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Items: 1 to 50 of 124


The parameter Houlihan: A solution to high-throughput identifiability indeterminacy for brutally ill-posed problems.

Albers DJ, Levine ME, Mamykina L, Hripcsak G.

Math Biosci. 2019 Oct;316:108242. doi: 10.1016/j.mbs.2019.108242. Epub 2019 Aug 24.


Associations of genetics, behaviors, and life course circumstances with a novel aging and healthspan measure: Evidence from the Health and Retirement Study.

Liu Z, Chen X, Gill TM, Ma C, Crimmins EM, Levine ME.

PLoS Med. 2019 Jun 18;16(6):e1002827. doi: 10.1371/journal.pmed.1002827. eCollection 2019 Jun.


The role of epigenetic aging in education and racial/ethnic mortality disparities among older U.S. Women.

Liu Z, Chen BH, Assimes TL, Ferrucci L, Horvath S, Levine ME.

Psychoneuroendocrinology. 2019 Jun;104:18-24. doi: 10.1016/j.psyneuen.2019.01.028. Epub 2019 Feb 6.


Effect of vocabulary mapping for conditions on phenotype cohorts.

Hripcsak G, Levine ME, Shang N, Ryan PB.

J Am Med Inform Assoc. 2018 Dec 1;25(12):1618-1625. doi: 10.1093/jamia/ocy124.


Time and the Metrics of Aging.

Ferrucci L, Levine ME, Kuo PL, Simonsick EM.

Circ Res. 2018 Sep 14;123(7):740-744. doi: 10.1161/CIRCRESAHA.118.312816. Review. No abstract available.


Mechanistic machine learning: how data assimilation leverages physiologic knowledge using Bayesian inference to forecast the future, infer the present, and phenotype.

Albers DJ, Levine ME, Stuart A, Mamykina L, Gluckman B, Hripcsak G.

J Am Med Inform Assoc. 2018 Oct 1;25(10):1392-1401. doi: 10.1093/jamia/ocy106.


Humanin Prevents Age-Related Cognitive Decline in Mice and is Associated with Improved Cognitive Age in Humans.

Yen K, Wan J, Mehta HH, Miller B, Christensen A, Levine ME, Salomon MP, Brandhorst S, Xiao J, Kim SJ, Navarrete G, Campo D, Harry GJ, Longo V, Pike CJ, Mack WJ, Hodis HN, Crimmins EM, Cohen P.

Sci Rep. 2018 Sep 21;8(1):14212. doi: 10.1038/s41598-018-32616-7.


Methodological variations in lagged regression for detecting physiologic drug effects in EHR data.

Levine ME, Albers DJ, Hripcsak G.

J Biomed Inform. 2018 Oct;86:149-159. doi: 10.1016/j.jbi.2018.08.014. Epub 2018 Aug 30.


A visual analytics approach for pattern-recognition in patient-generated data.

Feller DJ, Burgermaster M, Levine ME, Smaldone A, Davidson PG, Albers DJ, Mamykina L.

J Am Med Inform Assoc. 2018 Oct 1;25(10):1366-1374. doi: 10.1093/jamia/ocy054.


An epigenetic biomarker of aging for lifespan and healthspan.

Levine ME, Lu AT, Quach A, Chen BH, Assimes TL, Bandinelli S, Hou L, Baccarelli AA, Stewart JD, Li Y, Whitsel EA, Wilson JG, Reiner AP, Aviv A, Lohman K, Liu Y, Ferrucci L, Horvath S.

Aging (Albany NY). 2018 Apr 18;10(4):573-591. doi: 10.18632/aging.101414.


Is 60 the New 50? Examining Changes in Biological Age Over the Past Two Decades.

Levine ME, Crimmins EM.

Demography. 2018 Apr;55(2):387-402. doi: 10.1007/s13524-017-0644-5.


GWAS of epigenetic aging rates in blood reveals a critical role for TERT.

Lu AT, Xue L, Salfati EL, Chen BH, Ferrucci L, Levy D, Joehanes R, Murabito JM, Kiel DP, Tsai PC, Yet I, Bell JT, Mangino M, Tanaka T, McRae AF, Marioni RE, Visscher PM, Wray NR, Deary IJ, Levine ME, Quach A, Assimes T, Tsao PS, Absher D, Stewart JD, Li Y, Reiner AP, Hou L, Baccarelli AA, Whitsel EA, Aviv A, Cardona A, Day FR, Wareham NJ, Perry JRB, Ong KK, Raj K, Lunetta KL, Horvath S.

Nat Commun. 2018 Jan 26;9(1):387. doi: 10.1038/s41467-017-02697-5.


Predictors and Implications of Accelerated Cognitive Aging.

Levine ME, Harrati A, Crimmins EM.

Biodemography Soc Biol. 2018;64(2):83-101. doi: 10.1080/19485565.2018.1552513. Epub 2018 Dec 20.


Eleven Telomere, Epigenetic Clock, and Biomarker-Composite Quantifications of Biological Aging: Do They Measure the Same Thing?

Belsky DW, Moffitt TE, Cohen AA, Corcoran DL, Levine ME, Prinz JA, Schaefer J, Sugden K, Williams B, Poulton R, Caspi A.

Am J Epidemiol. 2018 Jun 1;187(6):1220-1230. doi: 10.1093/aje/kwx346.


Biological Age, Not Chronological Age, Is Associated with Late-Life Depression.

Brown PJ, Wall MM, Chen C, Levine ME, Yaffe K, Roose SP, Rutherford BR.

J Gerontol A Biol Sci Med Sci. 2018 Sep 11;73(10):1370-1376. doi: 10.1093/gerona/glx162.


Contemporaneous Social Environment and the Architecture of Late-Life Gene Expression Profiles.

Levine ME, Crimmins EM, Weir DR, Cole SW.

Am J Epidemiol. 2017 Sep 1;186(5):503-509. doi: 10.1093/aje/kwx147.


A Weighted SNP Correlation Network Method for Estimating Polygenic Risk Scores.

Levine ME, Langfelder P, Horvath S.

Methods Mol Biol. 2017;1613:277-290. doi: 10.1007/978-1-4939-7027-8_10.


Single-Incision Approach to Implantation of the Pulse Generator and Leads for Dorsal Root Ganglion Stimulation: A Case Report.

van Velsen V, van Helmond N, Levine ME, Chapman KB.

A A Pract. 2018 Jan 1;10(1):23-27. doi: 10.1213/XAA.0000000000000625.


Genetic architecture of epigenetic and neuronal ageing rates in human brain regions.

Lu AT, Hannon E, Levine ME, Crimmins EM, Lunnon K, Mill J, Geschwind DH, Horvath S.

Nat Commun. 2017 May 18;8:15353. doi: 10.1038/ncomms15353.


Epigenetic clock analysis of diet, exercise, education, and lifestyle factors.

Quach A, Levine ME, Tanaka T, Lu AT, Chen BH, Ferrucci L, Ritz B, Bandinelli S, Neuhouser ML, Beasley JM, Snetselaar L, Wallace RB, Tsao PS, Absher D, Assimes TL, Stewart JD, Li Y, Hou L, Baccarelli AA, Whitsel EA, Horvath S.

Aging (Albany NY). 2017 Feb 14;9(2):419-446. doi: 10.18632/aging.101168.


DNA methylation-based measures of biological age: meta-analysis predicting time to death.

Chen BH, Marioni RE, Colicino E, Peters MJ, Ward-Caviness CK, Tsai PC, Roetker NS, Just AC, Demerath EW, Guan W, Bressler J, Fornage M, Studenski S, Vandiver AR, Moore AZ, Tanaka T, Kiel DP, Liang L, Vokonas P, Schwartz J, Lunetta KL, Murabito JM, Bandinelli S, Hernandez DG, Melzer D, Nalls M, Pilling LC, Price TR, Singleton AB, Gieger C, Holle R, Kretschmer A, Kronenberg F, Kunze S, Linseisen J, Meisinger C, Rathmann W, Waldenberger M, Visscher PM, Shah S, Wray NR, McRae AF, Franco OH, Hofman A, Uitterlinden AG, Absher D, Assimes T, Levine ME, Lu AT, Tsao PS, Hou L, Manson JE, Carty CL, LaCroix AZ, Reiner AP, Spector TD, Feinberg AP, Levy D, Baccarelli A, van Meurs J, Bell JT, Peters A, Deary IJ, Pankow JS, Ferrucci L, Horvath S.

Aging (Albany NY). 2016 Sep 28;8(9):1844-1865. doi: 10.18632/aging.101020.


An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease.

Horvath S, Gurven M, Levine ME, Trumble BC, Kaplan H, Allayee H, Ritz BR, Chen B, Lu AT, Rickabaugh TM, Jamieson BD, Sun D, Li S, Chen W, Quintana-Murci L, Fagny M, Kobor MS, Tsao PS, Reiner AP, Edlefsen KL, Absher D, Assimes TL.

Genome Biol. 2016 Aug 11;17(1):171. doi: 10.1186/s13059-016-1030-0.


Menopause accelerates biological aging.

Levine ME, Lu AT, Chen BH, Hernandez DG, Singleton AB, Ferrucci L, Bandinelli S, Salfati E, Manson JE, Quach A, Kusters CD, Kuh D, Wong A, Teschendorff AE, Widschwendter M, Ritz BR, Absher D, Assimes TL, Horvath S.

Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):9327-32. doi: 10.1073/pnas.1604558113. Epub 2016 Jul 25.


Education and Psychosocial Functioning Among Older Adults: 4-Year Change in Sense of Control and Hopelessness.

Mitchell UA, Ailshire JA, Brown LL, Levine ME, Crimmins EM.

J Gerontol B Psychol Sci Soc Sci. 2018 Jun 14;73(5):849-859. doi: 10.1093/geronb/gbw031.


Data-driven health management: reasoning about personally generated data in diabetes with information technologies.

Mamykina L, Levine ME, Davidson PG, Smaldone AM, Elhadad N, Albers DJ.

J Am Med Inform Assoc. 2016 May;23(3):526-31. doi: 10.1093/jamia/ocv187. Epub 2016 Mar 16.


Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum.

Lu AT, Hannon E, Levine ME, Hao K, Crimmins EM, Lunnon K, Kozlenkov A, Mill J, Dracheva S, Horvath S.

Nat Commun. 2016 Feb 2;7:10561. doi: 10.1038/ncomms10561.


DNA methylation age of blood predicts future onset of lung cancer in the women's health initiative.

Levine ME, Hosgood HD, Chen B, Absher D, Assimes T, Horvath S.

Aging (Albany NY). 2015 Sep;7(9):690-700.


A Genetic Network Associated With Stress Resistance, Longevity, and Cancer in Humans.

Levine ME, Crimmins EM.

J Gerontol A Biol Sci Med Sci. 2016 Jun;71(6):703-12. doi: 10.1093/gerona/glv141. Epub 2015 Sep 9.


Effects of Recent Stress and Variation in the Serotonin Transporter Polymorphism (5-HTTLPR) on Depressive Symptoms: A Repeated-Measures Study of Adults Age 50 and Older.

Arpawong TE, Lee J, Phillips DF, Crimmins EM, Levine ME, Prescott CA.

Behav Genet. 2016 Jan;46(1):72-88. doi: 10.1007/s10519-015-9740-8. Epub 2015 Sep 2.


Loneliness, eudaimonia, and the human conserved transcriptional response to adversity.

Cole SW, Levine ME, Arevalo JM, Ma J, Weir DR, Crimmins EM.

Psychoneuroendocrinology. 2015 Dec;62:11-7. doi: 10.1016/j.psyneuen.2015.07.001. Epub 2015 Jul 8.


Quantification of biological aging in young adults.

Belsky DW, Caspi A, Houts R, Cohen HJ, Corcoran DL, Danese A, Harrington H, Israel S, Levine ME, Schaefer JD, Sugden K, Williams B, Yashin AI, Poulton R, Moffitt TE.

Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):E4104-10. doi: 10.1073/pnas.1506264112. Epub 2015 Jul 6.


Early-Life Intelligence Predicts Midlife Biological Age.

Schaefer JD, Caspi A, Belsky DW, Harrington H, Houts R, Israel S, Levine ME, Sugden K, Williams B, Poulton R, Moffitt TE.

J Gerontol B Psychol Sci Soc Sci. 2016 Nov;71(6):968-977. Epub 2015 May 26.


Childhood and later life stressors and increased inflammatory gene expression at older ages.

Levine ME, Cole SW, Weir DR, Crimmins EM.

Soc Sci Med. 2015 Apr;130:16-22. doi: 10.1016/j.socscimed.2015.01.030. Epub 2015 Jan 21.


A polygenic risk score associated with measures of depressive symptoms among older adults.

Levine ME, Crimmins EM, Prescott CA, Phillips D, Arpawong TE, Lee J.

Biodemography Soc Biol. 2014;60(2):199-211. doi: 10.1080/19485565.2014.952705.


Lipase Supplementation before a High-Fat Meal Reduces Perceptions of Fullness in Healthy Subjects.

Levine ME, Koch SY, Koch KL.

Gut Liver. 2015 Jul;9(4):464-9. doi: 10.5009/gnl14005.


A comparison of methods for assessing mortality risk.

Levine ME, Crimmins EM.

Am J Hum Biol. 2014 Nov-Dec;26(6):768-76. doi: 10.1002/ajhb.22595. Epub 2014 Aug 4.


Evidence of accelerated aging among African Americans and its implications for mortality.

Levine ME, Crimmins EM.

Soc Sci Med. 2014 Oct;118:27-32. doi: 10.1016/j.socscimed.2014.07.022. Epub 2014 Jul 15.


Enhanced perceptions of control and predictability reduce motion-induced nausea and gastric dysrhythmia.

Levine ME, Stern RM, Koch KL.

Exp Brain Res. 2014 Aug;232(8):2675-84. doi: 10.1007/s00221-014-3950-9. Epub 2014 Apr 20.


Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population.

Levine ME, Suarez JA, Brandhorst S, Balasubramanian P, Cheng CW, Madia F, Fontana L, Mirisola MG, Guevara-Aguirre J, Wan J, Passarino G, Kennedy BK, Wei M, Cohen P, Crimmins EM, Longo VD.

Cell Metab. 2014 Mar 4;19(3):407-17. doi: 10.1016/j.cmet.2014.02.006.


Response to Dr. Mitnitski's and Dr. Rockwood's letter to the editor: Biological age revisited.

Levine ME.

J Gerontol A Biol Sci Med Sci. 2014 Mar;69(3):297-8. doi: 10.1093/gerona/glt138. Epub 2013 Oct 10. No abstract available.


Treatment of primary hip osteoarthritis for the primary care physician and the indications for total hip arthroplasty.

Levine ME, Nace J, Kapadia BH, Issa K, Banerjee S, Cherian JJ, Mont MA.

J Long Term Eff Med Implants. 2013;23(4):323-30. Review.


The role of physiological markers of health in the association between demographic factors and periodontal disease.

Levine ME, Kim JK, Crimmins EM.

J Periodontal Res. 2013 Jun;48(3):367-72. doi: 10.1111/jre.12016. Epub 2012 Dec 11.


Modeling the rate of senescence: can estimated biological age predict mortality more accurately than chronological age?

Levine ME.

J Gerontol A Biol Sci Med Sci. 2013 Jun;68(6):667-74. doi: 10.1093/gerona/gls233. Epub 2012 Dec 3.


Sarcopenic obesity and cognitive functioning: the mediating roles of insulin resistance and inflammation?

Levine ME, Crimmins EM.

Curr Gerontol Geriatr Res. 2012;2012:826398. doi: 10.1155/2012/826398. Epub 2012 May 7.


The impact of insulin resistance and inflammation on the association between sarcopenic obesity and physical functioning.

Levine ME, Crimmins EM.

Obesity (Silver Spring). 2012 Oct;20(10):2101-6. doi: 10.1038/oby.2012.20. Epub 2012 Feb 7.


Protein and ginger for the treatment of chemotherapy-induced delayed nausea.

Levine ME, Gillis MG, Koch SY, Voss AC, Stern RM, Koch KL.

J Altern Complement Med. 2008 Jun;14(5):545-51. doi: 10.1089/acm.2007.0817.


Susceptibility to nausea and motion sickness as a function of the menstrual cycle.

Matchock RL, Levine ME, Gianaros PJ, Stern RM.

Womens Health Issues. 2008 Jul-Aug;18(4):328-35. doi: 10.1016/j.whi.2008.01.006. Epub 2008 May 15.


A statistical method to evaluate dental classification systems used by military dental services.

Simecek JW, McGinley JL, Levine ME, Diefenderfer KE, Ahlf RL.

Mil Med. 2008 Jan;173(1 Suppl):51-5.


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