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Items: 1 to 50 of 137

1.

The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice.

Murthy SE, Loud MC, Daou I, Marshall KL, Schwaller F, Kühnemund J, Francisco AG, Keenan WT, Dubin AE, Lewin GR, Patapoutian A.

Sci Transl Med. 2018 Oct 10;10(462). pii: eaat9897. doi: 10.1126/scitranslmed.aat9897.

PMID:
30305457
2.

Specialized mechanoreceptor systems in rodent glabrous skin.

Walcher J, Ojeda-Alonso J, Haseleu J, Oosthuizen MK, Rowe AH, Bennett NC, Lewin GR.

J Physiol. 2018 Oct;596(20):4995-5016. doi: 10.1113/JP276608. Epub 2018 Sep 15.

PMID:
30132906
3.

Maf links Neuregulin1 signaling to cholesterol synthesis in myelinating Schwann cells.

Kim M, Wende H, Walcher J, Kühnemund J, Cheret C, Kempa S, McShane E, Selbach M, Lewin GR, Birchmeier C.

Genes Dev. 2018 May 1;32(9-10):645-657. doi: 10.1101/gad.310490.117. Epub 2018 May 10. Erratum in: Genes Dev. 2018 Aug 1;32(15-16):1101.

4.

The neural circuits of thermal perception.

Bokiniec P, Zampieri N, Lewin GR, Poulet JF.

Curr Opin Neurobiol. 2018 Oct;52:98-106. doi: 10.1016/j.conb.2018.04.006. Epub 2018 May 15. Review.

5.

Voltage gating of mechanosensitive PIEZO channels.

Moroni M, Servin-Vences MR, Fleischer R, Sánchez-Carranza O, Lewin GR.

Nat Commun. 2018 Mar 15;9(1):1096. doi: 10.1038/s41467-018-03502-7.

6.

The Absence of Sensory Axon Bifurcation Affects Nociception and Termination Fields of Afferents in the Spinal Cord.

Tröster P, Haseleu J, Petersen J, Drees O, Schmidtko A, Schwaller F, Lewin GR, Ter-Avetisyan G, Winter Y, Peters S, Feil S, Feil R, Rathjen FG, Schmidt H.

Front Mol Neurosci. 2018 Feb 8;11:19. doi: 10.3389/fnmol.2018.00019. eCollection 2018.

7.

Immune or Genetic-Mediated Disruption of CASPR2 Causes Pain Hypersensitivity Due to Enhanced Primary Afferent Excitability.

Dawes JM, Weir GA, Middleton SJ, Patel R, Chisholm KI, Pettingill P, Peck LJ, Sheridan J, Shakir A, Jacobson L, Gutierrez-Mecinas M, Galino J, Walcher J, Kühnemund J, Kuehn H, Sanna MD, Lang B, Clark AJ, Themistocleous AC, Iwagaki N, West SJ, Werynska K, Carroll L, Trendafilova T, Menassa DA, Giannoccaro MP, Coutinho E, Cervellini I, Tewari D, Buckley C, Leite MI, Wildner H, Zeilhofer HU, Peles E, Todd AJ, McMahon SB, Dickenson AH, Lewin GR, Vincent A, Bennett DL.

Neuron. 2018 Feb 21;97(4):806-822.e10. doi: 10.1016/j.neuron.2018.01.033. Epub 2018 Feb 8.

8.

Mechanoelectrical transduction in chondrocytes.

Servin-Vences MR, Richardson J, Lewin GR, Poole K.

Clin Exp Pharmacol Physiol. 2018 May;45(5):481-488. doi: 10.1111/1440-1681.12917. Epub 2018 Feb 19.

PMID:
29359488
9.

Congenital deafness is associated with specific somatosensory deficits in adolescents.

Moshourab R, Bégay V, Wetzel C, Walcher J, Middleton S, Gross M, Lewin GR.

Sci Rep. 2017 Jun 26;7(1):4251. doi: 10.1038/s41598-017-04074-0.

10.

Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat.

Park TJ, Reznick J, Peterson BL, Blass G, Omerbašić D, Bennett NC, Kuich PHJL, Zasada C, Browe BM, Hamann W, Applegate DT, Radke MH, Kosten T, Lutermann H, Gavaghan V, Eigenbrod O, Bégay V, Amoroso VG, Govind V, Minshall RD, Smith ESJ, Larson J, Gotthardt M, Kempa S, Lewin GR.

Science. 2017 Apr 21;356(6335):307-311. doi: 10.1126/science.aab3896.

PMID:
28428423
11.

Genetic Tracing of Cav3.2 T-Type Calcium Channel Expression in the Peripheral Nervous System.

Bernal Sierra YA, Haseleu J, Kozlenkov A, Bégay V, Lewin GR.

Front Mol Neurosci. 2017 Mar 15;10:70. doi: 10.3389/fnmol.2017.00070. eCollection 2017.

12.

Direct measurement of TRPV4 and PIEZO1 activity reveals multiple mechanotransduction pathways in chondrocytes.

Servin-Vences MR, Moroni M, Lewin GR, Poole K.

Elife. 2017 Jan 30;6. pii: e21074. doi: 10.7554/eLife.21074.

13.

Lipidome determinants of maximal lifespan in mammals.

Bozek K, Khrameeva EE, Reznick J, Omerbašić D, Bennett NC, Lewin GR, Azpurua J, Gorbunova V, Seluanov A, Regnard P, Wanert F, Marchal J, Pifferi F, Aujard F, Liu Z, Shi P, Pääbo S, Schroeder F, Willmitzer L, Giavalisco P, Khaitovich P.

Sci Rep. 2017 Jan 31;7(1):5. doi: 10.1038/s41598-017-00037-7.

14.

Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity.

Wetzel C, Pifferi S, Picci C, Gök C, Hoffmann D, Bali KK, Lampe A, Lapatsina L, Fleischer R, Smith ES, Bégay V, Moroni M, Estebanez L, Kühnemund J, Walcher J, Specker E, Neuenschwander M, von Kries JP, Haucke V, Kuner R, Poulet JF, Schmoranzer J, Poole K, Lewin GR.

Nat Neurosci. 2017 Feb;20(2):209-218. doi: 10.1038/nn.4454. Epub 2016 Dec 12.

PMID:
27941788
15.

Fxyd2 regulates Aδ- and C-fiber mechanosensitivity and is required for the maintenance of neuropathic pain.

Ventéo S, Laffray S, Wetzel C, Rivat C, Scamps F, Méchaly I, Bauchet L, Raoul C, Bourinet E, Lewin GR, Carroll P, Pattyn A.

Sci Rep. 2016 Nov 2;6:36407. doi: 10.1038/srep36407.

16.

Hypofunctional TrkA Accounts for the Absence of Pain Sensitization in the African Naked Mole-Rat.

Omerbašić D, Smith ES, Moroni M, Homfeld J, Eigenbrod O, Bennett NC, Reznick J, Faulkes CG, Selbach M, Lewin GR.

Cell Rep. 2016 Oct 11;17(3):748-758. doi: 10.1016/j.celrep.2016.09.035.

17.

Measurement of Vibration Detection Threshold and Tactile Spatial Acuity in Human Subjects.

Moshourab R, Frenzel H, Lechner S, Haseleu J, Bégay V, Omerbašić D, Lewin GR.

J Vis Exp. 2016 Sep 1;(115). doi: 10.3791/52966.

18.

Evolution and Ecology of Actinobacteria and Their Bioenergy Applications.

Lewin GR, Carlos C, Chevrette MG, Horn HA, McDonald BR, Stankey RJ, Fox BG, Currie CR.

Annu Rev Microbiol. 2016 Sep 8;70:235-54. doi: 10.1146/annurev-micro-102215-095748. Review.

19.

A Molecular Signature of Myalgia in Myotonic Dystrophy 2.

Moshourab R, Palada V, Grunwald S, Grieben U, Lewin GR, Spuler S.

EBioMedicine. 2016 May;7:205-11. doi: 10.1016/j.ebiom.2016.03.017. Epub 2016 Mar 14.

20.

Evolution of High Cellulolytic Activity in Symbiotic Streptomyces through Selection of Expanded Gene Content and Coordinated Gene Expression.

Book AJ, Lewin GR, McDonald BR, Takasuka TE, Wendt-Pienkowski E, Doering DT, Suh S, Raffa KF, Fox BG, Currie CR.

PLoS Biol. 2016 Jun 8;14(6):e1002475. doi: 10.1371/journal.pbio.1002475. eCollection 2016 Jun.

21.

Cellulose-Enriched Microbial Communities from Leaf-Cutter Ant (Atta colombica) Refuse Dumps Vary in Taxonomic Composition and Degradation Ability.

Lewin GR, Johnson AL, Soto RD, Perry K, Book AJ, Horn HA, Pinto-Tomás AA, Currie CR.

PLoS One. 2016 Mar 21;11(3):e0151840. doi: 10.1371/journal.pone.0151840. eCollection 2016.

22.

A Probabilistic Model for Estimating the Depth and Threshold Temperature of C-fiber Nociceptors.

Dezhdar T, Moshourab RA, Fründ I, Lewin GR, Schmuker M.

Sci Rep. 2015 Dec 7;5:17670. doi: 10.1038/srep17670.

23.

Photoswitchable fatty acids enable optical control of TRPV1.

Frank JA, Moroni M, Moshourab R, Sumser M, Lewin GR, Trauner D.

Nat Commun. 2015 May 22;6:7118. doi: 10.1038/ncomms8118.

24.

GABA blocks pathological but not acute TRPV1 pain signals.

Hanack C, Moroni M, Lima WC, Wende H, Kirchner M, Adelfinger L, Schrenk-Siemens K, Tappe-Theodor A, Wetzel C, Kuich PH, Gassmann M, Roggenkamp D, Bettler B, Lewin GR, Selbach M, Siemens J.

Cell. 2015 Feb 12;160(4):759-770. doi: 10.1016/j.cell.2015.01.022.

25.

ASICs and mammalian mechanoreceptor function.

Omerbašić D, Schuhmacher LN, Bernal Sierra YA, Smith ES, Lewin GR.

Neuropharmacology. 2015 Jul;94:80-6. doi: 10.1016/j.neuropharm.2014.12.007. Epub 2014 Dec 18. Review.

26.

Piezo2 is the major transducer of mechanical forces for touch sensation in mice.

Ranade SS, Woo SH, Dubin AE, Moshourab RA, Wetzel C, Petrus M, Mathur J, Bégay V, Coste B, Mainquist J, Wilson AJ, Francisco AG, Reddy K, Qiu Z, Wood JN, Lewin GR, Patapoutian A.

Nature. 2014 Dec 4;516(7529):121-5. doi: 10.1038/nature13980.

27.

PIEZO2 is required for mechanotransduction in human stem cell-derived touch receptors.

Schrenk-Siemens K, Wende H, Prato V, Song K, Rostock C, Loewer A, Utikal J, Lewin GR, Lechner SG, Siemens J.

Nat Neurosci. 2015 Jan;18(1):10-6. doi: 10.1038/nn.3894. Epub 2014 Dec 3.

PMID:
25469543
28.

A somatosensory circuit for cooling perception in mice.

Milenkovic N, Zhao WJ, Walcher J, Albert T, Siemens J, Lewin GR, Poulet JF.

Nat Neurosci. 2014 Nov;17(11):1560-6. doi: 10.1038/nn.3828. Epub 2014 Sep 28.

PMID:
25262494
29.

Sensory mechanotransduction at membrane-matrix interfaces.

Poole K, Moroni M, Lewin GR.

Pflugers Arch. 2015 Jan;467(1):121-32. doi: 10.1007/s00424-014-1563-6. Epub 2014 Jul 2. Review.

30.

Neurotrophic factors. Preface.

Lewin GR, Carter BD.

Handb Exp Pharmacol. 2014;220:v-vi. No abstract available.

PMID:
24941498
31.

Cellulolytic Streptomyces strains associated with herbivorous insects share a phylogenetically linked capacity to degrade lignocellulose.

Book AJ, Lewin GR, McDonald BR, Takasuka TE, Doering DT, Adams AS, Blodgett JA, Clardy J, Raffa KF, Fox BG, Currie CR.

Appl Environ Microbiol. 2014 Aug;80(15):4692-701.

32.

Nerve growth factor and nociception: from experimental embryology to new analgesic therapy.

Lewin GR, Lechner SG, Smith ES.

Handb Exp Pharmacol. 2014;220:251-82. doi: 10.1007/978-3-642-45106-5_10. Review.

PMID:
24668476
33.

Inhibition of c-Kit signaling is associated with reduced heat and cold pain sensitivity in humans.

Ceko M, Milenkovic N, le Coutre P, Westermann J, Lewin GR.

Pain. 2014 Jul;155(7):1222-8. doi: 10.1016/j.pain.2014.03.010. Epub 2014 Mar 21.

34.

Tuning Piezo ion channels to detect molecular-scale movements relevant for fine touch.

Poole K, Herget R, Lapatsina L, Ngo HD, Lewin GR.

Nat Commun. 2014 Mar 24;5:3520. doi: 10.1038/ncomms4520.

35.

Pro-neurotrophins, sortilin, and nociception.

Lewin GR, Nykjaer A.

Eur J Neurosci. 2014 Feb;39(3):363-74. doi: 10.1111/ejn.12466. Review.

36.

Activation of MAPK overrides the termination of myelin growth and replaces Nrg1/ErbB3 signals during Schwann cell development and myelination.

Sheean ME, McShane E, Cheret C, Walcher J, Müller T, Wulf-Goldenberg A, Hoelper S, Garratt AN, Krüger M, Rajewsky K, Meijer D, Birchmeier W, Lewin GR, Selbach M, Birchmeier C.

Genes Dev. 2014 Feb 1;28(3):290-303. doi: 10.1101/gad.230045.113.

37.

Water-induced finger wrinkles do not affect touch acuity or dexterity in handling wet objects.

Haseleu J, Omerbašić D, Frenzel H, Gross M, Lewin GR.

PLoS One. 2014 Jan 8;9(1):e84949. doi: 10.1371/journal.pone.0084949. eCollection 2014.

38.

Subunit-specific inhibition of acid sensing ion channels by stomatin-like protein 1.

Kozlenkov A, Lapatsina L, Lewin GR, Smith ES.

J Physiol. 2014 Feb 15;592(4):557-69. doi: 10.1113/jphysiol.2013.258657. Epub 2013 Nov 18.

39.

Evolution. Natural selection and pain meet at a sodium channel.

Lewin GR.

Science. 2013 Oct 25;342(6157):428-9. doi: 10.1126/science.1244375. No abstract available.

PMID:
24159033
40.

Stomatin-domain protein interactions with acid-sensing ion channels modulate nociceptor mechanosensitivity.

Moshourab RA, Wetzel C, Martinez-Salgado C, Lewin GR.

J Physiol. 2013 Nov 15;591(22):5555-74. doi: 10.1113/jphysiol.2013.261180. Epub 2013 Aug 19.

41.

Hairy sensation.

Lechner SG, Lewin GR.

Physiology (Bethesda). 2013 May;28(3):142-50. doi: 10.1152/physiol.00059.2012. Review.

42.

Aerobic deconstruction of cellulosic biomass by an insect-associated Streptomyces.

Takasuka TE, Book AJ, Lewin GR, Currie CR, Fox BG.

Sci Rep. 2013;3:1030. doi: 10.1038/srep01030. Epub 2013 Jan 7.

43.

A stomatin dimer modulates the activity of acid-sensing ion channels.

Brand J, Smith ES, Schwefel D, Lapatsina L, Poole K, Omerbašić D, Kozlenkov A, Behlke J, Lewin GR, Daumke O.

EMBO J. 2012 Aug 29;31(17):3635-46. doi: 10.1038/emboj.2012.203. Epub 2012 Jul 31.

44.

Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1.

Stock K, Kumar J, Synowitz M, Petrosino S, Imperatore R, Smith ES, Wend P, Purfürst B, Nuber UA, Gurok U, Matyash V, Wälzlein JH, Chirasani SR, Dittmar G, Cravatt BF, Momma S, Lewin GR, Ligresti A, De Petrocellis L, Cristino L, Di Marzo V, Kettenmann H, Glass R.

Nat Med. 2012 Aug;18(8):1232-8. doi: 10.1038/nm.2827. Epub 2012 Jul 22.

45.

Regulation of ASIC channels by a stomatin/STOML3 complex located in a mobile vesicle pool in sensory neurons.

Lapatsina L, Jira JA, Smith ES, Poole K, Kozlenkov A, Bilbao D, Lewin GR, Heppenstall PA.

Open Biol. 2012 Jun;2(6):120096. doi: 10.1098/rsob.120096.

46.

A genetic basis for mechanosensory traits in humans.

Frenzel H, Bohlender J, Pinsker K, Wohlleben B, Tank J, Lechner SG, Schiska D, Jaijo T, Rüschendorf F, Saar K, Jordan J, Millán JM, Gross M, Lewin GR.

PLoS Biol. 2012;10(5):e1001318. doi: 10.1371/journal.pbio.1001318. Epub 2012 May 1.

47.

Specific paucity of unmyelinated C-fibers in cutaneous peripheral nerves of the African naked-mole rat: comparative analysis using six species of Bathyergidae.

St John Smith E, Purfürst B, Grigoryan T, Park TJ, Bennett NC, Lewin GR.

J Comp Neurol. 2012 Aug 15;520(12):2785-803. doi: 10.1002/cne.23133.

48.

The transcription factor c-Maf controls touch receptor development and function.

Wende H, Lechner SG, Cheret C, Bourane S, Kolanczyk ME, Pattyn A, Reuter K, Munier FL, Carroll P, Lewin GR, Birchmeier C.

Science. 2012 Mar 16;335(6074):1373-6. doi: 10.1126/science.1214314. Epub 2012 Feb 16.

49.

The molecular basis of acid insensitivity in the African naked mole-rat.

Smith ES, Omerbašić D, Lechner SG, Anirudhan G, Lapatsina L, Lewin GR.

Science. 2011 Dec 16;334(6062):1557-60. doi: 10.1126/science.1213760.

50.

KCNQ4 K(+) channels tune mechanoreceptors for normal touch sensation in mouse and man.

Heidenreich M, Lechner SG, Vardanyan V, Wetzel C, Cremers CW, De Leenheer EM, Aránguez G, Moreno-Pelayo MÁ, Jentsch TJ, Lewin GR.

Nat Neurosci. 2011 Nov 20;15(1):138-45. doi: 10.1038/nn.2985.

PMID:
22101641

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