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Items: 1 to 50 of 89

1.

High Arterial Glucose is Associated with Poor Pressure Autoregulation, High Cerebral Lactate/Pyruvate Ratio and Poor Outcome Following Traumatic Brain Injury.

Svedung Wettervik T, Howells T, Ronne-Engström E, Hillered L, Lewén A, Enblad P, Rostami E.

Neurocrit Care. 2019 May 23. doi: 10.1007/s12028-019-00743-2. [Epub ahead of print]

PMID:
31123993
2.

Monitoring of Protein Biomarkers of Inflammation in Human Traumatic Brain Injury Using Microdialysis and Proximity Extension Assay Technology in Neurointensive Care.

Dyhrfort P, Shen Q, Clausen F, Thulin M, Enblad P, Kamali-Moghaddam M, Hillered L, Lewén A.

J Neurotrauma. 2019 Apr 24. doi: 10.1089/neu.2018.6320. [Epub ahead of print]

PMID:
31017044
3.

Clinical outcome and prognostic factors in elderly traumatic brain injury patients receiving neurointensive care.

Lenell S, Nyholm L, Lewén A, Enblad P.

Acta Neurochir (Wien). 2019 Jun;161(6):1243-1254. doi: 10.1007/s00701-019-03893-6. Epub 2019 Apr 13.

4.

Priming of microglia with IFN-γ slows neuronal gamma oscillations in situ.

Ta TT, Dikmen HO, Schilling S, Chausse B, Lewen A, Hollnagel JO, Kann O.

Proc Natl Acad Sci U S A. 2019 Feb 19. pii: 201813562. doi: 10.1073/pnas.1813562116. [Epub ahead of print]

PMID:
30782788
5.

Temporal Neurophysiological Dynamics in Traumatic Brain Injury: Role of Pressure Reactivity and Optimal Cerebral Perfusion Pressure for Predicting Outcome.

Svedung Wettervik T, Howells T, Enblad P, Lewén A.

J Neurotrauma. 2019 Jun;36(11):1818-1827. doi: 10.1089/neu.2018.6157. Epub 2019 Feb 25.

PMID:
30595128
6.

Intracranial pressure elevations in diffuse axonal injury: association with nonhemorrhagic MR lesions in central mesencephalic structures.

Abu Hamdeh S, Marklund N, Lewén A, Howells T, Raininko R, Wikström J, Enblad P.

J Neurosurg. 2018 Sep 1:1-8. doi: 10.3171/2018.4.JNS18185. [Epub ahead of print]

PMID:
30215559
7.

Metabolic modulation of neuronal gamma-band oscillations.

Vodovozov W, Schneider J, Elzoheiry S, Hollnagel JO, Lewen A, Kann O.

Pflugers Arch. 2018 Sep;470(9):1377-1389. doi: 10.1007/s00424-018-2156-6. Epub 2018 May 28.

PMID:
29808353
8.

Dual lumen balloon catheter - An effective substitute for two single lumen catheters in treatment of vascular targets with challenging anatomy.

Borota L, Mahmoud E, Nyberg C, Lewén A, Enblad P, Ronne-Engström E.

J Clin Neurosci. 2018 May;51:91-99. doi: 10.1016/j.jocn.2018.01.070. Epub 2018 Feb 23.

PMID:
29483004
9.

Decompressive craniectomy in traumatic brain injury: usage and clinical outcome in a single centre.

Wettervik TS, Lenell S, Nyholm L, Howells T, Lewén A, Enblad P.

Acta Neurochir (Wien). 2018 Feb;160(2):229-237. doi: 10.1007/s00701-017-3418-3. Epub 2017 Dec 12.

10.

Effect of HHH-Therapy on Regional CBF after Severe Subarachnoid Hemorrhage Studied by Bedside Xenon-Enhanced CT.

Engquist H, Rostami E, Ronne-Engström E, Nilsson P, Lewén A, Enblad P.

Neurocrit Care. 2018 Apr;28(2):143-151. doi: 10.1007/s12028-017-0439-y.

11.

The Correlation between Cerebral Blood Flow Measured by Bedside Xenon-CT and Brain Chemistry Monitored by Microdialysis in the Acute Phase following Subarachnoid Hemorrhage.

Rostami E, Engquist H, Howells T, Ronne-Engström E, Nilsson P, Hillered LT, Lewén A, Enblad P.

Front Neurol. 2017 Aug 2;8:369. doi: 10.3389/fneur.2017.00369. eCollection 2017.

12.

Early low cerebral blood flow and high cerebral lactate: prediction of delayed cerebral ischemia in subarachnoid hemorrhage.

Rostami E, Engquist H, Howells T, Johnson U, Ronne-Engström E, Nilsson P, Hillered L, Lewén A, Enblad P.

J Neurosurg. 2018 Jun;128(6):1762-1770. doi: 10.3171/2016.11.JNS161140. Epub 2017 Jun 2.

PMID:
28574309
13.

The influence of hyperthermia on intracranial pressure, cerebral oximetry and cerebral metabolism in traumatic brain injury.

Nyholm L, Howells T, Lewén A, Hillered L, Enblad P.

Ups J Med Sci. 2017 Aug;122(3):177-184. doi: 10.1080/03009734.2017.1319440. Epub 2017 May 2.

14.

Increased risk of critical CBF levels in SAH patients with actual CPP below calculated optimal CPP.

Johnson U, Engquist H, Lewén A, Howells T, Nilsson P, Ronne-Engström E, Rostami E, Enblad P.

Acta Neurochir (Wien). 2017 Jun;159(6):1065-1071. doi: 10.1007/s00701-017-3139-7. Epub 2017 Mar 30.

15.

Hemodynamic Disturbances in the Early Phase After Subarachnoid Hemorrhage: Regional Cerebral Blood Flow Studied by Bedside Xenon-enhanced CT.

Engquist H, Lewén A, Howells T, Johnson U, Ronne-Engström E, Nilsson P, Enblad P, Rostami E.

J Neurosurg Anesthesiol. 2018 Jan;30(1):49-58. doi: 10.1097/ANA.0000000000000395.

PMID:
27906765
16.

Diffuse traumatic axonal injury in mice induces complex behavioural alterations that are normalized by neutralization of interleukin-1β.

Ekmark-Lewén S, Flygt J, Fridgeirsdottir GA, Kiwanuka O, Hånell A, Meyerson BJ, Mir AK, Gram H, Lewén A, Clausen F, Hillered L, Marklund N.

Eur J Neurosci. 2016 Apr;43(8):1016-33. doi: 10.1111/ejn.13190. Epub 2016 Mar 11.

PMID:
27091435
17.

Bedside Xenon-CT Shows Lower CBF in SAH Patients with Impaired CBF Pressure Autoregulation as Defined by Pressure Reactivity Index (PRx).

Johnson U, Engquist H, Howells T, Nilsson P, Ronne-Engström E, Lewén A, Rostami E, Enblad P.

Neurocrit Care. 2016 Aug;25(1):47-55. doi: 10.1007/s12028-016-0240-3.

PMID:
26842717
18.

TLR4-activated microglia require IFN-γ to induce severe neuronal dysfunction and death in situ.

Papageorgiou IE, Lewen A, Galow LV, Cesetti T, Scheffel J, Regen T, Hanisch UK, Kann O.

Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):212-7. doi: 10.1073/pnas.1513853113. Epub 2015 Dec 22.

19.

Promising clinical outcome of elderly with TBI after modern neurointensive care.

Merzo A, Lenell S, Nyholm L, Enblad P, Lewén A.

Acta Neurochir (Wien). 2016 Jan;158(1):125-33. doi: 10.1007/s00701-015-2639-6. Epub 2015 Nov 18.

PMID:
26577639
20.

Positive correlation between occlusion rate and nidus size of proton beam treated brain arteriovenous malformations (AVMs).

Blomquist E, Engström ER, Borota L, Gál G, Nilsson K, Lewén A, Montelius A, Grusell E, Isacsson U, Enblad P.

Acta Oncol. 2016;55(1):105-12. doi: 10.3109/0284186X.2015.1043023. Epub 2015 May 14.

PMID:
25972265
21.

A reliable model for gamma oscillations in hippocampal tissue.

Schneider J, Lewen A, Ta TT, Galow LV, Isola R, Papageorgiou IE, Kann O.

J Neurosci Res. 2015 Jul;93(7):1067-78. doi: 10.1002/jnr.23590. Epub 2015 Mar 24.

PMID:
25808046
22.

Updated periodic evaluation of standardized neurointensive care shows that it is possible to maintain a high level of favorable outcome even with increasing mean age.

Lenell S, Nyholm L, Lewén A, Enblad P.

Acta Neurochir (Wien). 2015 Mar;157(3):417-25. doi: 10.1007/s00701-014-2329-9. Epub 2015 Jan 17.

PMID:
25591801
23.

Energy substrates that fuel fast neuronal network oscillations.

Galow LV, Schneider J, Lewen A, Ta TT, Papageorgiou IE, Kann O.

Front Neurosci. 2014 Dec 5;8:398. doi: 10.3389/fnins.2014.00398. eCollection 2014.

24.

Cerebral microdialysis for protein biomarker monitoring in the neurointensive care setting - a technical approach.

Hillered L, Dahlin AP, Clausen F, Chu J, Bergquist J, Hjort K, Enblad P, Lewén A.

Front Neurol. 2014 Dec 3;5:245. doi: 10.3389/fneur.2014.00245. eCollection 2014. Review.

25.

Refined microdialysis method for protein biomarker sampling in acute brain injury in the neurointensive care setting.

Dahlin AP, Purins K, Clausen F, Chu J, Sedigh A, Lorant T, Enblad P, Lewén A, Hillered L.

Anal Chem. 2014 Sep 2;86(17):8671-9. doi: 10.1021/ac501880u. Epub 2014 Aug 11.

PMID:
25075428
26.

Monitoring of Cerebral Blood Flow and Metabolism Bedside in Patients with Subarachnoid Hemorrhage - A Xenon-CT and Microdialysis Study.

Rostami E, Engquist H, Johnson U, Howells T, Ronne-Engström E, Nilsson P, Hillered L, Lewén A, Enblad P.

Front Neurol. 2014 Jun 2;5:89. doi: 10.3389/fneur.2014.00089. eCollection 2014.

27.

Widespread activation of microglial cells in the hippocampus of chronic epileptic rats correlates only partially with neurodegeneration.

Papageorgiou IE, Fetani AF, Lewen A, Heinemann U, Kann O.

Brain Struct Funct. 2015 Jul;220(4):2423-39. doi: 10.1007/s00429-014-0802-0. Epub 2014 May 31.

PMID:
24878824
28.

Brain tissue oxygenation and cerebral metabolic patterns in focal and diffuse traumatic brain injury.

Purins K, Lewén A, Hillered L, Howells T, Enblad P.

Front Neurol. 2014 May 1;5:64. doi: 10.3389/fneur.2014.00064. eCollection 2014.

29.

Should the neurointensive care management of traumatic brain injury patients be individualized according to autoregulation status and injury subtype?

Johnson U, Lewén A, Ronne-Engström E, Howells T, Enblad P.

Neurocrit Care. 2014 Oct;21(2):259-65. doi: 10.1007/s12028-014-9954-2.

PMID:
24515639
30.

Acute neurosurgery for traumatic brain injury by general surgeons in Swedish county hospitals: a regional study.

Fischerström A, Nyholm L, Lewén A, Enblad P.

Acta Neurochir (Wien). 2014 Jan;156(1):177-85. doi: 10.1007/s00701-013-1932-5. Epub 2013 Nov 24.

PMID:
24272412
31.

Outcome from spontaneous subarachnoid haemorrhage--results from 2007-2011 and comparison with our previous series.

Ronne-Engström E, Borota L, Kothimbakam R, Marklund N, Lewén A, Enblad P.

Ups J Med Sci. 2014 Mar;119(1):38-43. doi: 10.3109/03009734.2013.849781. Epub 2013 Oct 23.

32.

The neurological wake-up test does not alter cerebral energy metabolism and oxygenation in patients with severe traumatic brain injury.

Skoglund K, Hillered L, Purins K, Tsitsopoulos PP, Flygt J, Engquist H, Lewén A, Enblad P, Marklund N.

Neurocrit Care. 2014 Jun;20(3):413-26. doi: 10.1007/s12028-013-9876-4.

PMID:
23934408
34.

Traumatic axonal injury in the mouse is accompanied by a dynamic inflammatory response, astroglial reactivity and complex behavioral changes.

Ekmark-Lewén S, Flygt J, Kiwanuka O, Meyerson BJ, Lewén A, Hillered L, Marklund N.

J Neuroinflammation. 2013 Apr 4;10:44. doi: 10.1186/1742-2094-10-44.

35.

The use of nurse checklists in a bedside computer-based information system to focus on avoiding secondary insults in neurointensive care.

Nyholm L, Lewén A, Fröjd C, Howells T, Nilsson P, Enblad P.

ISRN Neurol. 2012;2012:903954. doi: 10.5402/2012/903954. Epub 2012 Jul 15.

36.

An evaluation of three measures of intracranial compliance in traumatic brain injury patients.

Howells T, Lewén A, Sköld MK, Ronne-Engström E, Enblad P.

Intensive Care Med. 2012 Jun;38(6):1061-8. doi: 10.1007/s00134-012-2571-7. Epub 2012 Apr 18.

PMID:
22527085
37.

Brain tissue oxygenation and cerebral perfusion pressure thresholds of ischemia in a standardized pig brain death model.

Purins K, Enblad P, Wiklund L, Lewén A.

Neurocrit Care. 2012 Jun;16(3):462-9. doi: 10.1007/s12028-012-9675-3.

PMID:
22302179
38.

Interstitial F(2)-isoprostane 8-iso-PGF(2α) as a biomarker of oxidative stress after severe human traumatic brain injury.

Clausen F, Marklund N, Lewén A, Enblad P, Basu S, Hillered L.

J Neurotrauma. 2012 Mar 20;29(5):766-75. doi: 10.1089/neu.2011.1754. Epub 2011 Sep 13.

PMID:
21639729
39.

Standardized experimental brain death model for studies of intracranial dynamics, organ preservation, and organ transplantation in the pig.

Purins K, Sedigh A, Molnar C, Jansson L, Korsgren O, Lorant T, Tufveson G, Wennberg L, Wiklund L, Lewén A, Enblad P.

Crit Care Med. 2011 Mar;39(3):512-7. doi: 10.1097/CCM.0b013e318206b824.

PMID:
21187748
40.

The multivariate concentric square field test reveals behavioral profiles of risk taking, exploration, and cognitive impairment in mice subjected to traumatic brain injury.

Ekmark-Lewén S, Lewén A, Meyerson BJ, Hillered L.

J Neurotrauma. 2010 Sep;27(9):1643-55. doi: 10.1089/neu.2009.0953.

PMID:
20578827
41.

Vimentin and GFAP responses in astrocytes after contusion trauma to the murine brain.

Ekmark-Lewén S, Lewén A, Israelsson C, Li GL, Farooque M, Olsson Y, Ebendal T, Hillered L.

Restor Neurol Neurosci. 2010;28(3):311-21. doi: 10.3233/RNN-2010-0529.

PMID:
20479526
42.

Brain tissue oxygen monitoring: a study of in vitro accuracy and stability of Neurovent-PTO and Licox sensors.

Purins K, Enblad P, Sandhagen B, Lewén A.

Acta Neurochir (Wien). 2010 Apr;152(4):681-8. doi: 10.1007/s00701-009-0532-x. Epub 2009 Oct 14.

PMID:
19826757
43.

Grafted neural progenitors migrate and form neurons after experimental traumatic brain injury.

Wallenquist U, Brännvall K, Clausen F, Lewén A, Hillered L, Forsberg-Nilsson K.

Restor Neurol Neurosci. 2009;27(4):323-34. doi: 10.3233/RNN-2009-0481.

PMID:
19738325
44.

The nitrone free radical scavenger NXY-059 is neuroprotective when administered after traumatic brain injury in the rat.

Clausen F, Marklund N, Lewén A, Hillered L.

J Neurotrauma. 2008 Dec;25(12):1449-57. doi: 10.1089/neu.2008.0585.

PMID:
19118455
45.

Distinct cellular patterns of upregulated chemokine expression supporting a prominent inflammatory role in traumatic brain injury.

Israelsson C, Bengtsson H, Kylberg A, Kullander K, Lewén A, Hillered L, Ebendal T.

J Neurotrauma. 2008 Aug;25(8):959-74. doi: 10.1089/neu.2008.0562.

PMID:
18665806
46.

T lymphocyte trafficking: a novel target for neuroprotection in traumatic brain injury.

Clausen F, Lorant T, Lewén A, Hillered L.

J Neurotrauma. 2007 Aug;24(8):1295-307.

PMID:
17711391
47.

Cerebral glutamine and glutamate levels in relation to compromised energy metabolism: a microdialysis study in subarachnoid hemorrhage patients.

Samuelsson C, Hillered L, Zetterling M, Enblad P, Hesselager G, Ryttlefors M, Kumlien E, Lewén A, Marklund N, Nilsson P, Salci K, Ronne-Engström E.

J Cereb Blood Flow Metab. 2007 Jul;27(7):1309-17. Epub 2007 Jan 17.

PMID:
17228333
48.

Genetically modified bone morphogenetic protein signalling alters traumatic brain injury-induced gene expression responses in the adult mouse.

Israelsson C, Lewén A, Kylberg A, Usoskin D, Althini S, Lindeberg J, Deng CX, Fukuda T, Wang Y, Kaartinen V, Mishina Y, Hillered L, Ebendal T.

J Neurosci Res. 2006 Jul;84(1):47-57.

PMID:
16583403
49.

Intracellular acidification in neurons induced by ammonium depends on KCC2 function.

Titz S, Hormuzdi S, Lewen A, Monyer H, Misgeld U.

Eur J Neurosci. 2006 Jan;23(2):454-64.

PMID:
16420452
50.

Correlation of hippocampal morphological changes and morris water maze performance after cortical contusion injury in rats.

Clausen F, Lewén A, Marklund N, Olsson Y, McArthur DL, Hillered L.

Neurosurgery. 2005 Jul;57(1):154-63; discussion 154-63.

PMID:
15987551

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