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Items: 28


Eicosapentaenoic acid in combination with EPHA2 inhibition shows efficacy in preclinical models of triple-negative breast cancer by disrupting cellular cholesterol efflux.

Torres-Adorno AM, Vitrac H, Qi Y, Tan L, Levental KR, Fan YY, Yang P, Chapkin RS, Eckhardt BL, Ueno NT.

Oncogene. 2019 Mar;38(12):2135-2150. doi: 10.1038/s41388-018-0569-5. Epub 2018 Nov 20.


Tuning Length Scales of Small Domains in Cell-Derived Membranes and Synthetic Model Membranes.

Cornell CE, Skinkle AD, He S, Levental I, Levental KR, Keller SL.

Biophys J. 2018 Aug 21;115(4):690-701. doi: 10.1016/j.bpj.2018.06.027. Epub 2018 Jul 11.


Author Correction: Structural determinants and functional consequences of protein affinity for membrane rafts.

Lorent JH, Diaz-Rohrer B, Lin X, Spring K, Gorfe AA, Levental KR, Levental I.

Nat Commun. 2018 May 1;9(1):1805. doi: 10.1038/s41467-018-04164-1.


Sphingomyelin Metabolism Is a Regulator of K-Ras Function.

van der Hoeven D, Cho KJ, Zhou Y, Ma X, Chen W, Naji A, Montufar-Solis D, Zuo Y, Kovar SE, Levental KR, Frost JA, van der Hoeven R, Hancock JF.

Mol Cell Biol. 2018 Jan 16;38(3). pii: e00373-17. doi: 10.1128/MCB.00373-17. Print 2018 Feb 1.


ω-3 polyunsaturated fatty acids direct differentiation of the membrane phenotype in mesenchymal stem cells to potentiate osteogenesis.

Levental KR, Surma MA, Skinkle AD, Lorent JH, Zhou Y, Klose C, Chang JT, Hancock JF, Levental I.

Sci Adv. 2017 Nov 8;3(11):eaao1193. doi: 10.1126/sciadv.aao1193. eCollection 2017 Nov.


Structural determinants and functional consequences of protein affinity for membrane rafts.

Lorent JH, Diaz-Rohrer B, Lin X, Spring K, Gorfe AA, Levental KR, Levental I.

Nat Commun. 2017 Oct 31;8(1):1219. doi: 10.1038/s41467-017-01328-3. Erratum in: Nat Commun. 2018 May 1;9(1):1805.


n-Alcohol Length Governs Shift in Lo-Ld Mixing Temperatures in Synthetic and Cell-Derived Membranes.

Cornell CE, McCarthy NLC, Levental KR, Levental I, Brooks NJ, Keller SL.

Biophys J. 2017 Sep 19;113(6):1200-1211. doi: 10.1016/j.bpj.2017.06.066. Epub 2017 Aug 9.


Lipin-1 regulation of phospholipid synthesis maintains endoplasmic reticulum homeostasis and is critical for triple-negative breast cancer cell survival.

He J, Zhang F, Tay LWR, Boroda S, Nian W, Levental KR, Levental I, Harris TE, Chang JT, Du G.

FASEB J. 2017 Jul;31(7):2893-2904. doi: 10.1096/fj.201601353R. Epub 2017 Mar 27.


Remodeling of the postsynaptic plasma membrane during neural development.

Tulodziecka K, Diaz-Rohrer BB, Farley MM, Chan RB, Di Paolo G, Levental KR, Waxham MN, Levental I.

Mol Biol Cell. 2016 Nov 7;27(22):3480-3489. Epub 2016 Aug 17.


Domain Stability in Biomimetic Membranes Driven by Lipid Polyunsaturation.

Lin X, Lorent JH, Skinkle AD, Levental KR, Waxham MN, Gorfe AA, Levental I.

J Phys Chem B. 2016 Nov 23;120(46):11930-11941. Epub 2016 Nov 10.


Modular GAG-matrices to promote mammary epithelial morphogenesis in vitro.

Nowak M, Freudenberg U, Tsurkan MV, Werner C, Levental KR.

Biomaterials. 2017 Jan;112:20-30. doi: 10.1016/j.biomaterials.2016.10.007. Epub 2016 Oct 6.


Polyunsaturated Lipids Regulate Membrane Domain Stability by Tuning Membrane Order.

Levental KR, Lorent JH, Lin X, Skinkle AD, Surma MA, Stockenbojer EA, Gorfe AA, Levental I.

Biophys J. 2016 Apr 26;110(8):1800-1810. doi: 10.1016/j.bpj.2016.03.012.


Heparin desulfation modulates VEGF release and angiogenesis in diabetic wounds.

Freudenberg U, Zieris A, Chwalek K, Tsurkan MV, Maitz MF, Atallah P, Levental KR, Eming SA, Werner C.

J Control Release. 2015 Dec 28;220(Pt A):79-88. doi: 10.1016/j.jconrel.2015.10.028. Epub 2015 Oct 22.


Giant plasma membrane vesicles: models for understanding membrane organization.

Levental KR, Levental I.

Curr Top Membr. 2015;75:25-57. doi: 10.1016/bs.ctm.2015.03.009. Epub 2015 Apr 17. Review.


Isolation of giant plasma membrane vesicles for evaluation of plasma membrane structure and protein partitioning.

Levental KR, Levental I.

Methods Mol Biol. 2015;1232:65-77. doi: 10.1007/978-1-4939-1752-5_6.


Rafting through traffic: Membrane domains in cellular logistics.

Diaz-Rohrer B, Levental KR, Levental I.

Biochim Biophys Acta. 2014 Dec;1838(12):3003-3013. doi: 10.1016/j.bbamem.2014.07.029. Epub 2014 Aug 15. Review.


Membrane raft association is a determinant of plasma membrane localization.

Diaz-Rohrer BB, Levental KR, Simons K, Levental I.

Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8500-5. doi: 10.1073/pnas.1404582111. Epub 2014 May 27.


Tissue mechanics modulate microRNA-dependent PTEN expression to regulate malignant progression.

Mouw JK, Yui Y, Damiano L, Bainer RO, Lakins JN, Acerbi I, Ou G, Wijekoon AC, Levental KR, Gilbert PM, Hwang ES, Chen YY, Weaver VM.

Nat Med. 2014 Apr;20(4):360-7. doi: 10.1038/nm.3497. Epub 2014 Mar 16.


Defined polymer-peptide conjugates to form cell-instructive starPEG-heparin matrices in situ.

Tsurkan MV, Chwalek K, Prokoph S, Zieris A, Levental KR, Freudenberg U, Werner C.

Adv Mater. 2013 May 14;25(18):2606-10. doi: 10.1002/adma.201300691. Epub 2013 Apr 10.


Sustained delivery of SDF-1α from heparin-based hydrogels to attract circulating pro-angiogenic cells.

Prokoph S, Chavakis E, Levental KR, Zieris A, Freudenberg U, Dimmeler S, Werner C.

Biomaterials. 2012 Jun;33(19):4792-800. doi: 10.1016/j.biomaterials.2012.03.039. Epub 2012 Apr 6.


Two-tier hydrogel degradation to boost endothelial cell morphogenesis.

Chwalek K, Levental KR, Tsurkan MV, Zieris A, Freudenberg U, Werner C.

Biomaterials. 2011 Dec;32(36):9649-57. doi: 10.1016/j.biomaterials.2011.08.078. Epub 2011 Sep 19.


Dual independent delivery of pro-angiogenic growth factors from starPEG-heparin hydrogels.

Zieris A, Chwalek K, Prokoph S, Levental KR, Welzel PB, Freudenberg U, Werner C.

J Control Release. 2011 Nov 30;156(1):28-36. doi: 10.1016/j.jconrel.2011.06.042. Epub 2011 Jul 6.


Modular StarPEG-Heparin Gels with Bifunctional Peptide Linkers.

Tsurkan MV, Chwalek K, Levental KR, Freudenberg U, Werner C.

Macromol Rapid Commun. 2010 Sep 1;31(17):1529-33. doi: 10.1002/marc.201000155. Epub 2010 Aug 16.


A simple indentation device for measuring micrometer-scale tissue stiffness.

Levental I, Levental KR, Klein EA, Assoian R, Miller RT, Wells RG, Janmey PA.

J Phys Condens Matter. 2010 May 19;22(19):194120. doi: 10.1088/0953-8984/22/19/194120. Epub 2010 Apr 26.


FGF-2 and VEGF functionalization of starPEG-heparin hydrogels to modulate biomolecular and physical cues of angiogenesis.

Zieris A, Prokoph S, Levental KR, Welzel PB, Grimmer M, Freudenberg U, Werner C.

Biomaterials. 2010 Nov;31(31):7985-94. doi: 10.1016/j.biomaterials.2010.07.021. Epub 2010 Aug 3.


Enzymatically degradable heparin-polyethylene glycol gels with controlled mechanical properties.

Tsurkan MV, Levental KR, Freudenberg U, Werner C.

Chem Commun (Camb). 2010 Feb 21;46(7):1141-3. doi: 10.1039/b921616b. Epub 2009 Dec 16.


Matrix crosslinking forces tumor progression by enhancing integrin signaling.

Levental KR, Yu H, Kass L, Lakins JN, Egeblad M, Erler JT, Fong SF, Csiszar K, Giaccia A, Weninger W, Yamauchi M, Gasser DL, Weaver VM.

Cell. 2009 Nov 25;139(5):891-906. doi: 10.1016/j.cell.2009.10.027.


Analytical approaches to uptake and release of hydrogel-associated FGF-2.

Zieris A, Prokoph S, Welzel PB, Grimmer M, Levental KR, Panyanuwat W, Freudenberg U, Werner C.

J Mater Sci Mater Med. 2010 Mar;21(3):915-23. doi: 10.1007/s10856-009-3913-z. Epub 2009 Oct 23.


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