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Identification of central mechanisms underlying anorexigenic effects of intraperitoneal L-tryptophan.

Gartner SN, Klockars A, Prosser C, Carpenter EA, Levine AS, Olszewski PK.

Neuroreport. 2018 Aug 6. doi: 10.1097/WNR.0000000000001110. [Epub ahead of print]


Scholarly Research Projects Benefit Medical Students' Research Productivity and Residency Choice: Outcomes From the University of Pittsburgh School of Medicine.

Conroy MB, Shaffiey S, Jones S, Hackam DJ, Sowa G, Winger DG, Wang L, Boninger ML, Wagner AK, Levine AS.

Acad Med. 2018 Jun 19. doi: 10.1097/ACM.0000000000002328. [Epub ahead of print]


Hypothalamic Integration of the Endocrine Signaling Related to Food Intake.

Klockars A, Levine AS, Olszewski PK.

Curr Top Behav Neurosci. 2018 Jun 10. doi: 10.1007/7854_2018_54. [Epub ahead of print]


SIRT6 facilitates directional telomere movement upon oxidative damage.

Gao Y, Tan J, Jin J, Ma H, Chen X, Leger B, Xu J, Spagnol ST, Dahl KN, Levine AS, Liu Y, Lan L.

Sci Rep. 2018 Mar 29;8(1):5407. doi: 10.1038/s41598-018-23602-0.


Oxytocin administration in the basolateral and central nuclei of amygdala moderately suppresses food intake.

Klockars OA, Klockars A, Levine AS, Olszewski PK.

Neuroreport. 2018 Apr 11;29(6):504-510. doi: 10.1097/WNR.0000000000001005.


Intragastric preloads of l-tryptophan reduce ingestive behavior via oxytocinergic neural mechanisms in male mice.

Gartner SN, Aidney F, Klockars A, Prosser C, Carpenter EA, Isgrove K, Levine AS, Olszewski PK.

Appetite. 2018 Jun 1;125:278-286. doi: 10.1016/j.appet.2018.02.015. Epub 2018 Feb 19.


RAD52 is required for RNA-templated recombination repair in post-mitotic neurons.

Welty S, Teng Y, Liang Z, Zhao W, Sanders LH, Greenamyre JT, Rubio ME, Thathiah A, Kodali R, Wetzel R, Levine AS, Lan L.

J Biol Chem. 2018 Jan 26;293(4):1353-1362. doi: 10.1074/jbc.M117.808402. Epub 2017 Dec 7.


Sino-U.S. partnerships in research, education, and patient care: The experience of the University of Pittsburgh and UPMC.

Levine AS, McDonald MC, Bogosta CE.

Sci China Life Sci. 2017 Oct;60(10):1150-1156. doi: 10.1007/s11427-017-9185-5. Epub 2017 Oct 23.


The oxidative DNA damage response: A review of research undertaken with Tsinghua and Xiangya students at the University of Pittsburgh.

Levine AS, Sun L, Tan R, Gao Y, Yang L, Chen H, Teng Y, Lan L.

Sci China Life Sci. 2017 Oct;60(10):1077-1080. doi: 10.1007/s11427-017-9184-6. Epub 2017 Oct 23. Review.


Neural Basis of Ventromedial Hypothalamic Oxytocin-Driven Decrease in Appetite.

Klockars OA, Waas JR, Klockars A, Levine AS, Olszewski PK.

Neuroscience. 2017 Dec 16;366:54-61. doi: 10.1016/j.neuroscience.2017.10.008. Epub 2017 Oct 14.


Oxytocin and potential benefits for obesity treatment.

Olszewski PK, Klockars A, Levine AS.

Curr Opin Endocrinol Diabetes Obes. 2017 Oct;24(5):320-325. doi: 10.1097/MED.0000000000000351. Review.


Intravenous administration of oxytocin in rats acutely decreases deprivation-induced chow intake, but it fails to affect consumption of palatable solutions.

Klockars A, Brunton C, Li L, Levine AS, Olszewski PK.

Peptides. 2017 Jul;93:13-19. doi: 10.1016/j.peptides.2017.04.010. Epub 2017 Apr 28.


SSRP1 Cooperates with PARP and XRCC1 to Facilitate Single-Strand DNA Break Repair by Chromatin Priming.

Gao Y, Li C, Wei L, Teng Y, Nakajima S, Chen X, Xu J, Leger B, Ma H, Spagnol ST, Wan Y, Dahl KN, Liu Y, Levine AS, Lan L.

Cancer Res. 2017 May 15;77(10):2674-2685. doi: 10.1158/0008-5472.CAN-16-3128. Epub 2017 Apr 17. Erratum in: Cancer Res. 2017 Nov 1;77(21):6047.


A Comprehensive Response: The Role of Nonstate Actors in the Global Plan.

Vitillo RJ, Merico F, Levine AS, Buonocore T.

J Acquir Immune Defic Syndr. 2017 May 1;75 Suppl 1:S99-S105. doi: 10.1097/QAI.0000000000001331. Review.


Nek7 Protects Telomeres from Oxidative DNA Damage by Phosphorylation and Stabilization of TRF1.

Tan R, Nakajima S, Wang Q, Sun H, Xue J, Wu J, Hellwig S, Zeng X, Yates NA, Smithgall TE, Lei M, Jiang Y, Levine AS, Su B, Lan L.

Mol Cell. 2017 Mar 2;65(5):818-831.e5. doi: 10.1016/j.molcel.2017.01.015. Epub 2017 Feb 16.


Tankyrase1-mediated poly(ADP-ribosyl)ation of TRF1 maintains cell survival after telomeric DNA damage.

Yang L, Sun L, Teng Y, Chen H, Gao Y, Levine AS, Nakajima S, Lan L.

Nucleic Acids Res. 2017 Apr 20;45(7):3906-3921. doi: 10.1093/nar/gkx083.


WRN is recruited to damaged telomeres via its RQC domain and tankyrase1-mediated poly-ADP-ribosylation of TRF1.

Sun L, Nakajima S, Teng Y, Chen H, Yang L, Chen X, Gao B, Levine AS, Lan L.

Nucleic Acids Res. 2017 Apr 20;45(7):3844-3859. doi: 10.1093/nar/gkx065.


EAF2 regulates DNA repair through Ku70/Ku80 in the prostate.

Ai J, Pascal LE, Wei L, Zang Y, Zhou Y, Yu X, Gong Y, Nakajima S, Nelson JB, Levine AS, Lan L, Wang Z.

Oncogene. 2017 Apr;36(15):2054-2065. doi: 10.1038/onc.2016.373. Epub 2016 Oct 10.


Central oxytocin receptor stimulation attenuates the orexigenic effects of butorphanol tartrate.

Olszewski PK, Klockars OA, Klockars A, Levine AS.

Neuroreport. 2016 Sep 28;27(14):1012-7. doi: 10.1097/WNR.0000000000000647.


Basic research on appetite regulation: Social context of a meal is missing.

Olszewski PK, Levine AS.

Pharmacol Biochem Behav. 2016 Sep;148:106-7. doi: 10.1016/j.pbb.2016.06.009. Epub 2016 Jun 29. Review. No abstract available.


Transcription-coupled homologous recombination after oxidative damage.

Wei L, Levine AS, Lan L.

DNA Repair (Amst). 2016 Aug;44:76-80. doi: 10.1016/j.dnarep.2016.05.009. Epub 2016 May 16. Review.


Tim Bartness, Ph.D. (1953-2015).

Cinti S, Garretson JT, Grill HJ, Levine AS, Trayhurn P.

Temperature (Austin). 2016 Feb 6;3(1):31-8. doi: 10.1080/23328940.2016.1150699. eCollection 2016 Jan-Mar. No abstract available.


Oxytocin Acting in the Nucleus Accumbens Core Decreases Food Intake.

Herisson FM, Waas JR, Fredriksson R, Schiöth HB, Levine AS, Olszewski PK.

J Neuroendocrinol. 2016 Apr;28(4). doi: 10.1111/jne.12381.


Oxytocin: A Conditional Anorexigen whose Effects on Appetite Depend on the Physiological, Behavioural and Social Contexts.

Olszewski PK, Klockars A, Levine AS.

J Neuroendocrinol. 2016 Apr;28(4). doi: 10.1111/jne.12376. Review.


Tim Bartness, Ph.D. (1953-2015).

Grill HJ, Levine AS.

Obesity (Silver Spring). 2015 Dec;23(12):2315-6. doi: 10.1002/oby.21373. Epub 2015 Nov 2. No abstract available.


DNA damage during the G0/G1 phase triggers RNA-templated, Cockayne syndrome B-dependent homologous recombination.

Wei L, Nakajima S, Böhm S, Bernstein KA, Shen Z, Tsang M, Levine AS, Lan L.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):E3495-504. doi: 10.1073/pnas.1507105112. Epub 2015 Jun 22.


Targeted DNA damage at individual telomeres disrupts their integrity and triggers cell death.

Sun L, Tan R, Xu J, LaFace J, Gao Y, Xiao Y, Attar M, Neumann C, Li GM, Su B, Liu Y, Nakajima S, Levine AS, Lan L.

Nucleic Acids Res. 2015 Jul 27;43(13):6334-47. doi: 10.1093/nar/gkv598. Epub 2015 Jun 16.


Research in academic medical centers: two threats to sustainable support.

Levine AS, Alpern RJ, Andrews NC, Antman K, Balser JR, Berg JM, Davis PB, Fitz JG, Golden RN, Goldman L, Jameson JL, Lee VS, Polonsky KS, Rappley MD, Reece EA, Rothman PB, Schwinn DA, Shapiro LJ, Spiegel AM.

Sci Transl Med. 2015 May 27;7(289):289fs22. doi: 10.1126/scitranslmed.aac5200.


Central oxytocin and food intake: focus on macronutrient-driven reward.

Klockars A, Levine AS, Olszewski PK.

Front Endocrinol (Lausanne). 2015 Apr 28;6:65. doi: 10.3389/fendo.2015.00065. eCollection 2015. Review.


Effect of oxytocin receptor blockade on appetite for sugar is modified by social context.

Olszewski PK, Allen K, Levine AS.

Appetite. 2015 Mar;86:81-7. doi: 10.1016/j.appet.2014.10.007. Epub 2014 Oct 22.


Synthesis, biophysical, and pharmacological evaluation of the melanocortin agonist AST3-88: modifications of peptide backbone at Trp 7 position lead to a potent, selective, and stable ligand of the melanocortin 4 receptor (MC4R).

Singh A, Dirain ML, Wilczynski A, Chen C, Gosnell BA, Levine AS, Edison AS, Haskell-Luevano C.

ACS Chem Neurosci. 2014 Oct 15;5(10):1020-31. doi: 10.1021/cn5000953. Epub 2014 Aug 26.


A non-peptide oxytocin receptor agonist, WAY-267,464, alleviates novelty-induced hypophagia in mice: insights into changes in c-Fos immunoreactivity.

Olszewski PK, Ulrich C, Ling N, Allen K, Levine AS.

Pharmacol Biochem Behav. 2014 Sep;124:367-72. doi: 10.1016/j.pbb.2014.07.007. Epub 2014 Jul 17.


Functional relationship between oxytocin and appetite for carbohydrates versus saccharin.

Herisson FM, Brooks LL, Waas JR, Levine AS, Olszewski PK.

Neuroreport. 2014 Aug 20;25(12):909-14. doi: 10.1097/WNR.0000000000000201.


Ubiquitin-specific protease 5 is required for the efficient repair of DNA double-strand breaks.

Nakajima S, Lan L, Wei L, Hsieh CL, Rapić-Otrin V, Yasui A, Levine AS.

PLoS One. 2014 Jan 14;9(1):e84899. doi: 10.1371/journal.pone.0084899. eCollection 2014.


Novel method for site-specific induction of oxidative DNA damage reveals differences in recruitment of repair proteins to heterochromatin and euchromatin.

Lan L, Nakajima S, Wei L, Sun L, Hsieh CL, Sobol RW, Bruchez M, Van Houten B, Yasui A, Levine AS.

Nucleic Acids Res. 2014 Feb;42(4):2330-45. doi: 10.1093/nar/gkt1233. Epub 2013 Nov 29.


Exposure to a high-fat high-sugar diet causes strong up-regulation of proopiomelanocortin and differentially affects dopamine D1 and D2 receptor gene expression in the brainstem of rats.

Alsiö J, Rask-Andersen M, Chavan RA, Olszewski PK, Levine AS, Fredriksson R, Schiöth HB.

Neurosci Lett. 2014 Jan 24;559:18-23. doi: 10.1016/j.neulet.2013.11.008. Epub 2013 Nov 19.


Oxytocin receptor blockade reduces acquisition but not retrieval of taste aversion and blunts responsiveness of amygdala neurons to an aversive stimulus.

Olszewski PK, Waas JR, Brooks LL, Herisson F, Levine AS.

Peptides. 2013 Dec;50:36-41. doi: 10.1016/j.peptides.2013.09.008. Epub 2013 Sep 21.


Damage response of XRCC1 at sites of DNA single strand breaks is regulated by phosphorylation and ubiquitylation after degradation of poly(ADP-ribose).

Wei L, Nakajima S, Hsieh CL, Kanno S, Masutani M, Levine AS, Yasui A, Lan L.

J Cell Sci. 2013 Oct 1;126(Pt 19):4414-23. doi: 10.1242/jcs.128272. Epub 2013 Jul 18.


The contribution of brain reward circuits to the obesity epidemic.

Stice E, Figlewicz DP, Gosnell BA, Levine AS, Pratt WE.

Neurosci Biobehav Rev. 2013 Nov;37(9 Pt A):2047-58. doi: 10.1016/j.neubiorev.2012.12.001. Epub 2012 Dec 10. Review.


A general path for large-scale solubilization of cellular proteins: from membrane receptors to multiprotein complexes.

Pullara F, Guerrero-Santoro J, Calero M, Zhang Q, Peng Y, Spåhr H, Kornberg GL, Cusimano A, Stevenson HP, Santamaria-Suarez H, Reynolds SL, Brown IS, Monga SP, Van Houten B, Rapić-Otrin V, Calero G, Levine AS.

Protein Expr Purif. 2013 Feb;87(2):111-9. doi: 10.1016/j.pep.2012.10.007. Epub 2012 Nov 5.


Yoga and quality-of-life improvement in patients with breast cancer: a literature review.

Levine AS, Balk JL.

Int J Yoga Therap. 2012;(22):95-9. Review.


Pilot study of yoga for breast cancer survivors with poor quality of life.

Levine AS, Balk JL.

Complement Ther Clin Pract. 2012 Nov;18(4):241-5. doi: 10.1016/j.ctcp.2012.06.007. Epub 2012 Aug 3.


Damaged DNA induced UV-damaged DNA-binding protein (UV-DDB) dimerization and its roles in chromatinized DNA repair.

Yeh JI, Levine AS, Du S, Chinte U, Ghodke H, Wang H, Shi H, Hsieh CL, Conway JF, Van Houten B, Rapić-Otrin V.

Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):E2737-46. doi: 10.1073/pnas.1110067109. Epub 2012 Jul 20.


Neurobeachin, a regulator of synaptic protein targeting, is associated with body fat mass and feeding behavior in mice and body-mass index in humans.

Olszewski PK, Rozman J, Jacobsson JA, Rathkolb B, Strömberg S, Hans W, Klockars A, Alsiö J, Risérus U, Becker L, Hölter SM, Elvert R, Ehrhardt N, Gailus-Durner V, Fuchs H, Fredriksson R, Wolf E, Klopstock T, Wurst W, Levine AS, Marcus C, de Angelis MH, Klingenspor M, Schiöth HB, Kilimann MW.

PLoS Genet. 2012;8(3):e1002568. doi: 10.1371/journal.pgen.1002568. Epub 2012 Mar 15.


Monoubiquitinated histone H2A destabilizes photolesion-containing nucleosomes with concomitant release of UV-damaged DNA-binding protein E3 ligase.

Lan L, Nakajima S, Kapetanaki MG, Hsieh CL, Fagerburg M, Thickman K, Rodriguez-Collazo P, Leuba SH, Levine AS, Rapić-Otrin V.

J Biol Chem. 2012 Apr 6;287(15):12036-49. doi: 10.1074/jbc.M111.307058. Epub 2012 Feb 10.


Feed-forward mechanisms: addiction-like behavioral and molecular adaptations in overeating.

Alsiö J, Olszewski PK, Levine AS, Schiöth HB.

Front Neuroendocrinol. 2012 Apr;33(2):127-39. doi: 10.1016/j.yfrne.2012.01.002. Epub 2012 Jan 28. Review.


Functional coupling analysis suggests link between the obesity gene FTO and the BDNF-NTRK2 signaling pathway.

Rask-Andersen M, Almén MS, Olausen HR, Olszewski PK, Eriksson J, Chavan RA, Levine AS, Fredriksson R, Schiöth HB.

BMC Neurosci. 2011 Nov 16;12:117. doi: 10.1186/1471-2202-12-117.


Effects of butorphanol on feeding and neuropeptide Y in the rat.

Mitra A, Kotz CM, Kim EM, Grace MK, Kuskowski MA, Billington CJ, Levine AS.

Pharmacol Biochem Behav. 2012 Jan;100(3):575-80. doi: 10.1016/j.pbb.2011.08.010. Epub 2011 Sep 7.


Expression levels of genes encoding melanin concentrating hormone (MCH) and MCH receptor change in taste aversion, but MCH injections do not alleviate aversive responses.

Mitra A, Klockars A, Gosnell BA, Le Grevès M, Olszewski PK, Levine AS, Schiöth HB.

Pharmacol Biochem Behav. 2012 Jan;100(3):581-6. doi: 10.1016/j.pbb.2011.08.009. Epub 2011 Sep 7.


Effects of acute sprint interval cycling and energy replacement on postprandial lipemia.

Freese EC, Levine AS, Chapman DP, Hausman DB, Cureton KJ.

J Appl Physiol (1985). 2011 Dec;111(6):1584-9. doi: 10.1152/japplphysiol.00416.2011. Epub 2011 Aug 18.

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