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The Selective Expansion and Targeted Accumulation of Bone Marrow-Derived Macrophages Drive Cardiac Vasculitis.

Stock AT, Collins N, Smyth GK, Hu Y, Hansen JA, D'Silva DB, Jama HA, Lew AM, Gebhardt T, McLean CA, Wicks IP.

J Immunol. 2019 Jun 1;202(11):3282-3296. doi: 10.4049/jimmunol.1900071. Epub 2019 Apr 19.


Macrophages, rather than DCs, are responsible for inflammasome activity in the GM-CSF BMDC model.

Erlich Z, Shlomovitz I, Edry-Botzer L, Cohen H, Frank D, Wang H, Lew AM, Lawlor KE, Zhan Y, Vince JE, Gerlic M.

Nat Immunol. 2019 Apr;20(4):397-406. doi: 10.1038/s41590-019-0313-5. Epub 2019 Feb 11.


Transcription Factor PU.1 Promotes Conventional Dendritic Cell Identity and Function via Induction of Transcriptional Regulator DC-SCRIPT.

Chopin M, Lun AT, Zhan Y, Schreuder J, Coughlan H, D'Amico A, Mielke LA, Almeida FF, Kueh AJ, Dickins RA, Belz GT, Naik SH, Lew AM, Bouillet P, Herold MJ, Smyth GK, Corcoran LM, Nutt SL.

Immunity. 2019 Jan 15;50(1):77-90.e5. doi: 10.1016/j.immuni.2018.11.010. Epub 2019 Jan 2.


CCR2 enhances CD25 expression by FoxP3+ regulatory T cells and regulates their abundance independently of chemotaxis and CCR2+ myeloid cells.

Zhan Y, Wang N, Vasanthakumar A, Zhang Y, Chopin M, Nutt SL, Kallies A, Lew AM.

Cell Mol Immunol. 2018 Dec 11. doi: 10.1038/s41423-018-0187-8. [Epub ahead of print]


Recipient BCL2 inhibition and NK cell ablation form part of a reduced intensity conditioning regime that improves allo-bone marrow transplantation outcomes.

Jiao Y, Davis JE, Rautela J, Carrington EM, Ludford-Menting MJ, Goh W, Delconte RB, Souza-Fonseca-Guimaraes F, Koldej R, Gray D, Huang D, Kile BT, Lew AM, Ritchie DS, Huntington ND.

Cell Death Differ. 2018 Nov 12. doi: 10.1038/s41418-018-0228-y. [Epub ahead of print]


GM-CSF Quantity Has a Selective Effect on Granulocytic vs. Monocytic Myeloid Development and Function.

Sun L, Rautela J, Delconte RB, Souza-Fonseca-Guimaraes F, Carrington EM, Schenk RL, Herold MJ, Huntington ND, Lew AM, Xu Y, Zhan Y.

Front Immunol. 2018 Aug 28;9:1922. doi: 10.3389/fimmu.2018.01922. eCollection 2018.


Life and Death of Activated T Cells: How Are They Different from Naïve T Cells?

Zhan Y, Carrington EM, Zhang Y, Heinzel S, Lew AM.

Front Immunol. 2017 Dec 13;8:1809. doi: 10.3389/fimmu.2017.01809. eCollection 2017. Review.


The life and death of immune cell types: the role of BCL-2 anti-apoptotic molecules.

Carrington EM, Tarlinton DM, Gray DH, Huntington ND, Zhan Y, Lew AM.

Immunol Cell Biol. 2017 Nov;95(10):870-877. doi: 10.1038/icb.2017.72. Epub 2017 Sep 6. Review.


Targeted insertion of an anti-CD2 monoclonal antibody transgene into the GGTA1 locus in pigs using FokI-dCas9.

Nottle MB, Salvaris EJ, Fisicaro N, McIlfatrick S, Vassiliev I, Hawthorne WJ, O'Connell PJ, Brady JL, Lew AM, Cowan PJ.

Sci Rep. 2017 Aug 16;7(1):8383. doi: 10.1038/s41598-017-09030-6.


Cognate antigen engagement on parenchymal cells stimulates CD8+ T cell proliferation in situ.

Sutherland RM, Londrigan SL, Brady JL, Carrington EM, Marchingo JM, Heinzel S, Hodgkin PD, Graham KL, Kay TW, Zhan Y, Lew AM.

Nat Commun. 2017 Apr 12;8:14809. doi: 10.1038/ncomms14809.


Anti-apoptotic proteins BCL-2, MCL-1 and A1 summate collectively to maintain survival of immune cell populations both in vitro and in vivo.

Carrington EM, Zhan Y, Brady JL, Zhang JG, Sutherland RM, Anstee NS, Schenk RL, Vikstrom IB, Delconte RB, Segal D, Huntington ND, Bouillet P, Tarlinton DM, Huang DC, Strasser A, Cory S, Herold MJ, Lew AM.

Cell Death Differ. 2017 May;24(5):878-888. doi: 10.1038/cdd.2017.30. Epub 2017 Mar 31.


Repurposed JAK1/JAK2 Inhibitor Reverses Established Autoimmune Insulitis in NOD Mice.

Trivedi PM, Graham KL, Scott NA, Jenkins MR, Majaw S, Sutherland RM, Fynch S, Lew AM, Burns CJ, Krishnamurthy B, Brodnicki TC, Mannering SI, Kay TW, Thomas HE.

Diabetes. 2017 Jun;66(6):1650-1660. doi: 10.2337/db16-1250. Epub 2017 Mar 14.


Characterisation of mice lacking all functional isoforms of the pro-survival BCL-2 family member A1 reveals minor defects in the haematopoietic compartment.

Schenk RL, Tuzlak S, Carrington EM, Zhan Y, Heinzel S, Teh CE, Gray DH, Tai L, Lew AM, Villunger A, Strasser A, Herold MJ.

Cell Death Differ. 2017 Mar;24(3):534-545. doi: 10.1038/cdd.2016.156. Epub 2017 Jan 13.


Heterogeneity, functional specialization and differentiation of monocyte-derived dendritic cells.

Chow KV, Sutherland RM, Zhan Y, Lew AM.

Immunol Cell Biol. 2017 Mar;95(3):244-251. doi: 10.1038/icb.2016.104. Epub 2016 Oct 17. Review.


Monocyte-Derived Dendritic Cells Impair Early Graft Function Following Allogeneic Islet Transplantation.

Chow KV, Carrington EM, Zhan Y, Lew AM, Sutherland RM.

Cell Transplant. 2017 Feb 16;26(2):319-326. doi: 10.3727/096368916X693482. Epub 2016 Oct 13.


MCL-1 is required throughout B-cell development and its loss sensitizes specific B-cell subsets to inhibition of BCL-2 or BCL-XL.

Vikström IB, Slomp A, Carrington EM, Moesbergen LM, Chang C, Kelly GL, Glaser SP, Jansen JH, Leusen JH, Strasser A, Huang DC, Lew AM, Peperzak V, Tarlinton DM.

Cell Death Dis. 2016 Aug 25;7(8):e2345. doi: 10.1038/cddis.2016.237.


Genetic strategies to bring islet xenotransplantation to the clinic.

Hawthorne WJ, Lew AM, Thomas HE.

Curr Opin Organ Transplant. 2016 Oct;21(5):476-83. doi: 10.1097/MOT.0000000000000353. Review.


Innate Allorecognition Results in Rapid Accumulation of Monocyte-Derived Dendritic Cells.

Chow KV, Delconte RB, Huntington ND, Tarlinton DM, Sutherland RM, Zhan Y, Lew AM.

J Immunol. 2016 Sep 1;197(5):2000-8. doi: 10.4049/jimmunol.1600181. Epub 2016 Jul 29.


Plasmacytoid dendritic cells are short-lived: reappraising the influence of migration, genetic factors and activation on estimation of lifespan.

Zhan Y, Chow KV, Soo P, Xu Z, Brady JL, Lawlor KE, Masters SL, O'keeffe M, Shortman K, Zhang JG, Lew AM.

Sci Rep. 2016 Apr 26;6:25060. doi: 10.1038/srep25060.


Monocyte-Derived Dendritic Cells Promote Th Polarization, whereas Conventional Dendritic Cells Promote Th Proliferation.

Chow KV, Lew AM, Sutherland RM, Zhan Y.

J Immunol. 2016 Jan 15;196(2):624-36. doi: 10.4049/jimmunol.1501202. Epub 2015 Dec 9.


Drosha controls dendritic cell development by cleaving messenger RNAs encoding inhibitors of myelopoiesis.

Johanson TM, Keown AA, Cmero M, Yeo JH, Kumar A, Lew AM, Zhan Y, Chong MM.

Nat Immunol. 2015 Nov;16(11):1134-41. doi: 10.1038/ni.3293. Epub 2015 Oct 5.


Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β.

Kim ML, Chae JJ, Park YH, De Nardo D, Stirzaker RA, Ko HJ, Tye H, Cengia L, DiRago L, Metcalf D, Roberts AW, Kastner DL, Lew AM, Lyras D, Kile BT, Croker BA, Masters SL.

J Exp Med. 2015 Jun 1;212(6):927-38. doi: 10.1084/jem.20142384. Epub 2015 May 25.


A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production.

Nachbur U, Stafford CA, Bankovacki A, Zhan Y, Lindqvist LM, Fiil BK, Khakham Y, Ko HJ, Sandow JJ, Falk H, Holien JK, Chau D, Hildebrand J, Vince JE, Sharp PP, Webb AI, Jackman KA, Mühlen S, Kennedy CL, Lowes KN, Murphy JM, Gyrd-Hansen M, Parker MW, Hartland EL, Lew AM, Huang DC, Lessene G, Silke J.

Nat Commun. 2015 Mar 17;6:6442. doi: 10.1038/ncomms7442.


Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells.

Carrington EM, Zhang JG, Sutherland RM, Vikstrom IB, Brady JL, Soo P, Vremec D, Allison C, Lee EF, Fairlie WD, Bouillet P, Grabow S, Ottina E, Herold MJ, Pellegrini M, Huang DC, Tarlinton DM, Strasser A, Lew AM, Zhan Y.

Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):4044-9. doi: 10.1073/pnas.1417620112. Epub 2015 Mar 16.


NOD mice are functionally deficient in the capacity of cross-presentation.

Lee CN, Lew AM, Shortman K, Wu L.

Immunol Cell Biol. 2015 Jul;93(6):548-57. doi: 10.1038/icb.2014.119. Epub 2015 Jan 20.


Preclinical screening for acute toxicity of therapeutic monoclonal antibodies in a hu-SCID model.

Brady JL, Harrison LC, Goodman DJ, Cowan PJ, Hawthorne WJ, O'Connell PJ, Sutherland RM, Lew AM.

Clin Transl Immunology. 2014 Dec 19;3(12):e29. doi: 10.1038/cti.2014.28. eCollection 2014 Dec.


A microRNA expression atlas of mouse dendritic cell development.

Johanson TM, Cmero M, Wettenhall J, Lew AM, Zhan Y, Chong MM.

Immunol Cell Biol. 2015 May-Jun;93(5):480-5. doi: 10.1038/icb.2014.109. Epub 2014 Dec 23.


T cell signaling. Antigen affinity, costimulation, and cytokine inputs sum linearly to amplify T cell expansion.

Marchingo JM, Kan A, Sutherland RM, Duffy KR, Wellard CJ, Belz GT, Lew AM, Dowling MR, Heinzel S, Hodgkin PD.

Science. 2014 Nov 28;346(6213):1123-7. doi: 10.1126/science.1260044.


Bcl-2 antagonists kill plasmacytoid dendritic cells from lupus-prone mice and dampen interferon-α production.

Zhan Y, Carrington EM, Ko HJ, Vikstrom IB, Oon S, Zhang JG, Vremec D, Brady JL, Bouillet P, Wu L, Huang DC, Wicks IP, Morand EF, Strasser A, Lew AM.

Arthritis Rheumatol. 2015 Mar;67(3):797-808. doi: 10.1002/art.38966.


Helping themselves: optimal virus-specific CD4 T cell responses require help via CD4 T cell licensing of dendritic cells.

Olson MR, Seah SG, Cullen J, Greyer M, Edenborough K, Doherty PC, Bedoui S, Lew AM, Turner SJ.

J Immunol. 2014 Dec 1;193(11):5420-33. doi: 10.4049/jimmunol.1303359. Epub 2014 Oct 22.


The polycomb repressive complex 2 governs life and death of peripheral T cells.

Zhang Y, Kinkel S, Maksimovic J, Bandala-Sanchez E, Tanzer MC, Naselli G, Zhang JG, Zhan Y, Lew AM, Silke J, Oshlack A, Blewitt ME, Harrison LC.

Blood. 2014 Jul 31;124(5):737-49. doi: 10.1182/blood-2013-12-544106. Epub 2014 Jun 20.


The role of microRNAs in lymphopoiesis.

Johanson TM, Skinner JP, Kumar A, Zhan Y, Lew AM, Chong MM.

Int J Hematol. 2014 Sep;100(3):246-53. doi: 10.1007/s12185-014-1606-y. Epub 2014 Jun 15. Review.


Control of IBMIR in neonatal porcine islet xenotransplantation in baboons.

Hawthorne WJ, Salvaris EJ, Phillips P, Hawkes J, Liuwantara D, Burns H, Barlow H, Stewart AB, Peirce SB, Hu M, Lew AM, Robson SC, Nottle MB, D'Apice AJ, O'Connell PJ, Cowan PJ.

Am J Transplant. 2014 Jun;14(6):1300-9. doi: 10.1111/ajt.12722. Epub 2014 May 19.


Functional cytotoxic T lymphocytes against IGRP206-214 predict diabetes in the non-obese diabetic mouse.

Ko HJ, Chee J, Sutherland RM, Thomas HE, Zhan Y, Krishnamurthy B, Kay TW, Lew AM.

Immunol Cell Biol. 2014 Aug;92(7):640-4. doi: 10.1038/icb.2014.29. Epub 2014 Apr 29.


CD154+ CD4+ T-cell dependence for effective memory influenza virus-specific CD8+ T-cell responses.

Olson MR, Seah SG, Edenborough K, Doherty PC, Lew AM, Turner SJ.

Immunol Cell Biol. 2014 Aug;92(7):605-11. doi: 10.1038/icb.2014.28. Epub 2014 Apr 29.


The closely related CD103+ dendritic cells (DCs) and lymphoid-resident CD8+ DCs differ in their inflammatory functions.

Jiao Z, Bedoui S, Brady JL, Walter A, Chopin M, Carrington EM, Sutherland RM, Nutt SL, Zhang Y, Ko HJ, Wu L, Lew AM, Zhan Y.

PLoS One. 2014 Mar 17;9(3):e91126. doi: 10.1371/journal.pone.0091126. eCollection 2014.


GM-CSF-responsive monocyte-derived dendritic cells are pivotal in Th17 pathogenesis.

Ko HJ, Brady JL, Ryg-Cornejo V, Hansen DS, Vremec D, Shortman K, Zhan Y, Lew AM.

J Immunol. 2014 Mar 1;192(5):2202-9. doi: 10.4049/jimmunol.1302040. Epub 2014 Jan 31.


Effector-memory T cells develop in islets and report islet pathology in type 1 diabetes.

Chee J, Ko HJ, Skowera A, Jhala G, Catterall T, Graham KL, Sutherland RM, Thomas HE, Lew AM, Peakman M, Kay TW, Krishnamurthy B.

J Immunol. 2014 Jan 15;192(2):572-80. doi: 10.4049/jimmunol.1302100. Epub 2013 Dec 11.


MicroRNA-independent roles of the RNase III enzymes Drosha and Dicer.

Johanson TM, Lew AM, Chong MM.

Open Biol. 2013 Oct 23;3(10):130144. doi: 10.1098/rsob.130144. Review.


Transplantation of xenogeneic islets: are we there yet?

O'Connell PJ, Cowan PJ, Hawthorne WJ, Yi S, Lew AM.

Curr Diab Rep. 2013 Oct;13(5):687-94. doi: 10.1007/s11892-013-0413-9. Review.


The potential role of dendritic cells in the therapy of Type 1 diabetes.

Lee CN, Lew AM, Wu L.

Immunotherapy. 2013 Jun;5(6):591-606. doi: 10.2217/imt.13.48. Review.



Caminschi I, Lew AM.

Curr Opin Immunol. 2013 Jun;25(3):356-8. doi: 10.1016/j.coi.2013.05.008. Epub 2013 May 25. No abstract available.


Regulation of asymmetric cell division and polarity by Scribble is not required for humoral immunity.

Hawkins ED, Oliaro J, Kallies A, Belz GT, Filby A, Hogan T, Haynes N, Ramsbottom KM, Van Ham V, Kinwell T, Seddon B, Davies D, Tarlinton D, Lew AM, Humbert PO, Russell SM.

Nat Commun. 2013;4:1801. doi: 10.1038/ncomms2796.


Mutually exclusive regulation of T cell survival by IL-7R and antigen receptor-induced signals.

Koenen P, Heinzel S, Carrington EM, Happo L, Alexander WS, Zhang JG, Herold MJ, Scott CL, Lew AM, Strasser A, Hodgkin PD.

Nat Commun. 2013;4:1735. doi: 10.1038/ncomms2719.


Anti-CD2 producing pig xenografts effect localized depletion of human T cells in a huSCID model.

Brady JL, Sutherland RM, Hancock M, Kitsoulis S, Lahoud MH, Phillips PM, Hawthorne WJ, d'Apice AJ, Cowan PJ, Harrison LC, O'Connell PJ, Lew AM.

Xenotransplantation. 2013 Mar-Apr;20(2):100-9. doi: 10.1111/xen.12025. Epub 2013 Feb 27.


Contribution of Thy1+ NK cells to protective IFN-γ production during Salmonella typhimurium infections.

Kupz A, Scott TA, Belz GT, Andrews DM, Greyer M, Lew AM, Brooks AG, Smyth MJ, Curtiss R 3rd, Bedoui S, Strugnell RA.

Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2252-7. doi: 10.1073/pnas.1222047110. Epub 2013 Jan 23.


Influenza-induced, helper-independent CD8+ T cell responses use CD40 costimulation at the late phase of the primary response.

Seah SG, Brady JL, Carrington EM, Ng WC, Sutherland RM, Hancock MS, La Gruta NL, Brown LE, Turner SJ, Lew AM, Zhan Y.

J Leukoc Biol. 2013 Jan;93(1):145-54. doi: 10.1189/jlb.0612266. Epub 2012 Oct 29.


The inflammatory cytokine, GM-CSF, alters the developmental outcome of murine dendritic cells.

Zhan Y, Vega-Ramos J, Carrington EM, Villadangos JA, Lew AM, Xu Y.

Eur J Immunol. 2012 Nov;42(11):2889-900. doi: 10.1002/eji.201242477. Epub 2012 Sep 3.


Unlike CD4+ T-cell help, CD28 costimulation is necessary for effective primary CD8+ T-cell influenza-specific immunity.

Seah SG, Carrington EM, Ng WC, Belz GT, Brady JL, Sutherland RM, Hancock MS, La Gruta NL, Brown LE, Turner SJ, Zhan Y, Lew AM.

Eur J Immunol. 2012 Jul;42(7):1744-54. doi: 10.1002/eji.201142211. Epub 2012 Jun 14.


The regulation of the development and function of dendritic cell subsets by GM-CSF: more than a hematopoietic growth factor.

Zhan Y, Xu Y, Lew AM.

Mol Immunol. 2012 Aug;52(1):30-7. doi: 10.1016/j.molimm.2012.04.009. Epub 2012 May 14. Review.


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