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Items: 1 to 50 of 103


Ratiometric GPCR signaling enables directional sensing in yeast.

Henderson NT, Pablo M, Ghose D, Clark-Cotton MR, Zyla TR, Nolen J, Elston TC, Lew DJ.

PLoS Biol. 2019 Oct 17;17(10):e3000484. doi: 10.1371/journal.pbio.3000484. eCollection 2019 Oct.


Unconventional Cell Division Cycles from Marine-Derived Yeasts.

Mitchison-Field LMY, Vargas-Muñiz JM, Stormo BM, Vogt EJD, Van Dierdonck S, Pelletier JF, Ehrlich C, Lew DJ, Field CM, Gladfelter AS.

Curr Biol. 2019 Oct 21;29(20):3439-3456.e5. doi: 10.1016/j.cub.2019.08.050. Epub 2019 Oct 10.


A role for Gic1 and Gic2 in Cdc42 polarization at elevated temperature.

Daniels CN, Zyla TR, Lew DJ.

PLoS One. 2018 Dec 19;13(12):e0200863. doi: 10.1371/journal.pone.0200863. eCollection 2018.


Cell-cycle control of cell polarity in yeast.

Moran KD, Kang H, Araujo AV, Zyla TR, Saito K, Tsygankov D, Lew DJ.

J Cell Biol. 2019 Jan 7;218(1):171-189. doi: 10.1083/jcb.201806196. Epub 2018 Nov 20.


Mating in wild yeast: delayed interest in sex after spore germination.

McClure AW, Jacobs KC, Zyla TR, Lew DJ.

Mol Biol Cell. 2018 Oct 24:mbcE18080528. doi: 10.1091/mbc.E18-08-0528. [Epub ahead of print]


Temporal regulation of morphogenetic events in Saccharomyces cerevisiae.

Lai H, Chiou JG, Zhurikhina A, Zyla TR, Tsygankov D, Lew DJ.

Mol Biol Cell. 2018 Aug 15;29(17):2069-2083. doi: 10.1091/mbc.E18-03-0188. Epub 2018 Jun 21.


Principles that govern competition or co-existence in Rho-GTPase driven polarization.

Chiou JG, Ramirez SA, Elston TC, Witelski TP, Schaeffer DG, Lew DJ.

PLoS Comput Biol. 2018 Apr 12;14(4):e1006095. doi: 10.1371/journal.pcbi.1006095. eCollection 2018 Apr.


Cell Polarity in Yeast.

Chiou JG, Balasubramanian MK, Lew DJ.

Annu Rev Cell Dev Biol. 2017 Oct 6;33:77-101. doi: 10.1146/annurev-cellbio-100616-060856. Epub 2017 Aug 7. Review.


Polarity establishment by Cdc42: Key roles for positive feedback and differential mobility.

Woods B, Lew DJ.

Small GTPases. 2019 Mar;10(2):130-137. doi: 10.1080/21541248.2016.1275370. Epub 2017 Mar 30.


Parallel Actin-Independent Recycling Pathways Polarize Cdc42 in Budding Yeast.

Woods B, Lai H, Wu CF, Zyla TR, Savage NS, Lew DJ.

Curr Biol. 2016 Aug 22;26(16):2114-26. doi: 10.1016/j.cub.2016.06.047. Epub 2016 Jul 28.


How do cells know what shape they are?

Kang H, Lew DJ.

Curr Genet. 2017 Feb;63(1):75-77. doi: 10.1007/s00294-016-0623-1. Epub 2016 Jun 16. Review.


Imaging Polarization in Budding Yeast.

McClure AW, Wu CF, Johnson SA, Lew DJ.

Methods Mol Biol. 2016;1407:13-23. doi: 10.1007/978-1-4939-3480-5_2.


Sensing a bud in the yeast morphogenesis checkpoint: a role for Elm1.

Kang H, Tsygankov D, Lew DJ.

Mol Biol Cell. 2016 Jun 1;27(11):1764-75. doi: 10.1091/mbc.E16-01-0014. Epub 2016 Apr 6.


Role of Polarized G Protein Signaling in Tracking Pheromone Gradients.

McClure AW, Minakova M, Dyer JM, Zyla TR, Elston TC, Lew DJ.

Dev Cell. 2015 Nov 23;35(4):471-82. doi: 10.1016/j.devcel.2015.10.024.


Role of competition between polarity sites in establishing a unique front.

Wu CF, Chiou JG, Minakova M, Woods B, Tsygankov D, Zyla TR, Savage NS, Elston TC, Lew DJ.

Elife. 2015 Nov 2;4. pii: e11611. doi: 10.7554/eLife.11611.


Polarity establishment requires localized activation of Cdc42.

Woods B, Kuo CC, Wu CF, Zyla TR, Lew DJ.

J Cell Biol. 2015 Oct 12;211(1):19-26. doi: 10.1083/jcb.201506108.


Dendritic spine geometry can localize GTPase signaling in neurons.

Ramirez SA, Raghavachari S, Lew DJ.

Mol Biol Cell. 2015 Nov 5;26(22):4171-81. doi: 10.1091/mbc.E15-06-0405. Epub 2015 Sep 2.


To avoid a mating mishap, yeast focus and communicate.

McClure AW, Lew DJ.

J Cell Biol. 2015 Mar 30;208(7):867-8. doi: 10.1083/jcb.201502095. Review.


Cell polarity: netrin calms an excitable system.

McClure AW, Lew DJ.

Curr Biol. 2014 Nov 3;24(21):R1050-2. doi: 10.1016/j.cub.2014.09.042. Epub 2014 Nov 3.


Inhibitory GEF phosphorylation provides negative feedback in the yeast polarity circuit.

Kuo CC, Savage NS, Chen H, Wu CF, Zyla TR, Lew DJ.

Curr Biol. 2014 Mar 31;24(7):753-9. doi: 10.1016/j.cub.2014.02.024. Epub 2014 Mar 13.


Interaction between bud-site selection and polarity-establishment machineries in budding yeast.

Wu CF, Savage NS, Lew DJ.

Philos Trans R Soc Lond B Biol Sci. 2013 Sep 23;368(1629):20130006. doi: 10.1098/rstb.2013.0006. Print 2013.


Inhibition of Cdc42 during mitotic exit is required for cytokinesis.

Atkins BD, Yoshida S, Saito K, Wu CF, Lew DJ, Pellman D.

J Cell Biol. 2013 Jul 22;202(2):231-40. doi: 10.1083/jcb.201301090.


Beyond symmetry-breaking: competition and negative feedback in GTPase regulation.

Wu CF, Lew DJ.

Trends Cell Biol. 2013 Oct;23(10):476-83. doi: 10.1016/j.tcb.2013.05.003. Epub 2013 May 31. Review.


Feedback control of Swe1p degradation in the yeast morphogenesis checkpoint.

King K, Kang H, Jin M, Lew DJ.

Mol Biol Cell. 2013 Apr;24(7):914-22. doi: 10.1091/mbc.E12-11-0812. Epub 2013 Feb 6.


Tracking shallow chemical gradients by actin-driven wandering of the polarization site.

Dyer JM, Savage NS, Jin M, Zyla TR, Elston TC, Lew DJ.

Curr Biol. 2013 Jan 7;23(1):32-41. doi: 10.1016/j.cub.2012.11.014. Epub 2012 Nov 29.


Cdc42p regulation of the yeast formin Bni1p mediated by the effector Gic2p.

Chen H, Kuo CC, Kang H, Howell AS, Zyla TR, Jin M, Lew DJ.

Mol Biol Cell. 2012 Oct;23(19):3814-26. doi: 10.1091/mbc.E12-05-0400. Epub 2012 Aug 23.


Negative feedback enhances robustness in the yeast polarity establishment circuit.

Howell AS, Jin M, Wu CF, Zyla TR, Elston TC, Lew DJ.

Cell. 2012 Apr 13;149(2):322-33. doi: 10.1016/j.cell.2012.03.012.


Mechanistic mathematical model of polarity in yeast.

Savage NS, Layton AT, Lew DJ.

Mol Biol Cell. 2012 May;23(10):1998-2013. doi: 10.1091/mbc.E11-10-0837. Epub 2012 Mar 21.


Morphogenesis and the cell cycle.

Howell AS, Lew DJ.

Genetics. 2012 Jan;190(1):51-77. doi: 10.1534/genetics.111.128314. Review.


Symmetry breaking and the establishment of cell polarity in budding yeast.

Johnson JM, Jin M, Lew DJ.

Curr Opin Genet Dev. 2011 Dec;21(6):740-6. doi: 10.1016/j.gde.2011.09.007. Epub 2011 Sep 28. Review.


Dynamics of septin ring and collar formation in Saccharomyces cerevisiae.

Chen H, Howell AS, Robeson A, Lew DJ.

Biol Chem. 2011 Aug;392(8-9):689-97. doi: 10.1515/BC.2011.075. Epub 2011 Jul 7.


Modeling vesicle traffic reveals unexpected consequences for Cdc42p-mediated polarity establishment.

Layton AT, Savage NS, Howell AS, Carroll SY, Drubin DG, Lew DJ.

Curr Biol. 2011 Feb 8;21(3):184-94. doi: 10.1016/j.cub.2011.01.012.


Singularity in polarization: rewiring yeast cells to make two buds.

Howell AS, Savage NS, Johnson SA, Bose I, Wagner AW, Zyla TR, Nijhout HF, Reed MC, Goryachev AB, Lew DJ.

Cell. 2009 Nov 13;139(4):731-43. doi: 10.1016/j.cell.2009.10.024.


Molecular dissection of the checkpoint kinase Hsl1p.

Crutchley J, King KM, Keaton MA, Szkotnicki L, Orlando DA, Zyla TR, Bardes ES, Lew DJ.

Mol Biol Cell. 2009 Apr;20(7):1926-36. doi: 10.1091/mbc.E08-08-0848. Epub 2009 Feb 11.


Cell structure and dynamics.

Lew DJ, Rout MP.

Curr Opin Cell Biol. 2009 Feb;21(1):1-3. doi: 10.1016/ No abstract available.


Symmetry-breaking polarization driven by a Cdc42p GEF-PAK complex.

Kozubowski L, Saito K, Johnson JM, Howell AS, Zyla TR, Lew DJ.

Curr Biol. 2008 Nov 25;18(22):1719-26. doi: 10.1016/j.cub.2008.09.060. Epub 2008 Nov 13.


The checkpoint kinase Hsl1p is activated by Elm1p-dependent phosphorylation.

Szkotnicki L, Crutchley JM, Zyla TR, Bardes ES, Lew DJ.

Mol Biol Cell. 2008 Nov;19(11):4675-86. doi: 10.1091/mbc.E08-06-0663. Epub 2008 Sep 3.


Nucleocytoplasmic trafficking of G2/M regulators in yeast.

Keaton MA, Szkotnicki L, Marquitz AR, Harrison J, Zyla TR, Lew DJ.

Mol Biol Cell. 2008 Sep;19(9):4006-18. doi: 10.1091/mbc.E08-03-0286. Epub 2008 Jun 18.


The immortal strand hypothesis: how could it work?

Lew DJ, Burke DJ, Dutta A.

Cell. 2008 Apr 4;133(1):21-3. doi: 10.1016/j.cell.2008.03.016. No abstract available.


Adjacent positioning of cellular structures enabled by a Cdc42 GTPase-activating protein-mediated zone of inhibition.

Tong Z, Gao XD, Howell AS, Bose I, Lew DJ, Bi E.

J Cell Biol. 2007 Dec 31;179(7):1375-84. doi: 10.1083/jcb.200705160.


IP7 guards the CDK gate.

York JD, Lew DJ.

Nat Chem Biol. 2008 Jan;4(1):16-7. No abstract available.


Differential susceptibility of yeast S and M phase CDK complexes to inhibitory tyrosine phosphorylation.

Keaton MA, Bardes ES, Marquitz AR, Freel CD, Zyla TR, Rudolph J, Lew DJ.

Curr Biol. 2007 Jul 17;17(14):1181-9. Epub 2007 Jul 5.


Microtubule organization: cell shape is destiny.

Haase SB, Lew DJ.

Curr Biol. 2007 Apr 3;17(7):R249-51.


Eavesdropping on the cytoskeleton: progress and controversy in the yeast morphogenesis checkpoint.

Keaton MA, Lew DJ.

Curr Opin Microbiol. 2006 Dec;9(6):540-6. Epub 2006 Oct 19. Review.


Swe1p responds to cytoskeletal perturbation, not bud size, in S. cerevisiae.

McNulty JJ, Lew DJ.

Curr Biol. 2005 Dec 20;15(24):2190-8.


Yeast polarity: negative feedback shifts the focus.

Lew DJ.

Curr Biol. 2005 Dec 20;15(24):R994-6. Review.


Interplay between septin organization, cell cycle and cell shape in yeast.

Gladfelter AS, Kozubowski L, Zyla TR, Lew DJ.

J Cell Sci. 2005 Apr 15;118(Pt 8):1617-28. Epub 2005 Mar 22.


Opposing roles for actin in Cdc42p polarization.

Irazoqui JE, Howell AS, Theesfeld CL, Lew DJ.

Mol Biol Cell. 2005 Mar;16(3):1296-304. Epub 2004 Dec 22.


Genetic interactions among regulators of septin organization.

Gladfelter AS, Zyla TR, Lew DJ.

Eukaryot Cell. 2004 Aug;3(4):847-54.


Cdc42p, GTP hydrolysis, and the cell's sense of direction.

Irazoqui JE, Gladfelter AS, Lew DJ.

Cell Cycle. 2004 Jul;3(7):861-4. Epub 2004 Jul 26. Review.


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