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Items: 1 to 50 of 114

1.

Suppressive and Gut Reparative Functions of Human Type 1 T-regulatory Cells.

Cook L, Stahl M, Han X, Nazli A, MacDonald KN, Wong MQ, Tsai K, Dizzell S, Jacobson K, Bressler B, Kaushic C, Vallance BA, Steiner TS, Levings MK.

Gastroenterology. 2019 Sep 9. pii: S0016-5085(19)41310-3. doi: 10.1053/j.gastro.2019.09.002. [Epub ahead of print]

PMID:
31513797
2.

A New Mechanism of Action in Human and Mouse Treg Cells: The Ke(y)to Suppression.

Wu D, Levings MK.

Immunity. 2019 May 21;50(5):1122-1124. doi: 10.1016/j.immuni.2019.04.008.

PMID:
31117006
3.

Cancer immunotherapies repurposed for use in autoimmunity.

Boardman DA, Levings MK.

Nat Biomed Eng. 2019 Apr;3(4):259-263. doi: 10.1038/s41551-019-0359-6. No abstract available.

PMID:
30952977
4.

Methods to manufacture regulatory T cells for cell therapy.

MacDonald KN, Piret JM, Levings MK.

Clin Exp Immunol. 2019 Jul;197(1):52-63. doi: 10.1111/cei.13297. Epub 2019 Apr 15. Review.

PMID:
30913302
5.

Innate Control of Tissue-Reparative Human Regulatory T Cells.

Lam AJ, MacDonald KN, Pesenacker AM, Juvet SC, Morishita KA, Bressler B; iGenoMed Consortium, Pan JG, Sidhu SS, Rioux JD, Levings MK.

J Immunol. 2019 Apr 15;202(8):2195-2209. doi: 10.4049/jimmunol.1801330. Epub 2019 Mar 8.

PMID:
30850479
6.

Systematic testing and specificity mapping of alloantigen-specific chimeric antigen receptors in regulatory T cells.

Dawson NA, Lamarche C, Hoeppli RE, Bergqvist P, Fung VC, McIver E, Huang Q, Gillies J, Speck M, Orban PC, Bush JW, Mojibian M, Levings MK.

JCI Insight. 2019 Mar 21;4(6). pii: 123672. doi: 10.1172/jci.insight.123672. eCollection 2019 Mar 21.

7.

Treg gene signatures predict and measure type 1 diabetes trajectory.

Pesenacker AM, Chen V, Gillies J, Speake C, Marwaha AK, Sun A, Chow S, Tan R, Elliott T, Dutz JP, Tebbutt SJ, Levings MK.

JCI Insight. 2019 Mar 21;4(6). pii: 123879. doi: 10.1172/jci.insight.123879. eCollection 2019 Mar 21.

8.

Characterization of regulatory T cells in obese omental adipose tissue in humans.

Wu D, Han JM, Yu X, Lam AJ, Hoeppli RE, Pesenacker AM, Huang Q, Chen V, Speake C, Yorke E, Nguyen N, Sampath S, Harris D, Levings MK.

Eur J Immunol. 2019 Feb;49(2):336-347. doi: 10.1002/eji.201847570. Epub 2019 Jan 8.

PMID:
30566246
9.

A standardized immune phenotyping and automated data analysis platform for multicenter biomarker studies.

Ivison S, Malek M, Garcia RV, Broady R, Halpin A, Richaud M, Brant RF, Wang SI, Goupil M, Guan Q, Ashton P, Warren J, Rajab A, Urschel S, Kumar D, Streitz M, Sawitzki B, Schlickeiser S, Bijl JJ, Wall DA, Delisle JS, West LJ, Brinkman RR, Levings MK.

JCI Insight. 2018 Dec 6;3(23). pii: 121867. doi: 10.1172/jci.insight.121867.

10.

Taking regulatory T-cell therapy one step further.

Sicard A, Boardman DA, Levings MK.

Curr Opin Organ Transplant. 2018 Oct;23(5):509-515. doi: 10.1097/MOT.0000000000000566. Review.

PMID:
30063480
11.

Tailoring the homing capacity of human Tregs for directed migration to sites of Th1-inflammation or intestinal regions.

Hoeppli RE, MacDonald KN, Leclair P, Fung VCW, Mojibian M, Gillies J, Rahavi SMR, Campbell AIM, Gandhi SK, Pesenacker AM, Reid G, Lim CJ, Levings MK.

Am J Transplant. 2019 Jan;19(1):62-76. doi: 10.1111/ajt.14936. Epub 2018 Jun 13.

PMID:
29766641
12.

An optimized method to measure human FOXP3+ regulatory T cells from multiple tissue types using mass cytometry.

Dawson NAJ, Lam AJ, Cook L, Hoeppli RE, Broady R, Pesenacker AM, Levings MK.

Eur J Immunol. 2018 Aug;48(8):1415-1419. doi: 10.1002/eji.201747407. Epub 2018 May 16.

13.

Engineering therapeutic T cells to suppress alloimmune responses using TCRs, CARs, or BARs.

Sicard A, Levings MK, Scott DW.

Am J Transplant. 2018 Jun;18(6):1305-1311. doi: 10.1111/ajt.14747. Epub 2018 Apr 21. Review.

14.

Engineered Tolerance: Tailoring Development, Function, and Antigen-Specificity of Regulatory T Cells.

Dawson NAJ, Vent-Schmidt J, Levings MK.

Front Immunol. 2017 Nov 3;8:1460. doi: 10.3389/fimmu.2017.01460. eCollection 2017. Review.

15.

Guiding regulatory T cells to the allograft.

Lamarche C, Levings MK.

Curr Opin Organ Transplant. 2018 Feb;23(1):106-113. doi: 10.1097/MOT.0000000000000483. Review.

PMID:
29140829
16.

Biomarker-guided stratification of autoimmune patients for biologic therapy.

Ivison S, Des Rosiers C, Lesage S, Rioux JD, Levings MK.

Curr Opin Immunol. 2017 Dec;49:56-63. doi: 10.1016/j.coi.2017.09.006. Epub 2017 Oct 17. Review.

PMID:
29053992
17.

Guidelines for the use of flow cytometry and cell sorting in immunological studies.

Cossarizza A, Chang HD, Radbruch A, Akdis M, Andrä I, Annunziato F, Bacher P, Barnaba V, Battistini L, Bauer WM, Baumgart S, Becher B, Beisker W, Berek C, Blanco A, Borsellino G, Boulais PE, Brinkman RR, Büscher M, Busch DH, Bushnell TP, Cao X, Cavani A, Chattopadhyay PK, Cheng Q, Chow S, Clerici M, Cooke A, Cosma A, Cosmi L, Cumano A, Dang VD, Davies D, De Biasi S, Del Zotto G, Della Bella S, Dellabona P, Deniz G, Dessing M, Diefenbach A, Di Santo J, Dieli F, Dolf A, Donnenberg VS, Dörner T, Ehrhardt GRA, Endl E, Engel P, Engelhardt B, Esser C, Everts B, Dreher A, Falk CS, Fehniger TA, Filby A, Fillatreau S, Follo M, Förster I, Foster J, Foulds GA, Frenette PS, Galbraith D, Garbi N, García-Godoy MD, Geginat J, Ghoreschi K, Gibellini L, Goettlinger C, Goodyear CS, Gori A, Grogan J, Gross M, Grützkau A, Grummitt D, Hahn J, Hammer Q, Hauser AE, Haviland DL, Hedley D, Herrera G, Herrmann M, Hiepe F, Holland T, Hombrink P, Houston JP, Hoyer BF, Huang B, Hunter CA, Iannone A, Jäck HM, Jávega B, Jonjic S, Juelke K, Jung S, Kaiser T, Kalina T, Keller B, Khan S, Kienhöfer D, Kroneis T, Kunkel D, Kurts C, Kvistborg P, Lannigan J, Lantz O, Larbi A, LeibundGut-Landmann S, Leipold MD, Levings MK, Litwin V, Liu Y, Lohoff M, Lombardi G, Lopez L, Lovett-Racke A, Lubberts E, Ludewig B, Lugli E, Maecker HT, Martrus G, Matarese G, Maueröder C, McGrath M, McInnes I, Mei HE, Melchers F, Melzer S, Mielenz D, Mills K, Mirrer D, Mjösberg J, Moore J, Moran B, Moretta A, Moretta L, Mosmann TR, Müller S, Müller W, Münz C, Multhoff G, Munoz LE, Murphy KM, Nakayama T, Nasi M, Neudörfl C, Nolan J, Nourshargh S, O'Connor JE, Ouyang W, Oxenius A, Palankar R, Panse I, Peterson P, Peth C, Petriz J, Philips D, Pickl W, Piconese S, Pinti M, Pockley AG, Podolska MJ, Pucillo C, Quataert SA, Radstake TRDJ, Rajwa B, Rebhahn JA, Recktenwald D, Remmerswaal EBM, Rezvani K, Rico LG, Robinson JP, Romagnani C, Rubartelli A, Ruckert B, Ruland J, Sakaguchi S, Sala-de-Oyanguren F, Samstag Y, Sanderson S, Sawitzki B, Scheffold A, Schiemann M, Schildberg F, Schimisky E, Schmid SA, Schmitt S, Schober K, Schüler T, Schulz AR, Schumacher T, Scotta C, Shankey TV, Shemer A, Simon AK, Spidlen J, Stall AM, Stark R, Stehle C, Stein M, Steinmetz T, Stockinger H, Takahama Y, Tarnok A, Tian Z, Toldi G, Tornack J, Traggiai E, Trotter J, Ulrich H, van der Braber M, van Lier RAW, Veldhoen M, Vento-Asturias S, Vieira P, Voehringer D, Volk HD, von Volkmann K, Waisman A, Walker R, Ward MD, Warnatz K, Warth S, Watson JV, Watzl C, Wegener L, Wiedemann A, Wienands J, Willimsky G, Wing J, Wurst P, Yu L, Yue A, Zhang Q, Zhao Y, Ziegler S, Zimmermann J.

Eur J Immunol. 2017 Oct;47(10):1584-1797. doi: 10.1002/eji.201646632. No abstract available.

18.

CD56bright natural killer regulatory cells in filgrastim primed donor blood or marrow products regulate chronic graft-versus-host disease: the Canadian Blood and Marrow Transplant Group randomized 0601 study results.

Kariminia A, Ivison S, Ng B, Rozmus J, Sung S, Varshney A, Aljurf M, Lachance S, Walker I, Toze C, Lipton J, Lee SJ, Szer J, Doocey R, Lewis I, Smith C, Chaudhri N, Levings MK, Broady R, Devins G, Szwajcer D, Foley R, Mostafavi S, Pavletic S, Wall DA, Couban S, Panzarella T, Schultz KR.

Haematologica. 2017 Nov;102(11):1936-1946. doi: 10.3324/haematol.2017.170928. Epub 2017 Sep 21.

19.

Adipose-tissue regulatory T cells: Critical players in adipose-immune crosstalk.

Becker M, Levings MK, Daniel C.

Eur J Immunol. 2017 Nov;47(11):1867-1874. doi: 10.1002/eji.201646739. Epub 2017 Sep 20. Review.

20.

Antigen-specific regulatory T cells: are police CARs the answer?

Dawson NAJ, Levings MK.

Transl Res. 2017 Sep;187:53-58. doi: 10.1016/j.trsl.2017.06.009. Epub 2017 Jun 19. Review.

PMID:
28688236
21.

Thymic progenitors of TCRαβ+ CD8αα intestinal intraepithelial lymphocytes require RasGRP1 for development.

Golec DP, Hoeppli RE, Henao Caviedes LM, McCann J, Levings MK, Baldwin TA.

J Exp Med. 2017 Aug 7;214(8):2421-2435. doi: 10.1084/jem.20170844. Epub 2017 Jun 26.

22.

Harnessing Advances in T Regulatory Cell Biology for Cellular Therapy in Transplantation.

Lam AJ, Hoeppli RE, Levings MK.

Transplantation. 2017 Oct;101(10):2277-2287. doi: 10.1097/TP.0000000000001757. Review.

PMID:
28376037
23.

Circulating gluten-specific FOXP3+CD39+ regulatory T cells have impaired suppressive function in patients with celiac disease.

Cook L, Munier CML, Seddiki N, van Bockel D, Ontiveros N, Hardy MY, Gillies JK, Levings MK, Reid HH, Petersen J, Rossjohn J, Anderson RP, Zaunders JJ, Tye-Din JA, Kelleher AD.

J Allergy Clin Immunol. 2017 Dec;140(6):1592-1603.e8. doi: 10.1016/j.jaci.2017.02.015. Epub 2017 Mar 8.

24.

The role of FOXP3 in autoimmunity.

Pesenacker AM, Cook L, Levings MK.

Curr Opin Immunol. 2016 Dec;43:16-23. doi: 10.1016/j.coi.2016.07.004. Epub 2016 Aug 19. Review.

PMID:
27544816
25.

How antigen specificity directs regulatory T-cell function: self, foreign and engineered specificity.

Hoeppli RE, MacDonald KG, Levings MK, Cook L.

HLA. 2016 Jul;88(1-2):3-13. doi: 10.1111/tan.12822. Epub 2016 Jun 3. Review.

PMID:
27256587
26.

Restimulation After Cryopreservation and Thawing Preserves the Phenotype and Function of Expanded Baboon Regulatory T Cells.

Weiner J, Duran-Struuck R, Zitsman J, Buhler L, Sondermeijer H, McMurchy AN, Levings MK, Sykes M, Griesemer A.

Transplant Direct. 2015 Feb 1;1(1):1-7.

27.

Alloantigen-specific regulatory T cells generated with a chimeric antigen receptor.

MacDonald KG, Hoeppli RE, Huang Q, Gillies J, Luciani DS, Orban PC, Broady R, Levings MK.

J Clin Invest. 2016 Apr 1;126(4):1413-24. doi: 10.1172/JCI82771. Epub 2016 Mar 21.

28.

T regulatory cell chemokine production mediates pathogenic T cell attraction and suppression.

Patterson SJ, Pesenacker AM, Wang AY, Gillies J, Mojibian M, Morishita K, Tan R, Kieffer TJ, Verchere CB, Panagiotopoulos C, Levings MK.

J Clin Invest. 2016 Mar 1;126(3):1039-51. doi: 10.1172/JCI83987. Epub 2016 Feb 8.

29.

A Regulatory T-Cell Gene Signature Is a Specific and Sensitive Biomarker to Identify Children With New-Onset Type 1 Diabetes.

Pesenacker AM, Wang AY, Singh A, Gillies J, Kim Y, Piccirillo CA, Nguyen D, Haining WN, Tebbutt SJ, Panagiotopoulos C, Levings MK.

Diabetes. 2016 Apr;65(4):1031-9. doi: 10.2337/db15-0572. Epub 2016 Jan 19.

30.

Obesity-Associated Adipose Tissue Inflammation and Transplantation.

Wu D, Dawson NA, Levings MK.

Am J Transplant. 2016 Mar;16(3):743-50. doi: 10.1111/ajt.13578. Epub 2016 Jan 11. Review.

31.

CCL22 Prevents Rejection of Mouse Islet Allografts and Induces Donor-Specific Tolerance.

Montane J, Obach M, Alvarez S, Bischoff L, Dai DL, Soukhatcheva G, Priatel JJ, Hardenberg G, Levings MK, Tan R, Orban PC, Verchere CB.

Cell Transplant. 2015;24(10):2143-54. doi: 10.3727/096368914X685249.

PMID:
26423995
32.

Discarded Human Thymus Is a Novel Source of Stable and Long-Lived Therapeutic Regulatory T Cells.

Dijke IE, Hoeppli RE, Ellis T, Pearcey J, Huang Q, McMurchy AN, Boer K, Peeters AM, Aubert G, Larsen I, Ross DB, Rebeyka I, Campbell A, Baan CC, Levings MK, West LJ.

Am J Transplant. 2016 Jan;16(1):58-71. doi: 10.1111/ajt.13456. Epub 2015 Sep 28.

33.

Tr1 Cells, but Not Foxp3+ Regulatory T Cells, Suppress NLRP3 Inflammasome Activation via an IL-10-Dependent Mechanism.

Yao Y, Vent-Schmidt J, McGeough MD, Wong M, Hoffman HM, Steiner TS, Levings MK.

J Immunol. 2015 Jul 15;195(2):488-97. doi: 10.4049/jimmunol.1403225. Epub 2015 Jun 8.

34.

IL-33 Reverses an Obesity-Induced Deficit in Visceral Adipose Tissue ST2+ T Regulatory Cells and Ameliorates Adipose Tissue Inflammation and Insulin Resistance.

Han JM, Wu D, Denroche HC, Yao Y, Verchere CB, Levings MK.

J Immunol. 2015 May 15;194(10):4777-83. doi: 10.4049/jimmunol.1500020. Epub 2015 Apr 13.

35.

The environment of regulatory T cell biology: cytokines, metabolites, and the microbiome.

Hoeppli RE, Wu D, Cook L, Levings MK.

Front Immunol. 2015 Feb 18;6:61. doi: 10.3389/fimmu.2015.00061. eCollection 2015. Review.

36.

Regulatory T cells produce profibrotic cytokines in the skin of patients with systemic sclerosis.

MacDonald KG, Dawson NA, Huang Q, Dunne JV, Levings MK, Broady R.

J Allergy Clin Immunol. 2015 Apr;135(4):946-.e9. doi: 10.1016/j.jaci.2014.12.1932. Epub 2015 Feb 10.

PMID:
25678090
37.

Control of tissue-localized immune responses by human regulatory T cells.

Pesenacker AM, Broady R, Levings MK.

Eur J Immunol. 2015 Feb;45(2):333-43. doi: 10.1002/eji.201344205. Epub 2014 Dec 8. Review.

38.

Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation.

Antignano F, Burrows K, Hughes MR, Han JM, Kron KJ, Penrod NM, Oudhoff MJ, Wang SK, Min PH, Gold MJ, Chenery AL, Braam MJ, Fung TC, Rossi FM, McNagny KM, Arrowsmith CH, Lupien M, Levings MK, Zaph C.

J Clin Invest. 2014 May;124(5):1945-55. doi: 10.1172/JCI69592. Epub 2014 Mar 25.

39.

Insulin inhibits IL-10-mediated regulatory T cell function: implications for obesity.

Han JM, Patterson SJ, Speck M, Ehses JA, Levings MK.

J Immunol. 2014 Jan 15;192(2):623-9. doi: 10.4049/jimmunol.1302181. Epub 2013 Dec 9.

40.

The role of FOXP3 in regulating immune responses.

Vent-Schmidt J, Han JM, MacDonald KG, Levings MK.

Int Rev Immunol. 2014 Mar;33(2):110-28. doi: 10.3109/08830185.2013.811657. Epub 2013 Aug 15. Review.

PMID:
23947341
41.

Immune regulation in obesity-associated adipose inflammation.

Han JM, Levings MK.

J Immunol. 2013 Jul 15;191(2):527-32. doi: 10.4049/jimmunol.1301035. Review.

42.

Response to comment on "helios+ and helios- cells coexist within the natural FOXP3+ T regulatory cell subset in humans".

MacDonald KG, Han JM, Himmel ME, Huang Q, Kan B, Campbell AI, Lavoie PM, Levings MK.

J Immunol. 2013 May 1;190(9):4440-1. doi: 10.4049/jimmunol.1390019. No abstract available.

43.

Helios+ and Helios- cells coexist within the natural FOXP3+ T regulatory cell subset in humans.

Himmel ME, MacDonald KG, Garcia RV, Steiner TS, Levings MK.

J Immunol. 2013 Mar 1;190(5):2001-8. doi: 10.4049/jimmunol.1201379. Epub 2013 Jan 28.

44.

In vitro generation of human T regulatory cells: generation, culture, and analysis of FOXP3-transduced T cells.

McMurchy AN, Levings MK.

Methods Mol Biol. 2013;946:115-32. doi: 10.1007/978-1-62703-128-8_8.

PMID:
23179829
45.

A novel function for FOXP3 in humans: intrinsic regulation of conventional T cells.

McMurchy AN, Gillies J, Gizzi MC, Riba M, Garcia-Manteiga JM, Cittaro D, Lazarevic D, Di Nunzio S, Piras IS, Bulfone A, Roncarolo MG, Stupka E, Bacchetta R, Levings MK.

Blood. 2013 Feb 21;121(8):1265-75. doi: 10.1182/blood-2012-05-431023. Epub 2012 Nov 20.

PMID:
23169781
46.

Active vitamin D (1,25-dihydroxyvitamin D3) increases host susceptibility to Citrobacter rodentium by suppressing mucosal Th17 responses.

Ryz NR, Patterson SJ, Zhang Y, Ma C, Huang T, Bhinder G, Wu X, Chan J, Glesby A, Sham HP, Dutz JP, Levings MK, Jacobson K, Vallance BA.

Am J Physiol Gastrointest Liver Physiol. 2012 Dec 15;303(12):G1299-311. doi: 10.1152/ajpgi.00320.2012. Epub 2012 Sep 27.

47.

ATP conditions intestinal epithelial cells to an inflammatory state that promotes components of DC maturation.

Yao Y, Levings MK, Steiner TS.

Eur J Immunol. 2012 Dec;42(12):3310-21. doi: 10.1002/eji.201142213. Epub 2012 Oct 26.

48.

The Role of the PI3K Signaling Pathway in CD4(+) T Cell Differentiation and Function.

Han JM, Patterson SJ, Levings MK.

Front Immunol. 2012 Aug 13;3:245. doi: 10.3389/fimmu.2012.00245. eCollection 2012.

49.

T regulatory cell therapy in transplantation: stability, localization and functional specialization.

MacDonald KG, Orban PC, Levings MK.

Curr Opin Organ Transplant. 2012 Aug;17(4):343-8. doi: 10.1097/MOT.0b013e328355aaaf. Review.

PMID:
22790068
50.

TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic?

Marwaha AK, Leung NJ, McMurchy AN, Levings MK.

Front Immunol. 2012 Jun 4;3:129. doi: 10.3389/fimmu.2012.00129. eCollection 2012.

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