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Items: 1 to 50 of 122

1.

FRET-based cyclic GMP biosensors measure low cGMP concentrations in cardiomyocytes and neurons.

Calamera G, Li D, Ulsund AH, Kim JJ, Neely OC, Moltzau LR, Bjørnerem M, Paterson D, Kim C, Levy FO, Andressen KW.

Commun Biol. 2019 Oct 29;2:394. doi: 10.1038/s42003-019-0641-x. eCollection 2019.

2.

Constitutive inhibitory G protein activity upon adenylyl cyclase-dependent cardiac contractility is limited to adenylyl cyclase type 6.

Bull Melsom C, Cosson MV, Ørstavik Ø, Lai NC, Hammond HK, Osnes JB, Skomedal T, Nikolaev V, Levy FO, Krobert KA.

PLoS One. 2019 Jun 7;14(6):e0218110. doi: 10.1371/journal.pone.0218110. eCollection 2019.

3.

Reduced ambient temperature exacerbates SIRS-induced cardiac autonomic dysregulation and myocardial dysfunction in mice.

Ndongson-Dongmo B, Lang GP, Mece O, Hechaichi N, Lajqi T, Hoyer D, Brodhun M, Heller R, Wetzker R, Franz M, Levy FO, Bauer R.

Basic Res Cardiol. 2019 Apr 23;114(3):26. doi: 10.1007/s00395-019-0734-1.

PMID:
31016449
4.

Knockout of adenylyl cyclase isoform 5 or 6 differentially modifies the β1-adrenoceptor-mediated inotropic response.

Cosson MV, Hiis HG, Moltzau LR, Levy FO, Krobert KA.

J Mol Cell Cardiol. 2019 Jun;131:132-145. doi: 10.1016/j.yjmcc.2019.04.017. Epub 2019 Apr 19.

PMID:
31009605
5.

Preassociation between the 5-HT7 serotonin receptor and G protein Gs: molecular determinants and association with low potency activation of adenylyl cyclase.

Ulsund AH, Dahl M, Frimurer TM, Manfra O, Schwartz TW, Levy FO, Andressen KW.

FASEB J. 2019 Mar;33(3):3870-3886. doi: 10.1096/fj.201800805RR. Epub 2018 Dec 3.

PMID:
30508496
6.

Hypothermia elongates the contraction-relaxation cycle in explanted human failing heart decreasing the time for ventricular filling during diastole.

Hiis HG, Cosson MV, Dahl CP, Fiane AE, Levy FO, Andersen GØ, Krobert KA.

Am J Physiol Heart Circ Physiol. 2018 Nov 1;315(5):H1137-H1147. doi: 10.1152/ajpheart.00208.2018. Epub 2018 Jul 13.

7.

Related GPCRs couple differently to Gs: preassociation between G protein and 5-HT7 serotonin receptor reveals movement of Gαs upon receptor activation.

Andressen KW, Ulsund AH, Krobert KA, Lohse MJ, Bünemann M, Levy FO.

FASEB J. 2018 Feb;32(2):1059-1069. doi: 10.1096/fj.201700486R. Epub 2018 Jan 3.

PMID:
29079700
8.

PDE3 inhibition by C-type natriuretic peptide-induced cGMP enhances cAMP-mediated signaling in both non-failing and failing hearts.

Meier S, Andressen KW, Aronsen JM, Sjaastad I, Hougen K, Skomedal T, Osnes JB, Qvigstad E, Levy FO, Moltzau LR.

Eur J Pharmacol. 2017 Oct 5;812:174-183. doi: 10.1016/j.ejphar.2017.07.014. Epub 2017 Jul 8.

PMID:
28697992
9.

Functional pharmacological characterization of SER100 in cardiovascular health and disease.

Villar IC, Bubb KJ, Moyes AJ, Steiness E, Gulbrandsen T, Levy FO, Hobbs AJ.

Br J Pharmacol. 2016 Dec;173(23):3386-3401. doi: 10.1111/bph.13634. Epub 2016 Nov 1.

10.

CaMKII and at least two unidentified kinases phosphorylate regulatory light chain in non-contracting cardiomyocytes.

Eikemo H, Moltzau LR, Nguyen CHT, Levy FO, Skomedal T, Osnes JB.

Biochem Biophys Res Commun. 2016 Aug 12;477(1):14-19. doi: 10.1016/j.bbrc.2016.05.138. Epub 2016 May 27.

PMID:
27237977
11.

Brain penetrant small molecule (18)F-GnRH receptor (GnRH-R) antagonists: Synthesis and preliminary positron emission tomography imaging in rats.

Olberg DE, Bauer N, Andressen KW, Hjørnevik T, Cumming P, Levy FO, Klaveness J, Haraldsen I, Sutcliffe JL.

Nucl Med Biol. 2016 Aug;43(8):478-89. doi: 10.1016/j.nucmedbio.2016.05.003. Epub 2016 May 10.

PMID:
27236283
12.

CaMKII in addition to MLCK contributes to phosphorylation of regulatory light chain in cardiomyocytes.

Eikemo H, Moltzau LR, Hussain RI, Nguyen CH, Qvigstad E, Levy FO, Skomedal T, Osnes JB.

Biochem Biophys Res Commun. 2016 Feb 26;471(1):219-25. doi: 10.1016/j.bbrc.2016.01.132. Epub 2016 Jan 22.

PMID:
26809094
13.

Low β₂-adrenergic receptor level may promote development of castration resistant prostate cancer and altered steroid metabolism.

Braadland PR, Grytli HH, Ramberg H, Katz B, Kellman R, Gauthier-Landry L, Fazli L, Krobert KA, Wang W, Levy FO, Bjartell A, Berge V, Rennie PS, Mellgren G, Mælandsmo GM, Svindland A, Barbier O, Taskén KA.

Oncotarget. 2016 Jan 12;7(2):1878-94. doi: 10.18632/oncotarget.6479.

14.

Identification of essential residues for binding and activation in the human 5-HT7(a) serotonin receptor by molecular modeling and site-directed mutagenesis.

Impellizzeri AA, Pappalardo M, Basile L, Manfra O, Andressen KW, Krobert KA, Messina A, Levy FO, Guccione S.

Front Behav Neurosci. 2015 May 8;9:92. doi: 10.3389/fnbeh.2015.00092. eCollection 2015.

15.

The atypical antipsychotics clozapine and olanzapine promote down-regulation and display functional selectivity at human 5-HT7 receptors.

Andressen KW, Manfra O, Brevik CH, Ulsund AH, Vanhoenacker P, Levy FO, Krobert KA.

Br J Pharmacol. 2015 Aug;172(15):3846-60. doi: 10.1111/bph.13169. Epub 2015 Jun 12.

16.

The inotropic effect of the active metabolite of levosimendan, OR-1896, is mediated through inhibition of PDE3 in rat ventricular myocardium.

Ørstavik Ø, Manfra O, Andressen KW, Andersen GØ, Skomedal T, Osnes JB, Levy FO, Krobert KA.

PLoS One. 2015 Mar 4;10(3):e0115547. doi: 10.1371/journal.pone.0115547. eCollection 2015.

17.

Downregulation of 5-HT7 Serotonin Receptors by the Atypical Antipsychotics Clozapine and Olanzapine. Role of Motifs in the C-Terminal Domain and Interaction with GASP-1.

Manfra O, Van Craenenbroeck K, Skieterska K, Frimurer T, Schwartz TW, Levy FO, Andressen KW.

ACS Chem Neurosci. 2015 Jul 15;6(7):1206-18. doi: 10.1021/cn500339p. Epub 2015 Apr 20.

PMID:
25706089
18.

In memory of Guro Valen (1960-2014).

Ytrehus K, Larsen T, Christensen G, Stensløkken KO, Levy FO.

J Mol Cell Cardiol. 2015 Feb;79:254-5. doi: 10.1016/j.yjmcc.2014.11.026. Epub 2014 Dec 7. No abstract available.

PMID:
25490150
19.

Non-classical regulation of β1- and β 2-adrenoceptor-mediated inotropic responses in rat heart ventricle by the G protein Gi.

Melsom CB, Hussain RI, Ørstavik Ø, Aronsen JM, Sjaastad I, Skomedal T, Osnes JB, Levy FO, Krobert KA.

Naunyn Schmiedebergs Arch Pharmacol. 2014 Dec;387(12):1177-86. doi: 10.1007/s00210-014-1036-7. Epub 2014 Sep 13.

PMID:
25216690
20.

Gi proteins regulate adenylyl cyclase activity independent of receptor activation.

Melsom CB, Ørstavik Ø, Osnes JB, Skomedal T, Levy FO, Krobert KA.

PLoS One. 2014 Sep 9;9(9):e106608. doi: 10.1371/journal.pone.0106608. eCollection 2014.

21.

Discovery and pharmacological profile of new hydrophilic 5-HT(4) receptor antagonists.

Brudeli B, Navaratnarajah M, Andressen KW, Manfra O, Moltzau LR, Nilsen NO, Levy FO, Klaveness J.

Bioorg Med Chem Lett. 2014 Sep 15;24(18):4598-4602. doi: 10.1016/j.bmcl.2014.06.083. Epub 2014 Jul 5.

PMID:
25149506
22.

Different compartmentation of responses to brain natriuretic peptide and C-type natriuretic peptide in failing rat ventricle.

Moltzau LR, Aronsen JM, Meier S, Skogestad J, Ørstavik Ø, Lothe GB, Sjaastad I, Skomedal T, Osnes JB, Levy FO, Qvigstad E.

J Pharmacol Exp Ther. 2014 Sep;350(3):681-90. doi: 10.1124/jpet.114.214882. Epub 2014 Jul 14.

PMID:
25022512
23.

Synthesis and in vitro evaluation of small-molecule [18F] labeled gonadotropin-releasing hormone (GnRH) receptor antagonists as potential PET imaging agents for GnRH receptor expression.

Olberg DE, Andressen KW, Levy FO, Klaveness J, Haraldsen I, Sutcliffe JL.

Bioorg Med Chem Lett. 2014 Apr 1;24(7):1846-50. doi: 10.1016/j.bmcl.2014.02.002. Epub 2014 Feb 10.

PMID:
24613701
24.

Inhibition of phosphodiesterase-3 by levosimendan is sufficient to account for its inotropic effect in failing human heart.

Orstavik O, Ata SH, Riise J, Dahl CP, Andersen GØ, Levy FO, Skomedal T, Osnes JB, Qvigstad E.

Br J Pharmacol. 2014 Dec;171(23):5169-81. doi: 10.1111/bph.12647.

25.

Disheveled regulates precoupling of heterotrimeric G proteins to Frizzled 6.

Kilander MB, Petersen J, Andressen KW, Ganji RS, Levy FO, Schuster J, Dahl N, Bryja V, Schulte G.

FASEB J. 2014 May;28(5):2293-305. doi: 10.1096/fj.13-246363. Epub 2014 Feb 5.

PMID:
24500924
26.

Differential regulation of C-type natriuretic peptide-induced cGMP and functional responses by PDE2 and PDE3 in failing myocardium.

Moltzau LR, Meier S, Aronsen JM, Afzal F, Sjaastad I, Skomedal T, Osnes JB, Levy FO, Qvigstad E.

Naunyn Schmiedebergs Arch Pharmacol. 2014 May;387(5):407-17. doi: 10.1007/s00210-013-0953-1. Epub 2014 Jan 15.

PMID:
24424715
27.

Identification of small molecule NPR-B antagonists by high throughput screening--potential use in heart failure.

Bach T, Bergholtz S, Riise J, Qvigstad E, Skomedal T, Osnes JB, Levy FO.

Naunyn Schmiedebergs Arch Pharmacol. 2014 Jan;387(1):5-14. doi: 10.1007/s00210-013-0940-6. Epub 2013 Dec 3.

PMID:
24297249
28.

Acidic biphenyl derivatives: synthesis and biological activity of a new series of potent 5-HT(4) receptor antagonists.

Brudeli B, Andressen KW, Moltzau LR, Nilsen NO, Levy FO, Klaveness J.

Bioorg Med Chem. 2013 Nov 15;21(22):7134-45. doi: 10.1016/j.bmc.2013.09.004. Epub 2013 Sep 11.

PMID:
24113240
29.

The serotonin 5-HT7 receptors: two decades of research.

Gellynck E, Heyninck K, Andressen KW, Haegeman G, Levy FO, Vanhoenacker P, Van Craenenbroeck K.

Exp Brain Res. 2013 Oct;230(4):555-68. doi: 10.1007/s00221-013-3694-y. Epub 2013 Sep 17. Review.

PMID:
24042216
30.

NSC23766, a widely used inhibitor of Rac1 activation, additionally acts as a competitive antagonist at muscarinic acetylcholine receptors.

Levay M, Krobert KA, Wittig K, Voigt N, Bermudez M, Wolber G, Dobrev D, Levy FO, Wieland T.

J Pharmacol Exp Ther. 2013 Oct;347(1):69-79. doi: 10.1124/jpet.113.207266. Epub 2013 Jul 25.

PMID:
23887096
31.

SERCA2 activity is involved in the CNP-mediated functional responses in failing rat myocardium.

Moltzau LR, Aronsen JM, Meier S, Nguyen CH, Hougen K, Ørstavik Ø, Sjaastad I, Christensen G, Skomedal T, Osnes JB, Levy FO, Qvigstad E.

Br J Pharmacol. 2013 Sep;170(2):366-79. doi: 10.1111/bph.12282.

32.

Connective tissue growth factor/CCN2 attenuates β-adrenergic receptor responsiveness and cardiotoxicity by induction of G protein-coupled receptor kinase-5 in cardiomyocytes.

Gravning J, Ahmed MS, Qvigstad E, Krobert K, Edvardsen T, Moe IT, Hagelin EM, Sagave J, Valen G, Levy FO, Osnes JB, Skomedal T, Attramadal H.

Mol Pharmacol. 2013 Sep;84(3):372-83. doi: 10.1124/mol.113.087312. Epub 2013 Jun 18.

PMID:
23778361
33.

Synthesis and pharmacological properties of a new hydrophilic and orally bioavailable 5-HT4 antagonist.

Brudeli B, Moltzau LR, Nguyen CH, Andressen KW, Nilsen NO, Levy FO, Klaveness J.

Eur J Med Chem. 2013 Jun;64:629-37. doi: 10.1016/j.ejmech.2013.03.060. Epub 2013 Apr 9.

PMID:
23711770
34.

Cardiac PDEs and crosstalk between cAMP and cGMP signalling pathways in the regulation of contractility.

Levy FO.

Naunyn Schmiedebergs Arch Pharmacol. 2013 Aug;386(8):665-70. doi: 10.1007/s00210-013-0874-z. Epub 2013 May 7.

PMID:
23649864
35.

PDE3, but not PDE4, reduces β₁ - and β₂-adrenoceptor-mediated inotropic and lusitropic effects in failing ventricle from metoprolol-treated patients.

Molenaar P, Christ T, Hussain RI, Engel A, Berk E, Gillette KT, Chen L, Galindo-Tovar A, Krobert KA, Ravens U, Levy FO, Kaumann AJ.

Br J Pharmacol. 2013 Jun;169(3):528-38. doi: 10.1111/bph.12167.

36.

The functional activity of inhibitory G protein (G(i)) is not increased in failing heart ventricle.

Hussain RI, Aronsen JM, Afzal F, Sjaastad I, Osnes JB, Skomedal T, Levy FO, Krobert KA.

J Mol Cell Cardiol. 2013 Mar;56:129-38. doi: 10.1016/j.yjmcc.2012.11.015. Epub 2012 Dec 7.

PMID:
23220156
37.

The cardiac ventricular 5-HT4 receptor is functional in late foetal development and is reactivated in heart failure.

Brattelid T, Qvigstad E, Moltzau LR, Bekkevold SV, Sandnes DL, Birkeland JA, Skomedal T, Osnes JB, Sjaastad I, Levy FO.

PLoS One. 2012;7(9):e45489. doi: 10.1371/journal.pone.0045489. Epub 2012 Sep 20.

38.

Retinoic acid signalling is activated in the postischemic heart and may influence remodelling.

Bilbija D, Haugen F, Sagave J, Baysa A, Bastani N, Levy FO, Sirsjö A, Blomhoff R, Valen G.

PLoS One. 2012;7(9):e44740. doi: 10.1371/journal.pone.0044740. Epub 2012 Sep 28.

39.

Prostaglandin E1 facilitates inotropic effects of 5-HT4 serotonin receptors and β-adrenoceptors in failing human heart.

Riise J, Ørstavik Ø, Qvigstad E, Dahl CP, Osnes JB, Skomedal T, Levy FO, Krobert KA.

Basic Res Cardiol. 2012 Sep;107(5):295. doi: 10.1007/s00395-012-0295-z. Epub 2012 Aug 25.

PMID:
22923058
40.

Prostanoid-mediated inotropic responses are attenuated in failing human and rat ventricular myocardium.

Riise J, Nguyen CH, Hussain RI, Dahl CP, Ege MS, Osnes JB, Skomedal T, Sandnes DL, Levy FO, Krobert KA.

Eur J Pharmacol. 2012 Jul 5;686(1-3):66-73. doi: 10.1016/j.ejphar.2012.04.022. Epub 2012 Apr 21.

PMID:
22546232
41.

Cardiomyocyte-restricted inhibition of G protein-coupled receptor kinase-3 attenuates cardiac dysfunction after chronic pressure overload.

von Lueder TG, Gravning J, How OJ, Vinge LE, Ahmed MS, Krobert KA, Levy FO, Larsen TS, Smiseth OA, Aasum E, Attramadal H.

Am J Physiol Heart Circ Physiol. 2012 Jul;303(1):H66-74. doi: 10.1152/ajpheart.00724.2011. Epub 2012 Apr 27.

42.

Biochemical and pharmacological study of N-linked glycosylation of the human serotonin 5-HT₇a receptor.

Gellynck E, Andressen KW, Lintermans B, Haegeman G, Levy FO, Vanhoenacker P, Van Craenenbroeck K.

FEBS J. 2012 Jun;279(11):1994-2003. doi: 10.1111/j.1742-4658.2012.08581.x. Epub 2012 Apr 25.

43.

Agents increasing cyclic GMP amplify 5-HT4-elicited positive inotropic response in failing rat cardiac ventricle.

Afzal F, Qvigstad E, Aronsen JM, Moltzau LR, Sjaastad I, Skomedal T, Osnes JB, Levy FO.

Naunyn Schmiedebergs Arch Pharmacol. 2011 Dec;384(6):543-53. doi: 10.1007/s00210-011-0670-6. Epub 2011 Sep 8.

44.

Quantification of GPCR mRNA using real-time RT-PCR.

Brattelid T, Levy FO.

Methods Mol Biol. 2011;746:165-93. doi: 10.1007/978-1-61779-126-0_9.

PMID:
21607857
45.

Novel benzo[b]thiophene derivatives as new potential antidepressants with rapid onset of action.

Berrade L, Aisa B, Ramirez MJ, Galiano S, Guccione S, Moltzau LR, Levy FO, Nicoletti F, Battaglia G, Molinaro G, Aldana I, Monge A, Perez-Silanes S.

J Med Chem. 2011 Apr 28;54(8):3086-90. doi: 10.1021/jm2000773. Epub 2011 Apr 6.

46.

Differential regulation of β2 -adrenoceptor-mediated inotropic and lusitropic response by PDE3 and PDE4 in failing and non-failing rat cardiac ventricle.

Afzal F, Aronsen JM, Moltzau LR, Sjaastad I, Levy FO, Skomedal T, Osnes JB, Qvigstad E.

Br J Pharmacol. 2011 Jan;162(1):54-71. doi: 10.1111/j.1476-5381.2010.00890.x.

47.

Synthesis and pharmacological properties of novel hydrophilic 5-HT4 receptor antagonists.

Brudeli B, Moltzau LR, Andressen KW, Krobert KA, Klaveness J, Levy FO.

Bioorg Med Chem. 2010 Dec 15;18(24):8600-13. doi: 10.1016/j.bmc.2010.10.011. Epub 2010 Nov 12.

PMID:
21075638
48.

Cyclic AMP-dependent inotropic effects are differentially regulated by muscarinic G(i)-dependent constitutive inhibition of adenylyl cyclase in failing rat ventricle.

Hussain RI, Afzal F, Mørk HK, Aronsen JM, Sjaastad I, Osnes JB, Skomedal T, Levy FO, Krobert KA.

Br J Pharmacol. 2011 Feb;162(4):908-16. doi: 10.1111/j.1476-5381.2010.01097.x.

49.

Reference gene alternatives to Gapdh in rodent and human heart failure gene expression studies.

Brattelid T, Winer LH, Levy FO, Liestøl K, Sejersted OM, Andersson KB.

BMC Mol Biol. 2010 Mar 23;11:22. doi: 10.1186/1471-2199-11-22.

50.

Natriuretic peptides increase beta1-adrenoceptor signalling in failing hearts through phosphodiesterase 3 inhibition.

Qvigstad E, Moltzau LR, Aronsen JM, Nguyen CH, Hougen K, Sjaastad I, Levy FO, Skomedal T, Osnes JB.

Cardiovasc Res. 2010 Mar 1;85(4):763-72. doi: 10.1093/cvr/cvp364. Epub 2009 Nov 9.

PMID:
19900965

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