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Items: 15


The pseudokinase domains of guanylyl cyclase-A and -B allosterically increase the affinity of their catalytic domains for substrate.

Edmund AB, Walseth TF, Levinson NM, Potter LR.

Sci Signal. 2019 Jan 29;12(566). pii: eaau5378. doi: 10.1126/scisignal.aau5378.


Quantitative conformational profiling of kinase inhibitors reveals origins of selectivity for Aurora kinase activation states.

Lake EW, Muretta JM, Thompson AR, Rasmussen DM, Majumdar A, Faber EB, Ruff EF, Thomas DD, Levinson NM.

Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):E11894-E11903. doi: 10.1073/pnas.1811158115. Epub 2018 Dec 5.


An Open Library of Human Kinase Domain Constructs for Automated Bacterial Expression.

Albanese SK, Parton DL, Işık M, Rodríguez-Laureano L, Hanson SM, Behr JM, Gradia S, Jeans C, Levinson NM, Seeliger MA, Chodera JD.

Biochemistry. 2018 Aug 7;57(31):4675-4689. doi: 10.1021/acs.biochem.7b01081. Epub 2018 Jul 26.


The multifaceted allosteric regulation of Aurora kinase A.

Levinson NM.

Biochem J. 2018 Jun 26;475(12):2025-2042. doi: 10.1042/BCJ20170771. Review.


A dynamic mechanism for allosteric activation of Aurora kinase A by activation loop phosphorylation.

Ruff EF, Muretta JM, Thompson AR, Lake EW, Cyphers S, Albanese SK, Hanson SM, Behr JM, Thomas DD, Chodera JD, Levinson NM.

Elife. 2018 Feb 21;7. pii: e32766. doi: 10.7554/eLife.32766.


A water-mediated allosteric network governs activation of Aurora kinase A.

Cyphers S, Ruff EF, Behr JM, Chodera JD, Levinson NM.

Nat Chem Biol. 2017 Apr;13(4):402-408. doi: 10.1038/nchembio.2296. Epub 2017 Feb 6.


A conserved water-mediated hydrogen bond network defines bosutinib's kinase selectivity.

Levinson NM, Boxer SG.

Nat Chem Biol. 2014 Feb;10(2):127-32. doi: 10.1038/nchembio.1404. Epub 2013 Dec 1.


Experimental quantification of electrostatics in X-H···π hydrogen bonds.

Saggu M, Levinson NM, Boxer SG.

J Am Chem Soc. 2012 Nov 21;134(46):18986-97. doi: 10.1021/ja305575t. Epub 2012 Nov 7.


Structural and spectroscopic analysis of the kinase inhibitor bosutinib and an isomer of bosutinib binding to the Abl tyrosine kinase domain.

Levinson NM, Boxer SG.

PLoS One. 2012;7(4):e29828. doi: 10.1371/journal.pone.0029828. Epub 2012 Apr 6.


Solvent-induced infrared frequency shifts in aromatic nitriles are quantitatively described by the vibrational Stark effect.

Levinson NM, Fried SD, Boxer SG.

J Phys Chem B. 2012 Sep 6;116(35):10470-6. doi: 10.1021/jp301054e. Epub 2012 Apr 5.


Direct measurements of electric fields in weak OH···π hydrogen bonds.

Saggu M, Levinson NM, Boxer SG.

J Am Chem Soc. 2011 Nov 2;133(43):17414-9. doi: 10.1021/ja2069592. Epub 2011 Oct 12.


Phosphate vibrations probe local electric fields and hydration in biomolecules.

Levinson NM, Bolte EE, Miller CS, Corcelli SA, Boxer SG.

J Am Chem Soc. 2011 Aug 31;133(34):13236-9. doi: 10.1021/ja2042589. Epub 2011 Aug 10.


The tyrosine kinase Csk dimerizes through Its SH3 domain.

Levinson NM, Visperas PR, Kuriyan J.

PLoS One. 2009 Nov 4;4(11):e7683. doi: 10.1371/journal.pone.0007683.


Structural basis for the recognition of c-Src by its inactivator Csk.

Levinson NM, Seeliger MA, Cole PA, Kuriyan J.

Cell. 2008 Jul 11;134(1):124-34. doi: 10.1016/j.cell.2008.05.051.


A Src-like inactive conformation in the abl tyrosine kinase domain.

Levinson NM, Kuchment O, Shen K, Young MA, Koldobskiy M, Karplus M, Cole PA, Kuriyan J.

PLoS Biol. 2006 May;4(5):e144. Epub 2006 May 2.

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