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Items: 1 to 50 of 233

1.

Chiral Specificity of Cholesterol Orientation Within Cholesterol Binding Sites in Inwardly Rectifying K+ Channels.

Barbera N, Levitan I.

Adv Exp Med Biol. 2019;1115:77-95. doi: 10.1007/978-3-030-04278-3_4.

PMID:
30649756
2.

Role of Matrix Metalloproteinases and Histone Deacetylase in Oxidative Stress-induced Degradation of the Endothelial Glycocalyx.

Ali M, Mahmoud AM, Le Master E, Levitan I, Phillips SA.

Am J Physiol Heart Circ Physiol. 2019 Jan 11. doi: 10.1152/ajpheart.00090.2018. [Epub ahead of print]

PMID:
30632766
3.

Potential Strategies to Reduce Blood Pressure in Treatment-Resistant Hypertension Using Food and Drug Administration-Approved Nanodrug Delivery Platforms.

Fancher IS, Rubinstein I, Levitan I.

Hypertension. 2019 Feb;73(2):250-257. doi: 10.1161/HYPERTENSIONAHA.118.12005. No abstract available.

PMID:
30624988
4.

Levels of Par-1 kinase determine the localization of Bruchpilot at the Drosophila neuromuscular junction synapses.

Barber KR, Hruska M, Bush KM, Martinez JA, Fei H, Levitan IB, Dalva MB, Wairkar YP.

Sci Rep. 2018 Oct 31;8(1):16099. doi: 10.1038/s41598-018-34250-9.

5.

Preface.

Levitan I, Delpire E.

Curr Top Membr. 2018;81:xv-xvii. doi: 10.1016/S1063-5823(18)30029-2. No abstract available.

PMID:
30243443
6.

Membrane Stiffening in Osmotic Swelling: Analysis of Membrane Tension and Elastic Modulus.

Ayee MAA, Levitan I.

Curr Top Membr. 2018;81:97-123. doi: 10.1016/bs.ctm.2018.07.003. Epub 2018 Aug 17.

PMID:
30243442
7.

Molecular Dynamics Simulations of Kir2.2 Interactions with an Ensemble of Cholesterol Molecules.

Barbera N, Ayee MAA, Akpa BS, Levitan I.

Biophys J. 2018 Oct 2;115(7):1264-1280. doi: 10.1016/j.bpj.2018.07.041. Epub 2018 Aug 23.

PMID:
30205899
8.

Comparative analysis of endothelial cell and sub-endothelial cell elastic moduli in young and aged mice: Role of CD36.

Le Master E, Fancher IS, Lee J, Levitan I.

J Biomech. 2018 Jul 25;76:263-268. doi: 10.1016/j.jbiomech.2018.06.007. Epub 2018 Jun 18.

PMID:
29954596
9.

Hypercholesterolemia-Induced Loss of Flow-Induced Vasodilation and Lesion Formation in Apolipoprotein E-Deficient Mice Critically Depend on Inwardly Rectifying K+ Channels.

Fancher IS, Ahn SJ, Adamos C, Osborn C, Oh MJ, Fang Y, Reardon CA, Getz GS, Phillips SA, Levitan I.

J Am Heart Assoc. 2018 Mar 3;7(5). pii: e007430. doi: 10.1161/JAHA.117.007430.

10.

Hypotonic Challenge of Endothelial Cells Increases Membrane Stiffness with No Effect on Tether Force.

Ayee MAA, LeMaster E, Teng T, Lee J, Levitan I.

Biophys J. 2018 Feb 27;114(4):929-938. doi: 10.1016/j.bpj.2017.12.032.

PMID:
29490252
11.

Proatherogenic Flow Increases Endothelial Stiffness via Enhanced CD36-Mediated Uptake of Oxidized Low-Density Lipoproteins.

Le Master E, Huang RT, Zhang C, Bogachkov Y, Coles C, Shentu TP, Sheng Y, Fancher IS, Ng C, Christoforidis T, Subbaiah PV, Berdyshev E, Qain Z, Eddington DT, Lee J, Cho M, Fang Y, Minshall RD, Levitan I.

Arterioscler Thromb Vasc Biol. 2018 Jan;38(1):64-75. doi: 10.1161/ATVBAHA.117.309907. Epub 2017 Oct 12.

12.

Preface.

Levitan I.

Curr Top Membr. 2017;80:xi-xii. doi: 10.1016/S1063-5823(17)30029-7. No abstract available.

PMID:
28863824
13.

Differential Effects of Sterols on Ion Channels: Stereospecific Binding vs Stereospecific Response.

Barbera N, Ayee MAA, Akpa BS, Levitan I.

Curr Top Membr. 2017;80:25-50. doi: 10.1016/bs.ctm.2017.06.001. Epub 2017 Jul 17. Review.

PMID:
28863819
14.

oxLDL induces endothelial cell proliferation via Rho/ROCK/Akt/p27kip1 signaling: opposite effects of oxLDL and cholesterol loading.

Zhang C, Adamos C, Oh MJ, Baruah J, Ayee MAA, Mehta D, Wary KK, Levitan I.

Am J Physiol Cell Physiol. 2017 Sep 1;313(3):C340-C351. doi: 10.1152/ajpcell.00249.2016. Epub 2017 Jul 12.

15.

Molecular-Scale Biophysical Modulation of an Endothelial Membrane by Oxidized Phospholipids.

Ayee MAA, LeMaster E, Shentu TP, Singh DK, Barbera N, Soni D, Tiruppathi C, Subbaiah PV, Berdyshev E, Bronova I, Cho M, Akpa BS, Levitan I.

Biophys J. 2017 Jan 24;112(2):325-338. doi: 10.1016/j.bpj.2016.12.002.

16.

Sugar and spice and potassium channel modulation.

Levitan IB.

Channels (Austin). 2017 Jul 4;11(4):263-264. doi: 10.1080/19336950.2017.1286829. Epub 2017 Jan 24. No abstract available.

17.

Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol.

Liu SL, Sheng R, Jung JH, Wang L, Stec E, O'Connor MJ, Song S, Bikkavilli RK, Winn RA, Lee D, Baek K, Ueda K, Levitan I, Kim KP, Cho W.

Nat Chem Biol. 2017 Mar;13(3):268-274. doi: 10.1038/nchembio.2268. Epub 2016 Dec 26.

18.

Inwardly rectifying K+ channels are major contributors to flow-induced vasodilatation in resistance arteries.

Ahn SJ, Fancher IS, Bian JT, Zhang CX, Schwab S, Gaffin R, Phillips SA, Levitan I.

J Physiol. 2017 Apr 1;595(7):2339-2364. doi: 10.1113/JP273255. Epub 2016 Dec 26.

19.

Paradoxical impact of cholesterol on lipid packing and cell stiffness.

Ayee MA, Levitan I.

Front Biosci (Landmark Ed). 2016 Jun 1;21:1245-59. Review.

PMID:
27100504
20.

Oxidized LDL signals through Rho-GTPase to induce endothelial cell stiffening and promote capillary formation.

Oh MJ, Zhang C, LeMaster E, Adamos C, Berdyshev E, Bogachkov Y, Kohler EE, Baruah J, Fang Y, Schraufnagel DE, Wary KK, Levitan I.

J Lipid Res. 2016 May;57(5):791-808. doi: 10.1194/jlr.M062539. Epub 2016 Mar 17.

21.

Cholesterol increases the open probability of cardiac KACh currents.

Bukiya AN, Osborn CV, Kuntamallappanavar G, Toth PT, Baki L, Kowalsky G, Oh MJ, Dopico AM, Levitan I, Rosenhouse-Dantsker A.

Biochim Biophys Acta. 2015 Oct;1848(10 Pt A):2406-13. doi: 10.1016/j.bbamem.2015.07.007. Epub 2015 Jul 18.

22.

Moesin and myosin phosphatase confine neutrophil orientation in a chemotactic gradient.

Liu X, Yang T, Suzuki K, Tsukita S, Ishii M, Zhou S, Wang G, Cao L, Qian F, Taylor S, Oh MJ, Levitan I, Ye RD, Carnegie GK, Zhao Y, Malik AB, Xu J.

J Exp Med. 2015 Feb 9;212(2):267-80. doi: 10.1084/jem.20140508. Epub 2015 Jan 19.

23.

Interplay Between Lipid Modulators of Kir2 Channels: Cholesterol and PIP2.

Rosenhouse-Dantsker A, Epshtein Y, Levitan I.

Comput Struct Biotechnol J. 2014 Sep 28;11(19):131-7. doi: 10.1016/j.csbj.2014.09.007. eCollection 2014 Sep.

24.

Regulation of synaptic development and function by the Drosophila PDZ protein Dyschronic.

Jepson JE, Shahidullah M, Liu D, le Marchand SJ, Liu S, Wu MN, Levitan IB, Dalva MB, Koh K.

Development. 2014 Dec;141(23):4548-57. doi: 10.1242/dev.109538. Epub 2014 Oct 30.

25.

Silencing of Kir2 channels by caveolin-1: cross-talk with cholesterol.

Han H, Rosenhouse-Dantsker A, Gnanasambandam R, Epshtein Y, Chen Z, Sachs F, Minshall RD, Levitan I.

J Physiol. 2014 Sep 15;592(18):4025-38. doi: 10.1113/jphysiol.2014.273177. Epub 2014 Jul 18.

26.

Oxidized low-density lipoprotein alters the effect of matrix stiffness on the formation of endothelial networks and capillary lumens.

Gundavaram MS, Shentu TP, Kowalsky GB, Volkov S, Schraufnagel DE, Levitan I.

Pulm Circ. 2013 Sep;3(3):622-31. doi: 10.1086/674309. Epub 2013 Dec 5.

27.

Cholesterol binding to ion channels.

Levitan I, Singh DK, Rosenhouse-Dantsker A.

Front Physiol. 2014 Feb 26;5:65. doi: 10.3389/fphys.2014.00065. eCollection 2014. Review.

28.

Upregulated copper transporters in hypoxia-induced pulmonary hypertension.

Zimnicka AM, Tang H, Guo Q, Kuhr FK, Oh MJ, Wan J, Chen J, Smith KA, Fraidenburg DR, Choudhury MS, Levitan I, Machado RF, Kaplan JH, Yuan JX.

PLoS One. 2014 Mar 10;9(3):e90544. doi: 10.1371/journal.pone.0090544. eCollection 2014.

29.

Defects in synapse structure and function precede motor neuron degeneration in Drosophila models of FUS-related ALS.

Shahidullah M, Le Marchand SJ, Fei H, Zhang J, Pandey UB, Dalva MB, Pasinelli P, Levitan IB.

J Neurosci. 2013 Dec 11;33(50):19590-8. doi: 10.1523/JNEUROSCI.3396-13.2013.

30.

Cell-specific fine-tuning of neuronal excitability by differential expression of modulator protein isoforms.

Jepson J, Sheldon A, Shahidullah M, Fei H, Koh K, Levitan IB.

J Neurosci. 2013 Oct 16;33(42):16767-77. doi: 10.1523/JNEUROSCI.1001-13.2013.

31.

Identification of novel cholesterol-binding regions in Kir2 channels.

Rosenhouse-Dantsker A, Noskov S, Durdagi S, Logothetis DE, Levitan I.

J Biol Chem. 2013 Oct 25;288(43):31154-64. doi: 10.1074/jbc.M113.496117. Epub 2013 Sep 9.

32.

Cholesterol sensitivity of KIR2.1 depends on functional inter-links between the N and C termini.

Rosenhouse-Dantsker A, Noskov S, Logothetis DE, Levitan I.

Channels (Austin). 2013 Jul-Aug;7(4):303-12. Epub 2013 Jun 27.

33.

Influence of membrane cholesterol and substrate elasticity on endothelial cell spreading behavior.

Hong Z, Ersoy I, Sun M, Bunyak F, Hampel P, Hong Z, Sun Z, Li Z, Levitan I, Meininger GA, Palaniappan K.

J Biomed Mater Res A. 2013 Jul;101(7):1994-2004. doi: 10.1002/jbm.a.34504. Epub 2012 Dec 13.

34.

How cholesterol regulates endothelial biomechanics.

Hong Z, Staiculescu MC, Hampel P, Levitan I, Forgacs G.

Front Physiol. 2012 Nov 15;3:426. doi: 10.3389/fphys.2012.00426. eCollection 2012.

35.

Micropipette aspiration of substrate-attached cells to estimate cell stiffness.

Oh MJ, Kuhr F, Byfield F, Levitan I.

J Vis Exp. 2012 Sep 27;(67). pii: 3886. doi: 10.3791/3886.

36.

Distant cytosolic residues mediate a two-way molecular switch that controls the modulation of inwardly rectifying potassium (Kir) channels by cholesterol and phosphatidylinositol 4,5-bisphosphate (PI(4,5)P(2)).

Rosenhouse-Dantsker A, Noskov S, Han H, Adney SK, Tang QY, Rodríguez-Menchaca AA, Kowalsky GB, Petrou VI, Osborn CV, Logothetis DE, Levitan I.

J Biol Chem. 2012 Nov 23;287(48):40266-78. doi: 10.1074/jbc.M111.336339. Epub 2012 Sep 20.

37.

OxLDL and substrate stiffness promote neutrophil transmigration by enhanced endothelial cell contractility and ICAM-1.

Stroka KM, Levitan I, Aranda-Espinoza H.

J Biomech. 2012 Jun 26;45(10):1828-34. doi: 10.1016/j.jbiomech.2012.04.011. Epub 2012 May 2.

38.

The role of oxysterols in control of endothelial stiffness.

Shentu TP, Singh DK, Oh MJ, Sun S, Sadaat L, Makino A, Mazzone T, Subbaiah PV, Cho M, Levitan I.

J Lipid Res. 2012 Jul;53(7):1348-58. doi: 10.1194/jlr.M027102. Epub 2012 Apr 11.

39.

Two novel EGFP insertion alleles reveal unique aspects of Pax2 function in embryonic and adult kidneys.

Soofi A, Levitan I, Dressler GR.

Dev Biol. 2012 May 1;365(1):241-50. doi: 10.1016/j.ydbio.2012.02.032. Epub 2012 Mar 3.

40.

New mechanisms of pulmonary arterial hypertension: role of Ca²⁺ signaling.

Kuhr FK, Smith KA, Song MY, Levitan I, Yuan JX.

Am J Physiol Heart Circ Physiol. 2012 Apr 15;302(8):H1546-62. doi: 10.1152/ajpheart.00944.2011. Epub 2012 Jan 13. Review.

41.

Regulation of ion channels by membrane lipids.

Rosenhouse-Dantsker A, Mehta D, Levitan I.

Compr Physiol. 2012 Jan;2(1):31-68. doi: 10.1002/cphy.c110001. Review.

PMID:
23728970
42.

Cholesterol depletion facilitates recovery from hypotonic cell swelling in CHO cells.

Kowalsky GB, Beam D, Oh MJ, Sachs F, Hua SZ, Levitan I.

Cell Physiol Biochem. 2011;28(6):1247-54. doi: 10.1159/000335856. Epub 2011 Dec 16.

43.

Hypercholesterolemia induces up-regulation of KACh cardiac currents via a mechanism independent of phosphatidylinositol 4,5-bisphosphate and Gβγ.

Deng W, Bukiya AN, Rodríguez-Menchaca AA, Zhang Z, Baumgarten CM, Logothetis DE, Levitan I, Rosenhouse-Dantsker A.

J Biol Chem. 2012 Feb 10;287(7):4925-35. doi: 10.1074/jbc.M111.306134. Epub 2011 Dec 15.

44.

Novel role of p66Shc in ROS-dependent VEGF signaling and angiogenesis in endothelial cells.

Oshikawa J, Kim SJ, Furuta E, Caliceti C, Chen GF, McKinney RD, Kuhr F, Levitan I, Fukai T, Ushio-Fukai M.

Am J Physiol Heart Circ Physiol. 2012 Feb 1;302(3):H724-32. doi: 10.1152/ajpheart.00739.2011. Epub 2011 Nov 18.

45.

SLOB, a SLOWPOKE channel binding protein, regulates insulin pathway signaling and metabolism in Drosophila.

Sheldon AL, Zhang J, Fei H, Levitan IB.

PLoS One. 2011;6(8):e23343. doi: 10.1371/journal.pone.0023343. Epub 2011 Aug 5.

46.

Cholesterol regulates prokaryotic Kir channel by direct binding to channel protein.

Singh DK, Shentu TP, Enkvetchakul D, Levitan I.

Biochim Biophys Acta. 2011 Oct;1808(10):2527-33. doi: 10.1016/j.bbamem.2011.07.006. Epub 2011 Jul 21.

47.

Impact of oxLDL on Cholesterol-Rich Membrane Rafts.

Levitan I, Shentu TP.

J Lipids. 2011;2011:730209. doi: 10.1155/2011/730209. Epub 2011 Jan 18.

48.

Modification of Cellular Cholesterol Content Affects Traction Force, Adhesion and Cell Spreading.

Norman LL, Oetama RJ, Dembo M, Byfield F, Hammer DA, Levitan I, Aranda-Espinoza H.

Cell Mol Bioeng. 2010 Jun 1;3(2):151-162.

49.

Anthrax lethal factor activates K(+) channels to induce IL-1β secretion in macrophages.

Thomas J, Epshtein Y, Chopra A, Ordog B, Ghassemi M, Christman JW, Nattel S, Cook JL, Levitan I.

J Immunol. 2011 May 1;186(9):5236-43. doi: 10.4049/jimmunol.1001078. Epub 2011 Mar 18.

50.

Slob, a Slowpoke channel-binding protein, modulates synaptic transmission.

Ma H, Zhang J, Levitan IB.

J Gen Physiol. 2011 Feb;137(2):225-38. doi: 10.1085/jgp.201010439.

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