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Items: 1 to 50 of 648

1.

Contrasting resistance and resilience to extreme drought and late spring frost in five major European tree species.

Vitasse Y, Bottero A, Cailleret M, Bigler C, Fonti P, Gessler A, Lévesque M, Rohner B, Weber P, Rigling A, Wohlgemuth T.

Glob Chang Biol. 2019 Aug 22. doi: 10.1111/gcb.14803. [Epub ahead of print]

PMID:
31436853
2.

Paradoxical effects of optogenetic stimulation in mesial temporal lobe epilepsy.

Lévesque M, Chen LY, Etter G, Shiri Z, Wang S, Williams S, Avoli M.

Ann Neurol. 2019 Aug 8. doi: 10.1002/ana.25572. [Epub ahead of print]

PMID:
31393618
3.

A fatty acid oxidation-dependent metabolic shift regulates the adaptation of BRAF-mutated melanoma to MAPK inhibitors.

Aloia A, Müllhaupt D, Chabbert CD, Eberhart T, Flueckiger S, Vukolic A, Eichhoff OM, Irmisch A, Alexander LT, Scibona E, Frederick DT, Miao B, Tian T, Cheng C, Kwong LN, Wei Z, Sullivan RJ, Boland GM, Herlyn M, Flaherty KT, Zamboni N, Dummer R, Zhang G, Levesque MP, Krek W, Kovacs WJ.

Clin Cancer Res. 2019 Aug 2. pii: clincanres.0253.2019. doi: 10.1158/1078-0432.CCR-19-0253. [Epub ahead of print]

PMID:
31375515
4.

KCC2 ANTAGONISM INCREASES NEURONAL NETWORK EXCITABILITY BUT DISRUPTS ICTOGENESIS IN VITRO.

Chen LY, Lévesque M, Avoli M.

J Neurophysiol. 2019 Jul 24. doi: 10.1152/jn.00266.2019. [Epub ahead of print]

PMID:
31339790
5.

Piriform cortex ictogenicity in vitro.

de Curtis M, Uva L, Lévesque M, Biella G, Avoli M.

Exp Neurol. 2019 Jul 16;321:113014. doi: 10.1016/j.expneurol.2019.113014. [Epub ahead of print] Review.

PMID:
31323250
6.

Osteoblasts contribute to a protective niche that supports melanoma cell proliferation and survival.

Ferguson J, Wilcock DJ, McEntegart S, Badrock AP, Levesque M, Dummer R, Wellbrock C, Smith MP.

Pigment Cell Melanoma Res. 2019 Jul 19. doi: 10.1111/pcmr.12812. [Epub ahead of print]

PMID:
31323160
7.

Whole-genome landscape of mucosal melanoma reveals diverse drivers and therapeutic targets.

Newell F, Kong Y, Wilmott JS, Johansson PA, Ferguson PM, Cui C, Li Z, Kazakoff SH, Burke H, Dodds TJ, Patch AM, Nones K, Tembe V, Shang P, van der Weyden L, Wong K, Holmes O, Lo S, Leonard C, Wood S, Xu Q, Rawson RV, Mukhopadhyay P, Dummer R, Levesque MP, Jönsson G, Wang X, Yeh I, Wu H, Joseph N, Bastian BC, Long GV, Spillane AJ, Shannon KF, Thompson JF, Saw RPM, Adams DJ, Si L, Pearson JV, Hayward NK, Waddell N, Mann GJ, Guo J, Scolyer RA.

Nat Commun. 2019 Jul 18;10(1):3163. doi: 10.1038/s41467-019-11107-x.

8.

Proteomic identification of a marker signature for MAPKi resistance in melanoma.

Paulitschke V, Eichhoff O, Gerner C, Paulitschke P, Bileck A, Mohr T, Cheng PF, Leitner A, Guenova E, Saulite I, Freiberger SN, Irmisch A, Knapp B, Zila N, Chatziisaak TP, Stephan J, Mangana J, Kunstfeld R, Pehamberger H, Aebersold R, Dummer R, Levesque MP.

EMBO J. 2019 Aug 1;38(15):e95874. doi: 10.15252/embj.201695874. Epub 2019 Jun 26.

PMID:
31267558
9.

Response to: 'Can IL-1 be used as a target for osteoarthritis?' by Cheng et al.

Kloppenburg M, Levesque M.

Ann Rheum Dis. 2019 Jun 27. pii: annrheumdis-2019-215612. doi: 10.1136/annrheumdis-2019-215612. [Epub ahead of print] No abstract available.

PMID:
31248854
10.

Neuroprotective benefits of grape seed and skin extract in a mouse model of Parkinson's disease.

Ben Youssef S, Brisson G, Doucet-Beaupré H, Castonguay AM, Gora C, Amri M, Lévesque M.

Nutr Neurosci. 2019 May 25:1-15. doi: 10.1080/1028415X.2019.1616435. [Epub ahead of print]

PMID:
31131731
11.

A Multiple Streams Approach to Understanding the Issues and Challenges of Lyme Disease Management in Canada's Maritime Provinces.

Levesque M, Klohn M.

Int J Environ Res Public Health. 2019 Apr 30;16(9). pii: E1531. doi: 10.3390/ijerph16091531.

12.

SMAD signaling promotes melanoma metastasis independently of phenotype switching.

Tuncer E, Calçada RR, Zingg D, Varum S, Cheng P, Freiberger SN, Deng CX, Kleiter I, Levesque MP, Dummer R, Sommer L.

J Clin Invest. 2019 Apr 30;129(7):2702-2716. doi: 10.1172/JCI94295.

13.

Early-onset emphysema in a large French-Canadian family: a genetic investigation.

Bossé Y, Lamontagne M, Gaudreault N, Racine C, Levesque MH, Smith BM, Auger D, Clemenceau A, Paré MÈ, Laviolette L, Tremblay V, Maranda B, Morissette MC, Maltais F.

Lancet Respir Med. 2019 May;7(5):427-436. doi: 10.1016/S2213-2600(19)30056-6. Epub 2019 Apr 15.

PMID:
31000475
14.

Yin Yang 1 Orchestrates a Metabolic Program Required for Both Neural Crest Development and Melanoma Formation.

Varum S, Baggiolini A, Zurkirchen L, Atak ZK, Cantù C, Marzorati E, Bossart R, Wouters J, Häusel J, Tuncer E, Zingg D, Veen D, John N, Balz M, Levesque MP, Basler K, Aerts S, Zamboni N, Dummer R, Sommer L.

Cell Stem Cell. 2019 Apr 4;24(4):637-653.e9. doi: 10.1016/j.stem.2019.03.011.

PMID:
30951662
15.

Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5-/- mice.

Li Y, Tinoco R, Elmén L, Segota I, Xian Y, Fujita Y, Sahu A, Zarecki R, Marie K, Feng Y, Khateb A, Frederick DT, Ashkenazi SK, Kim H, Perez EG, Day CP, Segura Muñoz RS, Schmaltz R, Yooseph S, Tam MA, Zhang T, Avitan-Hersh E, Tzur L, Roizman S, Boyango I, Bar-Sela G, Orian A, Kaufman RJ, Bosenberg M, Goding CR, Baaten B, Levesque MP, Dummer R, Brown K, Merlino G, Ruppin E, Flaherty K, Ramer-Tait A, Long T, Peterson SN, Bradley LM, Ronai ZA.

Nat Commun. 2019 Apr 2;10(1):1492. doi: 10.1038/s41467-019-09525-y.

16.

Transition from status epilepticus to interictal spiking in a rodent model of mesial temporal epilepsy.

Wang S, Lévesque M, Avoli M.

Epilepsy Res. 2019 May;152:73-76. doi: 10.1016/j.eplepsyres.2019.03.005. Epub 2019 Mar 11.

PMID:
30913455
17.

[Effects of Lifestyle Redesign on older adults: A systematic review].

Lévesque MH, Trépanier J, Sirois MJ, Levasseur M.

Can J Occup Ther. 2019 Feb;86(1):48-60. doi: 10.1177/0008417419830429. Epub 2019 Mar 18. French.

PMID:
30884959
18.

A molecular density functional theory approach to electron transfer reactions.

Jeanmairet G, Rotenberg B, Levesque M, Borgis D, Salanne M.

Chem Sci. 2018 Dec 12;10(7):2130-2143. doi: 10.1039/c8sc04512g. eCollection 2019 Feb 21.

19.

The presence of a hernia sac in isolated congenital diaphragmatic hernia is associated with less disease severity: A retrospective cohort study.

Levesque M, Derraugh G, Schantz D, Morris MI, Shawyer A, Lum Min SA, Keijzer R.

J Pediatr Surg. 2019 May;54(5):899-902. doi: 10.1016/j.jpedsurg.2019.01.016. Epub 2019 Jan 31.

PMID:
30824242
20.

Antibodies as biomarker candidates for response and survival to checkpoint inhibitors in melanoma patients.

Fässler M, Diem S, Mangana J, Hasan Ali O, Berner F, Bomze D, Ring S, Niederer R, Del Carmen Gil Cruz C, Pérez Shibayama CI, Krolik M, Siano M, Joerger M, Recher M, Risch L, Güsewell S, Risch M, Speiser DE, Ludewig B, Levesque MP, Dummer R, Flatz L.

J Immunother Cancer. 2019 Feb 20;7(1):50. doi: 10.1186/s40425-019-0523-2.

21.

Genetic and Environmental Determinants of Immune Response to Cutaneous Melanoma.

Poźniak J, Nsengimana J, Laye JP, O'Shea SJ, Diaz JMS, Droop AP, Filia A, Harland M, Davies JR, Mell T, Randerson-Moor JA, Muralidhar S, Hogan SA, Freiberger SN, Levesque MP, Cook GP, Bishop DT, Newton-Bishop J.

Cancer Res. 2019 May 15;79(10):2684-2696. doi: 10.1158/0008-5472.CAN-18-2864. Epub 2019 Feb 17.

PMID:
30773503
22.

Immunoglobulin G and Subclasses as Potential Biomarkers in Metastatic Melanoma Patients Starting Checkpoint Inhibitor Treatment.

Diem S, Fässler M, Bomze D, Ali OH, Berner F, Niederer R, Hillmann D, Mangana J, Levesque MP, Dummer R, Risch L, Recher M, Risch M, Flatz L.

J Immunother. 2019 Apr;42(3):89-93. doi: 10.1097/CJI.0000000000000255.

PMID:
30768543
23.

Tree-ring isotopes capture interannual vegetation productivity dynamics at the biome scale.

Levesque M, Andreu-Hayles L, Smith WK, Williams AP, Hobi ML, Allred BW, Pederson N.

Nat Commun. 2019 Feb 14;10(1):742. doi: 10.1038/s41467-019-08634-y.

24.

The NLRP1 Inflammasome Pathway Is Silenced in Cutaneous Squamous Cell Carcinoma.

Sand J, Fenini G, Grossi S, Hennig P, Di Filippo M, Levesque M, Werner S, French LE, Beer HD.

J Invest Dermatol. 2019 Aug;139(8):1788-1797.e6. doi: 10.1016/j.jid.2019.01.025. Epub 2019 Feb 7.

PMID:
30738816
25.

A Phase II Trial of Lutikizumab, an Anti-Interleukin-1α/β Dual Variable Domain Immunoglobulin, in Knee Osteoarthritis Patients With Synovitis.

Fleischmann RM, Bliddal H, Blanco FJ, Schnitzer TJ, Peterfy C, Chen S, Wang L, Feng S, Conaghan PG, Berenbaum F, Pelletier JP, Martel-Pelletier J, Vaeterlein O, Kaeley GS, Liu W, Kosloski MP, Levy G, Zhang L, Medema JK, Levesque MC.

Arthritis Rheumatol. 2019 Jul;71(7):1056-1069. doi: 10.1002/art.40840. Epub 2019 Jun 7.

PMID:
30653843
26.

Brain structure, cognition, and brain age in schizophrenia, bipolar disorder, and healthy controls.

Shahab S, Mulsant BH, Levesque ML, Calarco N, Nazeri A, Wheeler AL, Foussias G, Rajji TK, Voineskos AN.

Neuropsychopharmacology. 2019 Apr;44(5):898-906. doi: 10.1038/s41386-018-0298-z. Epub 2018 Dec 20.

PMID:
30635616
27.

The 17β-estradiol induced upregulation of the adhesion G-protein coupled receptor (ADGRG7) is modulated by ESRα and SP1 complex.

Hassan A, Bagu ET, Levesque M, Patten SA, Benhadjeba S, Edjekouane L, Villemure I, Tremblay A, Moldovan F.

Biol Open. 2019 Jan 14;8(1). pii: bio037390. doi: 10.1242/bio.037390.

28.

High-frequency oscillations and focal seizures in epileptic rodents.

Lévesque M, Avoli M.

Neurobiol Dis. 2019 Apr;124:396-407. doi: 10.1016/j.nbd.2018.12.016. Epub 2018 Dec 24. Review.

PMID:
30590178
29.

Longitudinal Reliability of the OMERACT Thumb Base Osteoarthritis Magnetic Resonance Imaging Scoring System (TOMS).

Kroon FPB, van Beest S, Gandjbakhch F, Peterfy CG, Chen S, Conaghan PG, Eshed I, Foltz V, Genant HK, Haugen IK, Medema JK, Østergaard M, Zhang L, Levesque MC, Kloppenburg M.

J Rheumatol. 2018 Dec 15. pii: jrheum.180949. doi: 10.3899/jrheum.180949. [Epub ahead of print]

PMID:
30554152
30.

Phase IIa, placebo-controlled, randomised study of lutikizumab, an anti-interleukin-1α and anti-interleukin-1β dual variable domain immunoglobulin, in patients with erosive hand osteoarthritis.

Kloppenburg M, Peterfy C, Haugen IK, Kroon F, Chen S, Wang L, Liu W, Levy G, Fleischmann RM, Berenbaum F, van der Heijde D, Bansal P, Wittoek R, Feng S, Fang Y, Saltarelli M, Medema JK, Levesque MC.

Ann Rheum Dis. 2019 Mar;78(3):413-420. doi: 10.1136/annrheumdis-2018-213336. Epub 2018 Dec 14.

31.

Correction: In Vivo E2F Reporting Reveals Efficacious Schedules of MEK1/2-CDK4/6 Targeting and mTOR-S6 Resistance Mechanisms.

Teh JLF, Cheng PF, Purwin TJ, Nikbakht N, Patel P, Chervoneva I, Ertel A, Fortina PM, Kleiber I, HooKim K, Davies MA, Kwong LN, Levesque MP, Dummer R, Aplin AE.

Cancer Discov. 2018 Dec;8(12):1654. doi: 10.1158/2159-8290.CD-18-1291. No abstract available.

PMID:
30510016
32.

Evolving Mechanistic Concepts Of Epileptiform Synchronization And Their Relevance In Curing Focal Epileptic Disorders.

Lévesque M, Ragsdale D, Avoli M.

Curr Neuropharmacol. 2018 Nov 27. doi: 10.2174/1570159X17666181127124803. [Epub ahead of print]

PMID:
30479217
33.

Molecular taxonomy of osteoarthritis for patient stratification, disease management and drug development: biochemical markers associated with emerging clinical phenotypes and molecular endotypes.

Mobasheri A, van Spil WE, Budd E, Uzieliene I, Bernotiene E, Bay-Jensen AC, Larkin J, Levesque MC, Gualillo O, Henrotin Y.

Curr Opin Rheumatol. 2019 Jan;31(1):80-89. doi: 10.1097/BOR.0000000000000567.

PMID:
30461544
34.

Peripheral Blood TCR Repertoire Profiling May Facilitate Patient Stratification for Immunotherapy against Melanoma.

Hogan SA, Courtier A, Cheng PF, Jaberg-Bentele NF, Goldinger SM, Manuel M, Perez S, Plantier N, Mouret JF, Nguyen-Kim TDL, Raaijmakers MIG, Kvistborg P, Pasqual N, Haanen JBAG, Dummer R, Levesque MP.

Cancer Immunol Res. 2019 Jan;7(1):77-85. doi: 10.1158/2326-6066.CIR-18-0136. Epub 2018 Nov 13.

PMID:
30425105
35.

Androgen receptor functions as transcriptional repressor of cancer-associated fibroblast activation.

Clocchiatti A, Ghosh S, Procopio MG, Mazzeo L, Bordignon P, Ostano P, Goruppi S, Bottoni G, Katarkar A, Levesque M, Kölblinger P, Dummer R, Neel V, Özdemir BC, Dotto GP.

J Clin Invest. 2018 Dec 3;128(12):5531-5548. doi: 10.1172/JCI99159. Epub 2018 Nov 5.

36.

Carbachol-Induced theta-like oscillations in the rodent brain limbic system: Underlying mechanisms and significance.

Lévesque M, Avoli M.

Neurosci Biobehav Rev. 2018 Dec;95:406-420. doi: 10.1016/j.neubiorev.2018.10.018. Epub 2018 Oct 28. Review.

PMID:
30381251
37.

SwissMTB: establishing comprehensive molecular cancer diagnostics in Swiss clinics.

Singer F, Irmisch A, Toussaint NC, Grob L, Singer J, Thurnherr T, Beerenwinkel N, Levesque MP, Dummer R, Quagliata L, Rothschild SI, Wicki A, Beisel C, Stekhoven DJ.

BMC Med Inform Decis Mak. 2018 Oct 29;18(1):89. doi: 10.1186/s12911-018-0680-0.

38.

Increased tumour cell PD-L1 expression, macrophage and dendritic cell infiltration characterise the tumour microenvironment of ulcerated primary melanomas.

Koelblinger P, Emberger M, Drach M, Cheng PF, Lang R, Levesque MP, Bauer JW, Dummer R.

J Eur Acad Dermatol Venereol. 2019 Apr;33(4):667-675. doi: 10.1111/jdv.15302. Epub 2018 Nov 26.

PMID:
30357969
39.

OpenProt: a more comprehensive guide to explore eukaryotic coding potential and proteomes.

Brunet MA, Brunelle M, Lucier JF, Delcourt V, Levesque M, Grenier F, Samandi S, Leblanc S, Aguilar JD, Dufour P, Jacques JF, Fournier I, Ouangraoua A, Scott MS, Boisvert FM, Roucou X.

Nucleic Acids Res. 2019 Jan 8;47(D1):D403-D410. doi: 10.1093/nar/gky936.

40.

Induction of Paracrine Signaling in Metastatic Melanoma Cells by PPARγ Agonist Rosiglitazone Activates Stromal Cells and Enhances Tumor Growth.

Pich C, Meylan P, Mastelic-Gavillet B, Nguyen TN, Loyon R, Trang BK, Moser H, Moret C, Goepfert C, Hafner J, Levesque MP, Romero P, Jandus C, Michalik L.

Cancer Res. 2018 Nov 15;78(22):6447-6461. doi: 10.1158/0008-5472.CAN-18-0912. Epub 2018 Sep 5.

PMID:
30185551
41.

Physician perceptions of recruitment and retention factors in an area with a regional medical campus.

Levesque M, Hatcher S, Savard D, Kamyap RV, Jean P, Larouche C.

Can Med Educ J. 2018 Mar 27;9(1):e74-e83. eCollection 2018 Mar.

42.

Evaluation of an evidence-based medicine educational intervention in a regional medical campus.

Lévesque M, Gauthier-Boudreau J, Gagnon P, Bertulies-Esposito B, Hatcher S, Gagnon L.

Can Med Educ J. 2018 Mar 27;9(1):e51-e58. eCollection 2018 Mar.

43.

Towards prevention of post-traumatic osteoarthritis: report from an international expert working group on considerations for the design and conduct of interventional studies following acute knee injury.

Watt FE, Corp N, Kingsbury SR, Frobell R, Englund M, Felson DT, Levesque M, Majumdar S, Wilson C, Beard DJ, Lohmander LS, Kraus VB, Roemer F, Conaghan PG, Mason DJ; Arthritis Research UK Osteoarthritis and Crystal Disease Clinical Study Group Expert Working Group.

Osteoarthritis Cartilage. 2019 Jan;27(1):23-33. doi: 10.1016/j.joca.2018.08.001. Epub 2018 Aug 18.

44.

Unexpected contribution of lymphatic vessels to promotion of distant metastatic tumor spread.

Ma Q, Dieterich LC, Ikenberg K, Bachmann SB, Mangana J, Proulx ST, Amann VC, Levesque MP, Dummer R, Baluk P, McDonald DM, Detmar M.

Sci Adv. 2018 Aug 8;4(8):eaat4758. doi: 10.1126/sciadv.aat4758. eCollection 2018 Aug.

45.

Serotonin transporter promoter methylation in peripheral cells and neural responses to negative stimuli: A study of adolescent monozygotic twins.

Ismaylova E, Lévesque ML, Pomares FB, Szyf M, Nemoda Z, Fahim C, Vitaro F, Brendgen M, Dionne G, Boivin M, Tremblay RE, Booij L.

Transl Psychiatry. 2018 Aug 8;8(1):147. doi: 10.1038/s41398-018-0195-6.

46.

Buttocks Hard as Rocks: Not Wanted after Aortic Dissection Repair.

Cameron-Gagné M, Bédard L, Lafrenière-Bessi V, Lévesque MH, Dagenais F, Langevin S, Laflamme M, Voisine P, Jacques F.

Aorta (Stamford). 2018 Feb;6(1):37-40. doi: 10.1055/s-0038-1639379. Epub 2018 Jul 27.

47.

Chronic Subdural Hematoma: Toward a New Management Paradigm for an Increasingly Complex Population.

Iorio-Morin C, Touchette C, Lévesque M, Effendi K, Fortin D, Mathieu D.

J Neurotrauma. 2018 Aug 15;35(16):1882-1885. doi: 10.1089/neu.2018.5872.

PMID:
30074869
48.

Toward Minimal Residual Disease-Directed Therapy in Melanoma.

Rambow F, Rogiers A, Marin-Bejar O, Aibar S, Femel J, Dewaele M, Karras P, Brown D, Chang YH, Debiec-Rychter M, Adriaens C, Radaelli E, Wolter P, Bechter O, Dummer R, Levesque M, Piris A, Frederick DT, Boland G, Flaherty KT, van den Oord J, Voet T, Aerts S, Lund AW, Marine JC.

Cell. 2018 Aug 9;174(4):843-855.e19. doi: 10.1016/j.cell.2018.06.025. Epub 2018 Jul 12.

49.

EZH2-Mediated Primary Cilium Deconstruction Drives Metastatic Melanoma Formation.

Zingg D, Debbache J, Peña-Hernández R, Antunes AT, Schaefer SM, Cheng PF, Zimmerli D, Haeusel J, Calçada RR, Tuncer E, Zhang Y, Bossart R, Wong KK, Basler K, Dummer R, Santoro R, Levesque MP, Sommer L.

Cancer Cell. 2018 Jul 9;34(1):69-84.e14. doi: 10.1016/j.ccell.2018.06.001. Epub 2018 Jun 28.

50.

Author Correction: High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy.

Krieg C, Nowicka M, Guglietta S, Schindler S, Hartmann FJ, Weber LM, Dummer R, Robinson MD, Levesque MP, Becher B.

Nat Med. 2018 Nov;24(11):1773-1775. doi: 10.1038/s41591-018-0094-7.

PMID:
29967347

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