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Items: 28

1.

Clinical framework for next generation sequencing based analysis of treatment predictive mutations and multiplexed gene fusion detection in non-small cell lung cancer.

Lindquist KE, Karlsson A, Levéen P, Brunnström H, Reuterswärd C, Holm K, Jönsson M, Annersten K, Rosengren F, Jirström K, Kosieradzki J, Ek L, Borg Å, Planck M, Jönsson G, Staaf J.

Oncotarget. 2017 May 23;8(21):34796-34810. doi: 10.18632/oncotarget.16276.

2.

Targeted sequencing may facilitate differential diagnostics of pulmonary tumours: a case series.

Ericson-Lindquist K, Johansson A, Levéen P, Elmberger G, Jönsson G, Staaf J, Brunnström H.

Diagn Pathol. 2017 Mar 27;12(1):31. doi: 10.1186/s13000-017-0621-8.

3.

Improved minimal residual disease detection by targeted quantitative polymerase chain reaction in Nucleophosmin 1 type a mutated acute myeloid leukemia.

Pettersson L, Levéen P, Axler O, Dvorakova D, Juliusson G, Ehinger M.

Genes Chromosomes Cancer. 2016 Oct;55(10):750-66. doi: 10.1002/gcc.22375. Epub 2016 Jun 24.

PMID:
27191933
4.

A mouse model of mitochondrial complex III dysfunction induced by myxothiazol.

Davoudi M, Kallijärvi J, Marjavaara S, Kotarsky H, Hansson E, Levéen P, Fellman V.

Biochem Biophys Res Commun. 2014 Apr 18;446(4):1079-84. doi: 10.1016/j.bbrc.2014.03.058. Epub 2014 Mar 21.

PMID:
24661880
5.

Metabolite profiles reveal energy failure and impaired beta-oxidation in liver of mice with complex III deficiency due to a BCS1L mutation.

Kotarsky H, Keller M, Davoudi M, Levéen P, Karikoski R, Enot DP, Fellman V.

PLoS One. 2012;7(7):e41156. doi: 10.1371/journal.pone.0041156. Epub 2012 Jul 19.

6.

Validation of podocalyxin-like protein as a biomarker of poor prognosis in colorectal cancer.

Larsson A, Fridberg M, Gaber A, Nodin B, Levéen P, Jönsson G, Uhlén M, Birgisson H, Jirström K.

BMC Cancer. 2012 Jul 8;12:282. doi: 10.1186/1471-2407-12-282.

7.

The GRACILE mutation introduced into Bcs1l causes postnatal complex III deficiency: a viable mouse model for mitochondrial hepatopathy.

Levéen P, Kotarsky H, Mörgelin M, Karikoski R, Elmér E, Fellman V.

Hepatology. 2011 Feb;53(2):437-47. doi: 10.1002/hep.24031. Epub 2010 Dec 28.

PMID:
21274865
8.

Brain area-specific effect of TGF-beta signaling on Wnt-dependent neural stem cell expansion.

Falk S, Wurdak H, Ittner LM, Ille F, Sumara G, Schmid MT, Draganova K, Lang KS, Paratore C, Leveen P, Suter U, Karlsson S, Born W, Ricci R, Götz M, Sommer L.

Cell Stem Cell. 2008 May 8;2(5):472-83. doi: 10.1016/j.stem.2008.03.006.

9.

Variants in the FFAR1 gene are associated with beta cell function.

Kalis M, Levéen P, Lyssenko V, Almgren P, Groop L, Cilio CM.

PLoS One. 2007 Nov 7;2(11):e1090.

10.

TGFbeta receptor II gene deletion in leucocytes prevents cerebral vasculitis in bacterial meningitis.

Malipiero U, Koedel U, Pfister HW, Levéen P, Bürki K, Reith W, Fontana A.

Brain. 2006 Sep;129(Pt 9):2404-15. Epub 2006 Aug 5.

11.

A critical developmental role for tgfbr2 in myogenic cell lineages is revealed in mice expressing SM22-Cre, not SMMHC-Cre.

Frutkin AD, Shi H, Otsuka G, Levéen P, Karlsson S, Dichek DA.

J Mol Cell Cardiol. 2006 Oct;41(4):724-31. Epub 2006 Aug 2.

PMID:
16887142
12.

Compound developmental eye disorders following inactivation of TGFbeta signaling in neural-crest stem cells.

Ittner LM, Wurdak H, Schwerdtfeger K, Kunz T, Ille F, Leveen P, Hjalt TA, Suter U, Karlsson S, Hafezi F, Born W, Sommer L.

J Biol. 2005;4(3):11. doi: 10.1186/jbiol29. Epub 2005 Dec 14.

13.

TGF-beta type II receptor-deficient thymocytes develop normally but demonstrate increased CD8+ proliferation in vivo.

Levéen P, Carlsén M, Makowska A, Oddsson S, Larsson J, Goumans MJ, Cilio CM, Karlsson S.

Blood. 2005 Dec 15;106(13):4234-40. Epub 2005 Aug 30.

PMID:
16131565
14.

Inactivation of TGFbeta signaling in neural crest stem cells leads to multiple defects reminiscent of DiGeorge syndrome.

Wurdak H, Ittner LM, Lang KS, Leveen P, Suter U, Fischer JA, Karlsson S, Born W, Sommer L.

Genes Dev. 2005 Mar 1;19(5):530-5.

15.

Intact signaling by transforming growth factor beta is not required for termination of liver regeneration in mice.

Oe S, Lemmer ER, Conner EA, Factor VM, Levéen P, Larsson J, Karlsson S, Thorgeirsson SS.

Hepatology. 2004 Nov;40(5):1098-105.

PMID:
15389868
16.

Targeted disruption of the ribosomal protein S19 gene is lethal prior to implantation.

Matsson H, Davey EJ, Draptchinskaia N, Hamaguchi I, Ooka A, Levéen P, Forsberg E, Karlsson S, Dahl N.

Mol Cell Biol. 2004 May;24(9):4032-7.

17.

Hoxb4-deficient mice undergo normal hematopoietic development but exhibit a mild proliferation defect in hematopoietic stem cells.

Brun AC, Björnsson JM, Magnusson M, Larsson N, Leveén P, Ehinger M, Nilsson E, Karlsson S.

Blood. 2004 Jun 1;103(11):4126-33. Epub 2004 Feb 12.

PMID:
14962901
18.

TGF-beta signaling-deficient hematopoietic stem cells have normal self-renewal and regenerative ability in vivo despite increased proliferative capacity in vitro.

Larsson J, Blank U, Helgadottir H, Björnsson JM, Ehinger M, Goumans MJ, Fan X, Levéen P, Karlsson S.

Blood. 2003 Nov 1;102(9):3129-35. Epub 2003 Jul 3.

PMID:
12842983
19.

Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable.

Levéen P, Larsson J, Ehinger M, Cilio CM, Sundler M, Sjöstrand LJ, Holmdahl R, Karlsson S.

Blood. 2002 Jul 15;100(2):560-8.

PMID:
12091349
20.

Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice.

Larsson J, Goumans MJ, Sjöstrand LJ, van Rooijen MA, Ward D, Levéen P, Xu X, ten Dijke P, Mummery CL, Karlsson S.

EMBO J. 2001 Apr 2;20(7):1663-73.

21.

Pericyte loss and microaneurysm formation in PDGF-B-deficient mice.

Lindahl P, Johansson BR, Levéen P, Betsholtz C.

Science. 1997 Jul 11;277(5323):242-5.

22.

PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis.

Boström H, Willetts K, Pekny M, Levéen P, Lindahl P, Hedstrand H, Pekna M, Hellström M, Gebre-Medhin S, Schalling M, Nilsson M, Kurland S, Törnell J, Heath JK, Betsholtz C.

Cell. 1996 Jun 14;85(6):863-73.

23.

Mice lacking glial fibrillary acidic protein display astrocytes devoid of intermediate filaments but develop and reproduce normally.

Pekny M, Levéen P, Pekna M, Eliasson C, Berthold CH, Westermark B, Betsholtz C.

EMBO J. 1995 Apr 18;14(8):1590-8.

24.

Mice deficient for PDGF B show renal, cardiovascular, and hematological abnormalities.

Levéen P, Pekny M, Gebre-Medhin S, Swolin B, Larsson E, Betsholtz C.

Genes Dev. 1994 Aug 15;8(16):1875-87.

25.
27.

Induction of platelet-derived growth factor alpha- and beta-receptor mRNA and protein by platelet-derived growth factor BB.

Eriksson A, Nistér M, Leveen P, Westermark B, Heldin CH, Claesson-Welsh L.

J Biol Chem. 1991 Nov 5;266(31):21138-44.

28.

Expression of messenger RNAs for platelet-derived growth factor and its receptors in human sarcoma cell lines.

Leveen P, Claesson-Welsh L, Heldin CH, Westermark B, Betsholtz C.

Int J Cancer. 1990 Dec 15;46(6):1066-70.

PMID:
2174413

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