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Items: 1 to 50 of 58

1.

Reduced level of docosahexaenoic acid shifts GPCR neuroreceptors to less ordered membrane regions.

Javanainen M, Enkavi G, Guixà-Gonzaléz R, Kulig W, Martinez-Seara H, Levental I, Vattulainen I.

PLoS Comput Biol. 2019 May 20;15(5):e1007033. doi: 10.1371/journal.pcbi.1007033. eCollection 2019 May.

2.

The desmosome is a mesoscale lipid raft-like membrane domain.

Lewis JD, Caldara AL, Zimmer SE, Stahley SN, Seybold A, Strong NL, Frangakis AS, Levental I, Wahl JK 3rd, Mattheyses AL, Sasaki T, Nakabayashi K, Hata K, Matsubara Y, Ishida-Yamamoto A, Amagai M, Kubo A, Kowalczyk AP.

Mol Biol Cell. 2019 Jun 1;30(12):1390-1405. doi: 10.1091/mbc.E18-10-0649. Epub 2019 Apr 3.

PMID:
30943110
3.

HRAS-driven cancer cells are vulnerable to TRPML1 inhibition.

Jung J, Cho KJ, Naji AK, Clemons KN, Wong CO, Villanueva M, Gregory S, Karagas NE, Tan L, Liang H, Rousseau MA, Tomasevich KM, Sikora AG, Levental I, van der Hoeven D, Zhou Y, Hancock JF, Venkatachalam K.

EMBO Rep. 2019 Apr;20(4). pii: e46685. doi: 10.15252/embr.201846685. Epub 2019 Feb 20.

PMID:
30787043
4.

Membrane cholesterol depletion reduces downstream signaling activity of the adenosine A2A receptor.

McGraw C, Yang L, Levental I, Lyman E, Robinson AS.

Biochim Biophys Acta Biomembr. 2019 Apr 1;1861(4):760-767. doi: 10.1016/j.bbamem.2019.01.001. Epub 2019 Jan 8.

PMID:
30629951
5.

Plasma Gelsolin: Indicator of Inflammation and Its Potential as a Diagnostic Tool and Therapeutic Target.

Piktel E, Levental I, Durnaś B, Janmey PA, Bucki R.

Int J Mol Sci. 2018 Aug 25;19(9). pii: E2516. doi: 10.3390/ijms19092516. Review.

6.

Tuning Length Scales of Small Domains in Cell-Derived Membranes and Synthetic Model Membranes.

Cornell CE, Skinkle AD, He S, Levental I, Levental KR, Keller SL.

Biophys J. 2018 Aug 21;115(4):690-701. doi: 10.1016/j.bpj.2018.06.027. Epub 2018 Jul 11.

PMID:
30049406
7.

Cellular mechanisms of physicochemical membrane homeostasis.

Ernst R, Ballweg S, Levental I.

Curr Opin Cell Biol. 2018 Aug;53:44-51. doi: 10.1016/j.ceb.2018.04.013. Epub 2018 May 19. Review.

PMID:
29787971
8.

Author Correction: Structural determinants and functional consequences of protein affinity for membrane rafts.

Lorent JH, Diaz-Rohrer B, Lin X, Spring K, Gorfe AA, Levental KR, Levental I.

Nat Commun. 2018 May 1;9(1):1805. doi: 10.1038/s41467-018-04164-1.

9.

Protein Partitioning into Ordered Membrane Domains: Insights from Simulations.

Lin X, Gorfe AA, Levental I.

Biophys J. 2018 Apr 24;114(8):1936-1944. doi: 10.1016/j.bpj.2018.03.020.

10.

ω-3 polyunsaturated fatty acids direct differentiation of the membrane phenotype in mesenchymal stem cells to potentiate osteogenesis.

Levental KR, Surma MA, Skinkle AD, Lorent JH, Zhou Y, Klose C, Chang JT, Hancock JF, Levental I.

Sci Adv. 2017 Nov 8;3(11):eaao1193. doi: 10.1126/sciadv.aao1193. eCollection 2017 Nov.

11.

Structural determinants and functional consequences of protein affinity for membrane rafts.

Lorent JH, Diaz-Rohrer B, Lin X, Spring K, Gorfe AA, Levental KR, Levental I.

Nat Commun. 2017 Oct 31;8(1):1219. doi: 10.1038/s41467-017-01328-3. Erratum in: Nat Commun. 2018 May 1;9(1):1805.

12.

n-Alcohol Length Governs Shift in Lo-Ld Mixing Temperatures in Synthetic and Cell-Derived Membranes.

Cornell CE, McCarthy NLC, Levental KR, Levental I, Brooks NJ, Keller SL.

Biophys J. 2017 Sep 19;113(6):1200-1211. doi: 10.1016/j.bpj.2017.06.066. Epub 2017 Aug 9.

13.

Miscibility Transition Temperature Scales with Growth Temperature in a Zebrafish Cell Line.

Burns M, Wisser K, Wu J, Levental I, Veatch SL.

Biophys J. 2017 Sep 19;113(6):1212-1222. doi: 10.1016/j.bpj.2017.04.052. Epub 2017 May 25.

14.

Phase Partitioning of GM1 and Its Bodipy-Labeled Analog Determine Their Different Binding to Cholera Toxin.

Rissanen S, Grzybek M, Orłowski A, Róg T, Cramariuc O, Levental I, Eggeling C, Sezgin E, Vattulainen I.

Front Physiol. 2017 May 9;8:252. doi: 10.3389/fphys.2017.00252. eCollection 2017.

15.

The mystery of membrane organization: composition, regulation and roles of lipid rafts.

Sezgin E, Levental I, Mayor S, Eggeling C.

Nat Rev Mol Cell Biol. 2017 Jun;18(6):361-374. doi: 10.1038/nrm.2017.16. Epub 2017 Mar 30. Review.

16.

Lipin-1 regulation of phospholipid synthesis maintains endoplasmic reticulum homeostasis and is critical for triple-negative breast cancer cell survival.

He J, Zhang F, Tay LWR, Boroda S, Nian W, Levental KR, Levental I, Harris TE, Chang JT, Du G.

FASEB J. 2017 Jul;31(7):2893-2904. doi: 10.1096/fj.201601353R. Epub 2017 Mar 27.

17.

Click-Chemistry Based High Throughput Screening Platform for Modulators of Ras Palmitoylation.

Ganesan L, Shieh P, Bertozzi CR, Levental I.

Sci Rep. 2017 Jan 23;7:41147. doi: 10.1038/srep41147.

18.

Remodeling of the postsynaptic plasma membrane during neural development.

Tulodziecka K, Diaz-Rohrer BB, Farley MM, Chan RB, Di Paolo G, Levental KR, Waxham MN, Levental I.

Mol Biol Cell. 2016 Nov 7;27(22):3480-3489. Epub 2016 Aug 17.

19.

Domain Stability in Biomimetic Membranes Driven by Lipid Polyunsaturation.

Lin X, Lorent JH, Skinkle AD, Levental KR, Waxham MN, Gorfe AA, Levental I.

J Phys Chem B. 2016 Nov 23;120(46):11930-11941. Epub 2016 Nov 10.

20.

The aliphatic chain of cholesterol modulates bilayer interleaflet coupling and domain registration.

Lin X, Zhang S, Ding H, Levental I, Gorfe AA.

FEBS Lett. 2016 Oct;590(19):3368-3374. doi: 10.1002/1873-3468.12383. Epub 2016 Sep 22.

21.

The Continuing Mystery of Lipid Rafts.

Levental I, Veatch S.

J Mol Biol. 2016 Dec 4;428(24 Pt A):4749-4764. doi: 10.1016/j.jmb.2016.08.022. Epub 2016 Aug 26. Review.

22.

Motility and stem cell properties induced by the epithelial-mesenchymal transition require destabilization of lipid rafts.

Tisza MJ, Zhao W, Fuentes JS, Prijic S, Chen X, Levental I, Chang JT.

Oncotarget. 2016 Aug 9;7(32):51553-51568. doi: 10.18632/oncotarget.9928.

23.

Polyunsaturated Lipids Regulate Membrane Domain Stability by Tuning Membrane Order.

Levental KR, Lorent JH, Lin X, Skinkle AD, Surma MA, Stockenbojer EA, Gorfe AA, Levental I.

Biophys J. 2016 Apr 26;110(8):1800-1810. doi: 10.1016/j.bpj.2016.03.012.

24.

Simvastatin prevents triple-negative breast cancer metastasis in pre-clinical models through regulation of FOXO3a.

Wolfe AR, Debeb BG, Lacerda L, Larson R, Bambhroliya A, Huang X, Bertucci F, Finetti P, Birnbaum D, Van Laere S, Diagaradjan P, Ruffell B, Trenton NJ, Chu K, Hittelman W, Diehl M, Levental I, Ueno NT, Woodward WA.

Breast Cancer Res Treat. 2015 Dec;154(3):495-508. doi: 10.1007/s10549-015-3645-3. Epub 2015 Nov 21.

25.

The Role of Cathelicidin LL-37 in Cancer Development.

Piktel E, Niemirowicz K, Wnorowska U, Wątek M, Wollny T, Głuszek K, Góźdź S, Levental I, Bucki R.

Arch Immunol Ther Exp (Warsz). 2016 Feb;64(1):33-46. doi: 10.1007/s00005-015-0359-5. Epub 2015 Sep 22. Review.

26.

Pharmacological Inhibition of Protein Lipidation.

Ganesan L, Levental I.

J Membr Biol. 2015 Dec;248(6):929-41. doi: 10.1007/s00232-015-9835-4. Epub 2015 Aug 18. Review.

27.

Structural determinants of protein partitioning into ordered membrane domains and lipid rafts.

Lorent JH, Levental I.

Chem Phys Lipids. 2015 Nov;192:23-32. doi: 10.1016/j.chemphyslip.2015.07.022. Epub 2015 Aug 1. Review.

PMID:
26241883
28.

Role played by Prx1-dependent extracellular matrix properties in vascular smooth muscle development in embryonic lungs.

Ihida-Stansbury K, Ames J, Chokshi M, Aiad N, Sanyal S, Kawabata KC, Levental I, Sundararaghavan HG, Burdick JA, Janmey P, Miyazono K, Wells RG, Jones PL.

Pulm Circ. 2015 Jun;5(2):382-97. doi: 10.1086/681272.

29.

Giant plasma membrane vesicles: models for understanding membrane organization.

Levental KR, Levental I.

Curr Top Membr. 2015;75:25-57. doi: 10.1016/bs.ctm.2015.03.009. Epub 2015 Apr 17. Review.

PMID:
26015280
30.

Adaptive lipid packing and bioactivity in membrane domains.

Sezgin E, Gutmann T, Buhl T, Dirkx R, Grzybek M, Coskun Ü, Solimena M, Simons K, Levental I, Schwille P.

PLoS One. 2015 Apr 23;10(4):e0123930. doi: 10.1371/journal.pone.0123930. eCollection 2015.

31.

Nanoclusters of the resting T cell antigen receptor (TCR) localize to non-raft domains.

Beck-García K, Beck-García E, Bohler S, Zorzin C, Sezgin E, Levental I, Alarcón B, Schamel WW.

Biochim Biophys Acta. 2015 Apr;1853(4):802-9. doi: 10.1016/j.bbamcr.2014.12.017. Epub 2014 Dec 20.

32.

Isolation of giant plasma membrane vesicles for evaluation of plasma membrane structure and protein partitioning.

Levental KR, Levental I.

Methods Mol Biol. 2015;1232:65-77. doi: 10.1007/978-1-4939-1752-5_6.

PMID:
25331128
33.

Rafting through traffic: Membrane domains in cellular logistics.

Diaz-Rohrer B, Levental KR, Levental I.

Biochim Biophys Acta. 2014 Dec;1838(12):3003-3013. doi: 10.1016/j.bbamem.2014.07.029. Epub 2014 Aug 15. Review.

34.

Membrane raft association is a determinant of plasma membrane localization.

Diaz-Rohrer BB, Levental KR, Simons K, Levental I.

Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8500-5. doi: 10.1073/pnas.1404582111. Epub 2014 May 27.

35.

The cholesterol-binding motif of the HIV-1 glycoprotein gp41 regulates lateral sorting and oligomerization.

Schwarzer R, Levental I, Gramatica A, Scolari S, Buschmann V, Veit M, Herrmann A.

Cell Microbiol. 2014 Oct;16(10):1565-81. doi: 10.1111/cmi.12314. Epub 2014 Jun 13.

PMID:
24844300
36.

Bile acids modulate signaling by functional perturbation of plasma membrane domains.

Zhou Y, Maxwell KN, Sezgin E, Lu M, Liang H, Hancock JF, Dial EJ, Lichtenberger LM, Levental I.

J Biol Chem. 2013 Dec 13;288(50):35660-70. doi: 10.1074/jbc.M113.519116. Epub 2013 Oct 28.

37.

Photoconversion of bodipy-labeled lipid analogues.

Sezgin E, Chwastek G, Aydogan G, Levental I, Simons K, Schwille P.

Chembiochem. 2013 Apr 15;14(6):695-8. doi: 10.1002/cbic.201300038. Epub 2013 Mar 19.

PMID:
23512865
38.

Elucidating membrane structure and protein behavior using giant plasma membrane vesicles.

Sezgin E, Kaiser HJ, Baumgart T, Schwille P, Simons K, Levental I.

Nat Protoc. 2012 May 3;7(6):1042-51. doi: 10.1038/nprot.2012.059.

PMID:
22555243
39.

Partitioning, diffusion, and ligand binding of raft lipid analogs in model and cellular plasma membranes.

Sezgin E, Levental I, Grzybek M, Schwarzmann G, Mueller V, Honigmann A, Belov VN, Eggeling C, Coskun U, Simons K, Schwille P.

Biochim Biophys Acta. 2012 Jul;1818(7):1777-84.

40.

Molecular convergence of bacterial and eukaryotic surface order.

Kaiser HJ, Surma MA, Mayer F, Levental I, Grzybek M, Klemm RW, Da Cruz S, Meisinger C, Müller V, Simons K, Lingwood D.

J Biol Chem. 2011 Nov 25;286(47):40631-7. doi: 10.1074/jbc.M111.276444. Epub 2011 Sep 30.

41.

Raft domains of variable properties and compositions in plasma membrane vesicles.

Levental I, Grzybek M, Simons K.

Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11411-6. doi: 10.1073/pnas.1105996108. Epub 2011 Jun 27.

42.
43.

A simple indentation device for measuring micrometer-scale tissue stiffness.

Levental I, Levental KR, Klein EA, Assoian R, Miller RT, Wells RG, Janmey PA.

J Phys Condens Matter. 2010 May 19;22(19):194120. doi: 10.1088/0953-8984/22/19/194120. Epub 2010 Apr 26.

44.

Palmitoylation regulates raft affinity for the majority of integral raft proteins.

Levental I, Lingwood D, Grzybek M, Coskun U, Simons K.

Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22050-4. doi: 10.1073/pnas.1016184107. Epub 2010 Dec 3.

45.

Greasing their way: lipid modifications determine protein association with membrane rafts.

Levental I, Grzybek M, Simons K.

Biochemistry. 2010 Aug 3;49(30):6305-16. doi: 10.1021/bi100882y. Review.

PMID:
20583817
46.

Cholesterol-dependent phase separation in cell-derived giant plasma-membrane vesicles.

Levental I, Byfield FJ, Chowdhury P, Gai F, Baumgart T, Janmey PA.

Biochem J. 2009 Nov 11;424(2):163-7. doi: 10.1042/BJ20091283.

47.

Order of lipid phases in model and plasma membranes.

Kaiser HJ, Lingwood D, Levental I, Sampaio JL, Kalvodova L, Rajendran L, Simons K.

Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16645-50. doi: 10.1073/pnas.0908987106. Epub 2009 Sep 15.

48.

Cell-cycle control by physiological matrix elasticity and in vivo tissue stiffening.

Klein EA, Yin L, Kothapalli D, Castagnino P, Byfield FJ, Xu T, Levental I, Hawthorne E, Janmey PA, Assoian RK.

Curr Biol. 2009 Sep 29;19(18):1511-8. doi: 10.1016/j.cub.2009.07.069. Epub 2009 Sep 17.

49.

Lipid rafts as functional heterogeneity in cell membranes.

Lingwood D, Kaiser HJ, Levental I, Simons K.

Biochem Soc Trans. 2009 Oct;37(Pt 5):955-60. doi: 10.1042/BST0370955. Review.

PMID:
19754431
50.

Spotted vesicles, striped micelles and Janus assemblies induced by ligand binding.

Christian DA, Tian A, Ellenbroek WG, Levental I, Rajagopal K, Janmey PA, Liu AJ, Baumgart T, Discher DE.

Nat Mater. 2009 Oct;8(10):843-9. doi: 10.1038/nmat2512. Epub 2009 Sep 6.

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