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Items: 26

1.

Dual Leucine Zipper Kinase Inhibitors for the Treatment of Neurodegeneration.

Siu M, Sengupta Ghosh A, Lewcock JW.

J Med Chem. 2018 Jun 4. doi: 10.1021/acs.jmedchem.8b00370. [Epub ahead of print]

PMID:
29863360
2.

The Ste20 Family Kinases MAP4K4, MINK1, and TNIK Converge to Regulate Stress-Induced JNK Signaling in Neurons.

Larhammar M, Huntwork-Rodriguez S, Rudhard Y, Sengupta-Ghosh A, Lewcock JW.

J Neurosci. 2017 Nov 15;37(46):11074-11084. doi: 10.1523/JNEUROSCI.0905-17.2017. Epub 2017 Oct 9.

3.

Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer's Disease.

Patel S, Meilandt WJ, Erickson RI, Chen J, Deshmukh G, Estrada AA, Fuji RN, Gibbons P, Gustafson A, Harris SF, Imperio J, Liu W, Liu X, Liu Y, Lyssikatos JP, Ma C, Yin J, Lewcock JW, Siu M.

J Med Chem. 2017 Oct 12;60(19):8083-8102. doi: 10.1021/acs.jmedchem.7b00843. Epub 2017 Sep 20.

PMID:
28929759
4.

Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease.

Le Pichon CE, Meilandt WJ, Dominguez S, Solanoy H, Lin H, Ngu H, Gogineni A, Sengupta Ghosh A, Jiang Z, Lee SH, Maloney J, Gandham VD, Pozniak CD, Wang B, Lee S, Siu M, Patel S, Modrusan Z, Liu X, Rudhard Y, Baca M, Gustafson A, Kaminker J, Carano RAD, Huang EJ, Foreman O, Weimer R, Scearce-Levie K, Lewcock JW.

Sci Transl Med. 2017 Aug 16;9(403). pii: eaag0394. doi: 10.1126/scitranslmed.aag0394.

5.

Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult.

Larhammar M, Huntwork-Rodriguez S, Jiang Z, Solanoy H, Sengupta Ghosh A, Wang B, Kaminker JS, Huang K, Eastham-Anderson J, Siu M, Modrusan Z, Farley MM, Tessier-Lavigne M, Lewcock JW, Watkins TA.

Elife. 2017 Apr 25;6. pii: e20725. doi: 10.7554/eLife.20725.

6.

Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12).

Patel S, Harris SF, Gibbons P, Deshmukh G, Gustafson A, Kellar T, Lin H, Liu X, Liu Y, Liu Y, Ma C, Scearce-Levie K, Ghosh AS, Shin YG, Solanoy H, Wang J, Wang B, Yin J, Siu M, Lewcock JW.

J Med Chem. 2015 Oct 22;58(20):8182-99. doi: 10.1021/acs.jmedchem.5b01072. Epub 2015 Oct 2.

PMID:
26431428
7.

Identification of 12/15-lipoxygenase as a regulator of axon degeneration through high-content screening.

Rudhard Y, Sengupta Ghosh A, Lippert B, Böcker A, Pedaran M, Krämer J, Ngu H, Foreman O, Liu Y, Lewcock JW.

J Neurosci. 2015 Feb 18;35(7):2927-41. doi: 10.1523/JNEUROSCI.2936-14.2015.

8.

Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models.

Patel S, Cohen F, Dean BJ, De La Torre K, Deshmukh G, Estrada AA, Ghosh AS, Gibbons P, Gustafson A, Huestis MP, Le Pichon CE, Lin H, Liu W, Liu X, Liu Y, Ly CQ, Lyssikatos JP, Ma C, Scearce-Levie K, Shin YG, Solanoy H, Stark KL, Wang J, Wang B, Zhao X, Lewcock JW, Siu M.

J Med Chem. 2015 Jan 8;58(1):401-18. doi: 10.1021/jm5013984. Epub 2014 Oct 23.

PMID:
25341110
9.

C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice.

Lobsiger CS, Boillée S, Pozniak C, Khan AM, McAlonis-Downes M, Lewcock JW, Cleveland DW.

Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):E4385-92. doi: 10.1073/pnas.1318309110. Epub 2013 Oct 29.

10.

Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration.

Pozniak CD, Sengupta Ghosh A, Gogineni A, Hanson JE, Lee SH, Larson JL, Solanoy H, Bustos D, Li H, Ngu H, Jubb AM, Ayalon G, Wu J, Scearce-Levie K, Zhou Q, Weimer RM, Kirkpatrick DS, Lewcock JW.

J Exp Med. 2013 Nov 18;210(12):2553-67. doi: 10.1084/jem.20122832. Epub 2013 Oct 28.

11.

JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis.

Huntwork-Rodriguez S, Wang B, Watkins T, Ghosh AS, Pozniak CD, Bustos D, Newton K, Kirkpatrick DS, Lewcock JW.

J Cell Biol. 2013 Sep 2;202(5):747-63. doi: 10.1083/jcb.201303066. Epub 2013 Aug 26.

12.

DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury.

Watkins TA, Wang B, Huntwork-Rodriguez S, Yang J, Jiang Z, Eastham-Anderson J, Modrusan Z, Kaminker JS, Tessier-Lavigne M, Lewcock JW.

Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4039-44. doi: 10.1073/pnas.1211074110. Epub 2013 Feb 19.

13.

Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6.

Heise CE, Murray J, Augustyn KE, Bravo B, Chugha P, Cohen F, Giannetti AM, Gibbons P, Hannoush RN, Hearn BR, Jaishankar P, Ly CQ, Shah K, Stanger K, Steffek M, Tang Y, Zhao X, Lewcock JW, Renslo AR, Flygare J, Arkin MR.

PLoS One. 2012;7(12):e50864. doi: 10.1371/journal.pone.0050864. Epub 2012 Dec 5.

14.

Spatially coordinated kinase signaling regulates local axon degeneration.

Chen M, Maloney JA, Kallop DY, Atwal JK, Tam SJ, Baer K, Kissel H, Kaminker JS, Lewcock JW, Weimer RM, Watts RJ.

J Neurosci. 2012 Sep 26;32(39):13439-53.

15.

Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization.

Stanger K, Steffek M, Zhou L, Pozniak CD, Quan C, Franke Y, Tom J, Tam C, Krylova I, Elliott JM, Lewcock JW, Zhang Y, Murray J, Hannoush RN.

Nat Chem Biol. 2012 Jul;8(7):655-60. doi: 10.1038/nchembio.967. Epub 2012 Jun 10. Erratum in: Nat Chem Biol. 2012 Jul;8(7). doi: 10.1038/nchembio.967. Krylova, Irina [added]. Nat Chem Biol. 2013 Jul;9(7):466.

PMID:
22683611
16.

A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/C.

Mintzer R, Ramaswamy S, Shah K, Hannoush RN, Pozniak CD, Cohen F, Zhao X, Plise E, Lewcock JW, Heise CE.

PLoS One. 2012;7(1):e30376. doi: 10.1371/journal.pone.0030376. Epub 2012 Jan 12.

17.

DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity.

Ghosh AS, Wang B, Pozniak CD, Chen M, Watts RJ, Lewcock JW.

J Cell Biol. 2011 Sep 5;194(5):751-64. doi: 10.1083/jcb.201103153.

18.

ACS chemical neuroscience spotlight on CEP-1347.

Sweeney ZK, Lewcock JW.

ACS Chem Neurosci. 2011 Jan 19;2(1):3-4. doi: 10.1021/cn1000793. Epub 2010 Sep 3. Review. No abstract available.

19.

Presenilin-dependent receptor processing is required for axon guidance.

Bai G, Chivatakarn O, Bonanomi D, Lettieri K, Franco L, Xia C, Stein E, Ma L, Lewcock JW, Pfaff SL.

Cell. 2011 Jan 7;144(1):106-18. doi: 10.1016/j.cell.2010.11.053.

20.

The ubiquitin ligase Phr1 regulates axon outgrowth through modulation of microtubule dynamics.

Lewcock JW, Genoud N, Lettieri K, Pfaff SL.

Neuron. 2007 Nov 21;56(4):604-20.

21.

FGF as a target-derived chemoattractant for developing motor axons genetically programmed by the LIM code.

Shirasaki R, Lewcock JW, Lettieri K, Pfaff SL.

Neuron. 2006 Jun 15;50(6):841-53.

22.

Cholinergic input is required during embryonic development to mediate proper assembly of spinal locomotor circuits.

Myers CP, Lewcock JW, Hanson MG, Gosgnach S, Aimone JB, Gage FH, Lee KF, Landmesser LT, Pfaff SL.

Neuron. 2005 Apr 7;46(1):37-49.

23.

Genetic disruptions of O/E2 and O/E3 genes reveal involvement in olfactory receptor neuron projection.

Wang SS, Lewcock JW, Feinstein P, Mombaerts P, Reed RR.

Development. 2004 Mar;131(6):1377-88.

24.

A feedback mechanism regulates monoallelic odorant receptor expression.

Lewcock JW, Reed RR.

Proc Natl Acad Sci U S A. 2004 Jan 27;101(4):1069-74. Epub 2004 Jan 19.

25.

Neuroscience. ORs rule the roost in the olfactory system.

Lewcock JW, Reed RR.

Science. 2003 Dec 19;302(5653):2078-9. No abstract available.

PMID:
14684811
26.

Sweet successes.

Lewcock JW, Reed RR.

Neuron. 2001 Aug 30;31(4):515-7. Review.

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