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Items: 8

1.

Novel prodrugs of tegafur that display improved anticancer activity and antiangiogenic properties.

Engel D, Nudelman A, Tarasenko N, Levovich I, Makarovsky I, Sochotnikov S, Tarasenko I, Rephaeli A.

J Med Chem. 2008 Jan 24;51(2):314-23. doi: 10.1021/jm7009827. Epub 2007 Dec 29.

PMID:
18163551
2.

Formaldehyde-releasing prodrugs specifically affect cancer cells by depletion of intracellular glutathione and augmentation of reactive oxygen species.

Levovich I, Nudelman A, Berkovitch G, Swift LP, Cutts SM, Phillips DR, Rephaeli A.

Cancer Chemother Pharmacol. 2008 Aug;62(3):471-82. Epub 2007 Nov 21.

PMID:
18030472
3.

Formaldehyde-releasing prodrugs in combination with adriamycin can overcome cellular drug resistance.

Cutts SM, Nudelman A, Pillay V, Spencer DM, Levovich I, Rephaeli A, Phillips DR.

Oncol Res. 2005;15(4):199-213.

PMID:
17822280
4.

The cardio-protecting agent and topoisomerase II catalytic inhibitor sobuzoxane enhances doxorubicin-DNA adduct mediated cytotoxicity.

Swift LP, Cutts SM, Nudelman A, Levovich I, Rephaeli A, Phillips DR.

Cancer Chemother Pharmacol. 2008 Apr;61(5):739-49. Epub 2007 Jun 27.

PMID:
17594094
5.

Mode of interaction between butyroyloxymethyl-diethyl phosphate (AN-7) and doxorubicin in MCF-7 and resistant MCF-7/Dx cell lines.

Engel D, Nudelman A, Levovich I, Gruss-Fischer T, Entin-Meer M, Phillips DR, Cutts SM, Rephaeli A.

J Cancer Res Clin Oncol. 2006 Oct;132(10):673-83. Epub 2006 Jul 7.

PMID:
16826403
6.

In vivo and in vitro antitumor activity of butyroyloxymethyl-diethyl phosphate (AN-7), a histone deacetylase inhibitor, in human prostate cancer.

Rephaeli A, Blank-Porat D, Tarasenko N, Entin-Meer M, Levovich I, Cutts SM, Phillips DR, Malik Z, Nudelman A.

Int J Cancer. 2005 Aug 20;116(2):226-35.

7.

The role of intracellularly released formaldehyde and butyric acid in the anticancer activity of acyloxyalkyl esters.

Nudelman A, Levovich I, Cutts SM, Phillips DR, Rephaeli A.

J Med Chem. 2005 Feb 24;48(4):1042-54.

PMID:
15715472
8.

A retinoid/butyric acid prodrug overcomes retinoic acid resistance in leukemias by induction of apoptosis.

Mann KK, Rephaeli A, Colosimo AL, Diaz Z, Nudelman A, Levovich I, Jing Y, Waxman S, Miller WH Jr.

Mol Cancer Res. 2003 Oct;1(12):903-12.

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