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Items: 1 to 50 of 90

1.

Mammalian pigmentation is regulated by a distinct cAMP-dependent mechanism that controls melanosome pH.

Zhou D, Ota K, Nardin C, Feldman M, Widman A, Wind O, Simon A, Reilly M, Levin LR, Buck J, Wakamatsu K, Ito S, Zippin JH.

Sci Signal. 2018 Nov 6;11(555). pii: eaau7987. doi: 10.1126/scisignal.aau7987.

PMID:
30401788
2.

Pharmacological modulation of the CO2/HCO3-/pH-, calcium-, and ATP-sensing soluble adenylyl cyclase.

Wiggins SV, Steegborn C, Levin LR, Buck J.

Pharmacol Ther. 2018 Oct;190:173-186. doi: 10.1016/j.pharmthera.2018.05.008. Epub 2018 May 26. Review.

PMID:
29807057
3.

Distinct intracellular sAC-cAMP domains regulate ER Ca2+ signaling and OXPHOS function.

Valsecchi F, Konrad C, D'Aurelio M, Ramos-Espiritu LS, Stepanova A, Burstein SR, Galkin A, Magranè J, Starkov A, Buck J, Levin LR, Manfredi G.

J Cell Sci. 2017 Nov 1;130(21):3713-3727. doi: 10.1242/jcs.206318. Epub 2017 Sep 1.

4.

Differential Intraocular Pressure Measurements by Tonometry and Direct Cannulation After Treatment with Soluble Adenylyl Cyclase Inhibitors.

Gandhi JK, Roy Chowdhury U, Manzar Z, Buck J, Levin LR, Fautsch MP, Marmorstein AD.

J Ocul Pharmacol Ther. 2017 Oct;33(8):574-581. doi: 10.1089/jop.2017.0027. Epub 2017 Jul 7.

5.

Soluble adenylyl cyclase is essential for proper lysosomal acidification.

Rahman N, Ramos-Espiritu L, Milner TA, Buck J, Levin LR.

J Gen Physiol. 2016 Oct;148(4):325-39. doi: 10.1085/jgp.201611606.

6.

Transient exposure to calcium ionophore enables in vitro fertilization in sterile mouse models.

Navarrete FA, Alvau A, Lee HC, Levin LR, Buck J, Leon PM, Santi CM, Krapf D, Mager J, Fissore RA, Salicioni AM, Darszon A, Visconti PE.

Sci Rep. 2016 Sep 15;6:33589. doi: 10.1038/srep33589.

7.

Discovery of LRE1 as a specific and allosteric inhibitor of soluble adenylyl cyclase.

Ramos-Espiritu L, Kleinboelting S, Navarrete FA, Alvau A, Visconti PE, Valsecchi F, Starkov A, Manfredi G, Buck H, Adura C, Zippin JH, van den Heuvel J, Glickman JF, Steegborn C, Levin LR, Buck J.

Nat Chem Biol. 2016 Oct;12(10):838-44. doi: 10.1038/nchembio.2151. Epub 2016 Aug 22.

8.

The metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein.

Ramos-Espiritu L, Diaz A, Nardin C, Saviola AJ, Shaw F, Plitt T, Yang X, Wolchok J, Pirog EC, Desman G, Sboner A, Zhang T, Xiang J, Merghoub T, Levin LR, Buck J, Zippin JH.

Oncotarget. 2016 Jul 19;7(29):45597-45607. doi: 10.18632/oncotarget.10056.

9.

Bithionol Potently Inhibits Human Soluble Adenylyl Cyclase through Binding to the Allosteric Activator Site.

Kleinboelting S, Ramos-Espiritu L, Buck H, Colis L, van den Heuvel J, Glickman JF, Levin LR, Buck J, Steegborn C.

J Biol Chem. 2016 Apr 29;291(18):9776-84. doi: 10.1074/jbc.M115.708255. Epub 2016 Mar 9.

10.

Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration.

Watson RL, Buck J, Levin LR, Winger RC, Wang J, Arase H, Muller WA.

J Exp Med. 2015 Jun 29;212(7):1021-41. doi: 10.1084/jem.20150354. Epub 2015 Jun 22.

11.

Physiological roles of acid-base sensors.

Levin LR, Buck J.

Annu Rev Physiol. 2015;77:347-62. doi: 10.1146/annurev-physiol-021014-071821. Epub 2014 Oct 17. Review.

PMID:
25340964
12.

The role of soluble adenylyl cyclase in health and disease.

Buck J, Levin LR.

Biochim Biophys Acta. 2014 Dec;1842(12 Pt B):2533-4. doi: 10.1016/j.bbadis.2014.09.009. Epub 2014 Oct 12. No abstract available.

13.

Soluble adenylyl cyclase is necessary and sufficient to overcome the block of axonal growth by myelin-associated factors.

Martinez J, Stessin AM, Campana A, Hou J, Nikulina E, Buck J, Levin LR, Filbin MT.

J Neurosci. 2014 Jul 9;34(28):9281-9. doi: 10.1523/JNEUROSCI.1434-14.2014.

14.

A mitochondrial CO2-adenylyl cyclase-cAMP signalosome controls yeast normoxic cytochrome c oxidase activity.

Hess KC, Liu J, Manfredi G, Mühlschlegel FA, Buck J, Levin LR, Barrientos A.

FASEB J. 2014 Oct;28(10):4369-80. doi: 10.1096/fj.14-252890. Epub 2014 Jul 1.

15.

A soluble adenylyl cyclase form targets to axonemes and rescues beat regulation in soluble adenylyl cyclase knockout mice.

Chen X, Baumlin N, Buck J, Levin LR, Fregien N, Salathe M.

Am J Respir Cell Mol Biol. 2014 Dec;51(6):750-60. doi: 10.1165/rcmb.2013-0542OC.

16.

Crystal structures of human soluble adenylyl cyclase reveal mechanisms of catalysis and of its activation through bicarbonate.

Kleinboelting S, Diaz A, Moniot S, van den Heuvel J, Weyand M, Levin LR, Buck J, Steegborn C.

Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3727-32. doi: 10.1073/pnas.1322778111. Epub 2014 Feb 24.

17.

pH sensing via bicarbonate-regulated "soluble" adenylyl cyclase (sAC).

Rahman N, Buck J, Levin LR.

Front Physiol. 2013 Nov 25;4:343. doi: 10.3389/fphys.2013.00343. Review.

18.

Nonpigmented ciliary epithelial cells respond to acetazolamide by a soluble adenylyl cyclase mechanism.

Shahidullah M, Mandal A, Wei G, Levin LR, Buck J, Delamere NA.

Invest Ophthalmol Vis Sci. 2014 Jan 9;55(1):187-97. doi: 10.1167/iovs.13-12717.

19.

Thiol changes during epididymal maturation: a link to flagellar angulation in mouse spermatozoa?

Ijiri TW, Vadnais ML, Huang AP, Lin AM, Levin LR, Buck J, Gerton GL.

Andrology. 2014 Jan;2(1):65-75. doi: 10.1111/j.2047-2927.2013.00147.x. Epub 2013 Nov 20.

20.

Compartmentalization of distinct cAMP signaling pathways in mammalian sperm.

Wertheimer E, Krapf D, de la Vega-Beltran JL, Sánchez-Cárdenas C, Navarrete F, Haddad D, Escoffier J, Salicioni AM, Levin LR, Buck J, Mager J, Darszon A, Visconti PE.

J Biol Chem. 2013 Dec 6;288(49):35307-20. doi: 10.1074/jbc.M113.489476. Epub 2013 Oct 15.

21.

CO2/HCO3(-)- and calcium-regulated soluble adenylyl cyclase as a physiological ATP sensor.

Zippin JH, Chen Y, Straub SG, Hess KC, Diaz A, Lee D, Tso P, Holz GG, Sharp GW, Levin LR, Buck J.

J Biol Chem. 2013 Nov 15;288(46):33283-91. doi: 10.1074/jbc.M113.510073. Epub 2013 Oct 7.

22.

Pharmacological distinction between soluble and transmembrane adenylyl cyclases.

Bitterman JL, Ramos-Espiritu L, Diaz A, Levin LR, Buck J.

J Pharmacol Exp Ther. 2013 Dec;347(3):589-98. doi: 10.1124/jpet.113.208496. Epub 2013 Oct 3.

23.

cAMP and mitochondria.

Valsecchi F, Ramos-Espiritu LS, Buck J, Levin LR, Manfredi G.

Physiology (Bethesda). 2013 May;28(3):199-209. doi: 10.1152/physiol.00004.2013. Review.

24.

Neuronal expression of soluble adenylyl cyclase in the mammalian brain.

Chen J, Martinez J, Milner TA, Buck J, Levin LR.

Brain Res. 2013 Jun 26;1518:1-8. doi: 10.1016/j.brainres.2013.04.027. Epub 2013 Apr 21.

25.

High adenylyl cyclase activity and in vivo cAMP fluctuations in corals suggest central physiological role.

Barott KL, Helman Y, Haramaty L, Barron ME, Hess KC, Buck J, Levin LR, Tresguerres M.

Sci Rep. 2013;3:1379. doi: 10.1038/srep01379.

26.

Metabolic communication between astrocytes and neurons via bicarbonate-responsive soluble adenylyl cyclase.

Choi HB, Gordon GR, Zhou N, Tai C, Rungta RL, Martinez J, Milner TA, Ryu JK, McLarnon JG, Tresguerres M, Levin LR, Buck J, MacVicar BA.

Neuron. 2012 Sep 20;75(6):1094-104. doi: 10.1016/j.neuron.2012.08.032.

27.

Activation of soluble adenylyl cyclase protects against secretagogue stimulated zymogen activation in rat pancreaic acinar cells.

Kolodecik TR, Shugrue CA, Thrower EC, Levin LR, Buck J, Gorelick FS.

PLoS One. 2012;7(7):e41320. doi: 10.1371/journal.pone.0041320. Epub 2012 Jul 23.

28.

Identification of a haem domain in human soluble adenylate cyclase.

Middelhaufe S, Leipelt M, Levin LR, Buck J, Steegborn C.

Biosci Rep. 2012 Oct;32(5):491-9. doi: 10.1042/BSR20120051.

29.

Characterization of Plasmodium falciparum adenylyl cyclase-β and its role in erythrocytic stage parasites.

Salazar E, Bank EM, Ramsey N, Hess KC, Deitsch KW, Levin LR, Buck J.

PLoS One. 2012;7(6):e39769. doi: 10.1371/journal.pone.0039769. Epub 2012 Jun 26.

30.

Crystal structure and regulation mechanisms of the CyaB adenylyl cyclase from the human pathogen Pseudomonas aeruginosa.

Topal H, Fulcher NB, Bitterman J, Salazar E, Buck J, Levin LR, Cann MJ, Wolfgang MC, Steegborn C.

J Mol Biol. 2012 Feb 17;416(2):271-86. doi: 10.1016/j.jmb.2011.12.045. Epub 2011 Dec 28.

31.

Role of soluble adenylyl cyclase in the heart.

Chen J, Levin LR, Buck J.

Am J Physiol Heart Circ Physiol. 2012 Feb 1;302(3):H538-43. doi: 10.1152/ajpheart.00701.2011. Epub 2011 Nov 4. Review.

32.

Gastric inhibitory peptide controls adipose insulin sensitivity via activation of cAMP-response element-binding protein and p110β isoform of phosphatidylinositol 3-kinase.

Mohammad S, Ramos LS, Buck J, Levin LR, Rubino F, McGraw TE.

J Biol Chem. 2011 Dec 16;286(50):43062-70. doi: 10.1074/jbc.M111.289009. Epub 2011 Oct 25.

33.

Regulation of anterior chamber drainage by bicarbonate-sensitive soluble adenylyl cyclase in the ciliary body.

Lee YS, Tresguerres M, Hess K, Marmorstein LY, Levin LR, Buck J, Marmorstein AD.

J Biol Chem. 2011 Dec 2;286(48):41353-8. doi: 10.1074/jbc.M111.284679. Epub 2011 Oct 12.

34.

A phosphodiesterase 2A isoform localized to mitochondria regulates respiration.

Acin-Perez R, Russwurm M, Günnewig K, Gertz M, Zoidl G, Ramos L, Buck J, Levin LR, Rassow J, Manfredi G, Steegborn C.

J Biol Chem. 2011 Sep 2;286(35):30423-32. doi: 10.1074/jbc.M111.266379. Epub 2011 Jul 1.

35.

The quorum-sensing molecules farnesol/homoserine lactone and dodecanol operate via distinct modes of action in Candida albicans.

Hall RA, Turner KJ, Chaloupka J, Cottier F, De Sordi L, Sanglard D, Levin LR, Buck J, Mühlschlegel FA.

Eukaryot Cell. 2011 Aug;10(8):1034-42. doi: 10.1128/EC.05060-11. Epub 2011 Jun 10.

36.

The soluble guanylyl cyclase activator YC-1 increases intracellular cGMP and cAMP via independent mechanisms in INS-1E cells.

Ramos-Espiritu LS, Hess KC, Buck J, Levin LR.

J Pharmacol Exp Ther. 2011 Sep;338(3):925-31. doi: 10.1124/jpet.111.184135. Epub 2011 Jun 10.

37.

Physiological sensing of carbon dioxide/bicarbonate/pH via cyclic nucleotide signaling.

Buck J, Levin LR.

Sensors (Basel). 2011;11(2):2112-28. doi: 10.3390/s110202112. Review.

38.

Intracellular cAMP signaling by soluble adenylyl cyclase.

Tresguerres M, Levin LR, Buck J.

Kidney Int. 2011 Jun;79(12):1277-88. doi: 10.1038/ki.2011.95. Epub 2011 Apr 13. Review.

39.

CO(2) acts as a signalling molecule in populations of the fungal pathogen Candida albicans.

Hall RA, De Sordi L, Maccallum DM, Topal H, Eaton R, Bloor JW, Robinson GK, Levin LR, Buck J, Wang Y, Gow NA, Steegborn C, Mühlschlegel FA.

PLoS Pathog. 2010 Nov 18;6(11):e1001193. doi: 10.1371/journal.ppat.1001193.

40.

Physiological carbon dioxide, bicarbonate, and pH sensing.

Tresguerres M, Buck J, Levin LR.

Pflugers Arch. 2010 Nov;460(6):953-64. doi: 10.1007/s00424-010-0865-6. Epub 2010 Aug 4. Review.

41.

Modulation of NaCl absorption by [HCO(3)(-)] in the marine teleost intestine is mediated by soluble adenylyl cyclase.

Tresguerres M, Levin LR, Buck J, Grosell M.

Am J Physiol Regul Integr Comp Physiol. 2010 Jul;299(1):R62-71. doi: 10.1152/ajpregu.00761.2009. Epub 2010 Apr 21.

42.

Soluble adenylyl cyclase defines a nuclear cAMP microdomain in keratinocyte hyperproliferative skin diseases.

Zippin JH, Chadwick PA, Levin LR, Buck J, Magro CM.

J Invest Dermatol. 2010 May;130(5):1279-87. doi: 10.1038/jid.2009.440. Epub 2010 Feb 4.

43.

Bicarbonate-sensing soluble adenylyl cyclase is an essential sensor for acid/base homeostasis.

Tresguerres M, Parks SK, Salazar E, Levin LR, Goss GG, Buck J.

Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):442-7. doi: 10.1073/pnas.0911790107. Epub 2009 Dec 14.

44.

Cyclic AMP produced inside mitochondria regulates oxidative phosphorylation.

Acin-Perez R, Salazar E, Kamenetsky M, Buck J, Levin LR, Manfredi G.

Cell Metab. 2009 Mar;9(3):265-76. doi: 10.1016/j.cmet.2009.01.012.

45.

Regulation of epithelial Na+ transport by soluble adenylyl cyclase in kidney collecting duct cells.

Hallows KR, Wang H, Edinger RS, Butterworth MB, Oyster NM, Li H, Buck J, Levin LR, Johnson JP, Pastor-Soler NM.

J Biol Chem. 2009 Feb 27;284(9):5774-83. doi: 10.1074/jbc.M805501200. Epub 2009 Jan 6.

46.

Somatic 'soluble' adenylyl cyclase isoforms are unaffected in Sacy tm1Lex/Sacy tm1Lex 'knockout' mice.

Farrell J, Ramos L, Tresguerres M, Kamenetsky M, Levin LR, Buck J.

PLoS One. 2008 Sep 22;3(9):e3251. doi: 10.1371/journal.pone.0003251.

47.

Glucose and GLP-1 stimulate cAMP production via distinct adenylyl cyclases in INS-1E insulinoma cells.

Ramos LS, Zippin JH, Kamenetsky M, Buck J, Levin LR.

J Gen Physiol. 2008 Sep;132(3):329-38. doi: 10.1085/jgp.200810044. Epub 2008 Aug 11.

48.

Structure-based development of novel adenylyl cyclase inhibitors.

Schlicker C, Rauch A, Hess KC, Kachholz B, Levin LR, Buck J, Steegborn C.

J Med Chem. 2008 Aug 14;51(15):4456-64. doi: 10.1021/jm800481q. Epub 2008 Jul 17.

49.

"Soluble" adenylyl cyclase-generated cyclic adenosine monophosphate promotes fast migration in PC12 cells.

Young JJ, Mehdi A, Stohl LL, Levin LR, Buck J, Wagner JA, Stessin AM.

J Neurosci Res. 2008 Jan;86(1):118-24.

50.

Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP.

Schmid A, Sutto Z, Nlend MC, Horvath G, Schmid N, Buck J, Levin LR, Conner GE, Fregien N, Salathe M.

J Gen Physiol. 2007 Jul;130(1):99-109.

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