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Items: 1 to 50 of 52

1.

The evolving research agenda for paediatric tuberculosis infection.

Seddon JA, Whittaker E, Kampmann B, Lewinsohn DA, Osman M, Hesseling AC, Rustomjee R, Amanullah F.

Lancet Infect Dis. 2019 Sep;19(9):e322-e329. doi: 10.1016/S1473-3099(18)30787-4. Epub 2019 Jun 17. Review.

PMID:
31221543
2.

Recognition of CD8+ T-cell epitopes to identify adults with pulmonary tuberculosis.

Lancioni C, Swarbrick GM, Park B, Nyendak M, Nsereko M, Mayanja-Kizza H, Null MD, Cansler ME, Duncan RB, Baseke J, Chervenak K, Malone L, Heaphy EG, Boom WH, Lewinsohn DM, Lewinsohn DA.

Eur Respir J. 2019 May 30;53(5). pii: 1802053. doi: 10.1183/13993003.02053-2018. Print 2019 May. No abstract available.

PMID:
30923183
3.

Moving toward Tuberculosis Elimination. Critical Issues for Research in Diagnostics and Therapeutics for Tuberculosis Infection.

Keshavjee S, Amanullah F, Cattamanchi A, Chaisson R, Dobos KM, Fox GJ, Gendelman HE, Gordon R, Hesseling A, Le Van H, Kampmann B, Kana B, Khuller G, Lewinsohn DM, Lewinsohn DA, Lin PL, Lu LL, Maartens G, Owen A, Protopopova M, Rengarajan J, Rubin E, Salgame P, Schurr E, Seddon JA, Swindells S, Tobin DM, Udwadia Z, Walzl G, Srinivasan S, Rustomjee R, Nahid P.

Am J Respir Crit Care Med. 2019 Mar 1;199(5):564-571. doi: 10.1164/rccm.201806-1053PP. No abstract available.

4.

MR1 displays the microbial metabolome driving selective MR1-restricted T cell receptor usage.

Harriff MJ, McMurtrey C, Froyd CA, Jin H, Cansler M, Null M, Worley A, Meermeier EW, Swarbrick G, Nilsen A, Lewinsohn DA, Hildebrand W, Adams EJ, Lewinsohn DM.

Sci Immunol. 2018 Jul 13;3(25). pii: eaao2556. doi: 10.1126/sciimmunol.aao2556.

PMID:
30006464
5.

Identification and Evaluation of Novel Protective Antigens for the Development of a Candidate Tuberculosis Subunit Vaccine.

Stylianou E, Harrington-Kandt R, Beglov J, Bull N, Pinpathomrat N, Swarbrick GM, Lewinsohn DA, Lewinsohn DM, McShane H.

Infect Immun. 2018 Jun 21;86(7). pii: e00014-18. doi: 10.1128/IAI.00014-18. Print 2018 Jul.

6.

T cell recognition of Mycobacterium tuberculosis peptides presented by HLA-E derived from infected human cells.

McMurtrey C, Harriff MJ, Swarbrick GM, Duncan A, Cansler M, Null M, Bardet W, Jackson KW, Lewinsohn DA, Hildebrand W, Lewinsohn DM.

PLoS One. 2017 Nov 27;12(11):e0188288. doi: 10.1371/journal.pone.0188288. eCollection 2017.

7.

Polyfunctional CD4+ T Cells As Targets for Tuberculosis Vaccination.

Lewinsohn DA, Lewinsohn DM, Scriba TJ.

Front Immunol. 2017 Oct 5;8:1262. doi: 10.3389/fimmu.2017.01262. eCollection 2017. Review.

8.

Comprehensive definition of human immunodominant CD8 antigens in tuberculosis.

Lewinsohn DA, Swarbrick GM, Park B, Cansler ME, Null MD, Toren KG, Baseke J, Zalwango S, Mayanja-Kizza H, Malone LL, Nyendak M, Wu G, Guinn K, McWeeney S, Mori T, Chervenak KA, Sherman DR, Boom WH, Lewinsohn DM.

NPJ Vaccines. 2017;2. pii: 8. doi: 10.1038/s41541-017-0008-6. Epub 2017 Apr 3.

9.

HLA-E Presents Glycopeptides from the Mycobacterium tuberculosis Protein MPT32 to Human CD8+ T cells.

Harriff MJ, Wolfe LM, Swarbrick G, Null M, Cansler ME, Canfield ET, Vogt T, Toren KG, Li W, Jackson M, Lewinsohn DA, Dobos KM, Lewinsohn DM.

Sci Rep. 2017 Jul 4;7(1):4622. doi: 10.1038/s41598-017-04894-0.

10.

Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of Tuberculosis in Adults and Children.

Lewinsohn DM, Leonard MK, LoBue PA, Cohn DL, Daley CL, Desmond E, Keane J, Lewinsohn DA, Loeffler AM, Mazurek GH, O'Brien RJ, Pai M, Richeldi L, Salfinger M, Shinnick TM, Sterling TR, Warshauer DM, Woods GL.

Clin Infect Dis. 2017 Jan 15;64(2):111-115. doi: 10.1093/cid/ciw778.

11.

Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of Tuberculosis in Adults and Children.

Lewinsohn DM, Leonard MK, LoBue PA, Cohn DL, Daley CL, Desmond E, Keane J, Lewinsohn DA, Loeffler AM, Mazurek GH, O'Brien RJ, Pai M, Richeldi L, Salfinger M, Shinnick TM, Sterling TR, Warshauer DM, Woods GL.

Clin Infect Dis. 2017 Jan 15;64(2):e1-e33. doi: 10.1093/cid/ciw694. Epub 2016 Dec 8.

PMID:
27932390
12.

Adenovirally-Induced Polyfunctional T Cells Do Not Necessarily Recognize the Infected Target: Lessons from a Phase I Trial of the AERAS-402 Vaccine.

Nyendak M, Swarbrick GM, Duncan A, Cansler M, Huff EW, Hokey D, Evans T, Barker L, Blatner G, Sadoff J, Douoguih M, Pau MG, Lewinsohn DA, Lewinsohn DM.

Sci Rep. 2016 Nov 2;6:36355. doi: 10.1038/srep36355.

13.

MR1-restricted mucosal-associated invariant T (MAIT) cells respond to mycobacterial vaccination and infection in nonhuman primates.

Greene JM, Dash P, Roy S, McMurtrey C, Awad W, Reed JS, Hammond KB, Abdulhaqq S, Wu HL, Burwitz BJ, Roth BF, Morrow DW, Ford JC, Xu G, Bae JY, Crank H, Legasse AW, Dang TH, Greenaway HY, Kurniawan M, Gold MC, Harriff MJ, Lewinsohn DA, Park BS, Axthelm MK, Stanton JJ, Hansen SG, Picker LJ, Venturi V, Hildebrand W, Thomas PG, Lewinsohn DM, Adams EJ, Sacha JB.

Mucosal Immunol. 2017 May;10(3):802-813. doi: 10.1038/mi.2016.91. Epub 2016 Oct 19.

14.

Direct TLR-2 Costimulation Unmasks the Proinflammatory Potential of Neonatal CD4+ T Cells.

Sinnott BD, Park B, Boer MC, Lewinsohn DA, Lancioni CL.

J Immunol. 2016 Jul 1;197(1):68-77. doi: 10.4049/jimmunol.1501297. Epub 2016 May 18.

15.

High expression of CD26 accurately identifies human bacteria-reactive MR1-restricted MAIT cells.

Sharma PK, Wong EB, Napier RJ, Bishai WR, Ndung'u T, Kasprowicz VO, Lewinsohn DA, Lewinsohn DM, Gold MC.

Immunology. 2015 Jul;145(3):443-53. doi: 10.1111/imm.12461. Epub 2015 Mar 29.

16.

MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage.

Gold MC, McLaren JE, Reistetter JA, Smyk-Pearson S, Ladell K, Swarbrick GM, Yu YY, Hansen TH, Lund O, Nielsen M, Gerritsen B, Kesmir C, Miles JJ, Lewinsohn DA, Price DA, Lewinsohn DM.

J Exp Med. 2014 Jul 28;211(8):1601-10. doi: 10.1084/jem.20140507. Epub 2014 Jul 21.

17.

Childhood tuberculosis in northern Viet Nam: a review of 103 cases.

Blount RJ, Tran B, Jarlsberg LG, Phan H, Thanh Hoang V, Nguyen NV, Lewinsohn DA, Nahid P.

PLoS One. 2014 May 12;9(5):e97267. doi: 10.1371/journal.pone.0097267. eCollection 2014.

18.

Mycobacterium tuberculosis specific CD8(+) T cells rapidly decline with antituberculosis treatment.

Nyendak MR, Park B, Null MD, Baseke J, Swarbrick G, Mayanja-Kizza H, Nsereko M, Johnson DF, Gitta P, Okwera A, Goldberg S, Bozeman L, Johnson JL, Boom WH, Lewinsohn DA, Lewinsohn DM; Tuberculosis Research Unit and the Tuberculosis Trials Consortium.

PLoS One. 2013 Dec 4;8(12):e81564. doi: 10.1371/journal.pone.0081564. eCollection 2013.

19.

TAP mediates import of Mycobacterium tuberculosis-derived peptides into phagosomes and facilitates loading onto HLA-I.

Harriff MJ, Burgdorf S, Kurts C, Wiertz EJ, Lewinsohn DA, Lewinsohn DM.

PLoS One. 2013 Nov 11;8(11):e79571. doi: 10.1371/journal.pone.0079571. eCollection 2013.

20.

Human Mycobacterium tuberculosis CD8 T Cell Antigens/Epitopes Identified by a Proteomic Peptide Library.

Lewinsohn DM, Swarbrick GM, Cansler ME, Null MD, Rajaraman V, Frieder MM, Sherman DR, McWeeney S, Lewinsohn DA.

PLoS One. 2013 Jun 21;8(6):e67016. doi: 10.1371/journal.pone.0067016. Print 2013.

21.

Human thymic MR1-restricted MAIT cells are innate pathogen-reactive effectors that adapt following thymic egress.

Gold MC, Eid T, Smyk-Pearson S, Eberling Y, Swarbrick GM, Langley SM, Streeter PR, Lewinsohn DA, Lewinsohn DM.

Mucosal Immunol. 2013 Jan;6(1):35-44. doi: 10.1038/mi.2012.45. Epub 2012 Jun 13.

22.

CD8+ T cells provide an immunologic signature of tuberculosis in young children.

Lancioni C, Nyendak M, Kiguli S, Zalwango S, Mori T, Mayanja-Kizza H, Balyejusa S, Null M, Baseke J, Mulindwa D, Byrd L, Swarbrick G, Scott C, Johnson DF, Malone L, Mudido-Musoke P, Boom WH, Lewinsohn DM, Lewinsohn DA; Tuberculosis Research Unit.

Am J Respir Crit Care Med. 2012 Jan 15;185(2):206-12. doi: 10.1164/rccm.201107-1355OC. Epub 2011 Oct 27.

23.

Safety and efficacy of CMX001 as salvage therapy for severe adenovirus infections in immunocompromised patients.

Florescu DF, Pergam SA, Neely MN, Qiu F, Johnston C, Way S, Sande J, Lewinsohn DA, Guzman-Cottrill JA, Graham ML, Papanicolaou G, Kurtzberg J, Rigdon J, Painter W, Mommeja-Marin H, Lanier R, Anderson M, van der Horst C.

Biol Blood Marrow Transplant. 2012 May;18(5):731-8. doi: 10.1016/j.bbmt.2011.09.007. Epub 2011 Sep 29.

24.

Views of immunology: effector T cells.

Lewinsohn DA, Gold MC, Lewinsohn DM.

Immunol Rev. 2011 Mar;240(1):25-39. doi: 10.1111/j.1600-065X.2010.00997.x. Review.

PMID:
21349084
25.

Secreted immunodominant Mycobacterium tuberculosis antigens are processed by the cytosolic pathway.

Grotzke JE, Siler AC, Lewinsohn DA, Lewinsohn DM.

J Immunol. 2010 Oct 1;185(7):4336-43. doi: 10.4049/jimmunol.1000801. Epub 2010 Aug 27.

26.

Human mucosal associated invariant T cells detect bacterially infected cells.

Gold MC, Cerri S, Smyk-Pearson S, Cansler ME, Vogt TM, Delepine J, Winata E, Swarbrick GM, Chua WJ, Yu YY, Lantz O, Cook MS, Null MD, Jacoby DB, Harriff MJ, Lewinsohn DA, Hansen TH, Lewinsohn DM.

PLoS Biol. 2010 Jun 29;8(6):e1000407. doi: 10.1371/journal.pbio.1000407.

27.

Loss of naive T cells and repertoire constriction predict poor response to vaccination in old primates.

Cicin-Sain L, Smyk-Pearson S, Currier N, Byrd L, Koudelka C, Robinson T, Swarbrick G, Tackitt S, Legasse A, Fischer M, Nikolich-Zugich D, Park B, Hobbs T, Doane CJ, Mori M, Axthelm MK, Lewinsohn DA, Nikolich-Zugich J.

J Immunol. 2010 Jun 15;184(12):6739-45. doi: 10.4049/jimmunol.0904193. Epub 2010 May 17. Erratum in: J Immunol. 2010 Oct 1;185(7):4509. Smyk-Paerson, Sue [corrected to Smyk-Pearson, Susan]; Axthelm, Michael T [corrected to Axthelm, Michael K].

28.

Interferon-gamma release assays: new diagnostic tests for Mycobacterium tuberculosis infection, and their use in children.

Lewinsohn DA, Lobato MN, Jereb JA.

Curr Opin Pediatr. 2010 Feb;22(1):71-6. doi: 10.1097/MOP.0b013e3283350301. Review.

PMID:
19952926
29.

Embracing interferon-gamma release assays for diagnosis of latent tuberculosis infection.

Lewinsohn DA.

Pediatr Infect Dis J. 2009 Aug;28(8):674-5. doi: 10.1097/INF.0b013e3181ad547d. No abstract available.

PMID:
19593251
30.

The Mycobacterium tuberculosis phagosome is a HLA-I processing competent organelle.

Grotzke JE, Harriff MJ, Siler AC, Nolt D, Delepine J, Lewinsohn DA, Lewinsohn DM.

PLoS Pathog. 2009 Apr;5(4):e1000374. doi: 10.1371/journal.ppat.1000374. Epub 2009 Apr 10.

31.

New diagnostic methods for tuberculosis.

Nyendak MR, Lewinsohn DA, Lewinsohn DM.

Curr Opin Infect Dis. 2009 Apr;22(2):174-82. Review.

32.

Whole blood interferon-gamma responses to mycobacterium tuberculosis antigens in young household contacts of persons with tuberculosis in Uganda.

Lewinsohn DA, Zalwango S, Stein CM, Mayanja-Kizza H, Okwera A, Boom WH, Mugerwa RD, Whalen CC.

PLoS One. 2008;3(10):e3407. doi: 10.1371/journal.pone.0003407. Epub 2008 Oct 15.

33.

Interferon-gamma release assays for diagnosing mycobacterium tuberculosis infection in renal dialysis patients.

Winthrop KL, Nyendak M, Calvet H, Oh P, Lo M, Swarbrick G, Johnson C, Lewinsohn DA, Lewinsohn DM, Mazurek GH.

Clin J Am Soc Nephrol. 2008 Sep;3(5):1357-63. doi: 10.2215/CJN.01010208. Epub 2008 Jun 11.

34.

Human innate Mycobacterium tuberculosis-reactive alphabetaTCR+ thymocytes.

Gold MC, Ehlinger HD, Cook MS, Smyk-Pearson SK, Wille PT, Ungerleider RM, Lewinsohn DA, Lewinsohn DM.

PLoS Pathog. 2008 Feb 8;4(2):e39. doi: 10.1371/journal.ppat.0040039.

35.

Immunologic susceptibility of young children to Mycobacterium tuberculosis.

Lewinsohn DA, Lewinsohn DM.

Pediatr Res. 2008 Feb;63(2):115. doi: 10.1203/PDR.0b013e3181652085. No abstract available.

PMID:
18209663
36.

Human neonatal dendritic cells are competent in MHC class I antigen processing and presentation.

Gold MC, Robinson TL, Cook MS, Byrd LK, Ehlinger HD, Lewinsohn DM, Lewinsohn DA.

PLoS One. 2007 Sep 26;2(9):e957.

37.

Immunodominant tuberculosis CD8 antigens preferentially restricted by HLA-B.

Lewinsohn DA, Winata E, Swarbrick GM, Tanner KE, Cook MS, Null MD, Cansler ME, Sette A, Sidney J, Lewinsohn DM.

PLoS Pathog. 2007 Sep 21;3(9):1240-9.

38.

High resolution radiographic and fine immunologic definition of TB disease progression in the rhesus macaque.

Lewinsohn DM, Tydeman IS, Frieder M, Grotzke JE, Lines RA, Ahmed S, Prongay KD, Primack SL, Colgin LM, Lewis AD, Lewinsohn DA.

Microbes Infect. 2006 Sep;8(11):2587-98. Epub 2006 Aug 14.

PMID:
16952476
39.

Purified neonatal plasmacytoid dendritic cells overcome intrinsic maturation defect with TLR agonist stimulation.

Gold MC, Donnelly E, Cook MS, Leclair CM, Lewinsohn DA.

Pediatr Res. 2006 Jul;60(1):34-7. Epub 2006 May 11.

40.

Tuberculosis immunology in children: diagnostic and therapeutic challenges and opportunities.

Lewinsohn DA, Gennaro ML, Scholvinck L, Lewinsohn DM.

Int J Tuberc Lung Dis. 2004 May;8(5):658-74. Review.

PMID:
15137550
41.

TB vaccines at the turn of the century: insights into immunity to M. tuberculosis and modern approaches for prevention of an ancient disease.

Lewinsohn DM, Lewinsohn DA, Grotzke JE.

Semin Respir Infect. 2003 Dec;18(4):320-38. Review.

PMID:
14679479
42.

Mycobacterium tuberculosis-specific CD8+ T cells preferentially recognize heavily infected cells.

Lewinsohn DA, Heinzel AS, Gardner JM, Zhu L, Alderson MR, Lewinsohn DM.

Am J Respir Crit Care Med. 2003 Dec 1;168(11):1346-52. Epub 2003 Sep 11.

PMID:
12969871
43.

HLA-E-dependent presentation of Mtb-derived antigen to human CD8+ T cells.

Heinzel AS, Grotzke JE, Lines RA, Lewinsohn DA, McNabb AL, Streblow DN, Braud VM, Grieser HJ, Belisle JT, Lewinsohn DM.

J Exp Med. 2002 Dec 2;196(11):1473-81.

44.

Human dendritic cells presenting adenovirally expressed antigen elicit Mycobacterium tuberculosis--specific CD8+ T cells.

Lewinsohn DA, Lines RA, Lewinsohn DM.

Am J Respir Crit Care Med. 2002 Sep 15;166(6):843-8.

PMID:
12231495
45.

HIV-1 Vpr does not inhibit CTL-mediated apoptosis of HIV-1 infected cells.

Lewinsohn DA, Lines R, Lewinsohn DM, Riddell SR, Greenberg PD, Emerman M, Bartz SR.

Virology. 2002 Mar 1;294(1):13-21.

46.

Rudimentary TCR signaling triggers default IL-10 secretion by human Th1 cells.

Burrows GG, Chou YK, Wang C, Chang JW, Finn TP, Culbertson NE, Kim J, Bourdette DN, Lewinsohn DA, Lewinsohn DM, Ikeda M, Yoshioka T, Allen CN, Offner H, Vandenbark AA.

J Immunol. 2001 Oct 15;167(8):4386-95.

47.
48.

HIV-specific cytotoxic T lymphocytes traffic to lymph nodes and localize at sites of HIV replication and cell death.

Brodie SJ, Patterson BK, Lewinsohn DA, Diem K, Spach D, Greenberg PD, Riddell SR, Corey L.

J Clin Invest. 2000 May;105(10):1407-17. Retraction in: J Clin Invest. 2010 Sep;120(9):3401.

49.

The antiviral activity of HIV-specific CD8+ CTL clones is limited by elimination due to encounter with HIV-infected targets.

McKinney DM, Lewinsohn DA, Riddell SR, Greenberg PD, Mosier DE.

J Immunol. 1999 Jul 15;163(2):861-7.

50.

In vivo migration and function of transferred HIV-1-specific cytotoxic T cells.

Brodie SJ, Lewinsohn DA, Patterson BK, Jiyamapa D, Krieger J, Corey L, Greenberg PD, Riddell SR.

Nat Med. 1999 Jan;5(1):34-41.

PMID:
9883837

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