Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 110

1.

A 24-week multicentre, randomized, open-label, parallel-group study comparing the efficacy and safety of ixekizumab vs. fumaric acid esters and methotrexate in patients with moderate-to-severe plaque psoriasis naive to systemic treatment.

Reich K, Augustin M, Thaçi D, Pinter A, Leutz A, Henneges C, Schneider E, Schacht A, Dossenbach M, Mrowietz U.

Br J Dermatol. 2019 Aug 3. doi: 10.1111/bjd.18384. [Epub ahead of print]

PMID:
31376153
2.

PRISMA: Protein Interaction Screen on Peptide Matrix Reveals Interaction Footprints and Modifications- Dependent Interactome of Intrinsically Disordered C/EBPβ.

Dittmar G, Hernandez DP, Kowenz-Leutz E, Kirchner M, Kahlert G, Wesolowski R, Baum K, Knoblich M, Hofstätter M, Muller A, Wolf J, Reimer U, Leutz A.

iScience. 2019 Mar 29;13:351-370. doi: 10.1016/j.isci.2019.02.026. Epub 2019 Mar 1.

3.

A C/EBPα-Wnt connection in gut homeostasis and carcinogenesis.

Heuberger J, Hill U, Förster S, Zimmermann K, Malchin V, Kühl AA, Stein U, Vieth M, Birchmeier W, Leutz A.

Life Sci Alliance. 2018 Dec 26;2(1):e201800173. doi: 10.26508/lsa.201800173. eCollection 2019 Feb.

4.

The C/EBPβ LIP isoform rescues loss of C/EBPβ function in the mouse.

Bégay V, Baumeier C, Zimmermann K, Heuser A, Leutz A.

Sci Rep. 2018 May 30;8(1):8417. doi: 10.1038/s41598-018-26579-y.

5.

Loss-of-function uORF mutations in human malignancies.

Schulz J, Mah N, Neuenschwander M, Kischka T, Ratei R, Schlag PM, Castaños-Vélez E, Fichtner I, Tunn PU, Denkert C, Klaas O, Berdel WE, von Kries JP, Makalowski W, Andrade-Navarro MA, Leutz A, Wethmar K.

Sci Rep. 2018 Feb 5;8(1):2395. doi: 10.1038/s41598-018-19201-8.

6.

SIRT1 regulates macrophage self-renewal.

Imperatore F, Maurizio J, Vargas Aguilar S, Busch CJ, Favret J, Kowenz-Leutz E, Cathou W, Gentek R, Perrin P, Leutz A, Berruyer C, Sieweke MH.

EMBO J. 2017 Aug 15;36(16):2353-2372. doi: 10.15252/embj.201695737. Epub 2017 Jul 12.

7.

Genomic Characterization of Murine Monocytes Reveals C/EBPβ Transcription Factor Dependence of Ly6C- Cells.

Mildner A, Schönheit J, Giladi A, David E, Lara-Astiaso D, Lorenzo-Vivas E, Paul F, Chappell-Maor L, Priller J, Leutz A, Amit I, Jung S.

Immunity. 2017 May 16;46(5):849-862.e7. doi: 10.1016/j.immuni.2017.04.018.

8.

C/EBP-Induced Transdifferentiation Reveals Granulocyte-Macrophage Precursor-like Plasticity of B Cells.

Cirovic B, Schönheit J, Kowenz-Leutz E, Ivanovska J, Klement C, Pronina N, Bégay V, Leutz A.

Stem Cell Reports. 2017 Feb 14;8(2):346-359. doi: 10.1016/j.stemcr.2016.12.015. Epub 2017 Jan 19.

9.

C/EBPβ regulates homeostatic and oncogenic gastric cell proliferation.

Regalo G, Förster S, Resende C, Bauer B, Fleige B, Kemmner W, Schlag PM, Meyer TF, Machado JC, Leutz A.

J Mol Med (Berl). 2016 Dec;94(12):1385-1395. doi: 10.1007/s00109-016-1447-7. Epub 2016 Aug 13.

10.

Functional interaction of CCAAT/enhancer-binding-protein-α basic region mutants with E2F transcription factors and DNA.

Kowenz-Leutz E, Schuetz A, Liu Q, Knoblich M, Heinemann U, Leutz A.

Biochim Biophys Acta. 2016 Jul;1859(7):841-7. doi: 10.1016/j.bbagrm.2016.04.008. Epub 2016 Apr 27.

PMID:
27131901
11.

Deficiency in mTORC1-controlled C/EBPβ-mRNA translation improves metabolic health in mice.

Zidek LM, Ackermann T, Hartleben G, Eichwald S, Kortman G, Kiehntopf M, Leutz A, Sonenberg N, Wang ZQ, von Maltzahn J, Müller C, Calkhoven CF.

EMBO Rep. 2015 Aug;16(8):1022-36. doi: 10.15252/embr.201439837. Epub 2015 Jun 25.

12.

Comprehensive translational control of tyrosine kinase expression by upstream open reading frames.

Wethmar K, Schulz J, Muro EM, Talyan S, Andrade-Navarro MA, Leutz A.

Oncogene. 2016 Mar 31;35(13):1736-42. doi: 10.1038/onc.2015.233. Epub 2015 Jun 22.

13.

Deregulation of the endogenous C/EBPβ LIP isoform predisposes to tumorigenesis.

Bégay V, Smink JJ, Loddenkemper C, Zimmermann K, Rudolph C, Scheller M, Steinemann D, Leser U, Schlegelberger B, Stein H, Leutz A.

J Mol Med (Berl). 2015 Jan;93(1):39-49. doi: 10.1007/s00109-014-1215-5. Epub 2014 Nov 18.

PMID:
25401168
14.

Dendritic cell-mediated survival signals in Eμ-Myc B-cell lymphoma depend on the transcription factor C/EBPβ.

Rehm A, Gätjen M, Gerlach K, Scholz F, Mensen A, Gloger M, Heinig K, Lamprecht B, Mathas S, Bégay V, Leutz A, Lipp M, Dörken B, Höpken UE.

Nat Commun. 2014 Sep 30;5:5057. doi: 10.1038/ncomms6057.

PMID:
25266931
15.

Chromatin dynamics during differentiation of myeloid cells.

Schönheit J, Leutz A, Rosenbauer F.

J Mol Biol. 2015 Feb 13;427(3):670-87. doi: 10.1016/j.jmb.2014.08.015. Epub 2014 Aug 27. Review.

PMID:
25172539
16.

Notch pathway inhibition controls myeloma bone disease in the murine MOPC315.BM model.

Schwarzer R, Nickel N, Godau J, Willie BM, Duda GN, Schwarzer R, Cirovic B, Leutz A, Manz R, Bogen B, Dörken B, Jundt F.

Blood Cancer J. 2014 Jun 13;4:e217. doi: 10.1038/bcj.2014.37.

17.

uORFdb--a comprehensive literature database on eukaryotic uORF biology.

Wethmar K, Barbosa-Silva A, Andrade-Navarro MA, Leutz A.

Nucleic Acids Res. 2014 Jan;42(Database issue):D60-7. doi: 10.1093/nar/gkt952. Epub 2013 Oct 24.

18.

Cross talk between Wnt/β-catenin and Irf8 in leukemia progression and drug resistance.

Scheller M, Schönheit J, Zimmermann K, Leser U, Rosenbauer F, Leutz A.

J Exp Med. 2013 Oct 21;210(11):2239-56. doi: 10.1084/jem.20130706. Epub 2013 Oct 7.

19.

Hacking cell differentiation: transcriptional rerouting in reprogramming, lineage infidelity and metaplasia.

Regalo G, Leutz A.

EMBO Mol Med. 2013 Aug;5(8):1154-64. doi: 10.1002/emmm.201302834. Epub 2013 Jul 4. Review.

20.

Lymphoid to myeloid cell trans-differentiation is determined by C/EBPβ structure and post-translational modifications.

Stoilova B, Kowenz-Leutz E, Scheller M, Leutz A.

PLoS One. 2013 Jun 5;8(6):e65169. doi: 10.1371/journal.pone.0065169. Print 2013.

21.

PU.1 level-directed chromatin structure remodeling at the Irf8 gene drives dendritic cell commitment.

Schönheit J, Kuhl C, Gebhardt ML, Klett FF, Riemke P, Scheller M, Huang G, Naumann R, Leutz A, Stocking C, Priller J, Andrade-Navarro MA, Rosenbauer F.

Cell Rep. 2013 May 30;3(5):1617-28. doi: 10.1016/j.celrep.2013.04.007. Epub 2013 Apr 25.

22.

Stable conditional expression and effect of C/ebpβ-LIP in adipocytes using the pSLIK system.

Esteves CL, Kelly V, Bégay V, Lillico SG, Leutz A, Seckl JR, Chapman KE.

J Mol Endocrinol. 2013 Jun 4;51(1):91-8. doi: 10.1530/JME-13-0029. Print 2013.

23.

Regulation of adipocyte 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) by CCAAT/enhancer-binding protein (C/EBP) β isoforms, LIP and LAP.

Esteves CL, Kelly V, Bégay V, Man TY, Morton NM, Leutz A, Seckl JR, Chapman KE.

PLoS One. 2012;7(5):e37953. doi: 10.1371/journal.pone.0037953. Epub 2012 May 25.

24.

A TORway to osteolytic disease.

Leutz A, Smink JJ.

Cell Cycle. 2012 Feb 15;11(4):637-8. doi: 10.4161/cc.11.4.19330. No abstract available.

PMID:
22374662
25.

Instruction of mesenchymal cell fate by the transcription factor C/EBPβ.

Smink JJ, Leutz A.

Gene. 2012 Apr 10;497(1):10-7. doi: 10.1016/j.gene.2012.01.043. Epub 2012 Jan 30.

PMID:
22306325
26.

Circadian clocks in mouse and human CD4+ T cells.

Bollinger T, Leutz A, Leliavski A, Skrum L, Kovac J, Bonacina L, Benedict C, Lange T, Westermann J, Oster H, Solbach W.

PLoS One. 2011;6(12):e29801. doi: 10.1371/journal.pone.0029801. Epub 2011 Dec 28.

27.

Rapamycin inhibits osteoclast formation in giant cell tumor of bone through the C/EBPβ - MafB axis.

Smink JJ, Tunn PU, Leutz A.

J Mol Med (Berl). 2012 Jan;90(1):25-30. doi: 10.1007/s00109-011-0823-6. Epub 2011 Nov 10.

PMID:
22071989
28.

Tal1 regulates osteoclast differentiation through suppression of the master regulator of cell fusion DC-STAMP.

Courtial N, Smink JJ, Kuvardina ON, Leutz A, Göthert JR, Lausen J.

FASEB J. 2012 Feb;26(2):523-32. doi: 10.1096/fj.11-190850. Epub 2011 Oct 11.

PMID:
21990371
29.

Glycyrrhizin exerts antioxidative effects in H5N1 influenza A virus-infected cells and inhibits virus replication and pro-inflammatory gene expression.

Michaelis M, Geiler J, Naczk P, Sithisarn P, Leutz A, Doerr HW, Cinatl J Jr.

PLoS One. 2011;6(5):e19705. doi: 10.1371/journal.pone.0019705. Epub 2011 May 17.

30.

Eukaryotic initiation factor 2alpha phosphorylation is required for B-cell maturation and function in mice.

Mielke N, Schwarzer R, Calkhoven CF, Kaufman RJ, Dörken B, Leutz A, Jundt F.

Haematologica. 2011 Sep;96(9):1261-8. doi: 10.3324/haematol.2011.042853. Epub 2011 May 12.

31.

A differential proteome screening system for post-translational modification-dependent transcription factor interactions.

Pless O, Kowenz-Leutz E, Dittmar G, Leutz A.

Nat Protoc. 2011 Mar;6(3):359-64. doi: 10.1038/nprot.2011.303. Epub 2011 Feb 24.

PMID:
21372816
32.

Crosstalk between phosphorylation and multi-site arginine/lysine methylation in C/EBPs.

Leutz A, Pless O, Lappe M, Dittmar G, Kowenz-Leutz E.

Transcription. 2011 Jan-Feb;2(1):3-8. doi: 10.4161/trns.2.1.13510.

33.

Upstream open reading frames: molecular switches in (patho)physiology.

Wethmar K, Smink JJ, Leutz A.

Bioessays. 2010 Oct;32(10):885-93. doi: 10.1002/bies.201000037. Epub 2010 Aug 19. Review.

34.

Glycyrrhizin inhibits highly pathogenic H5N1 influenza A virus-induced pro-inflammatory cytokine and chemokine expression in human macrophages.

Michaelis M, Geiler J, Naczk P, Sithisarn P, Ogbomo H, Altenbrandt B, Leutz A, Doerr HW, Cinatl J Jr.

Med Microbiol Immunol. 2010 Nov;199(4):291-7. doi: 10.1007/s00430-010-0155-0. Epub 2010 Apr 13.

PMID:
20386921
35.

Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes.

Zaragoza K, Bégay V, Schuetz A, Heinemann U, Leutz A.

Mol Cell Biol. 2010 May;30(9):2293-304. doi: 10.1128/MCB.01619-09. Epub 2010 Feb 22.

36.

Crosstalk between C/EBPbeta phosphorylation, arginine methylation, and SWI/SNF/Mediator implies an indexing transcription factor code.

Kowenz-Leutz E, Pless O, Dittmar G, Knoblich M, Leutz A.

EMBO J. 2010 Mar 17;29(6):1105-15. doi: 10.1038/emboj.2010.3. Epub 2010 Jan 28.

37.

C/EBPbetaDeltauORF mice--a genetic model for uORF-mediated translational control in mammals.

Wethmar K, Bégay V, Smink JJ, Zaragoza K, Wiesenthal V, Dörken B, Calkhoven CF, Leutz A.

Genes Dev. 2010 Jan 1;24(1):15-20. doi: 10.1101/gad.557910.

38.

B cell to myeloid reprogramming by the transcription factor C/EBPβ.

Stoilova B, Kowenz-Leutz E, Scheller M, Leutz A.

J Stem Cells Regen Med. 2010 Oct 23;6(2):84. eCollection 2010. No abstract available.

PMID:
24693102
39.

Targets of the Tal1 transcription factor in erythrocytes: E2 ubiquitin conjugase regulation by Tal1.

Lausen J, Pless O, Leonard F, Kuvardina ON, Koch B, Leutz A.

J Biol Chem. 2010 Feb 19;285(8):5338-46. doi: 10.1074/jbc.M109.030296. Epub 2009 Dec 22.

40.

Rapamycin and the transcription factor C/EBPbeta as a switch in osteoclast differentiation: implications for lytic bone diseases.

Smink JJ, Leutz A.

J Mol Med (Berl). 2010 Mar;88(3):227-33. doi: 10.1007/s00109-009-0567-8. Epub 2009 Nov 27. Review.

41.

Measurement of cytotoxic T lymphocyte activity of human cytomegalovirus seropositive individuals by a highly sensitive coupled luminescent method.

Ogbomo H, Geiler J, Leutz A, von Kietzell K, Michaelis M, Doerr HW, Cinatl J Jr.

Med Microbiol Immunol. 2009 Nov;198(4):257-62. doi: 10.1007/s00430-009-0126-5. Epub 2009 Oct 8.

PMID:
19813020
42.

DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction.

Bröske AM, Vockentanz L, Kharazi S, Huska MR, Mancini E, Scheller M, Kuhl C, Enns A, Prinz M, Jaenisch R, Nerlov C, Leutz A, Andrade-Navarro MA, Jacobsen SE, Rosenbauer F.

Nat Genet. 2009 Nov;41(11):1207-15. doi: 10.1038/ng.463. Epub 2009 Oct 4.

PMID:
19801979
43.

N-acetyl-L-cysteine (NAC) inhibits virus replication and expression of pro-inflammatory molecules in A549 cells infected with highly pathogenic H5N1 influenza A virus.

Geiler J, Michaelis M, Naczk P, Leutz A, Langer K, Doerr HW, Cinatl J Jr.

Biochem Pharmacol. 2010 Feb 1;79(3):413-20. doi: 10.1016/j.bcp.2009.08.025. Epub 2009 Sep 2.

PMID:
19732754
44.

Measurements of HCV neutralizing antibodies and of HCV-specific CD4+ and CD8+ cells using hepatitis C virus pseudo-particles (HCVpp).

Berger A, Giroglou T, Leutz A, Ogbomo H, Pfaff K, Teuber G, Cinatl J, van Laer D, Doerr HW.

J Clin Virol. 2009 Sep;46(1):55-60. doi: 10.1016/j.jcv.2009.05.036. Epub 2009 Jun 26.

PMID:
19560398
45.

Transcription factor C/EBPbeta isoform ratio regulates osteoclastogenesis through MafB.

Smink JJ, Bégay V, Schoenmaker T, Sterneck E, de Vries TJ, Leutz A.

EMBO J. 2009 Jun 17;28(12):1769-81. doi: 10.1038/emboj.2009.127. Epub 2009 May 14.

46.

G9a-mediated lysine methylation alters the function of CCAAT/enhancer-binding protein-beta.

Pless O, Kowenz-Leutz E, Knoblich M, Lausen J, Beyermann M, Walsh MJ, Leutz A.

J Biol Chem. 2008 Sep 26;283(39):26357-63. doi: 10.1074/jbc.M802132200. Epub 2008 Jul 21.

47.

Early patterning of the chorion leads to the trilaminar trophoblast cell structure in the placental labyrinth.

Simmons DG, Natale DR, Begay V, Hughes M, Leutz A, Cross JC.

Development. 2008 Jun;135(12):2083-91. doi: 10.1242/dev.020099. Epub 2008 Apr 30.

48.

Long-term, multilineage hematopoiesis occurs in the combined absence of beta-catenin and gamma-catenin.

Jeannet G, Scheller M, Scarpellino L, Duboux S, Gardiol N, Back J, Kuttler F, Malanchi I, Birchmeier W, Leutz A, Huelsken J, Held W.

Blood. 2008 Jan 1;111(1):142-9. Epub 2007 Sep 28.

PMID:
17906078
49.

The c-Myb functions as a downstream target of PDGF-mediated survival signal in vascular smooth muscle cells.

Chen Y, Xu H, Liu J, Zhang C, Leutz A, Mo X.

Biochem Biophys Res Commun. 2007 Aug 24;360(2):433-6. Epub 2007 Jun 21.

PMID:
17599807
50.

Analysis of translation initiation using a translation control reporter system.

Wiesenthal V, Leutz A, Calkhoven CF.

Nat Protoc. 2006;1(3):1531-7.

PMID:
17406445

Supplemental Content

Support Center