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Items: 1 to 50 of 351

1.

The sigma receptor ligand N-phenylpropyl-N'-(4-methoxyphenethyl)3piperazine (YZ-067) enhances the cocaine conditioned-rewarding properties while inhibiting the development of sensitization of cocaine in mice.

Tapia MA, Sage AS, Fullerton EI, Judd JM, Hildebrant PC, Will MJ, Lever SZ, Lever JR, Miller DK.

Psychopharmacology (Berl). 2019 Dec 10. doi: 10.1007/s00213-019-05411-z. [Epub ahead of print]

PMID:
31822924
2.

PGxMine: Text mining for curation of PharmGKB.

Lever J, Barbarino JM, Gong L, Huddart R, Sangkuhl K, Whaley R, Whirl-Carrillo M, Woon M, Klein TE, Altman RB.

Pac Symp Biocomput. 2020;25:611-622.

3.

Text-mining clinically relevant cancer biomarkers for curation into the CIViC database.

Lever J, Jones MR, Danos AM, Krysiak K, Bonakdar M, Grewal JK, Culibrk L, Griffith OL, Griffith M, Jones SJM.

Genome Med. 2019 Dec 3;11(1):78. doi: 10.1186/s13073-019-0686-y.

4.

Identification and Analyses of Extra-Cranial and Cranial Rhabdoid Tumor Molecular Subgroups Reveal Tumors with Cytotoxic T Cell Infiltration.

Chun HE, Johann PD, Milne K, Zapatka M, Buellesbach A, Ishaque N, Iskar M, Erkek S, Wei L, Tessier-Cloutier B, Lever J, Titmuss E, Topham JT, Bowlby R, Chuah E, Mungall KL, Ma Y, Mungall AJ, Moore RA, Taylor MD, Gerhard DS, Jones SJM, Korshunov A, Gessler M, Kerl K, Hasselblatt M, Frühwald MC, Perlman EJ, Nelson BH, Pfister SM, Marra MA, Kool M.

Cell Rep. 2019 Nov 19;29(8):2338-2354.e7. doi: 10.1016/j.celrep.2019.10.013. Epub 2019 Nov 7.

5.

Foreseeing the future of mutualistic communities beyond collapse.

Lever JJ, van de Leemput IA, Weinans E, Quax R, Dakos V, van Nes EH, Bascompte J, Scheffer M.

Ecol Lett. 2020 Jan;23(1):2-15. doi: 10.1111/ele.13401. Epub 2019 Nov 10.

6.

Finding the direction of lowest resilience in multivariate complex systems.

Weinans E, Lever JJ, Bathiany S, Quax R, Bascompte J, van Nes EH, Scheffer M, van de Leemput IA.

J R Soc Interface. 2019 Oct 31;16(159):20190629. doi: 10.1098/rsif.2019.0629. Epub 2019 Oct 30.

7.

Characterisation of the intestinal microbiota of commercially farmed saltwater crocodiles, Crocodylus porosus.

Willson NL, Van TTH, Lever J, Moore RJ, Stanley D.

Appl Microbiol Biotechnol. 2019 Nov;103(21-22):8977-8985. doi: 10.1007/s00253-019-10143-3. Epub 2019 Oct 19.

PMID:
31630239
8.

Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human Tuberculosis.

Chinta KC, Rahman MA, Saini V, Glasgow JN, Reddy VP, Lever JM, Nhamoyebonde S, Leslie A, Wells RM, Traylor A, Madansein R, Siegal GP, Antony VB, Deshane J, Wells G, Nargan K, George JF, Ramdial PK, Agarwal A, Steyn AJC.

Cell Rep. 2019 Sep 17;28(12):3286. doi: 10.1016/j.celrep.2019.08.081. No abstract available.

9.

Comprehensive genomic profiling of glioblastoma tumors, BTICs, and xenografts reveals stability and adaptation to growth environments.

Shen Y, Grisdale CJ, Islam SA, Bose P, Lever J, Zhao EY, Grinshtein N, Ma Y, Mungall AJ, Moore RA, Lun X, Senger DL, Robbins SM, Wang AY, MacIsaac JL, Kobor MS, Luchman HA, Weiss S, Chan JA, Blough MD, Kaplan DR, Cairncross JG, Marra MA, Jones SJM.

Proc Natl Acad Sci U S A. 2019 Sep 17;116(38):19098-19108. doi: 10.1073/pnas.1813495116. Epub 2019 Aug 30.

PMID:
31471491
10.

Bromophenolics from the Red Alga Polysiphonia decipiens.

Lever J, Curtis G, Brkljača R, Urban S.

Mar Drugs. 2019 Aug 26;17(9). pii: E497. doi: 10.3390/md17090497.

11.

Tissue-Resident Macrophages Promote Renal Cystic Disease.

Zimmerman KA, Song CJ, Li Z, Lever JM, Crossman DK, Rains A, Aloria EJ, Gonzalez NM, Bassler JR, Zhou J, Crowley MR, Revell DZ, Yan Z, Shan D, Benveniste EN, George JF, Mrug M, Yoder BK.

J Am Soc Nephrol. 2019 Oct;30(10):1841-1856. doi: 10.1681/ASN.2018080810. Epub 2019 Jul 23.

PMID:
31337691
12.

Sigma-1 receptor ligand PD144418 and sigma-2 receptor ligand YUN-252 attenuate the stimulant effects of methamphetamine in mice.

Tapia MA, Lever JR, Lever SZ, Will MJ, Park ES, Miller DK.

Psychopharmacology (Berl). 2019 Nov;236(11):3147-3158. doi: 10.1007/s00213-019-05268-2. Epub 2019 May 28.

PMID:
31139878
13.

Renal Inflammation and Fibrosis: A Double-edged Sword.

Black LM, Lever JM, Agarwal A.

J Histochem Cytochem. 2019 Sep;67(9):663-681. doi: 10.1369/0022155419852932. Epub 2019 May 22.

PMID:
31116067
14.

CancerMine: a literature-mined resource for drivers, oncogenes and tumor suppressors in cancer.

Lever J, Zhao EY, Grewal J, Jones MR, Jones SJM.

Nat Methods. 2019 Jun;16(6):505-507. doi: 10.1038/s41592-019-0422-y. Epub 2019 May 20.

PMID:
31110280
15.

Single-Cell RNA Sequencing Identifies Candidate Renal Resident Macrophage Gene Expression Signatures across Species.

Zimmerman KA, Bentley MR, Lever JM, Li Z, Crossman DK, Song CJ, Liu S, Crowley MR, George JF, Mrug M, Yoder BK.

J Am Soc Nephrol. 2019 May;30(5):767-781. doi: 10.1681/ASN.2018090931. Epub 2019 Apr 4.

PMID:
30948627
16.

Design, synthesis and evaluation of 111In labeled DOTA-conjugated tetrapeptides having high affinity and selectivity for mu opioid receptors.

Lever JR, Fergason-Cantrell EA, Carmack TL, Watkinson LD, Gallazzi F.

Nucl Med Biol. 2019 Mar;70:53-66. doi: 10.1016/j.nucmedbio.2019.02.001. Epub 2019 Mar 7.

PMID:
30933866
17.

Gendered perceptions of fairness in housework and shared expenses: Implications for relationship satisfaction and sex frequency.

Gillespie BJ, Peterson G, Lever J.

PLoS One. 2019 Mar 20;14(3):e0214204. doi: 10.1371/journal.pone.0214204. eCollection 2019.

18.

LIONS: analysis suite for detecting and quantifying transposable element initiated transcription from RNA-seq.

Babaian A, Thompson IR, Lever J, Gagnier L, Karimi MM, Mager DL.

Bioinformatics. 2019 Oct 1;35(19):3839-3841. doi: 10.1093/bioinformatics/btz130.

PMID:
30793157
19.

Allosteric modulation of sigma receptors by BH3 mimetics ABT-737, ABT-263 (Navitoclax) and ABT-199 (Venetoclax).

Lever JR, Fergason-Cantrell EA.

Pharmacol Res. 2019 Apr;142:87-100. doi: 10.1016/j.phrs.2019.01.040. Epub 2019 Feb 3.

PMID:
30721730
20.

Resident macrophages reprogram toward a developmental state after acute kidney injury.

Lever JM, Hull TD, Boddu R, Pepin ME, Black LM, Adedoyin OO, Yang Z, Traylor AM, Jiang Y, Li Z, Peabody JE, Eckenrode HE, Crossman DK, Crowley MR, Bolisetty S, Zimmerman KA, Wende AR, Mrug M, Yoder BK, Agarwal A, George JF.

JCI Insight. 2019 Jan 24;4(2). pii: 125503. doi: 10.1172/jci.insight.125503. [Epub ahead of print]

21.

Training the physician-scientist: views from program directors and aspiring young investigators.

Williams CS, Iness AN, Baron RM, Ajijola OA, Hu PJ, Vyas JM, Baiocchi R, Adami AJ, Lever JM, Klein PS, Demer L, Madaio M, Geraci M, Brass LF, Blanchard M, Salata R, Zaidi M.

JCI Insight. 2018 Dec 6;3(23). pii: 125651. doi: 10.1172/jci.insight.125651.

22.

Tauroursodeoxycholic acid (TUDCA) abolishes chronic high salt-induced renal injury and inflammation.

De Miguel C, Sedaka R, Kasztan M, Lever JM, Sonnenberger M, Abad A, Jin C, Carmines PK, Pollock DM, Pollock JS.

Acta Physiol (Oxf). 2019 May;226(1):e13227. doi: 10.1111/apha.13227. Epub 2018 Dec 23.

PMID:
30501003
23.

Distribution, biosynthesis, and biological activity of phenylphenalenone-type compounds derived from the family of plants, Haemodoraceae.

Norman EO, Lever J, Brkljača R, Urban S.

Nat Prod Rep. 2019 May 22;36(5):753-768. doi: 10.1039/c8np00067k. Review.

PMID:
30488050
24.

Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human Tuberculosis.

Chinta KC, Rahman MA, Saini V, Glasgow JN, Reddy VP, Lever JM, Nhamoyebonde S, Leslie A, Wells RM, Traylor A, Madansein R, Siegal GP, Antony VB, Deshane J, Wells G, Nargan K, George JF, Ramdial PK, Agarwal A, Steyn AJC.

Cell Rep. 2018 Nov 13;25(7):1938-1952.e5. doi: 10.1016/j.celrep.2018.10.073. Erratum in: Cell Rep. 2019 Sep 17;28(12):3286.

25.

Identification of the benztropine analog [125I]GA II 34 binding site on the human dopamine transporter.

Tomlinson MJ, Krout D, Pramod AB, Lever JR, Newman AH, Henry LK, Vaughan RA.

Neurochem Int. 2019 Feb;123:34-45. doi: 10.1016/j.neuint.2018.08.008. Epub 2018 Aug 17.

PMID:
30125594
26.

Real-World Implications of Changing Blood Pressure Targets in Urban Primary Care.

Bolen SD, Einstadter D, Love TE, Husak S, Lever J, Cebul RD.

J Gen Intern Med. 2018 Dec;33(12):2027-2029. doi: 10.1007/s11606-018-4595-3. No abstract available.

27.

Divergent effects of AKI to CKD models on inflammation and fibrosis.

Black LM, Lever JM, Traylor AM, Chen B, Yang Z, Esman SK, Jiang Y, Cutter GR, Boddu R, George JF, Agarwal A.

Am J Physiol Renal Physiol. 2018 Oct 1;315(4):F1107-F1118. doi: 10.1152/ajprenal.00179.2018. Epub 2018 Jun 13.

28.

Text-based phenotypic profiles incorporating biochemical phenotypes of inborn errors of metabolism improve phenomics-based diagnosis.

Lee JJY, Gottlieb MM, Lever J, Jones SJM, Blau N, van Karnebeek CDM, Wasserman WW.

J Inherit Metab Dis. 2018 May;41(3):555-562. doi: 10.1007/s10545-017-0125-4. Epub 2018 Jan 16.

29.

Parabiosis reveals leukocyte dynamics in the kidney.

Lever JM, Yang Z, Boddu R, Adedoyin OO, Guo L, Joseph R, Traylor AM, Agarwal A, George JF.

Lab Invest. 2018 Mar;98(3):391-402. doi: 10.1038/labinvest.2017.130. Epub 2017 Dec 18.

30.

PubRunner: A light-weight framework for updating text mining results.

Anekalla KR, Courneya JP, Fiorini N, Lever J, Muchow M, Busby B.

Version 2. F1000Res. 2017 May 2 [revised 2017 Jan 1];6:612. doi: 10.12688/f1000research.11389.2. eCollection 2017.

31.

A collaborative filtering-based approach to biomedical knowledge discovery.

Lever J, Gakkhar S, Gottlieb M, Rashnavadi T, Lin S, Siu C, Smith M, Jones MR, Krzywinski M, Jones SJM, Wren J.

Bioinformatics. 2018 Feb 15;34(4):652-659. doi: 10.1093/bioinformatics/btx613.

PMID:
29028901
32.

Inhibitor mechanisms in the S1 binding site of the dopamine transporter defined by multi-site molecular tethering of photoactive cocaine analogs.

Krout D, Pramod AB, Dahal RA, Tomlinson MJ, Sharma B, Foster JD, Zou MF, Boatang C, Newman AH, Lever JR, Vaughan RA, Henry LK.

Biochem Pharmacol. 2017 Oct 15;142:204-215. doi: 10.1016/j.bcp.2017.07.015. Epub 2017 Jul 19.

PMID:
28734777
33.

Heme oxygenase-1 mitigates ferroptosis in renal proximal tubule cells.

Adedoyin O, Boddu R, Traylor A, Lever JM, Bolisetty S, George JF, Agarwal A.

Am J Physiol Renal Physiol. 2018 May 1;314(5):F702-F714. doi: 10.1152/ajprenal.00044.2017. Epub 2017 May 17.

34.

The Structural Invisibility of Outsiders: The Role of Migrant Labour in the Meat-Processing Industry.

Lever J, Milbourne P.

Sociology. 2017 Apr;51(2):306-322. doi: 10.1177/0038038515616354. Epub 2016 Sep 29.

35.

Cryopreservation of saltwater crocodile (Crocodylus porosus) spermatozoa.

Johnston SD, Qualischefski E, Cooper J, McLeod R, Lever J, Nixon B, Anderson AL, Hobbs R, Gosálvez J, López-Fernández C, Keeley T.

Reprod Fertil Dev. 2017 Oct;29(11):2235-2244. doi: 10.1071/RD16511.

PMID:
28356183
36.

Synthesis and opioid receptor binding of indium (III) and [111In]-labeled macrocyclic conjugates of diprenorphine: novel ligands designed for imaging studies of peripheral opioid receptors.

Srivastava S, Fergason-Cantrell EA, Nahas RI, Lever JR.

Tetrahedron. 2016 Oct 6;72(40):6127-6135. doi: 10.1016/j.tet.2016.08.015. Epub 2016 Aug 4.

37.

Mononuclear phagocyte subpopulations in the mouse kidney.

George JF, Lever JM, Agarwal A.

Am J Physiol Renal Physiol. 2017 Apr 1;312(4):F640-F646. doi: 10.1152/ajprenal.00369.2016. Epub 2017 Jan 18. Review.

38.

N-phenylpropyl-N'-substituted piperazines occupy sigma receptors and alter methamphetamine-induced hyperactivity in mice.

Miller DK, Park ES, Lever SZ, Lever JR.

Pharmacol Biochem Behav. 2016 Nov - Dec;150-151:198-206. doi: 10.1016/j.pbb.2016.11.003. Epub 2016 Nov 13.

39.

Tactics for preclinical validation of receptor-binding radiotracers.

Lever SZ, Fan KH, Lever JR.

Nucl Med Biol. 2017 Jan;44:4-30. doi: 10.1016/j.nucmedbio.2016.08.015. Epub 2016 Sep 3. Review.

40.

Small molecule epigenetic screen identifies novel EZH2 and HDAC inhibitors that target glioblastoma brain tumor-initiating cells.

Grinshtein N, Rioseco CC, Marcellus R, Uehling D, Aman A, Lun X, Muto O, Podmore L, Lever J, Shen Y, Blough MD, Cairncross GJ, Robbins SM, Jones SJ, Marra MA, Al-Awar R, Senger DL, Kaplan DR.

Oncotarget. 2016 Sep 13;7(37):59360-59376. doi: 10.18632/oncotarget.10661.

41.

Heme Oxygenase-1 in Kidney Health and Disease.

Lever JM, Boddu R, George JF, Agarwal A.

Antioxid Redox Signal. 2016 Jul 20;25(3):165-83. doi: 10.1089/ars.2016.6659. Epub 2016 May 26. Review.

42.

What Keeps Passion Alive? Sexual Satisfaction Is Associated With Sexual Communication, Mood Setting, Sexual Variety, Oral Sex, Orgasm, and Sex Frequency in a National U.S. Study.

Frederick DA, Lever J, Gillespie BJ, Garcia JR.

J Sex Res. 2017 Feb;54(2):186-201. doi: 10.1080/00224499.2015.1137854. Epub 2016 Feb 22.

43.

Cocaine occupancy of sigma1 receptors and dopamine transporters in mice.

Lever JR, Fergason-Cantrell EA, Watkinson LD, Carmack TL, Lord SA, Xu R, Miller DK, Lever SZ.

Synapse. 2016 Mar;70(3):98-111. doi: 10.1002/syn.21877. Epub 2015 Dec 24.

44.

Novel Azido-Iodo Photoaffinity Ligands for the Human Serotonin Transporter Based on the Selective Serotonin Reuptake Inhibitor (S)-Citalopram.

Kumar V, Yarravarapu N, Lapinsky DJ, Perley D, Felts B, Tomlinson MJ, Vaughan RA, Henry LK, Lever JR, Newman AH.

J Med Chem. 2015 Jul 23;58(14):5609-19. doi: 10.1021/acs.jmedchem.5b00682. Epub 2015 Jul 8.

45.

Characterization of pulmonary sigma receptors by radioligand binding.

Lever JR, Litton TP, Fergason-Cantrell EA.

Eur J Pharmacol. 2015 Sep 5;762:118-26. doi: 10.1016/j.ejphar.2015.05.026. Epub 2015 May 22.

46.

Ether modifications to 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine (SA4503): effects on binding affinity and selectivity for sigma receptors and monoamine transporters.

Xu R, Lord SA, Peterson RM, Fergason-Cantrell EA, Lever JR, Lever SZ.

Bioorg Med Chem. 2015 Jan 1;23(1):222-30. doi: 10.1016/j.bmc.2014.11.007. Epub 2014 Nov 11.

47.

Computational and biochemical docking of the irreversible cocaine analog RTI 82 directly demonstrates ligand positioning in the dopamine transporter central substrate-binding site.

Dahal RA, Pramod AB, Sharma B, Krout D, Foster JD, Cha JH, Cao J, Newman AH, Lever JR, Vaughan RA, Henry LK.

J Biol Chem. 2014 Oct 24;289(43):29712-27. doi: 10.1074/jbc.M114.571521. Epub 2014 Aug 31.

48.

Relationship between cerebral sigma-1 receptor occupancy and attenuation of cocaine's motor stimulatory effects in mice by PD144418.

Lever JR, Miller DK, Fergason-Cantrell EA, Green CL, Watkinson LD, Carmack TL, Lever SZ.

J Pharmacol Exp Ther. 2014 Oct;351(1):153-63. doi: 10.1124/jpet.114.216671. Epub 2014 Aug 6.

49.

The sudden collapse of pollinator communities.

Lever JJ, van Nes EH, Scheffer M, Bascompte J.

Ecol Lett. 2014 Mar;17(3):350-9. doi: 10.1111/ele.12236. Epub 2014 Jan 6.

PMID:
24386999
50.

A selective sigma-2 receptor ligand antagonizes cocaine-induced hyperlocomotion in mice.

Lever JR, Miller DK, Green CL, Fergason-Cantrell EA, Watkinson LD, Carmack TL, Fan KH, Lever SZ.

Synapse. 2014 Feb;68(2):73-84. doi: 10.1002/syn.21717. Epub 2013 Oct 24.

PMID:
24123353

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