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"Should the definition of CKD be changed to include age-adapted GFR criteria?": Con: the evaluation and management of CKD, not the definition, should be age-adapted.

Levey AS, Inker LA, Coresh J.

Kidney Int. 2020 Jan;97(1):37-40. doi: 10.1016/j.kint.2019.08.032. No abstract available.


Comparability of Plasma Iohexol Clearance Across Population-Based Cohorts.

Eriksen BO, Schaeffner E, Melsom T, Ebert N, van der Giet M, Gudnason V, Indridasson OS, Karger AB, Levey AS, Schuchardt M, Sørensen LK, Palsson R.

Am J Kidney Dis. 2019 Dec 23. pii: S0272-6386(19)31122-9. doi: 10.1053/j.ajkd.2019.10.008. [Epub ahead of print]


Novel associations between blood metabolites and kidney function among Bogalusa Heart Study and Multi-Ethnic Study of Atherosclerosis participants.

Nierenberg JL, He J, Li C, Gu X, Shi M, Razavi AC, Mi X, Li S, Bazzano LA, Anderson AH, He H, Chen W, Kinchen JM, Rebholz CM, Coresh J, Levey AS, Inker LA, Shlipak M, Kelly TN.

Metabolomics. 2019 Nov 13;15(12):149. doi: 10.1007/s11306-019-1613-3.


Strengths and limitations of estimated and measured GFR.

Levey AS, Coresh J, Tighiouart H, Greene T, Inker LA.

Nat Rev Nephrol. 2019 Dec;15(12):784. doi: 10.1038/s41581-019-0213-9. No abstract available.


Measured and estimated glomerular filtration rate: current status and future directions.

Levey AS, Coresh J, Tighiouart H, Greene T, Inker LA.

Nat Rev Nephrol. 2020 Jan;16(1):51-64. doi: 10.1038/s41581-019-0191-y. Epub 2019 Sep 16. Review.


Change in Albuminuria and GFR as End Points for Clinical Trials in Early Stages of CKD: A Scientific Workshop Sponsored by the National Kidney Foundation in Collaboration With the US Food and Drug Administration and European Medicines Agency.

Levey AS, Gansevoort RT, Coresh J, Inker LA, Heerspink HL, Grams ME, Greene T, Tighiouart H, Matsushita K, Ballew SH, Sang Y, Vonesh E, Ying J, Manley T, de Zeeuw D, Eckardt KU, Levin A, Perkovic V, Zhang L, Willis K.

Am J Kidney Dis. 2020 Jan;75(1):84-104. doi: 10.1053/j.ajkd.2019.06.009. Epub 2019 Aug 28.


Imprecise Kidney Function Thresholds in Cancer Clinical Trials and the Potential for Harm.

Wang E, Paulus JK, Hackenyos D, Inker LA, Levey AS, Mathew P.

JNCI Cancer Spectr. 2018 Dec 17;2(4):pky060. doi: 10.1093/jncics/pky060. eCollection 2018 Oct.


Knowing your GFR-when is the number not (exactly) the number?

Inker LA, Levey AS.

Kidney Int. 2019 Aug;96(2):280-282. doi: 10.1016/j.kint.2019.03.026.


Evaluating Glomerular Filtration Rate Slope as a Surrogate End Point for ESKD in Clinical Trials: An Individual Participant Meta-Analysis of Observational Data.

Grams ME, Sang Y, Ballew SH, Matsushita K, Astor BC, Carrero JJ, Chang AR, Inker LA, Kenealy T, Kovesdy CP, Lee BJ, Levin A, Naimark D, Pena MJ, Schold JD, Shalev V, Wetzels JFM, Woodward M, Gansevoort RT, Levey AS, Coresh J.

J Am Soc Nephrol. 2019 Sep;30(9):1746-1755. doi: 10.1681/ASN.2019010008. Epub 2019 Jul 10.


Performance of GFR Slope as a Surrogate End Point for Kidney Disease Progression in Clinical Trials: A Statistical Simulation.

Greene T, Ying J, Vonesh EF, Tighiouart H, Levey AS, Coresh J, Herrick JS, Imai E, Jafar TH, Maes BD, Perrone RD, Del Vecchio L, Wetzels JFM, Heerspink HJL, Inker LA.

J Am Soc Nephrol. 2019 Sep;30(9):1756-1769. doi: 10.1681/ASN.2019010009. Epub 2019 Jul 10.


GFR Slope as a Surrogate End Point for Kidney Disease Progression in Clinical Trials: A Meta-Analysis of Treatment Effects of Randomized Controlled Trials.

Inker LA, Heerspink HJL, Tighiouart H, Levey AS, Coresh J, Gansevoort RT, Simon AL, Ying J, Beck GJ, Wanner C, Floege J, Li PK, Perkovic V, Vonesh EF, Greene T.

J Am Soc Nephrol. 2019 Sep;30(9):1735-1745. doi: 10.1681/ASN.2019010007. Epub 2019 Jul 10.


Blood Pressure, Chronic Kidney Disease Progression, and Kidney Allograft Failure in Kidney Transplant Recipients: A Secondary Analysis of the FAVORIT Trial.

Malhotra R, Katz R, Weiner DE, Levey AS, Cheung AK, Bostom AG, Ix JH.

Am J Hypertens. 2019 Aug 14;32(9):816-823. doi: 10.1093/ajh/hpz095.


A Combination of Change in Albuminuria and GFR as a Surrogate End Point for Progression of CKD.

Coresh J, Levey AS.

Clin J Am Soc Nephrol. 2019 Jun 7;14(6):792-794. doi: 10.2215/CJN.04160419. Epub 2019 Jun 3. No abstract available.


Chronic Kidney Disease and Kidney Cancer Surgery: New Perspectives.

Huang WC, Donin NM, Levey AS, Campbell SC.

J Urol. 2019 May 7:101097JU0000000000000326. doi: 10.1097/JU.0000000000000326. [Epub ahead of print]


Improving glomerular filtration rate estimation.

Levey AS, Inker LA.

Kidney Int. 2019 May;95(5):1017-1019. doi: 10.1016/j.kint.2019.01.016.


Incidence and Prognosis of Acute Kidney Diseases and Disorders Using an Integrated Approach to Laboratory Measurements in a Universal Health Care System.

James MT, Levey AS, Tonelli M, Tan Z, Barry R, Pannu N, Ravani P, Klarenbach SW, Manns BJ, Hemmelgarn BR.

JAMA Netw Open. 2019 Apr 5;2(4):e191795. doi: 10.1001/jamanetworkopen.2019.1795.


The Serum Metabolome Identifies Biomarkers of Dietary Acid Load in 2 Studies of Adults with Chronic Kidney Disease.

Rebholz CM, Surapaneni A, Levey AS, Sarnak MJ, Inker LA, Appel LJ, Coresh J, Grams ME.

J Nutr. 2019 Apr 1;149(4):578-585. doi: 10.1093/jn/nxy311.


Serum metabolites associated with dietary protein intake: results from the Modification of Diet in Renal Disease (MDRD) randomized clinical trial.

Rebholz CM, Zheng Z, Grams ME, Appel LJ, Sarnak MJ, Inker LA, Levey AS, Coresh J.

Am J Clin Nutr. 2019 Mar 1;109(3):517-525. doi: 10.1093/ajcn/nqy202.


Serum Metabolomic Alterations Associated with Proteinuria in CKD.

Luo S, Coresh J, Tin A, Rebholz CM, Appel LJ, Chen J, Vasan RS, Anderson AH, Feldman HI, Kimmel PL, Waikar SS, Köttgen A, Evans AM, Levey AS, Inker LA, Sarnak MJ, Grams ME; Chronic Kidney Disease Biomarkers Consortium Investigators.

Clin J Am Soc Nephrol. 2019 Mar 7;14(3):342-353. doi: 10.2215/CJN.10010818. Epub 2019 Feb 7.


Metformin use and cardiovascular events in patients with type 2 diabetes and chronic kidney disease.

Charytan DM, Solomon SD, Ivanovich P, Remuzzi G, Cooper ME, McGill JB, Parving HH, Parfrey P, Singh AK, Burdmann EA, Levey AS, Eckardt KU, McMurray JJV, Weinrauch LA, Liu J, Claggett B, Lewis EF, Pfeffer MA.

Diabetes Obes Metab. 2019 May;21(5):1199-1208. doi: 10.1111/dom.13642. Epub 2019 Mar 4.


Kidney Transplantation in Lupus Nephritis: Can We Do Even Better?

Goyal N, Weiner DE, Levey AS.

Ann Intern Med. 2019 Feb 19;170(4):266-267. doi: 10.7326/M18-3721. Epub 2019 Jan 22. No abstract available.


Validation of a Metabolite Panel for a More Accurate Estimation of Glomerular Filtration Rate Using Quantitative LC-MS/MS.

Freed TA, Coresh J, Inker LA, Toal DR, Perichon R, Chen J, Goodman KD, Zhang Q, Conner JK, Hauser DM, Vroom KET, Oyaski ML, Wulff JE, Eiríksdóttir G, Gudnason V, Torres VE, Ford LA, Levey AS.

Clin Chem. 2019 Mar;65(3):406-418. doi: 10.1373/clinchem.2018.288092. Epub 2019 Jan 15.


Change in albuminuria as a surrogate endpoint for progression of kidney disease: a meta-analysis of treatment effects in randomised clinical trials.

Heerspink HJL, Greene T, Tighiouart H, Gansevoort RT, Coresh J, Simon AL, Chan TM, Hou FF, Lewis JB, Locatelli F, Praga M, Schena FP, Levey AS, Inker LA; Chronic Kidney Disease Epidemiology Collaboration.

Lancet Diabetes Endocrinol. 2019 Feb;7(2):128-139. doi: 10.1016/S2213-8587(18)30314-0. Epub 2019 Jan 8.


Change in albuminuria and subsequent risk of end-stage kidney disease: an individual participant-level consortium meta-analysis of observational studies.

Coresh J, Heerspink HJL, Sang Y, Matsushita K, Arnlov J, Astor BC, Black C, Brunskill NJ, Carrero JJ, Feldman HI, Fox CS, Inker LA, Ishani A, Ito S, Jassal S, Konta T, Polkinghorne K, Romundstad S, Solbu MD, Stempniewicz N, Stengel B, Tonelli M, Umesawa M, Waikar SS, Wen CP, Wetzels JFM, Woodward M, Grams ME, Kovesdy CP, Levey AS, Gansevoort RT; Chronic Kidney Disease Prognosis Consortium and Chronic Kidney Disease Epidemiology Collaboration.

Lancet Diabetes Endocrinol. 2019 Feb;7(2):115-127. doi: 10.1016/S2213-8587(18)30313-9. Epub 2019 Jan 8.


Adiposity and risk of decline in glomerular filtration rate: meta-analysis of individual participant data in a global consortium.

Chang AR, Grams ME, Ballew SH, Bilo H, Correa A, Evans M, Gutierrez OM, Hosseinpanah F, Iseki K, Kenealy T, Klein B, Kronenberg F, Lee BJ, Li Y, Miura K, Navaneethan SD, Roderick PJ, Valdivielso JM, Visseren FLJ, Zhang L, Gansevoort RT, Hallan SI, Levey AS, Matsushita K, Shalev V, Woodward M; CKD Prognosis Consortium (CKD-PC).

BMJ. 2019 Jan 10;364:k5301. doi: 10.1136/bmj.k5301.


Treatment of Anemia With Darbepoetin Prior to Dialysis Initiation and Clinical Outcomes: Analyses From the Trial to Reduce Cardiovascular Events With Aranesp Therapy (TREAT).

Mc Causland FR, Claggett B, Burdmann EA, Chertow GM, Cooper ME, Eckardt KU, Ivanovich P, Levey AS, Lewis EF, McGill JB, McMurray JJV, Parfrey P, Parving HH, Remuzzi G, Singh AK, Solomon SD, Toto RD, Pfeffer MA.

Am J Kidney Dis. 2019 Mar;73(3):309-315. doi: 10.1053/j.ajkd.2018.10.006. Epub 2018 Dec 19.


Relationship of Estimated GFR and Albuminuria to Concurrent Laboratory Abnormalities: An Individual Participant Data Meta-analysis in a Global Consortium.

Inker LA, Grams ME, Levey AS, Coresh J, Cirillo M, Collins JF, Gansevoort RT, Gutierrez OM, Hamano T, Heine GH, Ishikawa S, Jee SH, Kronenberg F, Landray MJ, Miura K, Nadkarni GN, Peralta CA, Rothenbacher D, Schaeffner E, Sedaghat S, Shlipak MG, Zhang L, van Zuilen AD, Hallan SI, Kovesdy CP, Woodward M, Levin A; CKD Prognosis Consortium.

Am J Kidney Dis. 2019 Feb;73(2):206-217. doi: 10.1053/j.ajkd.2018.08.013. Epub 2018 Oct 19.


Hereditary Kidney Disease: All Family Members Are Affected.

Falke RM, Levey AS.

J Am Soc Nephrol. 2018 Oct;29(10):2451-2452. doi: 10.1681/ASN.2018080854. Epub 2018 Sep 11. No abstract available.


Effects of Body Size and Composition on Sex Differences in Measured GFR in a US Community-Based Older Cohort (MESA-Kidney).

Abraham AG, Shafi T, Tighiouart H, Moseley KF, Post WS, Inker LA, Coresh J, Shlipak MG, Levey AS.

Am J Kidney Dis. 2018 Nov;72(5):767-770. doi: 10.1053/j.ajkd.2018.05.012. Epub 2018 Jul 21. No abstract available.


Albuminuria and Allograft Failure, Cardiovascular Disease Events, and All-Cause Death in Stable Kidney Transplant Recipients: A Cohort Analysis of the FAVORIT Trial.

Weiner DE, Park M, Tighiouart H, Joseph AA, Carpenter MA, Goyal N, House AA, Hsu CY, Ix JH, Jacques PF, Kew CE, Kim SJ, Kusek JW, Pesavento TE, Pfeffer MA, Smith SR, Weir MR, Levey AS, Bostom AG.

Am J Kidney Dis. 2019 Jan;73(1):51-61. doi: 10.1053/j.ajkd.2018.05.015. Epub 2018 Jul 20.


The AGES-Reykjavik Study suggests that change in kidney measures is associated with subclinical brain pathology in older community-dwelling persons.

Sedaghat S, Ding J, Eiriksdottir G, van Buchem MA, Sigurdsson S, Ikram MA, Meirelles O, Gudnason V, Levey AS, Launer LJ.

Kidney Int. 2018 Sep;94(3):608-615. doi: 10.1016/j.kint.2018.04.022. Epub 2018 Jun 28.


Soluble Urokinase-Type Plasminogen Activator Receptor in Black Americans with CKD.

Luo S, Coresh J, Tin A, Rebholz CM, Chen TK, Hayek SS, Tracy M, Lipkowitz MS, Appel LJ, Levey AS, Inker LA, Reiser J, Grams ME.

Clin J Am Soc Nephrol. 2018 Jul 6;13(7):1013-1021. doi: 10.2215/CJN.13631217. Epub 2018 Jun 14.


Serum metabolites are associated with all-cause mortality in chronic kidney disease.

Hu JR, Coresh J, Inker LA, Levey AS, Zheng Z, Rebholz CM, Tin A, Appel LJ, Chen J, Sarnak MJ, Grams ME.

Kidney Int. 2018 Aug;94(2):381-389. doi: 10.1016/j.kint.2018.03.008. Epub 2018 Jun 2.


Acute Kidney Injury.

Levey AS, James MT.

Ann Intern Med. 2018 Jun 5;168(11):837. doi: 10.7326/L18-0017. No abstract available.


Serum 6-Bromotryptophan Levels Identified as a Risk Factor for CKD Progression.

Tin A, Nadkarni G, Evans AM, Winkler CA, Bottinger E, Rebholz CM, Sarnak MJ, Inker LA, Levey AS, Lipkowitz MS, Appel LJ, Arking DE, Coresh J, Grams ME.

J Am Soc Nephrol. 2018 Jul;29(7):1939-1947. doi: 10.1681/ASN.2017101064. Epub 2018 May 18.


Metabolomic profiling to improve glomerular filtration rate estimation: a proof-of-concept study.

Coresh J, Inker LA, Sang Y, Chen J, Shafi T, Post WS, Shlipak MG, Ford L, Goodman K, Perichon R, Greene T, Levey AS.

Nephrol Dial Transplant. 2019 May 1;34(5):825-833. doi: 10.1093/ndt/gfy094.


Serum Uromodulin: A Biomarker of Long-Term Kidney Allograft Failure.

Bostom A, Steubl D, Garimella PS, Franceschini N, Roberts MB, Pasch A, Ix JH, Tuttle KR, Ivanova A, Shireman T, Kim SJ, Gohh R, Weiner DE, Levey AS, Hsu CY, Kusek JW, Eaton CB.

Am J Nephrol. 2018;47(4):275-282. doi: 10.1159/000489095. Epub 2018 Apr 26.


Core Assessment of Predonation Kidney Function: Clarification of the 2017 KDIGO Living Donor Guideline.

Lentine KL, Levey AS, Garg AX; KDIGO Living Kidney Donor Work Group.

Am J Kidney Dis. 2018 Jul;72(1):154-155. doi: 10.1053/j.ajkd.2018.01.059. Epub 2018 Apr 16. No abstract available.


Predicting timing of clinical outcomes in patients with chronic kidney disease and severely decreased glomerular filtration rate.

Grams ME, Sang Y, Ballew SH, Carrero JJ, Djurdjev O, Heerspink HJL, Ho K, Ito S, Marks A, Naimark D, Nash DM, Navaneethan SD, Sarnak M, Stengel B, Visseren FLJ, Wang AY, Köttgen A, Levey AS, Woodward M, Eckardt KU, Hemmelgarn B, Coresh J.

Kidney Int. 2018 Jun;93(6):1442-1451. doi: 10.1016/j.kint.2018.01.009. Epub 2018 Mar 29. Erratum in: Kidney Int. 2018 Nov;94(5):1025-1026.


Measurement and Estimation of Residual Kidney Function in Patients on Dialysis.

Shafi T, Levey AS.

Adv Chronic Kidney Dis. 2018 Jan;25(1):93-104. doi: 10.1053/j.ackd.2017.09.001. Review.


Estimated Glomerular Filtration Rate From a Panel of Filtration Markers-Hope for Increased Accuracy Beyond Measured Glomerular Filtration Rate?

Inker LA, Levey AS, Coresh J.

Adv Chronic Kidney Dis. 2018 Jan;25(1):67-75. doi: 10.1053/j.ackd.2017.10.004. Review.


Novel Filtration Markers for GFR Estimation.

Karger AB, Inker LA, Coresh J, Levey AS, Eckfeldt JH.

EJIFCC. 2017 Dec 19;28(4):277-288. eCollection 2017 Dec.


In Reply to 'How Valid Are GFR Estimation Results From the CKD-EPI Databases?'

Levey AS, Tighiouart H, Simon AL, Inker LA.

Am J Kidney Dis. 2018 Mar;71(3):447. doi: 10.1053/j.ajkd.2017.11.004. Epub 2017 Dec 26. No abstract available.


Change in Hemoglobin Trajectory and Darbepoetin Dose Approaching End-Stage Renal Disease: Data from the Trial to Reduce Cardiovascular Events with Aranesp Therapy Trial.

Mc Causland FR, Claggett B, Pfeffer MA, Burdmann EA, Eckardt KU, Levey AS, McMurray JJV, Remuzzi G, Singh AK, Solomon SD, Toto RD, Parfrey P.

Am J Nephrol. 2017;46(6):488-497. doi: 10.1159/000485326. Epub 2017 Dec 14.


Improving Carboplatin Dosing Based on Estimated GFR.

Beumer JH, Inker LA, Levey AS.

Am J Kidney Dis. 2018 Feb;71(2):163-165. doi: 10.1053/j.ajkd.2017.10.005. Epub 2017 Dec 6. No abstract available.


BP in Dialysis: Results of a Pilot Study.

Miskulin DC, Gassman J, Schrader R, Gul A, Jhamb M, Ploth DW, Negrea L, Kwong RY, Levey AS, Singh AK, Harford A, Paine S, Kendrick C, Rahman M, Zager P.

J Am Soc Nephrol. 2018 Jan;29(1):307-316. doi: 10.1681/ASN.2017020135. Epub 2017 Dec 6.


Acute Kidney Injury.

Levey AS, James MT.

Ann Intern Med. 2017 Nov 7;167(9):ITC66-ITC80. doi: 10.7326/AITC201711070. Review. Erratum in: Ann Intern Med. 2018 Jan 2;168(1):84.


Comparison of glomerular filtration rate estimating equations derived from creatinine and cystatin C: validation in the Age, Gene/Environment Susceptibility-Reykjavik elderly cohort.

Björk J, Grubb A, Gudnason V, Indridason OS, Levey AS, Palsson R, Nyman U.

Nephrol Dial Transplant. 2018 Aug 1;33(8):1380-1388. doi: 10.1093/ndt/gfx272.


Metabolomic Alterations Associated with Cause of CKD.

Grams ME, Tin A, Rebholz CM, Shafi T, Köttgen A, Perrone RD, Sarnak MJ, Inker LA, Levey AS, Coresh J.

Clin J Am Soc Nephrol. 2017 Nov 7;12(11):1787-1794. doi: 10.2215/CJN.02560317. Epub 2017 Sep 28.


Action plan for optimizing the design of clinical trials in chronic kidney disease.

Perkovic V, Craig JC, Chailimpamontree W, Fox CS, Garcia-Garcia G, Benghanem Gharbi M, Jardine MJ, Okpechi IG, Pannu N, Stengel B, Tuttle KR, Uhlig K, Levey AS.

Kidney Int Suppl (2011). 2017 Oct;7(2):138-144. doi: 10.1016/j.kisu.2017.07.009. Epub 2017 Sep 20. Review.

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