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Items: 1 to 50 of 165

1.

Neutrophil cytoplasts induce TH17 differentiation and skew inflammation toward neutrophilia in severe asthma.

Krishnamoorthy N, Douda DN, Brüggemann TR, Ricklefs I, Duvall MG, Abdulnour RE, Martinod K, Tavares L, Wang X, Cernadas M, Israel E, Mauger DT, Bleecker ER, Castro M, Erzurum SC, Gaston BM, Jarjour NN, Wenzel S, Dunican E, Fahy JV, Irimia D, Wagner DD, Levy BD; National Heart, Lung, and Blood Institute Severe Asthma Research Program-3 Investigators.

Sci Immunol. 2018 Aug 3;3(26). pii: eaao4747. doi: 10.1126/sciimmunol.aao4747.

PMID:
30076281
2.

Early Intravascular Events Are Associated with Development of Acute Respiratory Distress Syndrome. A Substudy of the LIPS-A Clinical Trial.

Abdulnour RE, Gunderson T, Barkas I, Timmons JY, Barnig C, Gong M, Kor DJ, Gajic O, Talmor D, Carter RE, Levy BD.

Am J Respir Crit Care Med. 2018 Jun 15;197(12):1575-1585. doi: 10.1164/rccm.201712-2530OC.

PMID:
29782179
3.

Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators.

Serhan CN, Levy BD.

J Clin Invest. 2018 May 14. pii: 97943. doi: 10.1172/JCI97943. [Epub ahead of print]

4.

Specialized Proresolving Mediators in Innate and Adaptive Immune Responses in Airway Diseases.

Krishnamoorthy N, Abdulnour RE, Walker KH, Engstrom BD, Levy BD.

Physiol Rev. 2018 Jul 1;98(3):1335-1370. doi: 10.1152/physrev.00026.2017.

PMID:
29717929
5.

Pruning of the Pulmonary Vasculature in Asthma. The Severe Asthma Research Program (SARP) Cohort.

Ash SY, Rahaghi FN, Come CE, Ross JC, Colon AG, Cardet-Guisasola JC, Dunican EM, Bleecker ER, Castro M, Fahy JV, Fain SB, Gaston BM, Hoffman EA, Jarjour NN, Mauger DT, Wenzel SE, Levy BD, San Jose Estepar R, Israel E, Washko GR; SARP Investigators.

Am J Respir Crit Care Med. 2018 Jul 1;198(1):39-50. doi: 10.1164/rccm.201712-2426OC.

PMID:
29672122
6.

ALX receptor ligands define a biochemical endotype for severe asthma.

Ricklefs I, Barkas I, Duvall MG, Cernadas M, Grossman NL, Israel E, Bleecker ER, Castro M, Erzurum SC, Fahy JV, Gaston BM, Denlinger LC, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Levy BD; National Heart Lung and Blood Institute’s Severe Asthma Research Program- Investigators.

JCI Insight. 2018 Mar 22;3(6). pii: 120932. doi: 10.1172/jci.insight.120932. [Epub ahead of print] No abstract available.

7.

Future Research Directions in Pneumonia. NHLBI Working Group Report.

Dela Cruz CS, Wunderink RG, Christiani DC, Cormier SA, Crothers K, Doerschuk CM, Evans SE, Goldstein DR, Khatri P, Kobzik L, Kolls JK, Levy BD, Metersky ML, Niederman MS, Nusrat R, Orihuela CJ, Peyrani P, Prince AS, Ramírez JA, Ridge KM, Sethi S, Suratt BT, Sznajder JI, Tsalik EL, Walkey AJ, Yende S, Aggarwal NR, Caler EV, Mizgerd JP.

Am J Respir Crit Care Med. 2018 Jul 15;198(2):256-263. doi: 10.1164/rccm.201801-0139WS.

PMID:
29546996
8.

Refractory airway type 2 inflammation in a large subgroup of asthmatic patients treated with inhaled corticosteroids.

Peters MC, Kerr S, Dunican EM, Woodruff PG, Fajt ML, Levy BD, Israel E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Hastie AT, Bleecker ER, Wenzel SE, Fahy JV; National Heart, Lung and Blood Institute Severe Asthma Research Program 3.

J Allergy Clin Immunol. 2018 Mar 7. pii: S0091-6749(18)30390-7. doi: 10.1016/j.jaci.2017.12.1009. [Epub ahead of print]

PMID:
29524537
9.

15-epi-Lipoxin A4, Resolvin D2, and Resolvin D3 Induce NF-κB Regulators in Bacterial Pneumonia.

Sham HP, Walker KH, Abdulnour RE, Krishnamoorthy N, Douda DN, Norris PC, Barkas I, Benito-Figueroa S, Colby JK, Serhan CN, Levy BD.

J Immunol. 2018 Apr 15;200(8):2757-2766. doi: 10.4049/jimmunol.1602090. Epub 2018 Mar 9.

PMID:
29523657
10.

Phospholipase D isoforms differentially regulate leukocyte responses to acute lung injury.

Abdulnour RE, Howrylak JA, Tavares AH, Douda DN, Henkels KM, Miller TE, Fredenburgh LE, Baron RM, Gomez-Cambronero J, Levy BD.

J Leukoc Biol. 2018 May;103(5):919-932. doi: 10.1002/JLB.3A0617-252RR. Epub 2018 Feb 13.

PMID:
29437245
11.

Mucus plugs in patients with asthma linked to eosinophilia and airflow obstruction.

Dunican EM, Elicker BM, Gierada DS, Nagle SK, Schiebler ML, Newell JD, Raymond WW, Lachowicz-Scroggins ME, Di Maio S, Hoffman EA, Castro M, Fain SB, Jarjour NN, Israel E, Levy BD, Erzurum SC, Wenzel SE, Meyers DA, Bleecker ER, Phillips BR, Mauger DT, Gordon ED, Woodruff PG, Peters MC, Fahy JV; National Heart Lung and Blood Institute (NHLBI) Severe Asthma Research Program (SARP).

J Clin Invest. 2018 Mar 1;128(3):997-1009. doi: 10.1172/JCI95693. Epub 2018 Feb 5.

12.

Towards targeting resolution pathways of airway inflammation in asthma.

Barnig C, Frossard N, Levy BD.

Pharmacol Ther. 2018 Jun;186:98-113. doi: 10.1016/j.pharmthera.2018.01.004. Epub 2018 Jan 20. Review.

PMID:
29352860
13.

Erratum: The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation.

Wallrapp A, Riesenfeld SJ, Burkett PR, Abdulnour RE, Nyman J, Dionne D, Hofree M, Cuoco MS, Rodman C, Farouq D, Haas BJ, Tickle TL, Trombetta JJ, Baral P, Klose CSN, Mahlakõiv T, Artis D, Rozenblatt-Rosen O, Chiu IM, Levy BD, Kowalczyk MS, Regev A, Kuchroo VK.

Nature. 2017 Nov 30;551(7682):658. doi: 10.1038/nature24480. Epub 2017 Nov 15.

PMID:
29143821
14.

An epoxide hydrolase secreted by Pseudomonas aeruginosa decreases mucociliary transport and hinders bacterial clearance from the lung.

Hvorecny KL, Dolben E, Moreau-Marquis S, Hampton TH, Shabaneh TB, Flitter BA, Bahl CD, Bomberger JM, Levy BD, Stanton BA, Hogan DA, Madden DR.

Am J Physiol Lung Cell Mol Physiol. 2018 Jan 1;314(1):L150-L156. doi: 10.1152/ajplung.00383.2017. Epub 2017 Oct 5.

PMID:
28982736
15.

Augmented Responses to Ozone in Obese Mice Require IL-17A and Gastrin-Releasing Peptide.

Mathews JA, Krishnamoorthy N, Kasahara DI, Hutchinson J, Cho Y, Brand JD, Williams AS, Wurmbrand AP, Ribeiro L, Cuttitta F, Sunday ME, Levy BD, Shore SA.

Am J Respir Cell Mol Biol. 2018 Mar;58(3):341-351. doi: 10.1165/rcmb.2017-0071OC.

PMID:
28957638
16.

The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation.

Wallrapp A, Riesenfeld SJ, Burkett PR, Abdulnour RE, Nyman J, Dionne D, Hofree M, Cuoco MS, Rodman C, Farouq D, Haas BJ, Tickle TL, Trombetta JJ, Baral P, Klose CSN, Mahlakõiv T, Artis D, Rozenblatt-Rosen O, Chiu IM, Levy BD, Kowalczyk MS, Regev A, Kuchroo VK.

Nature. 2017 Sep 21;549(7672):351-356. doi: 10.1038/nature24029. Epub 2017 Sep 13. Erratum in: Nature. 2017 Nov 15;:.

17.

Natural killer cell-mediated inflammation resolution is disabled in severe asthma.

Duvall MG, Barnig C, Cernadas M, Ricklefs I, Krishnamoorthy N, Grossman NL, Bhakta NR, Fahy JV, Bleecker ER, Castro M, Erzurum SC, Gaston BM, Jarjour NN, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Israel E, Levy BD; National Heart, Lung, and Blood Institute’s Severe Asthma Research Program-3 Investigators.

Sci Immunol. 2017 Mar 10;2(9). pii: eaam5446. doi: 10.1126/sciimmunol.aam5446.

18.

ALX receptor ligands define a biochemical endotype for severe asthma.

Ricklefs I, Barkas I, Duvall MG, Cernadas M, Grossman NL, Israel E, Bleecker ER, Castro M, Erzurum SC, Fahy JV, Gaston BM, Denlinger LC, Mauger DT, Wenzel SE, Comhair SA, Coverstone AM, Fajt ML, Hastie AT, Johansson MW, Peters MC, Phillips BR, Levy BD; National Heart Lung and Blood Institute’s Severe Asthma Research Program-3 Investigators.

JCI Insight. 2017 Jul 20;2(14). pii: 93534. doi: 10.1172/jci.insight.93534. [Epub ahead of print]

19.

Back to the History.

Montgomery MW, Yawetz S, Levy BD, Loscalzo J.

N Engl J Med. 2017 May 4;376(18):1783-1788. doi: 10.1056/NEJMcps1607608. No abstract available.

PMID:
28467866
20.

Bronchoprotective mechanisms for specialized pro-resolving mediators in the resolution of lung inflammation.

Duvall MG, Bruggemann TR, Levy BD.

Mol Aspects Med. 2017 Dec;58:44-56. doi: 10.1016/j.mam.2017.04.003. Epub 2017 May 17. Review.

PMID:
28455109
21.

Brain MRS glutamine as a biomarker to guide therapy of hyperammonemic coma.

O'Donnell-Luria AH, Lin AP, Merugumala SK, Rohr F, Waisbren SE, Lynch R, Tchekmedyian V, Goldberg AD, Bellinger A, McFaline-Figueroa JR, Simon T, Gershanik EF, Levy BD, Cohen DE, Samuels MA, Berry GT, Frank NY.

Mol Genet Metab. 2017 May;121(1):9-15. doi: 10.1016/j.ymgme.2017.03.003. Epub 2017 Mar 10.

PMID:
28408159
22.

Fish Oil Supplementation in Pregnancy.

Ramaswami R, Serhan CN, Levy BD, Makrides M.

N Engl J Med. 2016 Dec 29;375(26):2599-2601. doi: 10.1056/NEJMclde1614333. No abstract available.

23.

Pseudomonas aeruginosa sabotages the generation of host proresolving lipid mediators.

Flitter BA, Hvorecny KL, Ono E, Eddens T, Yang J, Kwak DH, Bahl CD, Hampton TH, Morisseau C, Hammock BD, Liu X, Lee JS, Kolls JK, Levy BD, Madden DR, Bomberger JM.

Proc Natl Acad Sci U S A. 2017 Jan 3;114(1):136-141. doi: 10.1073/pnas.1610242114. Epub 2016 Dec 15.

24.

Effects of Age and Disease Severity on Systemic Corticosteroid Responses in Asthma.

Phipatanakul W, Mauger DT, Sorkness RL, Gaffin JM, Holguin F, Woodruff PG, Ly NP, Bacharier LB, Bhakta NR, Moore WC, Bleecker ER, Hastie AT, Meyers DA, Castro M, Fahy JV, Fitzpatrick AM, Gaston BM, Jarjour NN, Levy BD, Peters SP, Teague WG, Fajt M, Wenzel SE, Erzurum SC, Israel E; Severe Asthma Research Program.

Am J Respir Crit Care Med. 2017 Jun 1;195(11):1439-1448. doi: 10.1164/rccm.201607-1453OC.

25.

Restoring Balance: Paraneoplastic Cerebellar Degeneration.

Klein JP, Stover DG, Oxnard GR, Levy BD, Loscalzo J.

Am J Med. 2017 Mar;130(3):e85-e87. doi: 10.1016/j.amjmed.2016.09.035. Epub 2016 Nov 2. No abstract available.

PMID:
27816447
26.

Monitoring sepsis using electrical cell profiling.

Prieto JL, Su HW, Hou HW, Vera MP, Levy BD, Baron RM, Han J, Voldman J.

Lab Chip. 2016 Nov 1;16(22):4333-4340.

27.

Testing Limits.

Massarotti EM, Sax PE, Compton L, Levy BD, Loscalzo J.

N Engl J Med. 2016 Oct 6;375(14):1383-1388. No abstract available.

PMID:
27705260
28.

Aspirin and Acute Respiratory Distress Syndrome-Reply.

Kor DJ, Gong MN, Levy BD.

JAMA. 2016 Sep 27;316(12):1318. doi: 10.1001/jama.2016.12327. No abstract available.

PMID:
27673315
29.

Human Sepsis Eicosanoid and Proresolving Lipid Mediator Temporal Profiles: Correlations With Survival and Clinical Outcomes.

Dalli J, Colas RA, Quintana C, Barragan-Bradford D, Hurwitz S, Levy BD, Choi AM, Serhan CN, Baron RM.

Crit Care Med. 2017 Jan;45(1):58-68.

30.

CLINICAL PROBLEM-SOLVING. Tip of the Tongue.

Lampson BL, Gray SW, Cibas ES, Levy BD, Loscalzo J.

N Engl J Med. 2016 Sep 1;375(9):880-6. doi: 10.1056/NEJMcps1414168. No abstract available.

PMID:
27579639
31.

Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent Exacerbations.

Denlinger LC, Phillips BR, Ramratnam S, Ross K, Bhakta NR, Cardet JC, Castro M, Peters SP, Phipatanakul W, Aujla S, Bacharier LB, Bleecker ER, Comhair SA, Coverstone A, DeBoer M, Erzurum SC, Fain SB, Fajt M, Fitzpatrick AM, Gaffin J, Gaston B, Hastie AT, Hawkins GA, Holguin F, Irani AM, Israel E, Levy BD, Ly N, Meyers DA, Moore WC, Myers R, Opina MT, Peters MC, Schiebler ML, Sorkness RL, Teague WG, Wenzel SE, Woodruff PG, Mauger DT, Fahy JV, Jarjour NN; National Heart, Lung, and Blood Institute’s Severe Asthma Research Program-3 Investigators.

Am J Respir Crit Care Med. 2017 Feb 1;195(3):302-313. doi: 10.1164/rccm.201602-0419OC.

32.

CLINICAL PROBLEM-SOLVING. Prevention as Precipitant.

Aday AW, Saavedra AP, Levy BD, Loscalzo J.

N Engl J Med. 2016 Aug 4;375(5):471-5. doi: 10.1056/NEJMcps1301580. No abstract available.

PMID:
27518666
33.

IL-33 Drives Augmented Responses to Ozone in Obese Mice.

Mathews JA, Krishnamoorthy N, Kasahara DI, Cho Y, Wurmbrand AP, Ribeiro L, Smith D, Umetsu D, Levy BD, Shore SA.

Environ Health Perspect. 2017 Feb;125(2):246-253. doi: 10.1289/EHP272. Epub 2016 Jul 29.

34.

Plasma interleukin-6 concentrations, metabolic dysfunction, and asthma severity: a cross-sectional analysis of two cohorts.

Peters MC, McGrath KW, Hawkins GA, Hastie AT, Levy BD, Israel E, Phillips BR, Mauger DT, Comhair SA, Erzurum SC, Johansson MW, Jarjour NN, Coverstone AM, Castro M, Holguin F, Wenzel SE, Woodruff PG, Bleecker ER, Fahy JV; National Heart, Lung, and Blood Institute Severe Asthma Research Program.

Lancet Respir Med. 2016 Jul;4(7):574-584. doi: 10.1016/S2213-2600(16)30048-0. Epub 2016 Jun 6. Erratum in: Lancet Respir Med. 2018 Mar;6(3):e10.

35.

Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Protective for Injured Epithelia.

Colby JK, Abdulnour RE, Sham HP, Dalli J, Colas RA, Winkler JW, Hellmann J, Wong B, Cui Y, El-Chemaly S, Petasis NA, Spite M, Serhan CN, Levy BD.

Am J Pathol. 2016 Jul;186(7):1801-1813. doi: 10.1016/j.ajpath.2016.03.011. Epub 2016 May 10.

36.

Recent advances in understanding and treating ARDS.

Baron RM, Levy BD.

F1000Res. 2016 Apr 22;5. pii: F1000 Faculty Rev-725. doi: 10.12688/f1000research.7646.1. eCollection 2016. Review.

37.

The anti-inflammatory and pro-resolution effects of aspirin-triggered RvD1 (AT-RvD1) on peripheral blood mononuclear cells from patients with severe asthma.

Zambalde ÉP, Teixeira MM, Favarin DC, de Oliveira JR, Magalhães ML, Cunha MM, Silva WC Junior, Okuma CH, Rodrigues V Junior, Levy BD, Rogerio AP.

Int Immunopharmacol. 2016 Jun;35:142-148. doi: 10.1016/j.intimp.2016.03.014. Epub 2016 Apr 16.

PMID:
27044027
38.

Effects of aspirin-triggered resolvin D1 on peripheral blood mononuclear cells from patients with Chagas' heart disease.

Ogata H, Teixeira MM, Sousa RC, Silva MV, Correia D, Rodrigues Junior V, Levy BD, Rogério Ade P.

Eur J Pharmacol. 2016 Apr 15;777:26-32. doi: 10.1016/j.ejphar.2016.02.058. Epub 2016 Feb 27.

PMID:
26927755
39.

Asthma Associates With Human Abdominal Aortic Aneurysm and Rupture.

Liu CL, Wemmelund H, Wang Y, Liao M, Lindholt JS, Johnsen SP, Vestergaard H, Fernandes C, Sukhova GK, Cheng X, Zhang JY, Yang C, Huang X, Daugherty A, Levy BD, Libby P, Shi GP.

Arterioscler Thromb Vasc Biol. 2016 Mar;36(3):570-8. doi: 10.1161/ATVBAHA.115.306497. Epub 2016 Feb 11.

40.

Mast cell-derived neurotrophin 4 mediates allergen-induced airway hyperinnervation in early life.

Patel KR, Aven L, Shao F, Krishnamoorthy N, Duvall MG, Levy BD, Ai X.

Mucosal Immunol. 2016 Nov;9(6):1466-1476. doi: 10.1038/mi.2016.11. Epub 2016 Feb 10.

41.

Broad spectrum immunomodulation using biomimetic blood cell margination for sepsis therapy.

Hou HW, Wu L, Amador-Munoz DP, Vera MP, Coronata A, Englert JA, Levy BD, Baron RM, Han J.

Lab Chip. 2016 Feb 21;16(4):688-99. doi: 10.1039/c5lc01110h. Epub 2016 Jan 15.

42.

Specialized pro-resolving mediators: endogenous regulators of infection and inflammation.

Basil MC, Levy BD.

Nat Rev Immunol. 2016 Jan;16(1):51-67. doi: 10.1038/nri.2015.4. Epub 2015 Dec 21. Review.

43.

Aspirin-triggered resolvin D1 is produced during self-resolving gram-negative bacterial pneumonia and regulates host immune responses for the resolution of lung inflammation.

Abdulnour RE, Sham HP, Douda DN, Colas RA, Dalli J, Bai Y, Ai X, Serhan CN, Levy BD.

Mucosal Immunol. 2016 Sep;9(5):1278-87. doi: 10.1038/mi.2015.129. Epub 2015 Dec 9.

44.

DHA- and EPA-derived resolvins, protectins, and maresins in airway inflammation.

Duvall MG, Levy BD.

Eur J Pharmacol. 2016 Aug 15;785:144-155. doi: 10.1016/j.ejphar.2015.11.001. Epub 2015 Nov 3. Review.

45.

Allergic Lung Inflammation Aggravates Angiotensin II-Induced Abdominal Aortic Aneurysms in Mice.

Liu CL, Wang Y, Liao M, Wemmelund H, Ren J, Fernandes C, Zhou Y, Sukhova GK, Lindholt JS, Johnsen SP, Zhang JY, Cheng X, Huang X, Daugherty A, Levy BD, Libby P, Shi GP.

Arterioscler Thromb Vasc Biol. 2016 Jan;36(1):69-77. doi: 10.1161/ATVBAHA.115.305911. Epub 2015 Nov 5.

46.

Future Research Directions in Asthma. An NHLBI Working Group Report.

Levy BD, Noel PJ, Freemer MM, Cloutier MM, Georas SN, Jarjour NN, Ober C, Woodruff PG, Barnes KC, Bender BG, Camargo CA Jr, Chupp GL, Denlinger LC, Fahy JV, Fitzpatrick AM, Fuhlbrigge A, Gaston BM, Hartert TV, Kolls JK, Lynch SV, Moore WC, Morgan WJ, Nadeau KC, Ownby DR, Solway J, Szefler SJ, Wenzel SE, Wright RJ, Smith RA, Erzurum SC.

Am J Respir Crit Care Med. 2015 Dec 1;192(11):1366-72. doi: 10.1164/rccm.201505-0963WS. Review.

47.

CLINICAL PROBLEM-SOLVING. A Man with Fever, Cough, and Rash.

Geller BJ, Stone RM, Merola JF, Levy BD, Loscalzo J.

N Engl J Med. 2015 Jul 2;373(1):74-80. doi: 10.1056/NEJMcps1404270. No abstract available.

PMID:
26132944
48.

Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation.

Talbot S, Abdulnour RE, Burkett PR, Lee S, Cronin SJ, Pascal MA, Laedermann C, Foster SL, Tran JV, Lai N, Chiu IM, Ghasemlou N, DiBiase M, Roberson D, Von Hehn C, Agac B, Haworth O, Seki H, Penninger JM, Kuchroo VK, Bean BP, Levy BD, Woolf CJ.

Neuron. 2015 Jul 15;87(2):341-54. doi: 10.1016/j.neuron.2015.06.007. Epub 2015 Jun 25.

49.

Human Mesenchymal Stem (Stromal) Cells Promote the Resolution of Acute Lung Injury in Part through Lipoxin A4.

Fang X, Abbott J, Cheng L, Colby JK, Lee JW, Levy BD, Matthay MA.

J Immunol. 2015 Aug 1;195(3):875-81. doi: 10.4049/jimmunol.1500244. Epub 2015 Jun 26.

50.

AT-RvD1 modulates CCL-2 and CXCL-8 production and NF-κB, STAT-6, SOCS1, and SOCS3 expression on bronchial epithelial cells stimulated with IL-4.

de Oliveira JR, Favarin DC, Tanaka SC, Balarin MA, Teixeira DN, Levy BD, Rogério Ade P.

Biomed Res Int. 2015;2015:178369. doi: 10.1155/2015/178369. Epub 2015 May 5.

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