeeney S, Lewinsohn DA.

PLoS One. 2013 Jun 21;8(6):e67016. doi: 10.1371/journal.pone.0067016. Print 2013.

49.

Lipoproteins are major targets of the polyclonal human T cell response to Mycobacterium tuberculosis.

Seshadri C, Turner MT, Lewinsohn DM, Moody DB, Van Rhijn I.

J Immunol. 2013 Jan 1;190(1):278-84. doi: 10.4049/jimmunol.1201667. Epub 2012 Nov 28.

50.

Co-dependents: MR1-restricted MAIT cells and their antimicrobial function.

Gold MC, Lewinsohn DM.

Nat Rev Microbiol. 2013 Jan;11(1):14-9. doi: 10.1038/nrmicro2918. Epub 2012 Nov 26. Review.

PMID:
23178389

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