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Items: 1 to 50 of 94

1.

Structural identification of a hotspot on CFTR for potentiation.

Liu F, Zhang Z, Levit A, Levring J, Touhara KK, Shoichet BK, Chen J.

Science. 2019 Jun 21;364(6446):1184-1188. doi: 10.1126/science.aaw7611.

PMID:
31221859
2.

Impaired behavioural flexibility related to white matter microgliosis in the TgAPP21 rat model of Alzheimer disease.

Levit A, Regis AM, Gibson A, Hough OH, Maheshwari S, Agca Y, Agca C, Hachinski V, Allman BL, Whitehead SN.

Brain Behav Immun. 2019 Aug;80:25-34. doi: 10.1016/j.bbi.2019.02.013. Epub 2019 Feb 15.

PMID:
30776475
3.

Ultra-large library docking for discovering new chemotypes.

Lyu J, Wang S, Balius TE, Singh I, Levit A, Moroz YS, O'Meara MJ, Che T, Algaa E, Tolmachova K, Tolmachev AA, Shoichet BK, Roth BL, Irwin JJ.

Nature. 2019 Feb;566(7743):224-229. doi: 10.1038/s41586-019-0917-9. Epub 2019 Feb 6.

4.

Scientific overview on CSCI-CITAC Annual General Meeting and 2017 Young Investigators' Forum.

Barton KI, Ma X, Babadagli ME, Zhou E, Tonial N, Newell C, Ishaque A, Leduc-Pessah H, Marvasti TB, Mirali S, Levit A, Kumar S, Steadman PE, Cook EK, Abraham J.

Clin Invest Med. 2018 Oct 5;41(3):E156-E164. doi: 10.25011/cim.v41i3.31020.

PMID:
30315752
5.

Corrigendum: Independent Evolution of Strychnine Recognition by Bitter Taste Receptor Subtypes.

Xue AY, Di Pizio A, Levit A, Yarnitzky T, Penn O, Pupko T, Niv MY.

Front Mol Biosci. 2018 Sep 11;5:84. doi: 10.3389/fmolb.2018.00084. eCollection 2018.

6.

The Recognition of Unrelated Ligands by Identical Proteins.

Pottel J, Levit A, Korczynska M, Fischer M, Shoichet BK.

ACS Chem Biol. 2018 Sep 21;13(9):2522-2533. doi: 10.1021/acschembio.8b00443. Epub 2018 Aug 27.

7.

Reengineering the ligand sensitivity of the broadly tuned human bitter taste receptor TAS2R14.

Nowak S, Di Pizio A, Levit A, Niv MY, Meyerhof W, Behrens M.

Biochim Biophys Acta Gen Subj. 2018 Oct;1862(10):2162-2173. doi: 10.1016/j.bbagen.2018.07.009. Epub 2018 Jul 19.

PMID:
30009876
8.

Independent Evolution of Strychnine Recognition by Bitter Taste Receptor Subtypes.

Xue AY, Di Pizio A, Levit A, Yarnitzky T, Penn O, Pupko T, Niv MY.

Front Mol Biosci. 2018 Mar 2;5:9. doi: 10.3389/fmolb.2018.00009. eCollection 2018. Erratum in: Front Mol Biosci. 2018 Sep 11;5:84.

9.

Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone.

Wang S, Che T, Levit A, Shoichet BK, Wacker D, Roth BL.

Nature. 2018 Mar 8;555(7695):269-273. doi: 10.1038/nature25758. Epub 2018 Jan 24.

10.

D4 dopamine receptor high-resolution structures enable the discovery of selective agonists.

Wang S, Wacker D, Levit A, Che T, Betz RM, McCorvy JD, Venkatakrishnan AJ, Huang XP, Dror RO, Shoichet BK, Roth BL.

Science. 2017 Oct 20;358(6361):381-386. doi: 10.1126/science.aan5468.

11.

Behavioural inflexibility in a comorbid rat model of striatal ischemic injury and mutant hAPP overexpression.

Levit A, Regis AM, Garabon JR, Oh SH, Desai SJ, Rajakumar N, Hachinski V, Agca Y, Agca C, Whitehead SN, Allman BL.

Behav Brain Res. 2017 Aug 30;333:267-275. doi: 10.1016/j.bbr.2017.07.006. Epub 2017 Jul 8.

PMID:
28693862
12.

Crystal Structure of an LSD-Bound Human Serotonin Receptor.

Wacker D, Wang S, McCorvy JD, Betz RM, Venkatakrishnan AJ, Levit A, Lansu K, Schools ZL, Che T, Nichols DE, Shoichet BK, Dror RO, Roth BL.

Cell. 2017 Jan 26;168(3):377-389.e12. doi: 10.1016/j.cell.2016.12.033.

13.

Structure-based discovery of opioid analgesics with reduced side effects.

Manglik A, Lin H, Aryal DK, McCorvy JD, Dengler D, Corder G, Levit A, Kling RC, Bernat V, Hübner H, Huang XP, Sassano MF, Giguère PM, Löber S, Da Duan, Scherrer G, Kobilka BK, Gmeiner P, Roth BL, Shoichet BK.

Nature. 2016 Sep 8;537(7619):185-190. doi: 10.1038/nature19112. Epub 2016 Aug 17.

14.

Comparing Class A GPCRs to bitter taste receptors: Structural motifs, ligand interactions and agonist-to-antagonist ratios.

Di Pizio A, Levit A, Slutzki M, Behrens M, Karaman R, Niv MY.

Methods Cell Biol. 2016;132:401-27. doi: 10.1016/bs.mcb.2015.10.005. Epub 2015 Dec 24.

PMID:
26928553
15.

[THE EFFICACY AND SAFETY OF DEXMEDETOMIDINE FOR SEDATION OF PATIENTS DURING PROLONGED MECHANICAL VENTILATION IN INTENSIVE CARE UNITS (RUSSIAN MULTICENTER STUDY RESULTS)].

Nikoda VV, Gritsan AI, Eremenko AA, Zabolotskikh IB, Kirov MY, Lebedinsky KM, Levit AL.

Anesteziol Reanimatol. 2015 Sep-Oct;60(5):47-53. Russian.

PMID:
26852580
16.
17.

In utero fetal ovarian torsion.

Levit A, Voci SL.

Ultrasound Q. 2014 Sep;30(3):249-50. doi: 10.1097/RUQ.0000000000000102. No abstract available.

PMID:
25148507
18.

[Changes in lipid and carbohydrate metabolism in patients with severe sepsis of different etiology].

Malkova OG, Leiderman IN, Levit AL, Alasheev AM.

Anesteziol Reanimatol. 2014 Mar-Apr;(2):15-21. Russian.

PMID:
25055487
19.

[Emergency care for eclampsia and its complications. Eclampsia, HELLP-syndrome].

Federation of Anaesthesiologists and Reanimatologists, Kulikov AV, Shifman EM, Belomestnov SR, Levit AL.

Anesteziol Reanimatol. 2013 Sep-Oct;(5):75-81. Russian. No abstract available.

PMID:
24624864
20.

[Perfusion-metabolic interaction in acute cerebral insufficiency. ACIPS study Part I. Cerebral blood flow evaluation].

Gromov VS, Ageev AN, Alasheev AM, Belkin AA, Levit AL.

Anesteziol Reanimatol. 2013 Jul-Aug;(4):37-41. Russian.

PMID:
24341040
21.

Predicting GPCR promiscuity using binding site features.

Levit A, Beuming T, Krilov G, Sherman W, Niv MY.

J Chem Inf Model. 2014 Jan 27;54(1):184-94. doi: 10.1021/ci400552z. Epub 2013 Dec 27.

PMID:
24328091
22.

The bitter pill: clinical drugs that activate the human bitter taste receptor TAS2R14.

Levit A, Nowak S, Peters M, Wiener A, Meyerhof W, Behrens M, Niv MY.

FASEB J. 2014 Mar;28(3):1181-97. doi: 10.1096/fj.13-242594. Epub 2013 Nov 27.

PMID:
24285091
23.

Inflammatory breast carcinoma.

Levit A, Voci SL.

Ultrasound Q. 2013 Sep;29(3):223-4. doi: 10.1097/RUQ.0b013e3182a0aebe. No abstract available.

PMID:
23945485
24.

[Characteristics of septic shock in obstetrics].

Kulikov AV, Spirin AV, Levit AL, Malkova OG.

Anesteziol Reanimatol. 2012 Nov-Dec;(6):58-62. Russian.

PMID:
23662524
25.

The human bitter taste receptor TAS2R10 is tailored to accommodate numerous diverse ligands.

Born S, Levit A, Niv MY, Meyerhof W, Behrens M.

J Neurosci. 2013 Jan 2;33(1):201-13. doi: 10.1523/JNEUROSCI.3248-12.2013.

26.

Homology model-assisted elucidation of binding sites in GPCRs.

Levit A, Barak D, Behrens M, Meyerhof W, Niv MY.

Methods Mol Biol. 2012;914:179-205. doi: 10.1007/978-1-62703-023-6_11. Review.

PMID:
22976029
27.

[Are we controlling the sedation in ICU? A multicenter study results].

Belyshev SIu, Levit A, Leĭderman I, Baĭbikov V, Batakov L, Bashkirova A, Besedina E, Boltaev P, Bulgakova I, Burtsev M, Gazenkampf A, Gapoian L, Gladkov N, Davydov A, Danchenko S, Dianov A, Drozd A, Dubina O, Zaryvnykh I, Zverev A, Zigmantovich E, Ivan'kov K, Il'in V, Kadnikov M, Kokarev E, Kolegova Zh, Kondrashkin M, Kotkova E, Kul'minskaia N, Leshkova V, Litiaĭkin A, Makhmutov Iu, Medvedeva G, Napol'skikh V, Orekhov A, Orlov A, Piontek A, Reshetnikova S, Samatov I, Samsonova M, Semen'kova G, Smirnov M, Sobetova G, Strel'tsova E, Tiul'pin A, Khanov D, Khardin E, Khlebnikova I, Cherniak A, Chipinskaia E, Shvedova M, Shevelev M, Shevchuk D, Shen' N, Shleĭkher V, Shliapnikova L.

Anesteziol Reanimatol. 2012 Mar-Apr;(2):72-7. Russian.

PMID:
22834294
28.

Effect of sulfasalazine on inflammation and endothelial function in patients with established coronary artery disease.

Tabit CE, Holbrook M, Shenouda SM, Dohadwala MM, Widlansky ME, Frame AA, Kim BH, Duess MA, Kluge MA, Levit A, Keaney JF Jr, Vita JA, Hamburg NM.

Vasc Med. 2012 Apr;17(2):101-7. doi: 10.1177/1358863X12440117.

29.

Expression and structure/function relationships of human defensin 5.

Chapnik N, Levit A, Niv MY, Froy O.

Appl Biochem Biotechnol. 2012 Apr;166(7):1703-10. doi: 10.1007/s12010-012-9571-5. Epub 2012 Feb 22.

PMID:
22354633
30.

Modeling of human prokineticin receptors: interactions with novel small-molecule binders and potential off-target drugs.

Levit A, Yarnitzky T, Wiener A, Meidan R, Niv MY.

PLoS One. 2011;6(11):e27990. doi: 10.1371/journal.pone.0027990. Epub 2011 Nov 21.

31.

Breast MR Imaging: What the Radiologist Needs to Know.

Dhillon GS, Bell N, Ginat DT, Levit A, Destounis S, O'Connell A.

J Clin Imaging Sci. 2011;1:48. doi: 10.4103/2156-7514.85655. Epub 2011 Oct 3.

32.

[Septic encephalopathy: theoretic provocation and clinical illustration].

Belkin AA, Leĭderman IN, Levit AL, Malkova OG, Alasheev AM, Kirillova IE, Gromov VS, Fedorov GE.

Anesteziol Reanimatol. 2011 Jul-Aug;(4):70-4. Russian. No abstract available.

PMID:
21957627
33.

BitterDB: a database of bitter compounds.

Wiener A, Shudler M, Levit A, Niv MY.

Nucleic Acids Res. 2012 Jan;40(Database issue):D413-9. doi: 10.1093/nar/gkr755. Epub 2011 Sep 22.

34.

Altered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitus.

Shenouda SM, Widlansky ME, Chen K, Xu G, Holbrook M, Tabit CE, Hamburg NM, Frame AA, Caiano TL, Kluge MA, Duess MA, Levit A, Kim B, Hartman ML, Joseph L, Shirihai OS, Vita JA.

Circulation. 2011 Jul 26;124(4):444-53. doi: 10.1161/CIRCULATIONAHA.110.014506. Epub 2011 Jul 11.

35.

Synthesis, testing and structure-activity studies on a library of 5-HT₄ ligands.

Hanna-Elias A, Manallack DT, Levit A, Nguyen W, Ayad F, Perera G, Shapiro M, Irving HR, Coupar IM, Iskander MN.

Med Chem. 2010 Nov;6(6):344-54.

PMID:
21175422
36.

Effects of Concord grape juice on ambulatory blood pressure in prehypertension and stage 1 hypertension.

Dohadwala MM, Hamburg NM, Holbrook M, Kim BH, Duess MA, Levit A, Titas M, Chung WB, Vincent FB, Caiano TL, Frame AA, Keaney JF Jr, Vita JA.

Am J Clin Nutr. 2010 Nov;92(5):1052-9. doi: 10.3945/ajcn.2010.29905. Epub 2010 Sep 15.

37.

[Modes of infusion provision of myocardial revascularization on the working heart].

Krasheninnikov SV, Levit AL.

Anesteziol Reanimatol. 2009 Sep-Oct;(5):17-9. Russian.

PMID:
20491143
38.

Homology modeling of G-protein-coupled receptors with X-ray structures on the rise.

Yarnitzky T, Levit A, Niv MY.

Curr Opin Drug Discov Devel. 2010 May;13(3):317-25. Review.

PMID:
20443165
39.

Two novel exonic point mutations in HEXA identified in a juvenile Tay-Sachs patient: role of alternative splicing and nonsense-mediated mRNA decay.

Levit A, Nutman D, Osher E, Kamhi E, Navon R.

Mol Genet Metab. 2010 Jun;100(2):176-83. doi: 10.1016/j.ymgme.2010.03.010. Epub 2010 Mar 19.

PMID:
20363167
40.

Induction of endothelin-2 expression by luteinizing hormone and hypoxia: possible role in bovine corpus luteum formation.

Klipper E, Levit A, Mastich Y, Berisha B, Schams D, Meidan R.

Endocrinology. 2010 Apr;151(4):1914-22. doi: 10.1210/en.2009-0767. Epub 2010 Feb 22.

PMID:
20176726
41.

[Evaluation of the effectiveness and safety of synthetic colloid solutions in the treatment of severe abdominal sepsis: a randomized comparative study].

Protsenko DN, Leĭderman IN, Grigor'ev EV, Kokarev EA, Levit AL, Gel'fand BR.

Anesteziol Reanimatol. 2009 Sep-Oct;(5):9-13. Russian.

PMID:
19938709
42.

[Changes in lipid metabolic parameters in patients with severe sepsis].

Malkova OG, Leĭderman IN, Levit AL.

Anesteziol Reanimatol. 2009 Mar-Apr;(2):23-6. Russian.

PMID:
19514436
43.

Stargazin involvement with bipolar disorder and response to lithium treatment.

Silberberg G, Levit A, Collier D, St Clair D, Munro J, Kerwin RW, Tondo L, Floris G, Breen G, Navon R.

Pharmacogenet Genomics. 2008 May;18(5):403-12. doi: 10.1097/FPC.0b013e3282f974ca.

PMID:
18408563
44.

[Multicentre study of comparative efficacy of meropenem and combined regimens for empirical antibacterial therapy of severe nosocomial infections: results of clinical and pharmacoeconomic analysis].

Iakovlev SV, Beloborodov VB, Sidorenko SV, Iakovlev VP, Grigor'ev KB, Eliseeva EV, Kon EM, Levit AL, Kostina GV, Kuprenkov AV, Mukhacheva SIu, Saturnov AV, Sergeev IN, Spasov GP, Stakanov AV, Ushakova MA.

Antibiot Khimioter. 2006;51(7):15-27. Russian.

PMID:
18035730
45.

[Choice of temperature extracorporeal circulation regimen during prosthetic repair of the aortic valve].

Petrishchev IuI, levit AL.

Anesteziol Reanimatol. 2007 May-Jun;(3):36-8. Russian.

PMID:
17684989
46.

[Effect of various colloidal solutions on pulmonary oxygenizing function in patients with acute lung lesion].

Krasheninnikov SV, Levit AL, Leĭderman IN, Malkova OG.

Anesteziol Reanimatol. 2007 May-Jun;(3):20-2. Russian.

PMID:
17684983
47.

A complete genetic association scan of the 22q11 deletion region and functional evidence reveal an association between DGCR2 and schizophrenia.

Shifman S, Levit A, Chen ML, Chen CH, Bronstein M, Weizman A, Yakir B, Navon R, Darvasi A.

Hum Genet. 2006 Sep;120(2):160-70. Epub 2006 Jun 17.

PMID:
16783572
48.

Radon exhalation of cementitious materials made with coal fly ash: Part 2--testing hardened cement-fly ash pastes.

Kovler K, Perevalov A, Levit A, Steiner V, Metzger LA.

J Environ Radioact. 2005;82(3):335-50. Epub 2005 Mar 31.

PMID:
15885379
49.

Accidental delivery through a vaginal incision (laparoelytrotomy) during caesarean section in the second stage of labour.

Peleg D, Perlitz Y, Pansky S, Levit A, Ben-Ami M.

BJOG. 2001 Jun;108(6):659-60. No abstract available.

50.

[A scale for estimating multiple organ dysfunction in surgical patients].

Levit AL, Prudkov MI, Korkin OV, Razzhigaeva NE.

Anesteziol Reanimatol. 2000 May-Jun;(3):26-8. Russian.

PMID:
10900716

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