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Evidence against a Role of Elevated Intracellular Ca2+ during Plasmodium falciparum Preinvasion.

Introini V, Crick A, Tiffert T, Kotar J, Lin YC, Cicuta P, Lew VL.

Biophys J. 2018 Apr 10;114(7):1695-1706. doi: 10.1016/j.bpj.2018.02.023.


On the Mechanism of Human Red Blood Cell Longevity: Roles of Calcium, the Sodium Pump, PIEZO1, and Gardos Channels.

Lew VL, Tiffert T.

Front Physiol. 2017 Dec 12;8:977. doi: 10.3389/fphys.2017.00977. eCollection 2017. Review.


Unexpected Connections between Humidity and Ion Transport Discovered Using a Model to Bridge Guard Cell-to-Leaf Scales.

Wang Y, Hills A, Vialet-Chabrand S, Papanatsiou M, Griffiths H, Rogers S, Lawson T, Lew VL, Blatt MR.

Plant Cell. 2017 Nov;29(11):2921-2939. doi: 10.1105/tpc.17.00694. Epub 2017 Nov 1.


Global Sensitivity Analysis of OnGuard Models Identifies Key Hubs for Transport Interaction in Stomatal Dynamics.

Vialet-Chabrand S, Hills A, Wang Y, Griffiths H, Lew VL, Lawson T, Blatt MR, Rogers S.

Plant Physiol. 2017 Jun;174(2):680-688. doi: 10.1104/pp.17.00170. Epub 2017 Apr 21.


An Optimal Frequency in Ca2+ Oscillations for Stomatal Closure Is an Emergent Property of Ion Transport in Guard Cells.

Minguet-Parramona C, Wang Y, Hills A, Vialet-Chabrand S, Griffiths H, Rogers S, Lawson T, Lew VL, Blatt MR.

Plant Physiol. 2016 Jan;170(1):33-42. doi: 10.1104/pp.15.01607. Epub 2015 Dec 1.


Quantitation of malaria parasite-erythrocyte cell-cell interactions using optical tweezers.

Crick AJ, Theron M, Tiffert T, Lew VL, Cicuta P, Rayner JC.

Biophys J. 2014 Aug 19;107(4):846-53. doi: 10.1016/j.bpj.2014.07.010.


Dynamic morphology and cytoskeletal protein changes during spontaneous inside-out vesiculation of red blood cell membranes.

Tiffert T, Lew VL.

Pflugers Arch. 2014 Dec;466(12):2279-88. doi: 10.1007/s00424-014-1483-5. Epub 2014 Mar 12.


The terminal density reversal phenomenon of aging human red blood cells.

Lew VL, Tiffert T.

Front Physiol. 2013 Jul 9;4:171. doi: 10.3389/fphys.2013.00171. eCollection 2013. No abstract available.


An automated live imaging platform for studying merozoite egress-invasion in malaria cultures.

Crick AJ, Tiffert T, Shah SM, Kotar J, Lew VL, Cicuta P.

Biophys J. 2013 Mar 5;104(5):997-1005. doi: 10.1016/j.bpj.2013.01.018.


The conceptual approach to quantitative modeling of guard cells.

Blatt MR, Hills A, Chen ZH, Wang Y, Papanatsiou M, Lew VL.

Plant Signal Behav. 2013 Jan;8(1):e22747. doi: 10.4161/psb.22747. Epub 2012 Dec 6.


Systems dynamic modeling of a guard cell Cl- channel mutant uncovers an emergent homeostatic network regulating stomatal transpiration.

Wang Y, Papanatsiou M, Eisenach C, Karnik R, Williams M, Hills A, Lew VL, Blatt MR.

Plant Physiol. 2012 Dec;160(4):1956-67. doi: 10.1104/pp.112.207704. Epub 2012 Oct 22.


OnGuard, a computational platform for quantitative kinetic modeling of guard cell physiology.

Hills A, Chen ZH, Amtmann A, Blatt MR, Lew VL.

Plant Physiol. 2012 Jul;159(3):1026-42. doi: 10.1104/pp.112.197244. Epub 2012 May 25.


Systems dynamic modeling of the stomatal guard cell predicts emergent behaviors in transport, signaling, and volume control.

Chen ZH, Hills A, Bätz U, Amtmann A, Lew VL, Blatt MR.

Plant Physiol. 2012 Jul;159(3):1235-51. doi: 10.1104/pp.112.197350. Epub 2012 May 25.


Elevated intracellular Ca2+ reveals a functional membrane nucleotide pool in intact human red blood cells.

Tiffert T, Lew VL.

J Gen Physiol. 2011 Oct;138(4):381-91. doi: 10.1085/jgp.201110660.


IKCa agonist (NS309)-elicited all-or-none dehydration response of human red blood cells is cell-age dependent.

Seear RV, Lew VL.

Cell Calcium. 2011 Nov;50(5):444-8. doi: 10.1016/j.ceca.2011.07.005. Epub 2011 Sep 21.


Malaria: surprising mechanism of merozoite egress revealed.

Lew VL.

Curr Biol. 2011 May 10;21(9):R314-6. doi: 10.1016/j.cub.2011.03.066.


X-ray microanalysis investigation of the changes in Na, K, and hemoglobin concentration in plasmodium falciparum-infected red blood cells.

Mauritz JM, Seear R, Esposito A, Kaminski CF, Skepper JN, Warley A, Lew VL, Tiffert T.

Biophys J. 2011 Mar 16;100(6):1438-45. doi: 10.1016/j.bpj.2011.02.007.


Hydrogen ion dynamics in human red blood cells.

Swietach P, Tiffert T, Mauritz JM, Seear R, Esposito A, Kaminski CF, Lew VL, Vaughan-Jones RD.

J Physiol. 2010 Dec 15;588(Pt 24):4995-5014. doi: 10.1113/jphysiol.2010.197392. Epub 2010 Oct 20.


Quantitative imaging of human red blood cells infected with Plasmodium falciparum.

Esposito A, Choimet JB, Skepper JN, Mauritz JM, Lew VL, Kaminski CF, Tiffert T.

Biophys J. 2010 Aug 4;99(3):953-60. doi: 10.1016/j.bpj.2010.04.065.


Curling and local shape changes of red blood cell membranes driven by cytoskeletal reorganization.

Kabaso D, Shlomovitz R, Auth T, Lew VL, Gov NS.

Biophys J. 2010 Aug 4;99(3):808-16. doi: 10.1016/j.bpj.2010.04.067.


Biophotonic techniques for the study of malaria-infected red blood cells.

Mauritz JM, Esposito A, Tiffert T, Skepper JN, Warley A, Yoon YZ, Cicuta P, Lew VL, Guck JR, Kaminski CF.

Med Biol Eng Comput. 2010 Oct;48(10):1055-63. doi: 10.1007/s11517-010-0668-0. Epub 2010 Jul 27. Review.


Detection of Plasmodium falciparum-infected red blood cells by optical stretching.

Mauritz JM, Tiffert T, Seear R, Lautenschläger F, Esposito A, Lew VL, Guck J, Kaminski CF.

J Biomed Opt. 2010 May-Jun;15(3):030517. doi: 10.1117/1.3458919.


Local membrane deformations activate Ca2+-dependent K+ and anionic currents in intact human red blood cells.

Dyrda A, Cytlak U, Ciuraszkiewicz A, Lipinska A, Cueff A, Bouyer G, Egée S, Bennekou P, Lew VL, Thomas SL.

PLoS One. 2010 Feb 26;5(2):e9447. doi: 10.1371/journal.pone.0009447.


Effects of elevated intracellular calcium on the osmotic fragility of human red blood cells.

Cueff A, Seear R, Dyrda A, Bouyer G, Egée S, Esposito A, Skepper J, Tiffert T, Lew VL, Thomas SL.

Cell Calcium. 2010 Jan;47(1):29-36. doi: 10.1016/j.ceca.2009.11.002. Epub 2009 Dec 1.


Flickering analysis of erythrocyte mechanical properties: dependence on oxygenation level, cell shape, and hydration level.

Yoon YZ, Hong H, Brown A, Kim DC, Kang DJ, Lew VL, Cicuta P.

Biophys J. 2009 Sep 16;97(6):1606-15. doi: 10.1016/j.bpj.2009.06.028.


The homeostasis of Plasmodium falciparum-infected red blood cells.

Mauritz JM, Esposito A, Ginsburg H, Kaminski CF, Tiffert T, Lew VL.

PLoS Comput Biol. 2009 Apr;5(4):e1000339. doi: 10.1371/journal.pcbi.1000339. Epub 2009 Apr 3.


Preserved function of the plasma membrane calcium pump of red blood cells from diabetic subjects with high levels of glycated haemoglobin.

Bookchin RM, Etzion Z, Lew VL, Tiffert T.

Cell Calcium. 2009 Mar;45(3):260-3. doi: 10.1016/j.ceca.2008.11.001. Epub 2008 Dec 13.


FRET imaging of hemoglobin concentration in Plasmodium falciparum-infected red cells.

Esposito A, Tiffert T, Mauritz JM, Schlachter S, Bannister LH, Kaminski CF, Lew VL.

PLoS One. 2008;3(11):e3780. doi: 10.1371/journal.pone.0003780. Epub 2008 Nov 21.


Free energy of sickle hemoglobin polymerization: a scaled-particle treatment for use with dextran as a crowding agent.

Liu Z, Weng W, Bookchin RM, Lew VL, Ferrone FA.

Biophys J. 2008 May 1;94(9):3629-34. doi: 10.1529/biophysj.107.117465. Epub 2008 Jan 22.


Is invasion efficiency in malaria controlled by pre-invasion events?

Lew VL, Tiffert T.

Trends Parasitol. 2007 Oct;23(10):481-4. Epub 2007 Sep 4.


Age decline in the activity of the Ca2+-sensitive K+ channel of human red blood cells.

Tiffert T, Daw N, Etzion Z, Bookchin RM, Lew VL.

J Gen Physiol. 2007 May;129(5):429-36.


Effects of age-dependent membrane transport changes on the homeostasis of senescent human red blood cells.

Lew VL, Daw N, Etzion Z, Tiffert T, Muoma A, Vanagas L, Bookchin RM.

Blood. 2007 Aug 15;110(4):1334-42. Epub 2007 Apr 24.


Malaria: endless fascination with merozoite release.

Lew VL.

Curr Biol. 2005 Sep 20;15(18):R760-1. Review.


The hydration state of human red blood cells and their susceptibility to invasion by Plasmodium falciparum.

Tiffert T, Lew VL, Ginsburg H, Krugliak M, Croisille L, Mohandas N.

Blood. 2005 Jun 15;105(12):4853-60. Epub 2005 Feb 22.


Ion transport pathology in the mechanism of sickle cell dehydration.

Lew VL, Bookchin RM.

Physiol Rev. 2005 Jan;85(1):179-200. Review.


Distribution of dehydration rates generated by maximal Gardos-channel activation in normal and sickle red blood cells.

Lew VL, Tiffert T, Etzion Z, Perdomo D, Daw N, Macdonald L, Bookchin RM.

Blood. 2005 Jan 1;105(1):361-7. Epub 2004 Aug 31.


Excess haemoglobin digestion by malaria parasites: a strategy to prevent premature host cell lysis.

Lew VL, Macdonald L, Ginsburg H, Krugliak M, Tiffert T.

Blood Cells Mol Dis. 2004 May-Jun;32(3):353-9.


Plasmodium falciparum and the permeation pathway of the host red blood cell.

Thomas SL, Lew VL.

Trends Parasitol. 2004 Mar;20(3):122-5. Review.


Distribution of plasma membrane Ca2+ pump activity in normal human red blood cells.

Lew VL, Daw N, Perdomo D, Etzion Z, Bookchin RM, Tiffert T.

Blood. 2003 Dec 1;102(12):4206-13. Epub 2003 Aug 14.


Excess hemoglobin digestion and the osmotic stability of Plasmodium falciparum-infected red blood cells.

Lew VL, Tiffert T, Ginsburg H.

Blood. 2003 May 15;101(10):4189-94. Epub 2003 Jan 16.


Do azoles and chloroquine share similar mechanisms of antimalarial action?

Lew VL, Tiffert T, Ginsburg H.

Trends Parasitol. 2002 Apr;18(4):156. No abstract available.


Dehydration response of sickle cells to sickling-induced Ca(++) permeabilization.

Lew VL, Etzion Z, Bookchin RM.

Blood. 2002 Apr 1;99(7):2578-85.


Sickle red cell dehydration: mechanisms and interventions.

Bookchin RM, Lew VL.

Curr Opin Hematol. 2002 Mar;9(2):107-10. Review.


Packaged merozoite release without immediate host cell lysis.

Lew VL.

Trends Parasitol. 2001 Sep;17(9):401-3.


Normal Ca2+ extrusion by the Ca2+ pump of intact red blood cells exposed to high glucose concentrations.

Raftos JE, Edgley A, Bookchin RM, Etzion Z, Lew VL, Tiffert T.

Am J Physiol Cell Physiol. 2001 Jun;280(6):C1449-54.


A fast and simple screening test to search for specific inhibitors of the plasma membrane calcium pump.

Tiffert T, Daw N, Perdomo D, Lew VL.

J Lab Clin Med. 2001 Mar;137(3):199-207.


Identification and characterization of a newly recognized population of high-Na+, low-K+, low-density sickle and normal red cells.

Bookchin RM, Etzion Z, Sorette M, Mohandas N, Skepper JN, Lew VL.

Proc Natl Acad Sci U S A. 2000 Jul 5;97(14):8045-50.


Effect of ferriprotoporphyrin IX and non-heme iron on the Ca(2+) pump of intact human red cells.

Tiffert T, Lew VL, Perdomo D, Ginsburg H.

J Membr Biol. 2000 May 15;175(2):107-13.


Functional state of the plasma membrane Ca2+ pump in Plasmodium falciparum-infected human red blood cells.

Tiffert T, Staines HM, Ellory JC, Lew VL.

J Physiol. 2000 May 15;525 Pt 1:125-34.

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