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Items: 1 to 50 of 56

1.

Admission diagnoses of patients later diagnosed with autoimmune encephalitis.

Baumgartner A, Rauer S, Hottenrott T, Leypoldt F, Ufer F, Hegen H, Prüss H, Lewerenz J, Deisenhammer F, Stich O.

J Neurol. 2018 Nov 12. doi: 10.1007/s00415-018-9105-3. [Epub ahead of print]

PMID:
30421340
2.

Oxytosis/Ferroptosis-(Re-) Emerging Roles for Oxidative Stress-Dependent Non-apoptotic Cell Death in Diseases of the Central Nervous System.

Lewerenz J, Ates G, Methner A, Conrad M, Maher P.

Front Neurosci. 2018 Apr 20;12:214. doi: 10.3389/fnins.2018.00214. eCollection 2018. Review.

3.

Genetic predisposition in anti-LGI1 and anti-NMDA receptor encephalitis.

Mueller SH, Färber A, Prüss H, Melzer N, Golombeck KS, Kümpfel T, Thaler F, Elisak M, Lewerenz J, Kaufmann M, Sühs KW, Ringelstein M, Kellinghaus C, Bien CG, Kraft A, Zettl UK, Ehrlich S, Handreka R, Rostásy K, Then Bergh F, Faiss JH, Lieb W, Franke A, Kuhlenbäumer G, Wandinger KP, Leypoldt F; German Network for Research on Autoimmune Encephalitis (GENERATE).

Ann Neurol. 2018 Apr;83(4):863-869. doi: 10.1002/ana.25216.

PMID:
29572931
4.

Bevacizumab in temozolomide refractory high-grade gliomas: single-centre experience and review of the literature.

Jeck J, Kassubek R, Coburger J, Edenhofer S, Schönsteiner SS, Ludolph AC, Schmitz B, Engelke J, Mayer-Steinacker R, Lewerenz J, Bullinger L.

Ther Adv Neurol Disord. 2018 Jan 21;11:1756285617753597. doi: 10.1177/1756285617753597. eCollection 2018.

5.

Bcl-xL knockout attenuates mitochondrial respiration and causes oxidative stress that is compensated by pentose phosphate pathway activity.

Pfeiffer A, Schneider J, Bueno D, Dolga A, Voss TD, Lewerenz J, Wüllner V, Methner A.

Free Radic Biol Med. 2017 Nov;112:350-359. doi: 10.1016/j.freeradbiomed.2017.08.007. Epub 2017 Aug 12.

PMID:
28807815
6.

Electroencephalographic findings in patients with circumscribed thalamic lesions.

Tsoures E, Lewerenz J, Pinkhardt E, Ludolph AC, Fauser S.

Epilepsy Res. 2017 Sep;135:115-122. doi: 10.1016/j.eplepsyres.2017.06.009. Epub 2017 Jun 15.

PMID:
28666153
7.

Clinical manifestations of the anti-IgLON5 disease.

Gaig C, Graus F, Compta Y, Högl B, Bataller L, Brüggemann N, Giordana C, Heidbreder A, Kotschet K, Lewerenz J, Macher S, Martí MJ, Montojo T, Pérez-Pérez J, Puertas I, Seitz C, Simabukuro M, Téllez N, Wandinger KP, Iranzo A, Ercilla G, Sabater L, Santamaría J, Dalmau J.

Neurology. 2017 May 2;88(18):1736-1743. doi: 10.1212/WNL.0000000000003887. Epub 2017 Apr 5.

8.

Identifying ischemic stroke associated with cancer: a multiple model derived from a case-control analysis.

Kassubek R, Bullinger L, Kassubek J, Dreyhaupt J, Ludolph AC, Althaus K, Lewerenz J.

J Neurol. 2017 Apr;264(4):781-791. doi: 10.1007/s00415-017-8432-0. Epub 2017 Feb 28.

PMID:
28247043
9.

Absence of system xc- on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis.

Merckx E, Albertini G, Paterka M, Jensen C, Albrecht P, Dietrich M, Van Liefferinge J, Bentea E, Verbruggen L, Demuyser T, Deneyer L, Lewerenz J, van Loo G, De Keyser J, Sato H, Maher P, Methner A, Massie A.

J Neuroinflammation. 2017 Jan 13;14(1):9. doi: 10.1186/s12974-016-0787-0.

10.

Zonisamide attenuates lactacystin-induced parkinsonism in mice without affecting system xc<sup/>.

Bentea E, Van Liefferinge J, Verbruggen L, Martens K, Kobayashi S, Deneyer L, Demuyser T, Albertini G, Maes K, Sato H, Smolders I, Lewerenz J, Massie A.

Exp Neurol. 2017 Apr;290:15-28. doi: 10.1016/j.expneurol.2016.12.009. Epub 2016 Dec 24.

PMID:
28024798
11.

[Autoantibody-associated autoimmune encephalitis and cerebellitis : Clinical presentation, diagnostic work-up and treatment].

Lewerenz J, Jarius S, Wildemann B, Wandinger KP, Leypoldt F.

Nervenarzt. 2016 Dec;87(12):1293-1299. Review. German.

PMID:
27847964
12.

Decreased IL-8 levels in CSF and serum of AD patients and negative correlation of MMSE and IL-1β.

Hesse R, Wahler A, Gummert P, Kirschmer S, Otto M, Tumani H, Lewerenz J, Schnack C, von Arnim CA.

BMC Neurol. 2016 Sep 26;16(1):185.

13.

Chronic Glutamate Toxicity in Neurodegenerative Diseases-What is the Evidence?

Lewerenz J, Maher P.

Front Neurosci. 2015 Dec 16;9:469. doi: 10.3389/fnins.2015.00469. eCollection 2015. Review.

14.

Long latency between GAD-antibody detection and development of limbic encephalitis--a case report.

Fauser S, Uttner I, Ariño H, Scherbaum WA, Saiz A, Lewerenz J.

BMC Neurol. 2015 Sep 30;15:177. doi: 10.1186/s12883-015-0435-9.

15.

Main path and byways: non-vesicular glutamate release by system xc(-) as an important modifier of glutamatergic neurotransmission.

Massie A, Boillée S, Hewett S, Knackstedt L, Lewerenz J.

J Neurochem. 2015 Dec;135(6):1062-79. doi: 10.1111/jnc.13348. Epub 2015 Sep 29. Review.

16.

Supratentorial white matter blurring associated with voltage-gated potassium channel-complex limbic encephalitis.

Urbach H, Rauer S, Mader I, Paus S, Wagner J, Malter MP, Prüss H, Lewerenz J, Kassubek J, Hegen H, Auer M, Deisenhammer F, Ufer F, Bien CG, Baumgartner A.

Neuroradiology. 2015 Dec;57(12):1203-9. doi: 10.1007/s00234-015-1581-x. Epub 2015 Aug 21.

PMID:
26293130
17.

Periventricular white matter lesion and incomplete MRZ reaction in a male patient with anti-N-methyl-D-aspartate receptor encephalitis presenting with dysphoric mania.

Gahr M, Lauda F, Wigand ME, Connemann BJ, Rosenbohm A, Tumani H, Reindl M, Uzelac Z, Lewerenz J.

BMJ Case Rep. 2015 Apr 26;2015. pii: bcr2014209075. doi: 10.1136/bcr-2014-209075.

18.

Internalized capillaries in skeletal muscle biopsy.

Hawlik A, Wassner A, Ludolph AC, Lewerenz J, Rosenbohm A.

Neuromuscul Disord. 2015 Jan;25(1):94-5. doi: 10.1016/j.nmd.2014.08.005. Epub 2014 Sep 10. No abstract available.

PMID:
25307855
19.

A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing disorder associated with antibodies to IgLON5: a case series, characterisation of the antigen, and post-mortem study.

Sabater L, Gaig C, Gelpi E, Bataller L, Lewerenz J, Torres-Vega E, Contreras A, Giometto B, Compta Y, Embid C, Vilaseca I, Iranzo A, Santamaría J, Dalmau J, Graus F.

Lancet Neurol. 2014 Jun;13(6):575-86. doi: 10.1016/S1474-4422(14)70051-1. Epub 2014 Apr 3. Erratum in: Lancet Neurol. 2015 Jan;14(1):28.

20.

Mitochondrial function and energy metabolism in neuronal HT22 cells resistant to oxidative stress.

Pfeiffer A, Jaeckel M, Lewerenz J, Noack R, Pouya A, Schacht T, Hoffmann C, Winter J, Schweiger S, Schäfer MK, Methner A.

Br J Pharmacol. 2014 Apr;171(8):2147-58. doi: 10.1111/bph.12549.

21.

Phosphoinositide 3-kinases upregulate system xc(-) via eukaryotic initiation factor 2α and activating transcription factor 4 - A pathway active in glioblastomas and epilepsy.

Lewerenz J, Baxter P, Kassubek R, Albrecht P, Van Liefferinge J, Westhoff MA, Halatsch ME, Karpel-Massler G, Meakin PJ, Hayes JD, Aronica E, Smolders I, Ludolph AC, Methner A, Conrad M, Massie A, Hardingham GE, Maher P.

Antioxid Redox Signal. 2014 Jun 20;20(18):2907-22. doi: 10.1089/ars.2013.5455. Epub 2014 Feb 6.

22.

Fumaric acid esters stimulate astrocytic VEGF expression through HIF-1α and Nrf2.

Wiesner D, Merdian I, Lewerenz J, Ludolph AC, Dupuis L, Witting A.

PLoS One. 2013 Oct 3;8(10):e76670. doi: 10.1371/journal.pone.0076670. eCollection 2013.

23.

[Current cerebrospinal fluid diagnostics for pathogen-related diseases].

Süssmuth SD, Brettschneider J, Spreer A, Wick M, Jesse S, Lewerenz J, Otto M, Tumani H.

Nervenarzt. 2013 Feb;84(2):229-44. doi: 10.1007/s00115-012-3701-8. Review. German.

PMID:
23371378
24.

Extracellular cyclic GMP and its derivatives GMP and guanosine protect from oxidative glutamate toxicity.

Albrecht P, Henke N, Tien ML, Issberner A, Bouchachia I, Maher P, Lewerenz J, Methner A.

Neurochem Int. 2013 Apr;62(5):610-9. doi: 10.1016/j.neuint.2013.01.019. Epub 2013 Jan 26.

PMID:
23357478
25.

The plasma membrane channel ORAI1 mediates detrimental calcium influx caused by endogenous oxidative stress.

Henke N, Albrecht P, Bouchachia I, Ryazantseva M, Knoll K, Lewerenz J, Kaznacheyeva E, Maher P, Methner A.

Cell Death Dis. 2013 Jan 24;4:e470. doi: 10.1038/cddis.2012.216.

26.

Effects of dimethyl fumarate on neuroprotection and immunomodulation.

Albrecht P, Bouchachia I, Goebels N, Henke N, Hofstetter HH, Issberner A, Kovacs Z, Lewerenz J, Lisak D, Maher P, Mausberg AK, Quasthoff K, Zimmermann C, Hartung HP, Methner A.

J Neuroinflammation. 2012 Jul 7;9:163. doi: 10.1186/1742-2094-9-163.

27.

The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities.

Lewerenz J, Hewett SJ, Huang Y, Lambros M, Gout PW, Kalivas PW, Massie A, Smolders I, Methner A, Pergande M, Smith SB, Ganapathy V, Maher P.

Antioxid Redox Signal. 2013 Feb 10;18(5):522-55. doi: 10.1089/ars.2011.4391. Epub 2012 Aug 3. Review.

28.

Fluorodeoxyglucose positron emission tomography in anti-N-methyl-D-aspartate receptor encephalitis: distinct pattern of disease.

Leypoldt F, Buchert R, Kleiter I, Marienhagen J, Gelderblom M, Magnus T, Dalmau J, Gerloff C, Lewerenz J.

J Neurol Neurosurg Psychiatry. 2012 Jul;83(7):681-6. doi: 10.1136/jnnp-2011-301969. Epub 2012 May 7.

29.

The flavonoid fisetin attenuates postischemic immune cell infiltration, activation and infarct size after transient cerebral middle artery occlusion in mice.

Gelderblom M, Leypoldt F, Lewerenz J, Birkenmayer G, Orozco D, Ludewig P, Thundyil J, Arumugam TV, Gerloff C, Tolosa E, Maher P, Magnus T.

J Cereb Blood Flow Metab. 2012 May;32(5):835-43. doi: 10.1038/jcbfm.2011.189. Epub 2012 Jan 11.

30.

Mutation of ATF4 mediates resistance of neuronal cell lines against oxidative stress by inducing xCT expression.

Lewerenz J, Sato H, Albrecht P, Henke N, Noack R, Methner A, Maher P.

Cell Death Differ. 2012 May;19(5):847-58. doi: 10.1038/cdd.2011.165. Epub 2011 Nov 18.

31.

Charcot-Marie-Tooth disease CMT4A: GDAP1 increases cellular glutathione and the mitochondrial membrane potential.

Noack R, Frede S, Albrecht P, Henke N, Pfeiffer A, Knoll K, Dehmel T, Meyer Zu Hörste G, Stettner M, Kieseier BC, Summer H, Golz S, Kochanski A, Wiedau-Pazos M, Arnold S, Lewerenz J, Methner A.

Hum Mol Genet. 2012 Jan 1;21(1):150-62. doi: 10.1093/hmg/ddr450. Epub 2011 Sep 28.

PMID:
21965300
32.

Regulation of xCT expression and system x (c) (-) function in neuronal cells.

Lewerenz J, Maher P, Methner A.

Amino Acids. 2012 Jan;42(1):171-9. doi: 10.1007/s00726-011-0862-x. Epub 2011 Mar 3. Review.

PMID:
21369940
33.

p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects.

Bartlett BJ, Isakson P, Lewerenz J, Sanchez H, Kotzebue RW, Cumming RC, Harris GL, Nezis IP, Schubert DR, Simonsen A, Finley KD.

Autophagy. 2011 Jun;7(6):572-83. Epub 2011 Jun 1.

34.

Nitroxyl in the central nervous system.

Choe CU, Lewerenz J, Gerloff C, Magnus T, Donzelli S.

Antioxid Redox Signal. 2011 May 1;14(9):1699-711. doi: 10.1089/ars.2010.3852. Epub 2011 Mar 1. Review.

PMID:
21235347
35.

Control of redox state and redox signaling by neural antioxidant systems.

Lewerenz J, Maher P.

Antioxid Redox Signal. 2011 Apr 15;14(8):1449-65. doi: 10.1089/ars.2010.3600. Epub 2011 Feb 3. Review.

PMID:
20812872
36.

Lactacidosis modulates glutathione metabolism and oxidative glutamate toxicity.

Lewerenz J, Dargusch R, Maher P.

J Neurochem. 2010 Apr;113(2):502-14. doi: 10.1111/j.1471-4159.2010.06621.x. Epub 2010 Jan 28.

37.

Mechanisms of oxidative glutamate toxicity: the glutamate/cystine antiporter system xc- as a neuroprotective drug target.

Albrecht P, Lewerenz J, Dittmer S, Noack R, Maher P, Methner A.

CNS Neurol Disord Drug Targets. 2010 Jul;9(3):373-82. Review.

PMID:
20053169
38.

A novel giant peroxisomal superoxide dismutase motif-containing protein.

Toutzaris D, Lewerenz J, Albrecht P, Jensen LT, Letz J, Geerts A, Golz S, Methner A.

Free Radic Biol Med. 2010 Mar 15;48(6):811-20. doi: 10.1016/j.freeradbiomed.2009.12.023. Epub 2010 Jan 4.

PMID:
20045724
39.

Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxone in vitro.

Lewerenz J, Albrecht P, Tien ML, Henke N, Karumbayaram S, Kornblum HI, Wiedau-Pazos M, Schubert D, Maher P, Methner A.

J Neurochem. 2009 Oct;111(2):332-43. doi: 10.1111/j.1471-4159.2009.06347.x. Epub 2009 Aug 18.

40.

Nitroxyl exacerbates ischemic cerebral injury and oxidative neurotoxicity.

Choe CU, Lewerenz J, Fischer G, Uliasz TF, Espey MG, Hummel FC, King SB, Schwedhelm E, Böger RH, Gerloff C, Hewett SJ, Magnus T, Donzelli S.

J Neurochem. 2009 Sep;110(6):1766-73. doi: 10.1111/j.1471-4159.2009.06266.x. Epub 2009 Jul 8.

41.

Dementia and leukoencephalopathy due to lymphomatosis cerebri.

Lewerenz J, Ding XQ, Matschke J, Schnabel C, Emami P, von Borczyskowski D, Buchert R, Krieger T, de Wit M, Münchau A.

BMJ Case Rep. 2009;2009. pii: bcr08.2008.0752. doi: 10.1136/bcr.08.2008.0752. Epub 2009 Feb 2.

42.

Basal levels of eIF2alpha phosphorylation determine cellular antioxidant status by regulating ATF4 and xCT expression.

Lewerenz J, Maher P.

J Biol Chem. 2009 Jan 9;284(2):1106-15. doi: 10.1074/jbc.M807325200. Epub 2008 Nov 18.

43.

A novel approach to enhancing cellular glutathione levels.

Maher P, Lewerenz J, Lozano C, Torres JL.

J Neurochem. 2008 Nov;107(3):690-700. doi: 10.1111/j.1471-4159.2008.05620.x. Epub 2008 Aug 12.

44.

Dementia and leukoencephalopathy due to lymphomatosis cerebri.

Lewerenz J, Ding X, Matschke J, Schnabel C, Emami P, von Borczyskowski D, Buchert R, Krieger T, de Wit M, Münchau A.

J Neurol Neurosurg Psychiatry. 2007 Jul;78(7):777-8. Epub 2007 Jan 8. No abstract available.

45.
46.

Successful immunosuppressive treatment and long-term follow-up of anti-Ri-associated paraneoplastic myelitis.

Leypoldt F, Eichhorn P, Saager C, Münchau A, Lewerenz J.

J Neurol Neurosurg Psychiatry. 2006 Oct;77(10):1199-200. No abstract available.

47.
48.

Lesion of the dorsorostral midbrain sparing the nigrostriatal tract mimics axial rigidity seen in progressive supranuclear palsy.

Lewerenz J, Zurowski B, Jenicke L, Bäumer T, Lees AJ, Münchau A.

Mov Disord. 2005 Aug;20(8):1071-5.

PMID:
15838851
49.

Short-term serum supplementation improves glucose-oxygen deprivation in primary cortical cultures grown under serum-free conditions.

Lewerenz J, Thomsen S, Steinbeck JA, Methner A.

Methods Cell Sci. 2003;25(3-4):227-36.

PMID:
15801169
50.

Multiple vascular abnormalities and a paradoxical combination of vitamin B12 deficiency and thrombocytosis in a case with POEMS syndrome.

Lewerenz J, Gocht A, Hoeger PH, von den Driesch P, Eckert B, Lamszus K, Stuerenburg HJ, Methner A.

J Neurol. 2003 Dec;250(12):1488-91.

PMID:
14673584

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