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Editor's Note: Inhibition of Platelet-derived Growth Factor-mediated Proliferation of Osteosarcoma Cells by the Novel Tyrosine Kinase Inhibitor STI571.

McGary EC, Weber K, Mills L, Doucet M, Lewis V, Lev DC, Fidler IJ, Bar-Eli M.

Clin Cancer Res. 2019 May 15;25(10):3196. doi: 10.1158/1078-0432.CCR-19-1101. No abstract available.


Editor's Note: Genomic and Molecular Characterization of Malignant Peripheral Nerve Sheath Tumor Identifies the IGF1R Pathway as a Primary Target for Treatment.

Yang J, Ylipää A, Sun Y, Zheng H, Chen K, Nykter M, Trent J, Ratner N, Lev DC, Zhang W.

Clin Cancer Res. 2019 May 15;25(10):3195. doi: 10.1158/1078-0432.CCR-19-1144. No abstract available.


Multimodality Treatment of Desmoplastic Small Round Cell Tumor: Chemotherapy and Complete Cytoreductive Surgery Improve Patient Survival.

Subbiah V, Lamhamedi-Cherradi SE, Cuglievan B, Menegaz BA, Camacho P, Huh W, Ramamoorthy V, Anderson PM, Pollock RE, Lev DC, Qiao W, McAleer MF, Benjamin RS, Patel S, Herzog CE, Daw NC, Feig BW, Lazar AJ, Hayes-Jordan A, Ludwig JA.

Clin Cancer Res. 2018 Oct 1;24(19):4865-4873. doi: 10.1158/1078-0432.CCR-18-0202. Epub 2018 Jun 5.


MicroRNA-182 drives metastasis of primary sarcomas by targeting multiple genes.

Sachdeva M, Mito JK, Lee CL, Zhang M, Li Z, Dodd RD, Cason D, Luo L, Ma Y, Van Mater D, Gladdy R, Lev DC, Cardona DM, Kirsch DG.

J Clin Invest. 2016 Apr 1;126(4):1606. doi: 10.1172/JCI86573. Epub 2016 Apr 1. No abstract available.


MicroRNA-16 suppresses metastasis in an orthotopic, but not autochthonous, mouse model of soft tissue sarcoma.

Sachdeva M, Whitley MJ, Mito JK, Ma Y, Lev DC, Cardona DM, Kirsch DG.

Dis Model Mech. 2015 Sep;8(9):1169. doi: 10.1242/dmm.022582. No abstract available.


Epigenetic silencing of Kruppel like factor-3 increases expression of pro-metastatic miR-182.

Sachdeva M, Dodd RD, Huang Z, Grenier C, Ma Y, Lev DC, Cardona DM, Murphy SK, Kirsch DG.

Cancer Lett. 2015 Dec 1;369(1):202-11. doi: 10.1016/j.canlet.2015.08.016. Epub 2015 Aug 24.


MicroRNA-16 suppresses metastasis in an orthotopic, but not autochthonous, mouse model of soft tissue sarcoma.

Sachdeva M, Whitley MJ, Mito JK, Ma Y, Lev DC, Cardona DM, Kirsch DG.

Dis Model Mech. 2015 Aug 1;8(8):867-75. doi: 10.1242/dmm.017897. Epub 2015 Jun 4. Erratum in: Dis Model Mech. 2015 Sep;8(9):1169.


The hepatocyte growth factor receptor as a potential therapeutic target for dedifferentiated liposarcoma.

Bill KL, Garnett J, Ma X, May CD, Bolshakov S, Lazar AJ, Lev DC, Pollock RE.

Lab Invest. 2015 Aug;95(8):951-61. doi: 10.1038/labinvest.2015.62. Epub 2015 Jun 1.


Analysis of the intratumoral adaptive immune response in well differentiated and dedifferentiated retroperitoneal liposarcoma.

Tseng WW, Malu S, Zhang M, Chen J, Sim GC, Wei W, Ingram D, Somaiah N, Lev DC, Pollock RE, Lizée G, Radvanyi L, Hwu P.

Sarcoma. 2015;2015:547460. doi: 10.1155/2015/547460. Epub 2015 Jan 29.


NY-ESO-1 (CTAG1B) expression in mesenchymal tumors.

Endo M, de Graaff MA, Ingram DR, Lim S, Lev DC, Briaire-de Bruijn IH, Somaiah N, Bovée JV, Lazar AJ, Nielsen TO.

Mod Pathol. 2015 Apr;28(4):587-95. doi: 10.1038/modpathol.2014.155. Epub 2014 Nov 21.


Estrogen receptor alpha and androgen receptor are commonly expressed in well-differentiated liposarcoma.

Ingram DR, Dillon LM, Lev DC, Lazar A, Demicco EG, Eisenberg BL, Miller TW.

BMC Clin Pathol. 2014 Oct 22;14:42. doi: 10.1186/1472-6890-14-42. eCollection 2014.


MicroRNA-182 drives metastasis of primary sarcomas by targeting multiple genes.

Sachdeva M, Mito JK, Lee CL, Zhang M, Li Z, Dodd RD, Cason D, Luo L, Ma Y, Van Mater D, Gladdy R, Lev DC, Cardona DM, Kirsch DG.

J Clin Invest. 2014 Oct;124(10):4305-19. doi: 10.1172/JCI77116. Epub 2014 Sep 2. Erratum in: J Clin Invest. 2016 Apr 1;126(4):1606.


Locoregional disease patterns in well-differentiated and dedifferentiated retroperitoneal liposarcoma: implications for the extent of resection?

Tseng WW, Madewell JE, Wei W, Somaiah N, Lazar AJ, Ghadimi MP, Hoffman A, Pisters PW, Lev DC, Pollock RE.

Ann Surg Oncol. 2014 Jul;21(7):2136-43. doi: 10.1245/s10434-014-3643-4. Epub 2014 Apr 7.


Analysis of prognostic factors impacting oncologic outcomes after neoadjuvant tyrosine kinase inhibitor therapy for gastrointestinal stromal tumors.

Bednarski BK, Araujo DM, Yi M, Torres KE, Lazar A, Trent JC, Cormier JN, Pisters PW, Lev DC, Pollock RE, Feig BW, Hunt KK.

Ann Surg Oncol. 2014 Aug;21(8):2499-505. doi: 10.1245/s10434-014-3632-7. Epub 2014 Mar 18.


Novel systemic therapies in advanced liposarcoma: a review of recent clinical trial results.

Tseng WW, Somaiah N, Lazar AJ, Lev DC, Pollock RE.

Cancers (Basel). 2013 May 10;5(2):529-49. doi: 10.3390/cancers5020529.


ERG and FLI1 protein expression in epithelioid sarcoma.

Stockman DL, Hornick JL, Deavers MT, Lev DC, Lazar AJ, Wang WL.

Mod Pathol. 2014 Apr;27(4):496-501. doi: 10.1038/modpathol.2013.161. Epub 2013 Sep 27.


Vascular tumors have increased p70 S6-kinase activation and are inhibited by topical rapamycin.

Du W, Gerald D, Perruzzi CA, Rodriguez-Waitkus P, Enayati L, Krishnan B, Edmonds J, Hochman ML, Lev DC, Phung TL.

Lab Invest. 2013 Oct;93(10):1115-27. doi: 10.1038/labinvest.2013.98. Epub 2013 Aug 12.


The role of chemotherapy in advanced solitary fibrous tumors: a retrospective analysis.

Park MS, Ravi V, Conley A, Patel SR, Trent JC, Lev DC, Lazar AJ, Wang WL, Benjamin RS, Araujo DM.

Clin Sarcoma Res. 2013 May 11;3(1):7. doi: 10.1186/2045-3329-3-7.


Outcome prediction in primary resected retroperitoneal soft tissue sarcoma: histology-specific overall survival and disease-free survival nomograms built on major sarcoma center data sets.

Gronchi A, Miceli R, Shurell E, Eilber FC, Eilber FR, Anaya DA, Kattan MW, Honoré C, Lev DC, Colombo C, Bonvalot S, Mariani L, Pollock RE.

J Clin Oncol. 2013 May 1;31(13):1649-55. doi: 10.1200/JCO.2012.44.3747. Epub 2013 Mar 25.


Noncontact measurement of elasticity for the detection of soft-tissue tumors using phase-sensitive optical coherence tomography combined with a focused air-puff system.

Wang S, Li J, Manapuram RK, Menodiado FM, Ingram DR, Twa MD, Lazar AJ, Lev DC, Pollock RE, Larin KV.

Opt Lett. 2012 Dec 15;37(24):5184-6. doi: 10.1364/OL.37.005184.


A small-molecule inhibitor targeting the mitotic spindle checkpoint impairs the growth of uterine leiomyosarcoma.

Shan W, Akinfenwa PY, Savannah KB, Kolomeyevskaya N, Laucirica R, Thomas DG, Odunsi K, Creighton CJ, Lev DC, Anderson ML.

Clin Cancer Res. 2012 Jun 15;18(12):3352-65. doi: 10.1158/1078-0432.CCR-11-3058. Epub 2012 Apr 25.


New therapeutic targets in soft tissue sarcoma.

Demicco EG, Maki RG, Lev DC, Lazar AJ.

Adv Anat Pathol. 2012 May;19(3):170-80. doi: 10.1097/PAP.0b013e318253462f. Review.


Lymphocyte composition and distribution in inflammatory, well-differentiated retroperitoneal liposarcoma: clues to a potential adaptive immune response and therapeutic implications.

Tseng WW, Demicco EG, Lazar AJ, Lev DC, Pollock RE.

Am J Surg Pathol. 2012 Jun;36(6):941-4. doi: 10.1097/PAS.0b013e31824f2594. No abstract available.


Multiple receptor tyrosine kinases promote the in vitro phenotype of metastatic human osteosarcoma cell lines.

Rettew AN, Young ED, Lev DC, Kleinerman ES, Abdul-Karim FW, Getty PJ, Greenfield EM.

Oncogenesis. 2012 Nov 19;1:e34. doi: 10.1038/oncsis.2012.34.


Genomic and molecular characterization of malignant peripheral nerve sheath tumor identifies the IGF1R pathway as a primary target for treatment.

Yang J, Ylipää A, Sun Y, Zheng H, Chen K, Nykter M, Trent J, Ratner N, Lev DC, Zhang W.

Clin Cancer Res. 2011 Dec 15;17(24):7563-73. doi: 10.1158/1078-0432.CCR-11-1707. Epub 2011 Oct 31.


Sarcoma metastases to the skin: a clinicopathologic study of 65 patients.

Wang WL, Bones-Valentin RA, Prieto VG, Pollock RE, Lev DC, Lazar AJ.

Cancer. 2012 Jun 1;118(11):2900-4. doi: 10.1002/cncr.26590. Epub 2011 Oct 11.


Dermatofibrosarcoma protuberans with unusual sarcomatous transformation: a series of 4 cases with molecular confirmation.

Swaby MG, Evans HL, Fletcher CD, Prieto VG, Patel KU, Lev DC, Lòpez-Terrada D, Lazar AJ, Wang WL.

Am J Dermatopathol. 2011 Jun;33(4):354-60. doi: 10.1097/DAD.0b013e3182014631.


Revealing retroperitoneal liposarcoma morphology using optical coherence tomography.

Carbajal EF, Baranov SA, Manne VG, Young ED, Lazar AJ, Lev DC, Pollock RE, Larin KV.

J Biomed Opt. 2011 Feb;16(2):020502. doi: 10.1117/1.3541789.


Integrative genomic characterization and a genomic staging system for gastrointestinal stromal tumors.

Ylipää A, Hunt KK, Yang J, Lazar AJ, Torres KE, Lev DC, Nykter M, Pollock RE, Trent J, Zhang W.

Cancer. 2011 Jan 15;117(2):380-9. doi: 10.1002/cncr.25594. Epub 2010 Sep 3.


Detection of myxoid liposarcoma-associated FUS-DDIT3 rearrangement variants including a newly identified breakpoint using an optimized RT-PCR assay.

Powers MP, Wang WL, Hernandez VS, Patel KS, Lev DC, Lazar AJ, López-Terrada DH.

Mod Pathol. 2010 Oct;23(10):1307-15. doi: 10.1038/modpathol.2010.118. Epub 2010 Jun 25.


Postoperative nomogram for survival of patients with retroperitoneal sarcoma treated with curative intent.

Anaya DA, Lahat G, Wang X, Xiao L, Pisters PW, Cormier JN, Hunt KK, Feig BW, Lev DC, Pollock RE.

Ann Oncol. 2010 Feb;21(2):397-402. doi: 10.1093/annonc/mdp298. Epub 2009 Jul 21.


Detection and characterization of EWSR1/ATF1 and EWSR1/CREB1 chimeric transcripts in clear cell sarcoma (melanoma of soft parts).

Wang WL, Mayordomo E, Zhang W, Hernandez VS, Tuvin D, Garcia L, Lev DC, Lazar AJ, López-Terrada D.

Mod Pathol. 2009 Sep;22(9):1201-9. doi: 10.1038/modpathol.2009.85. Epub 2009 Jun 26.


Combining PCI-24781, a novel histone deacetylase inhibitor, with chemotherapy for the treatment of soft tissue sarcoma.

Lopez G, Liu J, Ren W, Wei W, Wang S, Lahat G, Zhu QS, Bornmann WG, McConkey DJ, Pollock RE, Lev DC.

Clin Cancer Res. 2009 May 15;15(10):3472-83. doi: 10.1158/1078-0432.CCR-08-2714. Epub 2009 May 5. Erratum in: Clin Cancer Res. 2015 Apr 1;21(7):1774-5.


Cutaneous and subcutaneous metastases of gastrointestinal stromal tumors: a series of 5 cases with molecular analysis.

Wang WL, Hornick JL, Mallipeddi R, Zelger BG, Rother JD, Yang D, Lev DC, Trent JC, Prieto VG, Brenn T, Robson A, Calonje E, Lazar AJ.

Am J Dermatopathol. 2009 May;31(3):297-300. doi: 10.1097/DAD.0b013e31818acb1a. Erratum in: Am J Dermatopathol. 2009 Oct;31(7):731. Robson, Alistair [added].


Computed tomography scan-driven selection of treatment for retroperitoneal liposarcoma histologic subtypes.

Lahat G, Madewell JE, Anaya DA, Qiao W, Tuvin D, Benjamin RS, Lev DC, Pollock RE.

Cancer. 2009 Mar 1;115(5):1081-90. doi: 10.1002/cncr.24045.


Multifocality in retroperitoneal sarcoma: a prognostic factor critical to surgical decision-making.

Anaya DA, Lahat G, Liu J, Xing Y, Cormier JN, Pisters PW, Lev DC, Pollock RE.

Ann Surg. 2009 Jan;249(1):137-42. doi: 10.1097/SLA.0b013e3181928f2f.


Establishing prognosis in retroperitoneal sarcoma: a new histology-based paradigm.

Anaya DA, Lahat G, Wang X, Xiao L, Tuvin D, Pisters PW, Lev DC, Pollock RE.

Ann Surg Oncol. 2009 Mar;16(3):667-75. doi: 10.1245/s10434-008-0250-2. Epub 2008 Dec 20.


The role of surgical margin status in retroperitoneal sarcoma.

Anaya DA, Lev DC, Pollock RE.

J Surg Oncol. 2008 Dec 15;98(8):607-10. doi: 10.1002/jso.21031. Review.


Tumor immunotherapy in melanoma: strategies for overcoming mechanisms of resistance and escape.

Zigler M, Villares GJ, Lev DC, Melnikova VO, Bar-Eli M.

Am J Clin Dermatol. 2008;9(5):307-11. Review.


Fluorescence in situ hybridization is a useful ancillary diagnostic tool for extraskeletal myxoid chondrosarcoma.

Wang WL, Mayordomo E, Czerniak BA, Abruzzo LV, Dal Cin P, Araujo DM, Lev DC, López-Terrada D, Lazar AJ.

Mod Pathol. 2008 Nov;21(11):1303-10. doi: 10.1038/modpathol.2008.114. Epub 2008 Jun 27.


A preclinical model for predicting drug response in soft-tissue sarcoma with targeted AAVP molecular imaging.

Hajitou A, Lev DC, Hannay JA, Korchin B, Staquicini FI, Soghomonyan S, Alauddin MM, Benjamin RS, Pollock RE, Gelovani JG, Pasqualini R, Arap W.

Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4471-6. doi: 10.1073/pnas.0712184105. Epub 2008 Mar 12.


IFN regulatory factor 8 mediates apoptosis in nonhemopoietic tumor cells via regulation of Fas expression.

Yang D, Thangaraju M, Browning DD, Dong Z, Korchin B, Lev DC, Ganapathy V, Liu K.

J Immunol. 2007 Oct 1;179(7):4775-82.


Staging soft tissue sarcoma: evolution and change.

Kotilingam D, Lev DC, Lazar AJ, Pollock RE.

CA Cancer J Clin. 2006 Sep-Oct;56(5):282-91; quiz 314-5. Review.


Inhibition of platelet-derived growth factor receptor signaling restricts the growth of human breast cancer in the bone of nude mice.

Lev DC, Kim SJ, Onn A, Stone V, Nam DH, Yazici S, Fidler IJ, Price JE.

Clin Cancer Res. 2005 Jan 1;11(1):306-14.


Dual blockade of EGFR and ERK1/2 phosphorylation potentiates growth inhibition of breast cancer cells.

Lev DC, Kim LS, Melnikova V, Ruiz M, Ananthaswamy HN, Price JE.

Br J Cancer. 2004 Aug 16;91(4):795-802.


Vascular endothelial growth factor expression promotes the growth of breast cancer brain metastases in nude mice.

Kim LS, Huang S, Lu W, Lev DC, Price JE.

Clin Exp Metastasis. 2004;21(2):107-18.


Exposure of melanoma cells to dacarbazine results in enhanced tumor growth and metastasis in vivo.

Lev DC, Onn A, Melinkova VO, Miller C, Stone V, Ruiz M, McGary EC, Ananthaswamy HN, Price JE, Bar-Eli M.

J Clin Oncol. 2004 Jun 1;22(11):2092-100. Epub 2004 May 3. Erratum in: J Clin Oncol. 2019 Jun 10;37(17):1518.


A fully human antimelanoma cellular adhesion molecule/MUC18 antibody inhibits spontaneous pulmonary metastasis of osteosarcoma cells in vivo.

McGary EC, Heimberger A, Mills L, Weber K, Thomas GW, Shtivelband M, Lev DC, Bar-Eli M.

Clin Cancer Res. 2003 Dec 15;9(17):6560-6.

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